Q9VRL2 (GOSR2_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Golgi SNAP receptor complex member 2

Gene names

Name:	membrin
ORF Names:	CG4780

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein Potential.
Sequence similarities	Belongs to the GOSR2 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phagocytosis, engulfment Inferred from mutant phenotype PubMed 16336044. Source: FlyBase protein transport Inferred from electronic annotation. Source: UniProtKB-KW terminal branching, open tracheal system Inferred from mutant phenotype PubMed 21750678. Source: FlyBase trachea morphogenesis Inferred from mutant phenotype PubMed 21750678. Source: FlyBase
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi stack Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	SNAP receptor activity Inferred from sequence or structural similarity Ref.5. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Probable Golgi SNAP receptor complex member 2		PRO_0000212553
Regions
	Topological domain	1 – 194	194	Cytoplasmic Potential
	Transmembrane	195 – 215	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	216	1	Vesicular Potential
	Coiled coil	62 – 103	42	Potential
Experimental info
	Sequence conflict	125	1	Y → H in AAM51119. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9VRL2 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3CD23EA81BA9851F	FASTA	216	24,833
	10 20 30 40 50 60 MESLYHQTNN VVKDIERDFQ RLSQLSAQES LDVENGIQLK ITQANANCDR LDVLLYKVPP 70 80 90 100 110 120 SQRQSSKLRV DQLKYDLRHL QTSLQTARER RQRRMQEISE REQLLNHRFT ANSAQPEETR 130 140 150 160 170 180 LQLDYELQHH TQLGNAHRGV DDMIASGSGI LESLISQRMT LGGAHKRIQA IGSTLGLSNH 190 200 210 TMKLIERRLV EDRRIFIGGV VVTLLIIALI IYFLVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[5]	"A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila." Littleton J.T. J. Cell Biol. 150:F77-F82(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF50783.1. AY119259 mRNA. Translation: AAM51119.1. BT044445 mRNA. Translation: ACH92510.1.
RefSeq	NP_647960.1. NM_139703.4.
UniGene	Dm.18872.
3D structure databases
ProteinModelPortal	Q9VRL2.
SMR	Q9VRL2. Positions 127-184.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-21257N.
IntAct	Q9VRL2. 1 interaction.
MINT	MINT-820161.
Proteomic databases
PaxDb	Q9VRL2.
PRIDE	Q9VRL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077145; FBpp0076849; FBgn0260856.
GeneID	38614.
KEGG	dme:Dmel_CG4780.
UCSC	CG4780-RA. d. melanogaster.
Organism-specific databases
CTD	38614.
FlyBase	FBgn0260856. membrin.
Phylogenomic databases
eggNOG	NOG148687.
GeneTree	ENSGT00490000043403.
InParanoid	Q9VRL2.
KO	K08496.
OMA	FQDKYFM.
OrthoDB	EOG4RFJ8V.
PhylomeDB	Q9VRL2.
Gene expression databases
Bgee	Q9VRL2.
GermOnline	CG4780. Drosophila melanogaster.
Family and domain databases
InterPro	IPR027027. GOSR2/Membrin/Bos1. [Graphical view]
PIRSF	PIRSF028865. Membrin-2. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	38614.
NextBio	809534.

Entry information

Entry name

GOSR2_DROME

Accession

Primary (citable) accession number: Q9VRL2
Secondary accession number(s): B5RJH1, Q8MRU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project