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Protein
Submitted name:

Glutathione S transferase O2, isoform B

Gene

GstO2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glutathione binding Source: FlyBase
  • glutathione dehydrogenase (ascorbate) activity Source: FlyBase
  • glutathione transferase activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • transferase activity, transferring sulfur-containing groups Source: FlyBase

GO - Biological processi

  • defense response to Gram-negative bacterium Source: FlyBase
  • glutathione metabolic process Source: FlyBase
  • negative regulation of innate immune response Source: FlyBase
  • sensory perception of pain Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported, TransferaseImported

Enzyme and pathway databases

ReactomeiR-DME-156581. Methylation.
R-DME-156590. Glutathione conjugation.
R-DME-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione S transferase O2, isoform BImported (EC:1.5.4.1Imported, EC:1.8.5.1Imported, EC:2.5.1.18Imported, EC:2.8.-.-Imported)
Submitted name:
Glutathione S-transferase omega classImported
Gene namesi
Name:GstO2Imported
ORF Names:CG6673Imported, CG6673-PBImported, CG6673-RBImported, Dmel_CG6673Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035906. GstO2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0035906.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

MINTiMINT-924762.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10383GST N-terminalInterPro annotationAdd
BLAST
Domaini109 – 243135GST C-terminalInterPro annotationAdd
BLAST

Phylogenomic databases

GeneTreeiENSGT00390000005479.
OMAiFAEGWQF.
OrthoDBiEOG091G0IEA.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VSL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPQKHFKR GSPKPEIPED GVLRYYSMRF CPYSQRAGLV LAAKKIPHHT
60 70 80 90 100
VYIDLSEKPE WYIDYSPLGK VPAIQLPNLP GQPALVESLV IAEYLDEQYP
110 120 130 140 150
GEGSLFPKDP LQKALDRILI ERLSPAVSAI YPVLFTKNPP ADAIKNFETA
160 170 180 190 200
LDVFEQEITK RGTPYFGGNK IGIADYMIWP WFERFPALKY TLDEPYELDK
210 220 230 240 250
TRYQNLLKWR DLVAQDEAVK ATALDARIHA KFMKTRHENK PDYDVAFQPL
Length:250
Mass (Da):28,725
Last modified:October 1, 2002 - v2
Checksum:i5F1D7F72980B0A00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50403.2.
GQ351317 Genomic DNA. Translation: ACZ02427.1.
GQ351318 Genomic DNA. Translation: ACZ02432.1.
RefSeqiNP_648236.1. NM_139979.3.
UniGeneiDm.3631.

Genome annotation databases

EnsemblMetazoaiFBtr0076653; FBpp0076377; FBgn0035906.
GeneIDi38974.
KEGGidme:Dmel_CG6673.
UCSCiCG6673-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50403.2.
GQ351317 Genomic DNA. Translation: ACZ02427.1.
GQ351318 Genomic DNA. Translation: ACZ02432.1.
RefSeqiNP_648236.1. NM_139979.3.
UniGeneiDm.3631.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-924762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076653; FBpp0076377; FBgn0035906.
GeneIDi38974.
KEGGidme:Dmel_CG6673.
UCSCiCG6673-RB. d. melanogaster.

Organism-specific databases

CTDi119391.
FlyBaseiFBgn0035906. GstO2.

Phylogenomic databases

GeneTreeiENSGT00390000005479.
OMAiFAEGWQF.
OrthoDBiEOG091G0IEA.

Enzyme and pathway databases

ReactomeiR-DME-156581. Methylation.
R-DME-156590. Glutathione conjugation.
R-DME-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

GenomeRNAii38974.

Gene expression databases

BgeeiFBgn0035906.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VSL4_DROME
AccessioniPrimary (citable) accession number: Q9VSL4
Secondary accession number(s): Q95RJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.