Q9VT28 (FRY_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein furry

Gene names

Name:	fry
ORF Names:	CG32045

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	3479 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity. Ref.1 Ref.5
Tissue specificity	Co-expressed with trc in all da neurons in third instar wild-type larvae; axons and dendritic branches. Ref.5
Developmental stage	Expression is very low in embryonic and early larval stages, increases to be high from third larval instar to adults. Ref.1
Disruption phenotype	Flies exhibit branched arista laterals, branched bristles and a strong multiple hair cell phenotype that consists of clusters of epidermal hairs and branched hairs. Dendrites of fry and trc mutants display excessive terminal branching. Branched laterals in mutant pupae arista are due to the splitting of individual laterals during elongation and abnormally shaped actin bundles. Ref.1
Sequence similarities	Belongs to the furry protein family.
Sequence caution	The sequence AAL40005.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antennal morphogenesis Inferred from mutant phenotype. Source: FlyBase chaeta morphogenesis Inferred from mutant phenotype Ref.1. Source: FlyBase imaginal disc-derived wing hair organization Inferred from genetic interaction. Source: FlyBase oocyte morphogenesis Inferred from direct assay. Source: FlyBase positive regulation of protein kinase activity Inferred from mutant phenotype Ref.5. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from mutant phenotype Ref.5. Source: UniProtKB regulation of dendrite morphogenesis Inferred from mutant phenotype Ref.5. Source: FlyBase rhabdomere development Inferred from mutant phenotype. Source: FlyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell cortex Inferred from direct assay. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform B Ref.1 (identifier: Q9VT28-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform D Ref.1 (identifier: Q9VT28-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1624-1629: EDDKVG → GMRFSY
     1630-3479: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3479	3479	Protein furry		PRO_0000282939
Regions
	Compositional bias	174 – 202	29	Gln-rich
Amino acid modifications
	Modified residue	129	1	Phosphoserine Ref.6
	Modified residue	1838	1	Phosphoserine Ref.6
	Modified residue	1841	1	Phosphoserine Ref.6
	Modified residue	2357	1	Phosphoserine Ref.6
	Modified residue	2842	1	Phosphothreonine Ref.6
	Modified residue	2845	1	Phosphoserine Ref.6
	Modified residue	2851	1	Phosphoserine Ref.6
	Modified residue	2853	1	Phosphoserine Ref.6
	Modified residue	2999	1	Phosphoserine Ref.6
	Modified residue	3001	1	Phosphoserine Ref.6
