Q9VRP5 (UBP36_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36

Gene names

Name:	scny
Synonyms:	Usp36
ORF Names:	CG5505

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1085 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Ref.6
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with atms/PAF1, but not with CycT. Ref.6
Subcellular location	Nucleus › nucleolus Ref.6.
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	germ-line stem cell maintenance Inferred from mutant phenotype Ref.6. Source: UniProtKB histone deubiquitination Inferred from direct assay Ref.6. Source: FlyBase negative regulation of innate immune response Inferred from mutant phenotype PubMed 19837371. Source: FlyBase regulation of apoptotic process Inferred from mutant phenotype PubMed 19217892. Source: FlyBase somatic stem cell maintenance Inferred from mutant phenotype Ref.6. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleolus Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from mutant phenotype Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9VRP5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform B (identifier: Q9VRP5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-110: ESVLENLKSK...TGKLVGANGH → MTVIMVDGFA...KLSTVLFTFA
     912-958: Missing.

Note: No experimental confirmation available.

Isoform C (identifier: Q9VRP5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-110: AINGFSGKNNTGKLVGANGH → MLHSPVPRYNKCVPFPTLRT
     912-958: Missing.

Note: No experimental confirmation available.

Isoform D (identifier: Q9VRP5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     912-958: Missing.

Note: No experimental confirmation available.

Isoform E (identifier: Q9VRP5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-110: ESVLENLKSK...TGKLVGANGH → MTVIMVDGFA...KLSTVLFTFA

Note: No experimental confirmation available.

