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Protein

Cytochrome P450 307a1

Gene

spo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.1 Publication

Miscellaneous

Member of the Halloween gene group.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi485Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: FlyBase
  • cuticle development Source: FlyBase
  • dorsal closure Source: FlyBase
  • ecdysone biosynthetic process Source: FlyBase
  • embryonic development via the syncytial blastoderm Source: FlyBase
  • embryonic digestive tract development Source: FlyBase
  • head involution Source: FlyBase
  • midgut development Source: FlyBase
  • oogenesis Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Monooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-193048 Androgen biosynthesis
R-DME-193993 Mineralocorticoid biosynthesis
R-DME-194002 Glucocorticoid biosynthesis
R-DME-211976 Endogenous sterols

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 307a1 (EC:1.14.-.-)
Alternative name(s):
CYPCCCVIIA1
Protein spook
Gene namesi
Name:spo
Synonyms:Cyp307a1
ORF Names:CG10594
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0003486 spo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523161 – 543Cytochrome P450 307a1Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VRM7
PRIDEiQ9VRM7

PTM databases

iPTMnetiQ9VRM7

Expressioni

Gene expression databases

BgeeiFBgn0003486
ExpressionAtlasiQ9VRM7 baseline and differential
GenevisibleiQ9VRM7 DM

Interactioni

Protein-protein interaction databases

BioGridi64094, 5 interactors
DIPiDIP-17643N
IntActiQ9VRM7, 4 interactors
STRINGi7227.FBpp0076836

Structurei

3D structure databases

ProteinModelPortaliQ9VRM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
InParanoidiQ9VRM7
KOiK14939
OMAiALPADCF
OrthoDBiEOG091G07DV
PhylomeDBiQ9VRM7

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VRM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAALIYTIL AILLSVLATS YICIIYGVKR RVLQPVKTKN STEINHNAYQ
60 70 80 90 100
KYTQAPGPRP WPIIGNLHLL DRYRDSPFAG FTALAQQYGD IYSLTFGHTR
110 120 130 140 150
CLVVNNLELI REVLNQNGKV MSGRPDFIRY HKLFGGERSN SLALCDWSQL
160 170 180 190 200
QQKRRNLARR HCSPREFSCF YMKMSQIGCE EMEHWNRELG NQLVPGEPIN
210 220 230 240 250
IKPLILKACA NMFSQYMCSL RFDYDDVDFQ QIVQYFDEIF WEINQGHPLD
260 270 280 290 300
FLPWLYPFYQ RHLNKIINWS STIRGFIMER IIRHRELSVD LDEPDRDFTD
310 320 330 340 350
ALLKSLLEDK DVSRNTIIFM LEDFIGGHSA VGNLVMLVLA YIAKNVDIGR
360 370 380 390 400
RIQEEIDAII EEENRSINLL DMNAMPYTMA TIFEVLRYSS SPIVPHVATE
410 420 430 440 450
DTVISGYGVT KGTIVFINNY VLNTSEKFWV NPKEFNPLRF LEPSKEQSPK
460 470 480 490 500
NSKGSDSGIE SDNEKLQLKR NIPHFLPFSI GKRTCIGQNL VRGFGFLVVV
510 520 530 540
NVMQRYNISS HNPSTIKISP ESLALPADCF PLVLTPREKI GPL
Length:543
Mass (Da):62,448
Last modified:August 15, 2003 - v3
Checksum:iF61DE137A0F5C219
GO

Sequence cautioni

The sequence AAL48675 differs from that shown. Reason: Frameshift at position 505.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484415 mRNA Translation: AAQ05973.1
AE014296 Genomic DNA Translation: AAF50766.3
AY071053 mRNA Translation: AAL48675.1 Frameshift.
RefSeqiNP_001286943.1, NM_001300014.1
NP_647975.2, NM_139718.3
UniGeneiDm.31174

Genome annotation databases

EnsemblMetazoaiFBtr0077130; FBpp0076836; FBgn0003486
FBtr0346640; FBpp0312220; FBgn0003486
GeneIDi38631
KEGGidme:Dmel_CG10594
UCSCiCG10594-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCP307_DROME
AccessioniPrimary (citable) accession number: Q9VRM7
Secondary accession number(s): Q8SZ84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 15, 2003
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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