	Modified residue	3004	1	Phosphothreonine Ref.6
	Modified residue	3018	1	Phosphoserine Ref.6
	Modified residue	3019	1	Phosphoserine Ref.6
	Modified residue	3025	1	Phosphoserine Ref.6
	Modified residue	3027	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1624 – 1629	6	EDDKVG → GMRFSY in isoform D. Ref.1		VSP_052372
	Alternative sequence	1630 – 3479	1850	Missing in isoform D. Ref.1		VSP_052373
Experimental info
	Sequence conflict	170	1	E → V in AAG41424. Ref.1
	Sequence conflict	170	1	E → V in AAK37558. Ref.1
	Sequence conflict	1876	1	M → I in AAG41424. Ref.1
	Sequence conflict	1933	1	I → L in AAG41424. Ref.1
	Sequence conflict	2530	1	T → I in AAG41424. Ref.1
	Sequence conflict	3375	1	I → V in AAL40005. Ref.4
	Sequence conflict	3403	1	I → M in AAL40005. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform B (Long) [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 281389C02117A0CF	FASTA	3,479	384,352
	10 20 30 40 50 60 MDQLELQDDL FGLEAGVAGT NQNPNEQHLS DPAASPSTSS PANNNATAGA ATTSTATVIT 70 80 90 100 110 120 AVGGAGGGVA AAGVGVVTPT KSPQRNAFQE DAYQANLAGG DSVDNIESAQ LDGGNPSGGS 130 140 150 160 170 180 PGQRHSINSA EYTSTPKTTR SGPNGSTTAS GTTSPINYQL PGDDYPYGIE YESQQLLYQQ 190 200 210 220 230 240 QQQQQQQQSQ QQQQQQQQQQ QQLPVGDVEQ SSAVTYQSLP VSRQSYASPP ALIIPQRQSL 250 260 270 280 290 300 LPWGAHSRSS IINVLPSYTQ AEMHALAARV ASVETSAPRP GEIVMRNLFS DFTAQAEKKI 310 320 330 340 350 360 ELVMLESADK NLSKLLQRGE DQQFDQLLSA LGSVAEHCLP SLLHTLLAWH RRQLSDMEIK 370 380 390 400 410 420 NDLKKPAPSG SSSQAATNKP TVDLDFQLQR REAAVEFIFC LALIEILKQL PYHPGHEDLV 430 440 450 460 470 480 RSIENLAFKH FKYKDGLQNN PNALNIHMIA DLYAEVIGVL AQSRFASVRK RFMSELKELR 490 500 510 520 530 540 GKEVSPTTTQ SIISLLMGMK FFRVKMVPIE EFEASFQFMH ECGQYFLEVK DKDIKHALAG 550 560 570 580 590 600 LFVEILVPVA AAVKNEVNVP CVKNFVELLY VQTLDASTKS KHRLALFPLV TCLLCVSQKT 610 620 630 640 650 660 FFLTNWHYFL AMCLSNLKNR DAKMSRVALE SLFRLLWVYM IRIKCESNSA THSRLQSIVN 670 680 690 700 710 720 SLFPKGSKGV VPRDTPLNIF VKIIQFIAQE RLDFAMREIV YDLLCVGRSI KLILNPERMS 730 740 750 760 770 780 IGLRAFLVVA DSLQQKAGEP PMPRTVPVLP SGNTLRVKKT FNKMYVLLTD DTARSIGMST 790 800 810 820 830 840 YFPHVRRVFV DILRALDVHY GRPLMMTNTQ NQNKEPDEML SGERKPRIDL FRTCVAAVPR 850 860 870 880 890 900 LIPDTMTPHE LVDMLSRLSV HMDEELRILT HQSLTTLVID FPDWRQDVVH GYTQFLVRDV 910 920 930 940 950 960 TDTYPQLLEN CTRILFTFLN IWRCATNVNG NNTTSAPSGA TNVVNTSQAK MTTATTTTTV 970 980 990 1000 1010 1020 VQATVVQVTS APAKDTASSQ LSKQQHLNTA SSAASSITTS SGMSSITQHT VLNMASDVGK 1030 1040 1050 1060 1070 1080 KNEIPLATTL HFVEGFALVL LCNYRTYLRK LAALILKEVK NLMRALGIPE TEPPLIDVMD 1090 1100 1110 1120 1130 1140 RCVPGIIEKC LPQLPQTEKT AILNANCIDL QWIAERSSGV WLAGLTDDNS KSSTSTLNLS 1150 1160 1170 1180 1190 1200 QSSSTPNASA TAASSPQLPF DPWATCLFGL LERQNVLQQC