Isoform F (identifier: Q9VRP5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-110: AINGFSGKNNTGKLVGANGH → MLHSPVPRYNKCVPFPTLRT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1085	1085	Ubiquitin carboxyl-terminal hydrolase 36		PRO_0000378498
Sites
	Active site	181	1	Nucleophile
	Active site	439	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	513	1	Phosphoserine Ref.5
	Modified residue	515	1	Phosphoserine Ref.5
	Modified residue	658	1	Phosphothreonine Ref.5
	Modified residue	662	1	Phosphothreonine Ref.5
	Modified residue	672	1	Phosphoserine Ref.5
	Modified residue	674	1	Phosphoserine Ref.5
	Modified residue	747	1	Phosphoserine Ref.5
	Modified residue	779	1	Phosphoserine Ref.5
	Modified residue	782	1	Phosphothreonine Ref.5
	Modified residue	785	1	Phosphoserine Ref.5
	Modified residue	819	1	Phosphoserine Ref.5
	Modified residue	825	1	Phosphothreonine Ref.5
	Modified residue	843	1	Phosphoserine Ref.5
	Modified residue	846	1	Phosphothreonine Ref.5
Natural variations
	Alternative sequence	1 – 90	90	Missing in isoform C and isoform F.		VSP_037590
	Alternative sequence	1 – 70	70	Missing in isoform B and isoform E.		VSP_037591
	Alternative sequence	71 – 110	40	ESVLE…GANGH → MTVIMVDGFALWLLYKLFLS PCCLLLWHVLKLSTVLFTFA in isoform B and isoform E.		VSP_037592
	Alternative sequence	91 – 110	20	AINGF…GANGH → MLHSPVPRYNKCVPFPTLRT in isoform C and isoform F.		VSP_037593
	Alternative sequence	912 – 958	47	Missing in isoform B, isoform C and isoform D.		VSP_037594
Experimental info
	Mutagenesis	181	1	C → S: Loss of H2B deubiquitination. Ref.6
	Sequence conflict	115	1	A → T in AAQ22589. Ref.4
	Sequence conflict	642	1	N → D in AAQ22589. Ref.4
	Sequence conflict	642	1	N → D in AAO42671. Ref.4
	Sequence conflict	766	1	P → T in AAQ22589. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 0C3EE5A70425B83C	FASTA	1,085	118,687
	10 20 30 40 50 60 MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV ANAKRILMAK 70 80 90 100 110 120 IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN TGKLVGANGH DNNGARKQAE 130 140 150 160 170 180 HPNNQSHHIN HHNHQHPTSN PNELPKPKRV LYPRENIRIG WKQSERKWQV GTGMINVGNT 190 200 210 220 230 240 CYLNSTLQAL LHIPALANWL VSEQAHLADC NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP 250 260 270 280 290 300 FLIYSKLKQI CKHMVVGRQE DAHEFLRFLV EAMERAYLMR FRNYKELDQL VKETTPLGQI 310 320 330 340 350 360 FGGYLRSEVR CLSCNHVSIT FQHFQDLLLD IRKADSLEDA FEGHFSRERL EDMGYKCEGC 370 380 390 400 410 420 KKKVSATKQF SLERAPITLC IQLKRFSMIG NKLTKQISFK SRIDLSKYAA RSQAAQAQPL 430 440 450 460 470 480 TYRLVSMVTH LGASQHCGHY TAIGSTDTGS FYNFDDSYVR PIAMHSVCNT NAYIMFFELD 490 500 510 520 530 540 LSQAASPAAN RPNGVRLTNG HSTTPVPAAT VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT 550 560 570 580 590 600 AIQFKQQNQQ SPQNGLQLGT GKFQDTAKPP LVGAHAKGEA TSAPTANGNK SSSPSSNSSS 610 620 630 640 650 660 NHKSINQQQY LPISSDDEDI EDEMKPRPTT AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV 670 680 690 700 710 720 KTPLKSLVPY ESASEEEEAP LPNPRKRPSG EDSSESDQES GQTNGHSKTN GSHTNGSASS 730 740 750 760 770 780 SVHVNNSKQK TDAIDEIFKS LKKSADSDED DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP 790 800 810 820 830 840 KTPPSPAVIK SKTGIWKVTR NDEVDAIEDD VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS 850 860 870 880 890 900 TDSPATPGAK RQKLLNGSAL KSHQQPRVGN GYQSNATSNG STINELLKQS YRGYGSPVLS 910 920 930 940 950 960 WNGKPAELEK ETFELVCAKR IAGHGSVEGS DIVEGSVAVD AAVTSGSDSK DVVVIAVALL 970 980 990 1000 1010 1020 VDAREQRQRD IDDDEENEMD RGRQRKVKSG SAKGNNASNS TPGYNPFQEY EGQKRWNKNG 1030 1040 1050 1060 1070 1080 GGGGFPRFYN QNYRQNFQQR NKFKFNRFGG PGSAKFQQQR ALQRHLSAGG GFSRRQPSAQ QQQQT
