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Protein

Protein melted

Gene

melt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning.3 Publications

GO - Molecular functioni

  • phosphatidylinositol-5-phosphate binding Source: FlyBase
  • phosphatidylinositol binding Source: FlyBase

GO - Biological processi

  • cell fate specification Source: FlyBase
  • ectoderm development Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • lipid metabolic process Source: UniProtKB-KW
  • metabolic process Source: UniProtKB
  • peripheral nervous system development Source: FlyBase
  • R8 cell fate specification Source: FlyBase
  • regulation of response to DNA damage stimulus Source: FlyBase
  • sequestering of triglyceride Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein melted
Gene namesi
Name:melt
ORF Names:CG8624
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0023001. melt.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 994994Protein meltedPRO_0000297961Add
BLAST

Proteomic databases

PaxDbiQ9VS24.
PRIDEiQ9VS24.

Expressioni

Gene expression databases

BgeeiQ9VS24.
ExpressionAtlasiQ9VS24. differential.
GenevisibleiQ9VS24. DM.

Interactioni

Subunit structurei

Interacts with TSC1 and FOXO.1 Publication

Protein-protein interaction databases

STRINGi7227.FBpp0291254.

Structurei

3D structure databases

ProteinModelPortaliQ9VS24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini872 – 96796PHPROSITE-ProRule annotationAdd
BLAST

Domaini

The PH domain is required for membrane targeting.

Sequence similaritiesi

Belongs to the MELT/VEPH family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3723. Eukaryota.
ENOG410XQXD. LUCA.
GeneTreeiENSGT00390000018660.
InParanoidiQ9VS24.
OMAiPQPINRH.
OrthoDBiEOG7GBFWC.
PhylomeDBiQ9VS24.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: Q9VS24-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHELFNKVLA KRDLSRAGDL FSVPDADIVD DITEVLSEIS PIISHADYVK
60 70 80 90 100
NNNDQSVVEI CVTRVLSCIR ETKTAERYCA ALVDLLRTCL LWNLQPSGTT
110 120 130 140 150
KEEPPHAKIA ADIISSIFLN YDKKELMKIA LPVAVQFLPK GNRELSRNLA
160 170 180 190 200
SYLSLAAIDH AGLLSPHTES VMESILSGNY GLLRVLSQVY EVAPEAVTPH
210 220 230 240 250
APLLMPLLPQ CDPQERMAVF QLYLLIVQKS PEVLESCVPQ LCGSLLDSDT
260 270 280 290 300
SSITMQILLK LSQHSPSLLV DHFEQLRLAA KTNPGTIPLC AQIMTTAGIG
310 320 330 340 350
SKETAQQALD FVLEHLPTQA LLQQEATRLC SAYPVLFTDK VLACVRQKNA
360 370 380 390 400
ALSSQQDVGN GLANKTSGGV TIVSLNSSSP SPPLKPVPVG APAINTTIVQ
410 420 430 440 450
PASVVSATPT PPPSSASAPI ASSTPVSAAT PTPQHAGYTR RVKLGDSRST
460 470 480 490 500
GRLHPASNTH RSVTRLNVAS GSVGGLHKSM TRLSNSQINQ QPGGSSNGNV
510 520 530 540 550
VVQSGATPKT PTGLSNPPVT PVPPLSNNVV ITGHNRHGIP VTSGGVTVTT
560 570 580 590 600
SPSKVRPHSQ GPSTLLNSST VLMKYSTDAL NQSVGSISIP QSAAVATLPS
610 620 630 640 650
TQTQNAVSVH HASPALPQSA SNGHAKSVMK LPVNGNSEVI VSGPTTNVAP
660 670 680 690 700
RRSDNTSRTL LNANSVMDQR MSTFEPYQIM RDPVQQFCEK NFNSIKSYMD
710 720 730 740 750
EVSQHLPPPT RCSIEVSNEF AERRTKKVAK LHFACQIRGP HCLYSKTCFT
760 770 780 790 800
MRTRNPKTWI HMMFLDFQVR HFVKEKCVLS TRESGISNLK NIWQILKCEN
810 820 830 840 850
RSFTELVTSQ FPQVKDREIL VNELRHSGFL DVFEVSKTDK SNPNCNELEY
860 870 880 890 900
QWGCFLCNHP DKAVGFLNGS NQPMIEGQLK EKKGKWRLFR RWRTRYFTLS
910 920 930 940 950
GAHLSCKGSS GGESIDVNQI RSVKVSRGAR NIPKAFEIFT ADQTLILKPK
960 970 980 990
DGKNAEEWVQ CLSIVVAHSQ ARDNPTAKTN SLPARSIGSS KPSF
Length:994
Mass (Da):108,105
Last modified:October 19, 2011 - v2
Checksum:iBE3A08490E2855E9
GO
Isoform B (identifier: Q9VS24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-721: Missing.