PSAVAQAWPI CFTRLNALYS 1210 1220 1230 1240 1250 1260 VIDPTPVSDN RASLLRSSAP TKKVPTESQK DSYLRLWRNQ VACAMRLVPQ IPSVAVRCAS 1270 1280 1290 1300 1310 1320 PDLSLSSSPD SLNADRSDKS AMGSASPQAL YKLVVPLLRC EVVDVRDAAV NALGLINHDA 1330 1340 1350 1360 1370 1380 LKDLMEELVV YIREAVDCKQ ENMRRRRRRD ALRLQVVRVL EKIAENGTFG VSTCVLERDT 1390 1400 1410 1420 1430 1440 MSLHPTFVLY ISGAMGYLTS ETDKDNLSIR EVKAHFCNFI RKMIKNFPLE ACATLLSRVL 1450 1460 1470 1480 1490 1500 KRNLFNLFAA WCGSFSKPLG YTMQSDHTLE EEKLQFSALQ AMSALLCCGQ IFNPSYLQDD 1510 1520 1530 1540 1550 1560 SIIYKWLDML LTSKNEKIYQ LARDTVVLLL ESNPDIGQLL EWVIDRCYTS TPREADACFL 1570 1580 1590 1600 1610 1620 ALASIFSAKE YPCDHYTSVI TVTLLMTGCP RVEVHATALQ LLQILDKRFF GSVVGTLHSD 1630 1640 1650 1660 1670 1680 SDKEDDKVGT LDVLLSSAYC RSQRFLSKQL AQLRPELTMS IFSEITHRFQ SAREDVRALL 1690 1700 1710 1720 1730 1740 LQCLLPWLQN MELVATSVPP ATPLSYIMYF PDSGTRGRRE GTGSTEATEM ILNNLFYITA 1750 1760 1770 1780 1790 1800 KFSDAHPRDI EELWGTLCQF WPNNLKVILR YLVIMSGMAP TELLPYAKRV ALYLVRSCPD 1810 1820 1830 1840 1850 1860 RLLDELMAEL QTVETLNCLI ERTETPPFYR LTSMRKASSH SADGQAAGGI NDSRIQDLAV 1870 1880 1890 1900 1910 1920 EKGTIHTKRH SGEDPMKIGT CKSDSGIRAY TQAAAAAAAA AVTPGSSGNR PPRGADKIRA 1930 1940 1950 1960 1970 1980 ASGPSILPRP EDILINDPEL RQEENVELRG TSDAAPNGHP HPLPMPEYGG YFAPLTEFLP 1990 2000 2010 2020 2030 2040 DVSLPISGFH RCNVAVMLLT DIVVDGIPGI DWTLHLPLML HILFLGLDHT RIIVREHCKQ 2050 2060 2070 2080 2090 2100 LCVNLLIVLA EHNDHLTVAR ILLNSETSKL DLGLTVPALP VIDNNFTELH QQFDSYLLHV 2110 2120 2130 2140 2150 2160 SPQAAAYALQ HNLSSSTIIA AHHQNLSQTP QSQQQTGSQN GQTTTPPGLT ATPAALQINP 2170 2180 2190 2200 2210 2220 NNSENSEVPL IHPDEHAPPQ PGPSMPIAHV IKSLLKFLAQ DTCQPLWNYE DITAKVWAVK 2230 2240 2250 2260 2270 2280 SAEQLSCFLK HMVKVFADSY PQARIAERWA QTALQLGLSC SSRHYAGRCL QIFRALNVPI 2290 2300 2310 2320 2330 2340 NSRMLSDILS RLVETVAEQG EDMQGYVTEL LLTLEAAVDS LDSDFRPLDV MKDIFKSTPN 2350 2360 2370 2380 2390 2400 LNNKDGGPNS ILPGKKSPSG MTPQSSNYSI PSHGRSTSYS VSYCGRKANN SPCDKQVELR 2410 2420 2430 2440 2450 2460 NRSSGIDLER SVVCKFGVGG GGAGSALSRS RSAQSLKMLG DTATQDDKMT ILAQLFWLSV 2470 2480 2490 2500 2510 2520 SLLESDYEHE FMLALRLLTR VLHRLPLDRP DARDKVEKLQ QQLKWTAYPG VHALLLKGCT 2530 2540 2550 2560 2570 2580 HSATYEPTIT LLSQFAPLLT LPVCDPTQSC AFPMNVIALL PYMLLHYEDA NEICIRSAEN 2590 2600 2610 2620 2630 2640 IAQVSTELGA KLENLGTVMT LYSRKTFCKE SFQWTKCVVK YLHDTYAHMG LHMVAFLIEV 2650 2660 2670 2680 2690 2700 LEKGPQQVQV PVLNVIHCML HYVDLSAPQA QSINADLLRA IGKYLDTAYW KDSLKILKLI 2710 2720 2730 2740 2750 2760 VTRSSSLQVV PPSDGSSAGL SFSFYGAYPD SDMFCKKELA GRTMEFTFDV SQTPLIGRRI 2770 2780 2790 2800 2810 2820 LLKTEEPVAG GAVSTTGSSS LNSTLTNATT VTVAPSAAQQ QTNVQMQQQR ANTNVAALAA 2830 2840 2850 2860 2870 2880 AAAAQHQQQQ HAIGAGSSVV GTPNSPRRSA SLSPADTVPL SGWKRPWMSQ CRVRECLVNL 2890 2900 