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Protein

Protein melted

Gene

melt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning.3 Publications

GO - Molecular functioni

  • phosphatidylinositol-5-phosphate binding Source: FlyBase
  • phosphatidylinositol binding Source: FlyBase

GO - Biological processi

  • cell fate specification Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • ectoderm development Source: FlyBase
  • lipid metabolic process Source: UniProtKB-KW
  • negative regulation of DNA binding transcription factor activity Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of insulin receptor signaling pathway Source: FlyBase
  • positive regulation of TORC1 signaling Source: FlyBase
  • R8 cell fate specification Source: FlyBase
  • regulation of cellular metabolic process Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processLipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein melted
Gene namesi
Name:melt
ORF Names:CG8624
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0023001 melt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979611 – 994Protein meltedAdd BLAST994

Proteomic databases

PaxDbiQ9VS24
PRIDEiQ9VS24

Expressioni

Gene expression databases

BgeeiFBgn0023001
ExpressionAtlasiQ9VS24 baseline and differential
GenevisibleiQ9VS24 DM

Interactioni

Subunit structurei

Interacts with TSC1 and FOXO.1 Publication

Protein-protein interaction databases

BioGridi64230, 13 interactors
STRINGi7227.FBpp0291254

Structurei

3D structure databases

ProteinModelPortaliQ9VS24
SMRiQ9VS24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini872 – 967PHPROSITE-ProRule annotationAdd BLAST96

Domaini

The PH domain is required for membrane targeting.

Sequence similaritiesi

Belongs to the MELT/VEPH family.Curated

Phylogenomic databases

eggNOGiKOG3723 Eukaryota
ENOG410XQXD LUCA
GeneTreeiENSGT00390000018660
InParanoidiQ9VS24
OMAiPQPINRH
OrthoDBiEOG091G023Q
PhylomeDBiQ9VS24

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: Q9VS24-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHELFNKVLA KRDLSRAGDL FSVPDADIVD DITEVLSEIS PIISHADYVK
60 70 80 90 100
NNNDQSVVEI CVTRVLSCIR ETKTAERYCA ALVDLLRTCL LWNLQPSGTT
110 120 130 140 150
KEEPPHAKIA ADIISSIFLN YDKKELMKIA LPVAVQFLPK GNRELSRNLA
160 170 180 190 200
SYLSLAAIDH AGLLSPHTES VMESILSGNY GLLRVLSQVY EVAPEAVTPH
210 220 230 240 250
APLLMPLLPQ CDPQERMAVF QLYLLIVQKS PEVLESCVPQ LCGSLLDSDT
260 270 280 290 300
SSITMQILLK LSQHSPSLLV DHFEQLRLAA KTNPGTIPLC AQIMTTAGIG
310 320 330 340 350
SKETAQQALD FVLEHLPTQA LLQQEATRLC SAYPVLFTDK VLACVRQKNA
360 370 380 390 400
ALSSQQDVGN GLANKTSGGV TIVSLNSSSP SPPLKPVPVG APAINTTIVQ
410 420 430 440 450
PASVVSATPT PPPSSASAPI ASSTPVSAAT PTPQHAGYTR RVKLGDSRST
460 470 480 490 500
GRLHPASNTH RSVTRLNVAS GSVGGLHKSM TRLSNSQINQ QPGGSSNGNV
510 520 530 540 550
VVQSGATPKT PTGLSNPPVT PVPPLSNNVV ITGHNRHGIP VTSGGVTVTT
560 570 580 590 600
SPSKVRPHSQ GPSTLLNSST VLMKYSTDAL NQSVGSISIP QSAAVATLPS
610 620 630 640 650
TQTQNAVSVH HASPALPQSA SNGHAKSVMK LPVNGNSEVI VSGPTTNVAP
660 670 680 690 700
RRSDNTSRTL LNANSVMDQR MSTFEPYQIM RDPVQQFCEK NFNSIKSYMD
710 720 730 740 750
EVSQHLPPPT RCSIEVSNEF AERRTKKVAK LHFACQIRGP HCLYSKTCFT
760 770 780 790 800
MRTRNPKTWI HMMFLDFQVR HFVKEKCVLS TRESGISNLK NIWQILKCEN
810 820 830 840 850
RSFTELVTSQ FPQVKDREIL VNELRHSGFL DVFEVSKTDK SNPNCNELEY
860 870 880 890 900
QWGCFLCNHP DKAVGFLNGS NQPMIEGQLK EKKGKWRLFR RWRTRYFTLS
910 920 930 940 950
GAHLSCKGSS GGESIDVNQI RSVKVSRGAR NIPKAFEIFT ADQTLILKPK
960 970 980 990
DGKNAEEWVQ CLSIVVAHSQ ARDNPTAKTN SLPARSIGSS KPSF
Length:994
Mass (Da):108,105
Last modified:October 19, 2011 - v2
Checksum:iBE3A08490E2855E9
GO
Isoform B (identifier: Q9VS24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-721: Missing.

Show »
Length:988
Mass (Da):107,457
Checksum:iB67970066F31F637
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405V → A in AAF14808 (PubMed:11102367).Curated1
Sequence conflicti414S → A in AAF14808 (PubMed:11102367).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027438716 – 721Missing in isoform B. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50606.2
AE014296 Genomic DNA Translation: AAX52758.1
BT029129 mRNA Translation: ABJ17062.1
AF205831 mRNA Translation: AAF14808.1
RefSeqiNP_001014572.1, NM_001014572.4 [Q9VS24-2]
NP_523953.2, NM_079229.4 [Q9VS24-3]
UniGeneiDm.9528

Genome annotation databases

EnsemblMetazoaiFBtr0100141; FBpp0099491; FBgn0023001 [Q9VS24-2]
FBtr0302044; FBpp0291254; FBgn0023001 [Q9VS24-3]
GeneIDi38785
KEGGidme:Dmel_CG8624
UCSCiCG8624-RA d. melanogaster [Q9VS24-3]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiMELT_DROME
AccessioniPrimary (citable) accession number: Q9VS24
Secondary accession number(s): Q058T9, Q59E21, Q9U422
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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