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Protein
Submitted name:

Nervous wreck, isoform D

Gene

nwk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • neuromuscular synaptic transmission Source: FlyBase
  • receptor recycling Source: FlyBase
  • regulation of actin filament polymerization Source: FlyBase
  • regulation of synaptic growth at neuromuscular junction Source: FlyBase

Names & Taxonomyi

Protein namesi
Submitted name:
Nervous wreck, isoform DImported
Submitted name:
Nervous wreck, isoform GImported
Gene namesi
Name:nwkImported
Synonyms:CG4641Imported, CG4684Imported, Dmel\CG43479Imported, NWKImported, NwkImported
ORF Names:CG43479Imported, Dmel_CG43479Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0263456 nwk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9VSU8

Expressioni

Gene expression databases

BgeeiFBgn0263456
ExpressionAtlasiQ9VSU8 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WASpQ9VAT03EBI-167691,EBI-132019

Protein-protein interaction databases

IntActiQ9VSU8, 1 interactor
STRINGi7227.FBpp0301205

Structurei

3D structure databases

SMRiQ9VSU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 289F-BARInterPro annotationAdd BLAST279
Domaini542 – 603SH3InterPro annotationAdd BLAST62
Domaini658 – 721SH3InterPro annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 210Sequence analysisAdd BLAST21
Coiled coili382 – 402Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
OrthoDBiEOG091G02AL

Family and domain databases

CDDicd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

Q9VSU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE
60 70 80 90 100
KSYSESLLKI SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL
110 120 130 140 150
ARARLAAIEV FQQQIADEAK VLRDYKLAIA KRSLAGIVNV QKELHLSVGD
160 170 180 190 200
VDKTKKSYFD EEHCAHDVRD KARDIEEKLK KKKGSFFQSI TSLQKNSARV
210 220 230 240 250
TSRKELLEEK SSGARNDYVL SLAAANAHQN RYFTVDLQTT MTTMENYVFE
260 270 280 290 300
RVAEYLMLMG RTELLTCSAT QNSFGKIRDQ AQQLTREYNL QCCYLFYPVL
310 320 330 340 350
KQHIQYDFEA CDNDPVRKVT AEHESAAETL TKEAKNLAGR VVKENASIRE
360 370 380 390 400
NAKKLALCQS LRDSGQRTDP NDPNGPDLDT KIEEFRDQIR RSETEKTKAE
410 420 430 440 450
ACLQCLRDGG INVDEWVQEA ENMGVQELTR SASSISMRTD ASGQGENPSS
460 470 480 490 500
DSFYDSDKEE TQAAAQTKPK QEQQLSRDRT FSDSEDEPEV RPSAAAASSA
510 520 530 540 550
AAASSSMMAS SAGGWDDPTE VNWGAGEEED DKDEPIVPEP KEAIFKCTAL
560 570 580 590 600
YSYTAQNPDE LTIVENEQLE VVGEGDGDGW LRARNYRGEE GYVPHNYLDI
610 620 630 640 650
DQETAGSAFN GTSGNQLRSQ ISFSSVDYTV DNEDQTVDSM QSPDQVSVIM
660 670 680 690 700
APQKRVKSDV EWCIALYDYD ATAEDELTFE EGDKIKIITK TAHGVDDGWW
710 720 730 740 750
EGELDGKFGN FPSLVVEECD EMGEPLSEGG DESPPPTAAP TFALPPAPAL
760 770 780 790 800
PPEYAHELEL ELTEDMFGSQ DTADEDSGYI PNGAAAPSIP PPVLIQEPGM
810 820 830 840 850
EDDLSDDGQP PPSLPPPQLA KAGGSAPGSG SKVEKGAAAG GANTLNLGMA
860 870 880 890 900
QIIVTAATPM VEDGADKSFP PVGESDAQPV EPVSKEQPAE VAKKPDIAPK
910 920 930 940 950
PLAKVAPQSA PAKEGNAGVR PVVSITLTEY PSCDAEDQQS FSEGTDSASV
960 970 980 990 1000
ADVPVLQDAE DPFNEKAKGE SGDGSGFEAN FEANFDANFD DAFAGIGGGG
1010 1020 1030 1040 1050
GGGGGGGEQS NELDINGEAA GEAIVSGSAA GDEDIEAPKQ VVGGRASIPE
1060
ELDSNQLARL QNLKESNA
Length:1,068
Mass (Da):116,237
Last modified:June 26, 2013 - v3
Checksum:iDE874B587D6FE903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50313.4
AE014296 Genomic DNA Translation: AFH04362.1
RefSeqiNP_001246691.1, NM_001259762.2
NP_648290.3, NM_140033.3
UniGeneiDm.3847

Genome annotation databases

EnsemblMetazoaiFBtr0309278; FBpp0301205; FBgn0263456
FBtr0331857; FBpp0304241; FBgn0263456
GeneIDi39052
UCSCiCG4684-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VSU8_DROME
AccessioniPrimary (citable) accession number: Q9VSU8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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