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Protein

Zinc transporter foi

Gene

foi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells.3 Publications

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: FlyBase

GO - Biological processi

  • branch fusion, open tracheal system Source: FlyBase
  • cell differentiation Source: UniProtKB-KW
  • cell migration Source: UniProtKB
  • cellular zinc ion homeostasis Source: GO_Central
  • central nervous system development Source: FlyBase
  • germ cell migration Source: FlyBase
  • gonadal mesoderm development Source: FlyBase
  • gonad development Source: FlyBase
  • gonad morphogenesis Source: FlyBase
  • pole cell migration Source: FlyBase
  • zinc II ion transmembrane import Source: GO_Central
  • zinc II ion transport Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Ion transport, Neurogenesis, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-DME-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

TCDBi2.A.5.4.16 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter foi
Alternative name(s):
Protein fear-of-intimacy
Protein kastchen
Gene namesi
Name:foiImported
ORF Names:CG6817
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0024236 foi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 261ExtracellularSequence analysisAdd BLAST240
Transmembranei262 – 282Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini283 – 292CytoplasmicSequence analysis10
Transmembranei293 – 313Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini314 – 329ExtracellularSequence analysisAdd BLAST16
Transmembranei330 – 350Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini351 – 604CytoplasmicSequence analysisAdd BLAST254
Transmembranei605 – 625Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini626 – 631ExtracellularSequence analysis6
Transmembranei632 – 652Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini653 – 665CytoplasmicSequence analysisAdd BLAST13
Transmembranei666 – 686Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini687 – 706ExtracellularSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi308D → A: 4-fold reduction in zinc transport activity in yeast assay. 1 Publication1
Mutagenesisi554H → A: Severely reduced zinc transport activity in yeast assay. 1 Publication1
Mutagenesisi584E → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-588 and A-591. 1 Publication1
Mutagenesisi588E → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-591. 1 Publication1
Mutagenesisi591D → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-588. 1 Publication1
Mutagenesisi646Y → A: 2-fold reduction zinc transport activity in yeast assay. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004165322 – 706Zinc transporter foiSequence analysisAdd BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei376Phosphoserine1 Publication1
Modified residuei377Phosphoserine1 Publication1
Modified residuei381Phosphoserine1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9VSL7
PRIDEiQ9VSL7

PTM databases

iPTMnetiQ9VSL7

Expressioni

Tissue specificityi

Maternal foi has almost completely disappeared by embryonic stage 3 except in the pole cells. In stage 6 embryos, expression is enriched in the invaginating mesoderm. In stage 9 embryos, high levels in the anterior and posterior midgut primordia. In stage 14 embryos, broad expression with low levels in the epidermis.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0024236
ExpressionAtlasiQ9VSL7 differential
GenevisibleiQ9VSL7 DM

Interactioni

Protein-protein interaction databases

BioGridi64386, 12 interactors
IntActiQ9VSL7, 4 interactors
STRINGi7227.FBpp0076350

Family & Domainsi

Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]1 Publication

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
InParanoidiQ9VSL7
KOiK14716
OMAiEFNYLCP
OrthoDBiEOG091G02WM
PhylomeDBiQ9VSL7

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VSL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHIMAVCV VCLLCAHRLH CQDHIESLLG PARVTTHNSQ DQLNARVYTN
60 70 80 90 100
LSPSSETTDR RQQRSASGDD DTFNYSISPP SRREKRHAGH EHGPTSESRV
110 120 130 140 150
PQITQYYLEK LMAQDELMNS SGFDGLLQQL SLHSLASGAS EGTCVPGSRL
160 170 180 190 200
VHHVQPHDHH HAHHHEEEDH SLQLNNCTLI QNGTTSNVIC PSLPNNNTHP
210 220 230 240 250
LGKEAKNFTL SDKDLLHLCP ILLYELKAQS GGCIEPAILS DIDTTEELLE
260 270 280 290 300
AEKDKDIFYV WIYAFISVFA CGILGLVGVA IIPFMGSRYY KYIIQYLVAL
310 320 330 340 350
AVGTMTGDAL LHLLPHSLAG QDERGMIMKG LGCLGGIIFF YVMEHALTMI
360 370 380 390 400
SEWRKSVEKK ETKKPSRAKV MRDPDSSVNN SVAGDKICKQ KYSSYPYCYD
410 420 430 440 450
EITMNNKQSE WMHLPFDVAA GAGGDAPSVA ELRNGVGDHD GSNDMAAAAE
460 470 480 490 500
SLISPLHTNC VEMNHHNHNH KHNSHQQNHE GQDSNTIVTD LDGNAVYAVN
510 520 530 540 550
KAKDKDSRND HVTVILREHE SSHHGHSHRH GHVHSPPETL SAVAWMIIMG
560 570 580 590 600
DGLHNFTDGM AIGAAFAENI AGGFSTSLAV FCHELPHELG DFAILIKAGM
610 620 630 640 650
SVKSAVYYNL LTGVLSFIGM IFGIAFGQSQ DVAQWMFAVA AGLFIYIALV
660 670 680 690 700
DMMPEISASH KSLGQFLLQI LGMLSGVGIM LLIALYEGDL MSAFGTAGAA

SHQHAH
Length:706
Mass (Da):77,376
Last modified:July 5, 2004 - v3
Checksum:i80212B9213D91B07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50401.3
RefSeqiNP_001261584.1, NM_001274655.1
NP_001261585.1, NM_001274656.1
NP_001286985.1, NM_001300056.1
NP_523974.3, NM_079250.2
UniGeneiDm.2818

Genome annotation databases

EnsemblMetazoaiFBtr0076624; FBpp0076350; FBgn0024236
FBtr0331417; FBpp0303834; FBgn0024236
FBtr0331418; FBpp0303835; FBgn0024236
FBtr0345601; FBpp0311670; FBgn0024236
GeneIDi38976
KEGGidme:Dmel_CG6817

Similar proteinsi

Entry informationi

Entry nameiFOI_DROME
AccessioniPrimary (citable) accession number: Q9VSL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health