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Q9VSU8

- Q9VSU8_DROME

UniProt

Q9VSU8 - Q9VSU8_DROME

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Protein
Submitted name: Nervous wreck, isoform D
Gene
nwk, CG4684, Dmel_CG43479
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phospholipid binding Source: FlyBase
  2. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  2. neuromuscular synaptic transmission Source: FlyBase
  3. regulation of actin filament polymerization Source: FlyBase
  4. regulation of synaptic growth at neuromuscular junction Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9VSU8.

Names & Taxonomyi

Protein namesi
Submitted name:
Nervous wreck, isoform DImported
Submitted name:
Nervous wreck, isoform GImported
Gene namesi
Name:nwkImported
ORF Names:CG4684Imported, Dmel_CG43479Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0263456. nwk.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. recycling endosome Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9VSU8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WASpQ9VAT03EBI-167691,EBI-132019

Protein-protein interaction databases

STRINGi7227.FBpp0076259.

Family & Domainsi

Sequence similaritiesi

Contains 2 SH3 domains.UniRule annotation
Contains FCH domain.SAAS annotations

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00510000046732.
InParanoidiQ9VSU8.
OMAiGVNVDEW.
OrthoDBiEOG722J81.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VSU8-1 [UniParc]FASTAAdd to Basket

« Hide

MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE     50
KSYSESLLKI SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL 100
ARARLAAIEV FQQQIADEAK VLRDYKLAIA KRSLAGIVNV QKELHLSVGD 150
VDKTKKSYFD EEHCAHDVRD KARDIEEKLK KKKGSFFQSI TSLQKNSARV 200
TSRKELLEEK SSGARNDYVL SLAAANAHQN RYFTVDLQTT MTTMENYVFE 250
RVAEYLMLMG RTELLTCSAT QNSFGKIRDQ AQQLTREYNL QCCYLFYPVL 300
KQHIQYDFEA CDNDPVRKVT AEHESAAETL TKEAKNLAGR VVKENASIRE 350
NAKKLALCQS LRDSGQRTDP NDPNGPDLDT KIEEFRDQIR RSETEKTKAE 400
ACLQCLRDGG INVDEWVQEA ENMGVQELTR SASSISMRTD ASGQGENPSS 450
DSFYDSDKEE TQAAAQTKPK QEQQLSRDRT FSDSEDEPEV RPSAAAASSA 500
AAASSSMMAS SAGGWDDPTE VNWGAGEEED DKDEPIVPEP KEAIFKCTAL 550
YSYTAQNPDE LTIVENEQLE VVGEGDGDGW LRARNYRGEE GYVPHNYLDI 600
DQETAGSAFN GTSGNQLRSQ ISFSSVDYTV DNEDQTVDSM QSPDQVSVIM 650
APQKRVKSDV EWCIALYDYD ATAEDELTFE EGDKIKIITK TAHGVDDGWW 700
EGELDGKFGN FPSLVVEECD EMGEPLSEGG DESPPPTAAP TFALPPAPAL 750
PPEYAHELEL ELTEDMFGSQ DTADEDSGYI PNGAAAPSIP PPVLIQEPGM 800
EDDLSDDGQP PPSLPPPQLA KAGGSAPGSG SKVEKGAAAG GANTLNLGMA 850
QIIVTAATPM VEDGADKSFP PVGESDAQPV EPVSKEQPAE VAKKPDIAPK 900
PLAKVAPQSA PAKEGNAGVR PVVSITLTEY PSCDAEDQQS FSEGTDSASV 950
ADVPVLQDAE DPFNEKAKGE SGDGSGFEAN FEANFDANFD DAFAGIGGGG 1000
GGGGGGGEQS NELDINGEAA GEAIVSGSAA GDEDIEAPKQ VVGGRASIPE 1050
ELDSNQLARL QNLKESNA 1068
Length:1,068
Mass (Da):116,237
Last modified:June 26, 2013 - v3
Checksum:iDE874B587D6FE903
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF50313.4.
AE014296 Genomic DNA. Translation: AFH04362.1.
RefSeqiNP_001246691.1. NM_001259762.2.
NP_648290.3. NM_140033.3.
UniGeneiDm.3847.

Genome annotation databases

EnsemblMetazoaiFBtr0309278; FBpp0301205; FBgn0263456.
FBtr0331857; FBpp0304241; FBgn0263456.
GeneIDi39052.
KEGGidme:Dmel_CG43479.
UCSCiCG4684-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF50313.4 .
AE014296 Genomic DNA. Translation: AFH04362.1 .
RefSeqi NP_001246691.1. NM_001259762.2.
NP_648290.3. NM_140033.3.
UniGenei Dm.3847.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0076259.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0309278 ; FBpp0301205 ; FBgn0263456 .
FBtr0331857 ; FBpp0304241 ; FBgn0263456 .
GeneIDi 39052.
KEGGi dme:Dmel_CG43479.
UCSCi CG4684-RA. d. melanogaster.

Organism-specific databases

CTDi 39052.
FlyBasei FBgn0263456. nwk.

Phylogenomic databases

GeneTreei ENSGT00510000046732.
InParanoidi Q9VSU8.
OMAi GVNVDEW.
OrthoDBi EOG722J81.

Enzyme and pathway databases

SignaLinki Q9VSU8.

Miscellaneous databases

GenomeRNAii 39052.
NextBioi 811678.
PROi Q9VSU8.

Gene expression databases

Bgeei Q9VSU8.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  11. FlyBase
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VSU8_DROME
AccessioniPrimary (citable) accession number: Q9VSU8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: June 11, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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