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Protein

Splicing factor 3B subunit 6-like protein

Gene

CG13298

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the splicing of pre-mRNA.By similarity

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • neurogenesis Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3B subunit 6-like protein
Alternative name(s):
Pre-mRNA branch site p14-like protein
Gene namesi
ORF Names:CG13298
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035692. CG13298.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: FlyBase
  • precatalytic spliceosome Source: FlyBase
  • U12-type spliceosomal complex Source: GO_Central
  • U2-type spliceosomal complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817281 – 121Splicing factor 3B subunit 6-like proteinAdd BLAST121

Proteomic databases

PaxDbiQ9VRV7.
PRIDEiQ9VRV7.

Expressioni

Gene expression databases

BgeeiFBgn0035692.
GenevisibleiQ9VRV7. DM.

Interactioni

Subunit structurei

Component of splicing factor SF3B complex.1 Publication

Protein-protein interaction databases

BioGridi64173. 5 interactors.
DIPiDIP-21174N.
IntActiQ9VRV7. 1 interactor.
MINTiMINT-921416.
STRINGi7227.FBpp0076723.

Structurei

3D structure databases

ProteinModelPortaliQ9VRV7.
SMRiQ9VRV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 90RRMPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 25Interaction with pre-mRNA branch siteBy similarityAdd BLAST14

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0114. Eukaryota.
ENOG4111IHX. LUCA.
GeneTreeiENSGT00390000005908.
InParanoidiQ9VRV7.
KOiK12833.
OMAiVNRVLFV.
OrthoDBiEOG091G0RTZ.
PhylomeDBiQ9VRV7.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VRV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKRNHIRLP PEVNRLLYVR NLPYKITSDE MYDIFGKFGA IRQIRVGNTP
60 70 80 90 100
ETRGTAFVVY EDIFDAKNAC DHLSGFNVCN RYLVVLYYQS NKAFKRVDMD
110 120
KKQEELNNIK AKYNLKTPEA P
Length:121
Mass (Da):14,194
Last modified:May 1, 2000 - v1
Checksum:i926D5B5199CF6652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50675.1.
AY089603 mRNA. Translation: AAL90341.1.
RefSeqiNP_648037.1. NM_139780.3.
UniGeneiDm.1519.

Genome annotation databases

EnsemblMetazoaiFBtr0077015; FBpp0076723; FBgn0035692.
GeneIDi38720.
KEGGidme:Dmel_CG13298.
UCSCiCG13298-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50675.1.
AY089603 mRNA. Translation: AAL90341.1.
RefSeqiNP_648037.1. NM_139780.3.
UniGeneiDm.1519.

3D structure databases

ProteinModelPortaliQ9VRV7.
SMRiQ9VRV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64173. 5 interactors.
DIPiDIP-21174N.
IntActiQ9VRV7. 1 interactor.
MINTiMINT-921416.
STRINGi7227.FBpp0076723.

Proteomic databases

PaxDbiQ9VRV7.
PRIDEiQ9VRV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077015; FBpp0076723; FBgn0035692.
GeneIDi38720.
KEGGidme:Dmel_CG13298.
UCSCiCG13298-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0035692. CG13298.

Phylogenomic databases

eggNOGiKOG0114. Eukaryota.
ENOG4111IHX. LUCA.
GeneTreeiENSGT00390000005908.
InParanoidiQ9VRV7.
KOiK12833.
OMAiVNRVLFV.
OrthoDBiEOG091G0RTZ.
PhylomeDBiQ9VRV7.

Enzyme and pathway databases

ReactomeiR-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

GenomeRNAii38720.
PROiQ9VRV7.

Gene expression databases

BgeeiFBgn0035692.
GenevisibleiQ9VRV7. DM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSF3B6_DROME
AccessioniPrimary (citable) accession number: Q9VRV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.