	Isoform B [UniParc]. Checksum: 941F6973D4435C8A	FASTA	968	107,252
	10 20 30 40 50 60 MTVIMVDGFA LWLLYKLFLS PCCLLLWHVL KLSTVLFTFA DNNGARKQAE HPNNQSHHIN 70 80 90 100 110 120 HHNHQHPTSN PNELPKPKRV LYPRENIRIG WKQSERKWQV GTGMINVGNT CYLNSTLQAL 130 140 150 160 170 180 LHIPALANWL VSEQAHLADC NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP FLIYSKLKQI 190 200 210 220 230 240 CKHMVVGRQE DAHEFLRFLV EAMERAYLMR FRNYKELDQL VKETTPLGQI FGGYLRSEVR 250 260 270 280 290 300 CLSCNHVSIT FQHFQDLLLD IRKADSLEDA FEGHFSRERL EDMGYKCEGC KKKVSATKQF 310 320 330 340 350 360 SLERAPITLC IQLKRFSMIG NKLTKQISFK SRIDLSKYAA RSQAAQAQPL TYRLVSMVTH 370 380 390 400 410 420 LGASQHCGHY TAIGSTDTGS FYNFDDSYVR PIAMHSVCNT NAYIMFFELD LSQAASPAAN 430 440 450 460 470 480 RPNGVRLTNG HSTTPVPAAT VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT AIQFKQQNQQ 490 500 510 520 530 540 SPQNGLQLGT GKFQDTAKPP LVGAHAKGEA TSAPTANGNK SSSPSSNSSS NHKSINQQQY 550 560 570 580 590 600 LPISSDDEDI EDEMKPRPTT AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV KTPLKSLVPY 610 620 630 640 650 660 ESASEEEEAP LPNPRKRPSG EDSSESDQES GQTNGHSKTN GSHTNGSASS SVHVNNSKQK 670 680 690 700 710 720 TDAIDEIFKS LKKSADSDED DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK 730 740 750 760 770 780 SKTGIWKVTR NDEVDAIEDD VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS TDSPATPGAK 790 800 810 820 830 840 RQKLLNGSAL KSHQQPRVGN GYQSNATSNG STINELLKQS YRGYGSPVLS WNGKPAELEK 850 860 870 880 890 900 ELLVDAREQR QRDIDDDEEN EMDRGRQRKV KSGSAKGNNA SNSTPGYNPF QEYEGQKRWN 910 920 930 940 950 960 KNGGGGGFPR FYNQNYRQNF QQRNKFKFNR FGGPGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT
	Isoform C [UniParc]. Checksum: 29E5A05BB8761243	FASTA	948	104,961
	10 20 30 40 50 60 MLHSPVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHIN HHNHQHPTSN PNELPKPKRV 70 80 90 100 110 120 LYPRENIRIG WKQSERKWQV GTGMINVGNT CYLNSTLQAL LHIPALANWL VSEQAHLADC 130 140 150 160 170 180 NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP FLIYSKLKQI CKHMVVGRQE DAHEFLRFLV 190 200 210 220 230 240 EAMERAYLMR FRNYKELDQL VKETTPLGQI FGGYLRSEVR CLSCNHVSIT FQHFQDLLLD 250 260 270 280 290 300 IRKADSLEDA FEGHFSRERL EDMGYKCEGC KKKVSATKQF SLERAPITLC IQLKRFSMIG 310 320 330 340 350 360 NKLTKQISFK SRIDLSKYAA RSQAAQAQPL TYRLVSMVTH LGASQHCGHY TAIGSTDTGS 370 380 390 400 410 420 FYNFDDSYVR PIAMHSVCNT NAYIMFFELD LSQAASPAAN RPNGVRLTNG HSTTPVPAAT 430 440 450 460 470 480 VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT AIQFKQQNQQ SPQNGLQLGT GKFQDTAKPP 490 500 510 520 530 540 LVGAHAKGEA TSAPTANGNK SSSPSSNSSS NHKSINQQQY LPISSDDEDI EDEMKPRPTT 550 560 570 580 590 600 AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV KTPLKSLVPY ESASEEEEAP LPNPRKRPSG 610 620 630 640 650 660 EDSSESDQES GQTNGHSKTN GSHTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDED 670 680 690 700 710 720 DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR NDEVDAIEDD 730 740 750 760 770 780 VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS TDSPATPGAK RQKLLNGSAL KSHQQPRVGN 790 800 810 820 830 840 GYQSNATSNG STINELLKQS YRGYGSPVLS WNGKPAELEK ELLVDAREQR QRDIDDDEEN 850 860 870 880 890 900 EMDRGRQRKV KSGSAKGNNA SNSTPGYNPF QEYEGQKRWN KNGGGGGFPR FYNQNYRQNF 910 920 930 940 QQRNKFKFNR FGGPGSAKFQ QQRALQRHLS AGGGFSRRQP SAQQQQQT
	Isoform D [UniParc]. Checksum: 98CECD6993333E22	FASTA	1,038	114,088
