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Protein
Submitted name:

Nervous wreck, isoform D

Gene

nwk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phospholipid binding Source: FlyBase

GO - Biological processi

  1. negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  2. neuromuscular synaptic transmission Source: FlyBase
  3. receptor recycling Source: FlyBase
  4. regulation of actin filament polymerization Source: FlyBase
  5. regulation of BMP signaling pathway Source: FlyBase
  6. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  7. regulation of Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nervous wreck, isoform DImported
Submitted name:
Nervous wreck, isoform GImported
Gene namesi
Name:nwkImported
ORF Names:CG43479Imported, Dmel_CG43479Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0263456. nwk.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. neuromuscular junction Source: FlyBase
  3. recycling endosome Source: FlyBase
Complete GO annotation...

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WASpQ9VAT03EBI-167691,EBI-132019

Protein-protein interaction databases

STRINGi7227.FBpp0076259.

Family & Domainsi

Sequence similaritiesi

Contains 2 SH3 domains.UniRule annotation
Contains F-BAR domain.SAAS annotation

Keywords - Domaini

Coiled coilSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00510000046732.
OMAiGVNVDEW.
OrthoDBiEOG722J81.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VSU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE
60 70 80 90 100
KSYSESLLKI SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL
110 120 130 140 150
ARARLAAIEV FQQQIADEAK VLRDYKLAIA KRSLAGIVNV QKELHLSVGD
160 170 180 190 200
VDKTKKSYFD EEHCAHDVRD KARDIEEKLK KKKGSFFQSI TSLQKNSARV
210 220 230 240 250
TSRKELLEEK SSGARNDYVL SLAAANAHQN RYFTVDLQTT MTTMENYVFE
260 270 280 290 300
RVAEYLMLMG RTELLTCSAT QNSFGKIRDQ AQQLTREYNL QCCYLFYPVL
310 320 330 340 350
KQHIQYDFEA CDNDPVRKVT AEHESAAETL TKEAKNLAGR VVKENASIRE
360 370 380 390 400
NAKKLALCQS LRDSGQRTDP NDPNGPDLDT KIEEFRDQIR RSETEKTKAE
410 420 430 440 450
ACLQCLRDGG INVDEWVQEA ENMGVQELTR SASSISMRTD ASGQGENPSS
460 470 480 490 500
DSFYDSDKEE TQAAAQTKPK QEQQLSRDRT FSDSEDEPEV RPSAAAASSA
510 520 530 540 550
AAASSSMMAS SAGGWDDPTE VNWGAGEEED DKDEPIVPEP KEAIFKCTAL
560 570 580 590 600
YSYTAQNPDE LTIVENEQLE VVGEGDGDGW LRARNYRGEE GYVPHNYLDI
610 620 630 640 650
DQETAGSAFN GTSGNQLRSQ ISFSSVDYTV DNEDQTVDSM QSPDQVSVIM
660 670 680 690 700
APQKRVKSDV EWCIALYDYD ATAEDELTFE EGDKIKIITK TAHGVDDGWW
710 720 730 740 750
EGELDGKFGN FPSLVVEECD EMGEPLSEGG DESPPPTAAP TFALPPAPAL
760 770 780 790 800
PPEYAHELEL ELTEDMFGSQ DTADEDSGYI PNGAAAPSIP PPVLIQEPGM
810 820 830 840 850
EDDLSDDGQP PPSLPPPQLA KAGGSAPGSG SKVEKGAAAG GANTLNLGMA
860 870 880 890 900
QIIVTAATPM VEDGADKSFP PVGESDAQPV EPVSKEQPAE VAKKPDIAPK
910 920 930 940 950
PLAKVAPQSA PAKEGNAGVR PVVSITLTEY PSCDAEDQQS FSEGTDSASV
960 970 980 990 1000
ADVPVLQDAE DPFNEKAKGE SGDGSGFEAN FEANFDANFD DAFAGIGGGG
1010 1020 1030 1040 1050
GGGGGGGEQS NELDINGEAA GEAIVSGSAA GDEDIEAPKQ VVGGRASIPE
1060
ELDSNQLARL QNLKESNA
Length:1,068
Mass (Da):116,237
Last modified:June 26, 2013 - v3
Checksum:iDE874B587D6FE903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50313.4.
AE014296 Genomic DNA. Translation: AFH04362.1.
RefSeqiNP_001246691.1. NM_001259762.2.
NP_648290.3. NM_140033.3.
UniGeneiDm.3847.

Genome annotation databases

EnsemblMetazoaiFBtr0309278; FBpp0301205; FBgn0263456.
FBtr0331857; FBpp0304241; FBgn0263456.
GeneIDi39052.
KEGGidme:Dmel_CG43479.
UCSCiCG4684-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50313.4.
AE014296 Genomic DNA. Translation: AFH04362.1.
RefSeqiNP_001246691.1. NM_001259762.2.
NP_648290.3. NM_140033.3.
UniGeneiDm.3847.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0076259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0309278; FBpp0301205; FBgn0263456.
FBtr0331857; FBpp0304241; FBgn0263456.
GeneIDi39052.
KEGGidme:Dmel_CG43479.
UCSCiCG4684-RA. d. melanogaster.

Organism-specific databases

CTDi39052.
FlyBaseiFBgn0263456. nwk.

Phylogenomic databases

GeneTreeiENSGT00510000046732.
OMAiGVNVDEW.
OrthoDBiEOG722J81.

Miscellaneous databases

GenomeRNAii39052.
NextBioi811678.
PROiQ9VSU8.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VSU8_DROME
AccessioniPrimary (citable) accession number: Q9VSU8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: April 29, 2015
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.