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Protein
Submitted name:

Glutathione S transferase O2, isoform A

Gene

GstO2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glutathione binding Source: FlyBase
  • glutathione dehydrogenase (ascorbate) activity Source: FlyBase
  • glutathione transferase activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • transferase activity, transferring sulfur-containing groups Source: FlyBase

GO - Biological processi

  • defense response to Gram-negative bacterium Source: FlyBase
  • glutathione metabolic process Source: FlyBase
  • negative regulation of innate immune response Source: FlyBase
  • toxin catabolic process Source: GO_Central

Keywordsi

Molecular functionOxidoreductaseImported, TransferaseImported

Enzyme and pathway databases

ReactomeiR-DME-156581. Methylation.
R-DME-156590. Glutathione conjugation.
R-DME-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione S transferase O2, isoform AImported (EC:1.5.4.1Imported, EC:1.8.5.1Imported, EC:2.5.1.18Imported, EC:2.8.-.-Imported)
Submitted name:
Glutathione S-transferase omega classImported
Gene namesi
Name:GstO2Imported
Synonyms:anon-EST:Posey29Imported, CG6673-AImported, CG6673-BImported, CG6673AImported, CG6673BImported, Dmel\CG6673Imported, DmGSTO1Imported, DmGSTO2aImported, DmGSTO2bImported, GSTO2Imported, gsto2Imported, GSTO2aImported, GSTO2bImported
ORF Names:CG6673Imported, CG6673-RAImported, Dmel_CG6673Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035906. GstO2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0035906.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0076378.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 103GST N-terminalInterPro annotationAdd BLAST83
Domaini108 – 251GST C-terminalInterPro annotationAdd BLAST144

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
GeneTreeiENSGT00390000005479.
OrthoDBiEOG091G0IEA.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF13417. GST_N_3. 1 hit.
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VSL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPQKHFKR GSTKPELPED GVPRFFSMAF CPFSHRVRLM LAAKHIEHHK
60 70 80 90 100
IYVDLIEKPE WYKDFSPLGK VPALQLTGVK DQPTLVESLI IAEYLDQQYP
110 120 130 140 150
QTRLFPTDPL QKALDKILIE RFAPVVSAIY PVLTCNPNAP KDAIPNFENA
160 170 180 190 200
LDVFEVELGK RGTPYFAGQH IGIVDYMIWP WFERFPSMKI NTEQKYELDT
210 220 230 240 250
KRFEKLLKWR DLMTQDEVVQ KTALDVQLHA EFQKSKTLGN PQYDIAFKGT

P
Length:251
Mass (Da):29,077
Last modified:March 1, 2001 - v2
Checksum:i6E9D9F456E9D1190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50404.2.
GQ351317 Genomic DNA. Translation: ACZ02426.1.
RefSeqiNP_729388.1. NM_168277.2.
UniGeneiDm.3631.

Genome annotation databases

EnsemblMetazoaiFBtr0076654; FBpp0076378; FBgn0035906.
GeneIDi38974.
UCSCiCG6673-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VSL5_DROME
AccessioniPrimary (citable) accession number: Q9VSL5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported