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Protein

Zinc transporter foi

Gene

foi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells.3 Publications

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • branch fusion, open tracheal system Source: FlyBase
  • cell migration Source: UniProtKB
  • central nervous system development Source: FlyBase
  • germ cell migration Source: FlyBase
  • gonadal mesoderm development Source: FlyBase
  • gonad development Source: FlyBase
  • gonad morphogenesis Source: FlyBase
  • neurogenesis Source: FlyBase
  • pole cell migration Source: FlyBase
  • zinc II ion transmembrane transport Source: GOC
  • zinc II ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Ion transport, Neurogenesis, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-DME-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.16. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter foi
Alternative name(s):
Protein fear-of-intimacy
Protein kastchen
Gene namesi
Name:foiImported
ORF Names:CG6817
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0024236. foi.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 261240ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini283 – 29210CytoplasmicSequence analysis
Transmembranei293 – 31321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini314 – 32916ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 35021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini351 – 604254CytoplasmicSequence analysisAdd
BLAST
Transmembranei605 – 62521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini626 – 6316ExtracellularSequence analysis
Transmembranei632 – 65221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini653 – 66513CytoplasmicSequence analysisAdd
BLAST
Transmembranei666 – 68621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini687 – 70620ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: FlyBase
  • cell surface Source: FlyBase
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi308 – 3081D → A: 4-fold reduction in zinc transport activity in yeast assay. 1 Publication
Mutagenesisi554 – 5541H → A: Severely reduced zinc transport activity in yeast assay. 1 Publication
Mutagenesisi584 – 5841E → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-588 and A-591. 1 Publication
Mutagenesisi588 – 5881E → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-591. 1 Publication
Mutagenesisi591 – 5911D → A: 2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-588. 1 Publication
Mutagenesisi646 – 6461Y → A: 2-fold reduction zinc transport activity in yeast assay. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 706685Zinc transporter foiSequence analysisPRO_0000041653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence analysis
Modified residuei376 – 3761Phosphoserine1 Publication
Modified residuei377 – 3771Phosphoserine1 Publication
Modified residuei381 – 3811Phosphoserine1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9VSL7.

PTM databases

iPTMnetiQ9VSL7.

Expressioni

Tissue specificityi

Maternal foi has almost completely disappeared by embryonic stage 3 except in the pole cells. In stage 6 embryos, expression is enriched in the invaginating mesoderm. In stage 9 embryos, high levels in the anterior and posterior midgut primordia. In stage 14 embryos, broad expression with low levels in the epidermis.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiQ9VSL7.
ExpressionAtlasiQ9VSL7. differential.
GenevisibleiQ9VSL7. DM.

Interactioni

Protein-protein interaction databases

BioGridi64386. 5 interactions.
IntActiQ9VSL7. 1 interaction.
MINTiMINT-293936.
STRINGi7227.FBpp0076350.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]1 Publication

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
InParanoidiQ9VSL7.
KOiK14716.
OMAiYCYDEIT.
OrthoDBiEOG7H791W.
PhylomeDBiQ9VSL7.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VSL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHIMAVCV VCLLCAHRLH CQDHIESLLG PARVTTHNSQ DQLNARVYTN
60 70 80 90 100
LSPSSETTDR RQQRSASGDD DTFNYSISPP SRREKRHAGH EHGPTSESRV
110 120 130 140 150
PQITQYYLEK LMAQDELMNS SGFDGLLQQL SLHSLASGAS EGTCVPGSRL
160 170 180 190 200
VHHVQPHDHH HAHHHEEEDH SLQLNNCTLI QNGTTSNVIC PSLPNNNTHP
210 220 230 240 250
LGKEAKNFTL SDKDLLHLCP ILLYELKAQS GGCIEPAILS DIDTTEELLE
260 270 280 290 300
AEKDKDIFYV WIYAFISVFA CGILGLVGVA IIPFMGSRYY KYIIQYLVAL
310 320 330 340 350
AVGTMTGDAL LHLLPHSLAG QDERGMIMKG LGCLGGIIFF YVMEHALTMI
360 370 380 390 400
SEWRKSVEKK ETKKPSRAKV MRDPDSSVNN SVAGDKICKQ KYSSYPYCYD
410 420 430 440 450
EITMNNKQSE WMHLPFDVAA GAGGDAPSVA ELRNGVGDHD GSNDMAAAAE
460 470 480 490 500
SLISPLHTNC VEMNHHNHNH KHNSHQQNHE GQDSNTIVTD LDGNAVYAVN
510 520 530 540 550
KAKDKDSRND HVTVILREHE SSHHGHSHRH GHVHSPPETL SAVAWMIIMG
560 570 580 590 600
DGLHNFTDGM AIGAAFAENI AGGFSTSLAV FCHELPHELG DFAILIKAGM
610 620 630 640 650
SVKSAVYYNL LTGVLSFIGM IFGIAFGQSQ DVAQWMFAVA AGLFIYIALV
660 670 680 690 700
DMMPEISASH KSLGQFLLQI LGMLSGVGIM LLIALYEGDL MSAFGTAGAA