Show »
Length:988
Mass (Da):107,457
Checksum:iB67970066F31F637
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051V → A in AAF14808 (PubMed:11102367).Curated
Sequence conflicti414 – 4141S → A in AAF14808 (PubMed:11102367).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei716 – 7216Missing in isoform B. CuratedVSP_027438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50606.2.
AE014296 Genomic DNA. Translation: AAX52758.1.
BT029129 mRNA. Translation: ABJ17062.1.
AF205831 mRNA. Translation: AAF14808.1.
RefSeqiNP_001014572.1. NM_001014572.4. [Q9VS24-2]
NP_523953.2. NM_079229.4. [Q9VS24-3]
UniGeneiDm.9528.

Genome annotation databases

EnsemblMetazoaiFBtr0302044; FBpp0291254; FBgn0023001. [Q9VS24-3]
GeneIDi38785.
KEGGidme:Dmel_CG8624.
UCSCiCG8624-RA. d. melanogaster. [Q9VS24-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50606.2.
AE014296 Genomic DNA. Translation: AAX52758.1.
BT029129 mRNA. Translation: ABJ17062.1.
AF205831 mRNA. Translation: AAF14808.1.
RefSeqiNP_001014572.1. NM_001014572.4. [Q9VS24-2]
NP_523953.2. NM_079229.4. [Q9VS24-3]
UniGeneiDm.9528.

3D structure databases

ProteinModelPortaliQ9VS24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0291254.

Proteomic databases

PaxDbiQ9VS24.
PRIDEiQ9VS24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0302044; FBpp0291254; FBgn0023001. [Q9VS24-3]
GeneIDi38785.
KEGGidme:Dmel_CG8624.
UCSCiCG8624-RA. d. melanogaster. [Q9VS24-3]

Organism-specific databases

CTDi38785.
FlyBaseiFBgn0023001. melt.

Phylogenomic databases

eggNOGiKOG3723. Eukaryota.
ENOG410XQXD. LUCA.
GeneTreeiENSGT00390000018660.
InParanoidiQ9VS24.
OMAiPQPINRH.
OrthoDBiEOG7GBFWC.
PhylomeDBiQ9VS24.

Miscellaneous databases

GenomeRNAii38785.
NextBioi810368.
PROiQ9VS24.

Gene expression databases

BgeeiQ9VS24.
ExpressionAtlasiQ9VS24. differential.
GenevisibleiQ9VS24. DM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING (ISOFORM B).
    Strain: Berkeley.
  3. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
    Strain: Berkeley.
  4. "Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins."
    Prokopenko S.N., He Y., Lu Y., Bellen H.J.
    Genetics 156:1691-1715(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-717 (ISOFORM C), FUNCTION.
  5. "The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors."
    Mikeladze-Dvali T., Wernet M.F., Pistillo D., Mazzoni E.O., Teleman A.A., Chen Y.-W., Cohen S., Desplan C.
    Cell 122:775-787(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Drosophila Melted modulates FOXO and TOR activity."
    Teleman A.A., Chen Y.-W., Cohen S.M.
    Dev. Cell 9:271-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TSC1 AND FOXO.

Entry informationi

Entry nameiMELT_DROME
AccessioniPrimary (citable) accession number: Q9VS24
Secondary accession number(s): Q058T9, Q59E21, Q9U422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 19, 2011
Last modified: January 20, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.