2910 2920 2930 2940 LTTCGQRVGL PKSPSVIFSQ SSDLMERQSS AASSTEETSG PQGDLSSGSR RDDGQPDFTV 2950 2960 2970 2980 2990 3000 FKDFDFLEYE DSIAGESTDN FNWGVRRHQL FEGDEDRLNC GSGIGGSIKG GHSSAFEDSF 3010 3020 3030 3040 3050 3060 SDKTPILSKR KRQIADDSSD EEAESESPLD EDHRQSFLKS GYSAVPPTSL SLRERRRRNS 3070 3080 3090 3100 3110 3120 VSRSDTSGSS AGDLGDLTPC NASPHLPGII RFSAAIHDEA EENWRRQVQA LLVNQPSAHT 3130 3140 3150 3160 3170 3180 SELLQQLYRL IKELTFKTVN ISKEAKKFFT GIGSQLGNRI SLFTDLLSSR ADPPQVWCSE 3190 3200 3210 3220 3230 3240 LQATSPKLFE TLRFNVLEVQ EHLETFFDRK DQVLECLDAV KTSCKLSLFN EADVAASGLE 3250 3260 3270 3280 3290 3300 LPSTSSIVYM PFDPASTEVV LDLGRSLYKL MFQLLLLIES NHKISSNVVN HFRMNEDMHD 3310 3320 3330 3340 3350 3360 ISDLYALVRD ALVRYISEAE LDCLESSTST EGEHTPTPSP GLPMTPEEFE AVLTEHIDLQ 3370 3380 3390 3400 3410 3420 RWPSAIAHVR QYRRISTLNA SGYQNVTIFS YNSADNRQKW DEISVILNAY AHGIMKDRTE 3430 3440 3450 3460 3470 AFIVSKSDSE VFEIYAILSE NLYQVSSALT NMEISMKSYS AGSASGNSHR SEQDIVTNL
	Isoform D (Short) [UniParc]. Checksum: 8447BDC5C3BF75D2	FASTA	1,629	180,448
	10 20 30 40 50 60 MDQLELQDDL FGLEAGVAGT NQNPNEQHLS DPAASPSTSS PANNNATAGA ATTSTATVIT 70 80 90 100 110 120 AVGGAGGGVA AAGVGVVTPT KSPQRNAFQE DAYQANLAGG DSVDNIESAQ LDGGNPSGGS 130 140 150 160 170 180 PGQRHSINSA EYTSTPKTTR SGPNGSTTAS GTTSPINYQL PGDDYPYGIE YESQQLLYQQ 190 200 210 220 230 240 QQQQQQQQSQ QQQQQQQQQQ QQLPVGDVEQ SSAVTYQSLP VSRQSYASPP ALIIPQRQSL 250 260 270 280 290 300 LPWGAHSRSS IINVLPSYTQ AEMHALAARV ASVETSAPRP GEIVMRNLFS DFTAQAEKKI 310 320 330 340 350 360 ELVMLESADK NLSKLLQRGE DQQFDQLLSA LGSVAEHCLP SLLHTLLAWH RRQLSDMEIK 370 380 390 400 410 420 NDLKKPAPSG SSSQAATNKP TVDLDFQLQR REAAVEFIFC LALIEILKQL PYHPGHEDLV 430 440 450 460 470 480 RSIENLAFKH FKYKDGLQNN PNALNIHMIA DLYAEVIGVL AQSRFASVRK RFMSELKELR 490 500 510 520 530 540 GKEVSPTTTQ SIISLLMGMK FFRVKMVPIE EFEASFQFMH ECGQYFLEVK DKDIKHALAG 550 560 570 580 590 600 LFVEILVPVA AAVKNEVNVP CVKNFVELLY VQTLDASTKS KHRLALFPLV TCLLCVSQKT 610 620 630 640 650 660 FFLTNWHYFL AMCLSNLKNR DAKMSRVALE SLFRLLWVYM IRIKCESNSA THSRLQSIVN 670 680 690 700 710 720 SLFPKGSKGV VPRDTPLNIF VKIIQFIAQE RLDFAMREIV YDLLCVGRSI KLILNPERMS 730 740 750 760 770 780 IGLRAFLVVA DSLQQKAGEP PMPRTVPVLP SGNTLRVKKT FNKMYVLLTD DTARSIGMST 790 800 810 820 830 840 YFPHVRRVFV DILRALDVHY GRPLMMTNTQ NQNKEPDEML SGERKPRIDL FRTCVAAVPR 850 860 870 880 890 900 LIPDTMTPHE LVDMLSRLSV HMDEELRILT HQSLTTLVID FPDWRQDVVH GYTQFLVRDV 910 920 930 940 950 960 TDTYPQLLEN CTRILFTFLN IWRCATNVNG NNTTSAPSGA TNVVNTSQAK MTTATTTTTV 970 980 990 1000 1010 1020 VQATVVQVTS APAKDTASSQ LSKQQHLNTA SSAASSITTS SGMSSITQHT VLNMASDVGK 1030 1040 1050 1060 1070 1080 KNEIPLATTL HFVEGFALVL LCNYRTYLRK LAALILKEVK NLMRALGIPE TEPPLIDVMD 1090 1100 1110 1120 1130 1140 RCVPGIIEKC LPQLPQTEKT AILNANCIDL