	10 20 30 40 50 60 MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV ANAKRILMAK 70 80 90 100 110 120 IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN TGKLVGANGH DNNGARKQAE 130 140 150 160 170 180 HPNNQSHHIN HHNHQHPTSN PNELPKPKRV LYPRENIRIG WKQSERKWQV GTGMINVGNT 190 200 210 220 230 240 CYLNSTLQAL LHIPALANWL VSEQAHLADC NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP 250 260 270 280 290 300 FLIYSKLKQI CKHMVVGRQE DAHEFLRFLV EAMERAYLMR FRNYKELDQL VKETTPLGQI 310 320 330 340 350 360 FGGYLRSEVR CLSCNHVSIT FQHFQDLLLD IRKADSLEDA FEGHFSRERL EDMGYKCEGC 370 380 390 400 410 420 KKKVSATKQF SLERAPITLC IQLKRFSMIG NKLTKQISFK SRIDLSKYAA RSQAAQAQPL 430 440 450 460 470 480 TYRLVSMVTH LGASQHCGHY TAIGSTDTGS FYNFDDSYVR PIAMHSVCNT NAYIMFFELD 490 500 510 520 530 540 LSQAASPAAN RPNGVRLTNG HSTTPVPAAT VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT 550 560 570 580 590 600 AIQFKQQNQQ SPQNGLQLGT GKFQDTAKPP LVGAHAKGEA TSAPTANGNK SSSPSSNSSS 610 620 630 640 650 660 NHKSINQQQY LPISSDDEDI EDEMKPRPTT AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV 670 680 690 700 710 720 KTPLKSLVPY ESASEEEEAP LPNPRKRPSG EDSSESDQES GQTNGHSKTN GSHTNGSASS 730 740 750 760 770 780 SVHVNNSKQK TDAIDEIFKS LKKSADSDED DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP 790 800 810 820 830 840 KTPPSPAVIK SKTGIWKVTR NDEVDAIEDD VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS 850 860 870 880 890 900 TDSPATPGAK RQKLLNGSAL KSHQQPRVGN GYQSNATSNG STINELLKQS YRGYGSPVLS 910 920 930 940 950 960 WNGKPAELEK ELLVDAREQR QRDIDDDEEN EMDRGRQRKV KSGSAKGNNA SNSTPGYNPF 970 980 990 1000 1010 1020 QEYEGQKRWN KNGGGGGFPR FYNQNYRQNF QQRNKFKFNR FGGPGSAKFQ QQRALQRHLS 1030 AGGGFSRRQP SAQQQQQT
	Isoform E [UniParc]. Checksum: C10690700F7876EA	FASTA	1,015	111,851
	10 20 30 40 50 60 MTVIMVDGFA LWLLYKLFLS PCCLLLWHVL KLSTVLFTFA DNNGARKQAE HPNNQSHHIN 70 80 90 100 110 120 HHNHQHPTSN PNELPKPKRV LYPRENIRIG WKQSERKWQV GTGMINVGNT CYLNSTLQAL 130 140 150 160 170 180 LHIPALANWL VSEQAHLADC NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP FLIYSKLKQI 190 200 210 220 230 240 CKHMVVGRQE DAHEFLRFLV EAMERAYLMR FRNYKELDQL VKETTPLGQI FGGYLRSEVR 250 260 270 280 290 300 CLSCNHVSIT FQHFQDLLLD IRKADSLEDA FEGHFSRERL EDMGYKCEGC KKKVSATKQF 310 320 330 340 350 360 SLERAPITLC IQLKRFSMIG NKLTKQISFK SRIDLSKYAA RSQAAQAQPL TYRLVSMVTH 370 380 390 400 410 420 LGASQHCGHY TAIGSTDTGS FYNFDDSYVR PIAMHSVCNT NAYIMFFELD LSQAASPAAN 430 440 450 460 470 480 RPNGVRLTNG HSTTPVPAAT VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT AIQFKQQNQQ 490 500 510 520 530 540 SPQNGLQLGT GKFQDTAKPP LVGAHAKGEA TSAPTANGNK SSSPSSNSSS NHKSINQQQY 550 560 570 580 590 600 LPISSDDEDI EDEMKPRPTT AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV KTPLKSLVPY 610 620 630 640 650 660 ESASEEEEAP LPNPRKRPSG EDSSESDQES GQTNGHSKTN GSHTNGSASS SVHVNNSKQK 670 680 690 700 710 720 TDAIDEIFKS LKKSADSDED DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK 730 740 750 760 770 780 SKTGIWKVTR NDEVDAIEDD VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS TDSPATPGAK 790 800 810 820 830 840 RQKLLNGSAL KSHQQPRVGN GYQSNATSNG STINELLKQS YRGYGSPVLS WNGKPAELEK 850 860 870 880 890 900 ETFELVCAKR IAGHGSVEGS DIVEGSVAVD AAVTSGSDSK DVVVIAVALL VDAREQRQRD 910 920 930 940 950 960 IDDDEENEMD RGRQRKVKSG SAKGNNASNS TPGYNPFQEY EGQKRWNKNG GGGGFPRFYN 970 980 990 1000 1010 QNYRQNFQQR NKFKFNRFGG PGSAKFQQQR ALQRHLSAGG GFSRRQPSAQ QQQQT
	Isoform F [UniParc]. Checksum: 219D6FB375DA0370	FASTA	995	109,560