SHQHAH
Length:706
Mass (Da):77,376
Last modified:July 5, 2004 - v3
Checksum:i80212B9213D91B07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50401.3.
RefSeqiNP_001261584.1. NM_001274655.1.
NP_001261585.1. NM_001274656.1.
NP_001286985.1. NM_001300056.1.
NP_523974.3. NM_079250.2.
UniGeneiDm.2818.

Genome annotation databases

EnsemblMetazoaiFBtr0076624; FBpp0076350; FBgn0024236.
FBtr0331417; FBpp0303834; FBgn0024236.
FBtr0331418; FBpp0303835; FBgn0024236.
FBtr0345601; FBpp0311670; FBgn0024236.
GeneIDi38976.
KEGGidme:Dmel_CG6817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50401.3.
RefSeqiNP_001261584.1. NM_001274655.1.
NP_001261585.1. NM_001274656.1.
NP_001286985.1. NM_001300056.1.
NP_523974.3. NM_079250.2.
UniGeneiDm.2818.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64386. 5 interactions.
IntActiQ9VSL7. 1 interaction.
MINTiMINT-293936.
STRINGi7227.FBpp0076350.

Protein family/group databases

TCDBi2.A.5.4.16. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ9VSL7.

Proteomic databases

PaxDbiQ9VSL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076624; FBpp0076350; FBgn0024236.
FBtr0331417; FBpp0303834; FBgn0024236.
FBtr0331418; FBpp0303835; FBgn0024236.
FBtr0345601; FBpp0311670; FBgn0024236.
GeneIDi38976.
KEGGidme:Dmel_CG6817.

Organism-specific databases

CTDi38976.
FlyBaseiFBgn0024236. foi.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
InParanoidiQ9VSL7.
KOiK14716.
OMAiYCYDEIT.
OrthoDBiEOG7H791W.
PhylomeDBiQ9VSL7.

Enzyme and pathway databases

ReactomeiR-DME-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSifoi. fly.
GenomeRNAii38976.
NextBioi811270.
PROiQ9VSL7.

Gene expression databases

BgeeiQ9VSL7.
ExpressionAtlasiQ9VSL7. differential.
GenevisibleiQ9VSL7. DM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila."
    Van Doren M., Mathews W.R., Samuels M., Moore L.A., Broihier H.T., Lehmann R.
    Development 130:2355-2364(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The Drosophila transmembrane protein Fear-of-intimacy controls glial cell migration."
    Pielage J., Kippert A., Zhu M., Klambt C.
    Dev. Biol. 275:245-257(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins."
    Mathews W.R., Wang F., Eide D.J., Van Doren M.
    J. Biol. Chem. 280:787-795(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, MUTAGENESIS OF ASP-308; HIS-554; GLU-584; GLU-588; ASP-591 AND TYR-646.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376; SER-377 AND SER-381, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiFOI_DROME
AccessioniPrimary (citable) accession number: Q9VSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.