QWIAERSSGV WLAGLTDDNS KSSTSTLNLS 1150 1160 1170 1180 1190 1200 QSSSTPNASA TAASSPQLPF DPWATCLFGL LERQNVLQQC PSAVAQAWPI CFTRLNALYS 1210 1220 1230 1240 1250 1260 VIDPTPVSDN RASLLRSSAP TKKVPTESQK DSYLRLWRNQ VACAMRLVPQ IPSVAVRCAS 1270 1280 1290 1300 1310 1320 PDLSLSSSPD SLNADRSDKS AMGSASPQAL YKLVVPLLRC EVVDVRDAAV NALGLINHDA 1330 1340 1350 1360 1370 1380 LKDLMEELVV YIREAVDCKQ ENMRRRRRRD ALRLQVVRVL EKIAENGTFG VSTCVLERDT 1390 1400 1410 1420 1430 1440 MSLHPTFVLY ISGAMGYLTS ETDKDNLSIR EVKAHFCNFI RKMIKNFPLE ACATLLSRVL 1450 1460 1470 1480 1490 1500 KRNLFNLFAA WCGSFSKPLG YTMQSDHTLE EEKLQFSALQ AMSALLCCGQ IFNPSYLQDD 1510 1520 1530 1540 1550 1560 SIIYKWLDML LTSKNEKIYQ LARDTVVLLL ESNPDIGQLL EWVIDRCYTS TPREADACFL 1570 1580 1590 1600 1610 1620 ALASIFSAKE YPCDHYTSVI TVTLLMTGCP RVEVHATALQ LLQILDKRFF GSVVGTLHSD SDKGMRFSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis." Cong J., Geng W., He B., Liu J., Charlton J., Adler P.N. Development 128:2793-2802(2001) [PubMed: 11526084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND D), FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE. Tissue: Imaginal disk.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2555-3479. Strain: Berkeley. Tissue: Embryo.
[5]	"Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons." Emoto K., He Y., Ye B., Grueber W.B., Adler P.N., Jan L.Y., Jan Y.-N. Cell 119:245-256(2004) [PubMed: 15479641] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129; SER-1838; SER-1841; SER-2357; THR-2842; SER-2845; SER-2851; SER-2853; SER-2999; SER-3001; THR-3004; SER-3018; SER-3019; SER-3025 AND SER-3027, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF310159 mRNA. Translation: AAG41424.1. AF351187 mRNA. Translation: AAK37558.1. AE014296 Genomic DNA. Translation: AAF50228.2. AE014296 Genomic DNA. Translation: ABI31247.1. AY069860 mRNA. Translation: AAL40005.1. Different initiation.
RefSeq	NP_001036598.1. NM_001043133.2. NP_729520.1. NM_168357.3.
UniGene	Dm.1919.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VT28. 16 interactions.
STRING	Q9VT28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0076417; FBpp0076146; FBgn0016081.
GeneID	39122.
KEGG	dme:Dmel_CG32045.
NMPDR	fig|7227.3.peg.9107.
Organism-specific databases
CTD	10129.
FlyBase	FBgn0016081. fry.
Phylogenomic databases
eggNOG	inNOG07816.
GeneTree	EMGT00050000008452.
InParanoid	Q9VT28.
OMA	VEREFAM.
OrthoDB	EOG4573NC.
PhylomeDB	Q9VT28.
Gene expression databases
Bgee	Q9VT28.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	812033.

Entry information

Entry name

FRY_DROME

Accession

Primary (citable) accession number: Q9VT28
Secondary accession number(s): Q0E8G4 , Q8T9A1, Q9BIR5, Q9GPT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project