	10 20 30 40 50 60 MLHSPVPRYN KCVPFPTLRT DNNGARKQAE HPNNQSHHIN HHNHQHPTSN PNELPKPKRV 70 80 90 100 110 120 LYPRENIRIG WKQSERKWQV GTGMINVGNT CYLNSTLQAL LHIPALANWL VSEQAHLADC 130 140 150 160 170 180 NVAEPGSGCI ICAMTKTLLA TQSNQSAVRP FLIYSKLKQI CKHMVVGRQE DAHEFLRFLV 190 200 210 220 230 240 EAMERAYLMR FRNYKELDQL VKETTPLGQI FGGYLRSEVR CLSCNHVSIT FQHFQDLLLD 250 260 270 280 290 300 IRKADSLEDA FEGHFSRERL EDMGYKCEGC KKKVSATKQF SLERAPITLC IQLKRFSMIG 310 320 330 340 350 360 NKLTKQISFK SRIDLSKYAA RSQAAQAQPL TYRLVSMVTH LGASQHCGHY TAIGSTDTGS 370 380 390 400 410 420 FYNFDDSYVR PIAMHSVCNT NAYIMFFELD LSQAASPAAN RPNGVRLTNG HSTTPVPAAT 430 440 450 460 470 480 VSSPSPTRFI GPQLPAGGAN GYTNGNAQKT AIQFKQQNQQ SPQNGLQLGT GKFQDTAKPP 490 500 510 520 530 540 LVGAHAKGEA TSAPTANGNK SSSPSSNSSS NHKSINQQQY LPISSDDEDI EDEMKPRPTT 550 560 570 580 590 600 AQLPSMPNMT ENHTEPKAKS PVKIQVKTPV KTPLKSLVPY ESASEEEEAP LPNPRKRPSG 610 620 630 640 650 660 EDSSESDQES GQTNGHSKTN GSHTNGSASS SVHVNNSKQK TDAIDEIFKS LKKSADSDED 670 680 690 700 710 720 DDEEEPSIQL TNGWHPQKQS QSQSKAPPSP KTPPSPAVIK SKTGIWKVTR NDEVDAIEDD 730 740 750 760 770 780 VDVVVVEGSP VKIPTPNKNH RNPFSSSKPS TDSPATPGAK RQKLLNGSAL KSHQQPRVGN 790 800 810 820 830 840 GYQSNATSNG STINELLKQS YRGYGSPVLS WNGKPAELEK ETFELVCAKR IAGHGSVEGS 850 860 870 880 890 900 DIVEGSVAVD AAVTSGSDSK DVVVIAVALL VDAREQRQRD IDDDEENEMD RGRQRKVKSG 910 920 930 940 950 960 SAKGNNASNS TPGYNPFQEY EGQKRWNKNG GGGGFPRFYN QNYRQNFQQR NKFKFNRFGG 970 980 990 PGSAKFQQQR ALQRHLSAGG GFSRRQPSAQ QQQQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Strain: Berkeley. Tissue: Embryo.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Booth B., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G. , Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C AND D). Strain: Berkeley. Tissue: Testis.
[5]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513; SER-515; THR-658; THR-662; SER-672; SER-674; SER-747; SER-779; THR-782; SER-785; SER-819; THR-825; SER-843 AND THR-846, MASS SPECTROMETRY. Tissue: Embryo.
[6]	"Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny." Buszczak M., Paterno S., Spradling A.C. Science 323:248-251(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ATMS, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-181.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF50748.2. AE014296 Genomic DNA. Translation: AAN12107.1. AE014296 Genomic DNA. Translation: AAN12108.1. AE014296 Genomic DNA. Translation: AAN12109.1. AE014296 Genomic DNA. Translation: AAN12110.1. AE014296 Genomic DNA. Translation: AAN12111.1. AY051916 mRNA. Translation: AAK93340.1. BT004507 mRNA. Translation: AAO42671.1. BT010120 mRNA. Translation: AAQ22589.1. BT046169 mRNA. Translation: ACI47091.1.
RefSeq	NP_647986.3. NM_139729.3. NP_729092.1. NM_168132.2. NP_729093.2. NM_168133.2. NP_729094.1. NM_168134.2. NP_729095.1. NM_168135.2.
UniGene	Dm.6825.
3D structure databases
ProteinModelPortal	Q9VRP5.
SMR	Q9VRP5. Positions 172-479.
ModBase	Search...
Protein-protein interaction databases
STRING	7227.FBpp0076805.
Protein family/group databases
MEROPS	C19.097.
Proteomic databases
PaxDb	Q9VRP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	38648.
KEGG	dme:Dmel_CG5505.
Organism-specific databases
CTD	38648.
FlyBase	FBgn0260936. scny.
Phylogenomic databases
eggNOG	COG5533.
InParanoid	Q86NM9.
KO	K11855.
OMA	PYESASE.
OrthoDB	EOG4WM38P.
PhylomeDB	Q9VRP5.
Gene expression databases
Bgee	Q9VRP5.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	38648.
NextBio	809699.

Entry information

Entry name

UBP36_DROME

Accession

Primary (citable) accession number: Q9VRP5
Secondary accession number(s): Q7YTX7 , Q86NM9, Q8IQ57, Q8IQ58, Q8IQ59, Q8IQ60, Q960Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project