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Q9VRL2

- GOSR2_DROME

UniProt

Q9VRL2 - GOSR2_DROME

Protein

Probable Golgi SNAP receptor complex member 2

Gene

membrin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.By similarity

    GO - Molecular functioni

    1. SNAP receptor activity Source: FlyBase

    GO - Biological processi

    1. phagocytosis Source: FlyBase
    2. protein transport Source: UniProtKB-KW
    3. terminal branching, open tracheal system Source: FlyBase
    4. trachea morphogenesis Source: FlyBase
    5. vesicle-mediated transport Source: FlyBase

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_180717. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable Golgi SNAP receptor complex member 2
    Gene namesi
    Name:membrin
    ORF Names:CG4780
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0260856. membrin.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi stack Source: InterPro
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Probable Golgi SNAP receptor complex member 2PRO_0000212553Add
    BLAST

    Proteomic databases

    PaxDbiQ9VRL2.
    PRIDEiQ9VRL2.

    Expressioni

    Gene expression databases

    BgeeiQ9VRL2.

    Interactioni

    Protein-protein interaction databases

    BioGridi64080. 26 interactions.
    DIPiDIP-21257N.
    IntActiQ9VRL2. 1 interaction.
    MINTiMINT-820161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VRL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 194194CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini216 – 2161VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei195 – 21521Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili62 – 10342Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOSR2 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148687.
    GeneTreeiENSGT00490000043403.
    InParanoidiQ9VRL2.
    KOiK08496.
    OMAiQNAHRGM.
    OrthoDBiEOG73RBCP.
    PhylomeDBiQ9VRL2.

    Family and domain databases

    InterProiIPR027027. GOSR2/Membrin/Bos1.
    [Graphical view]
    PIRSFiPIRSF028865. Membrin-2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9VRL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLYHQTNN VVKDIERDFQ RLSQLSAQES LDVENGIQLK ITQANANCDR    50
    LDVLLYKVPP SQRQSSKLRV DQLKYDLRHL QTSLQTARER RQRRMQEISE 100
    REQLLNHRFT ANSAQPEETR LQLDYELQHH TQLGNAHRGV DDMIASGSGI 150
    LESLISQRMT LGGAHKRIQA IGSTLGLSNH TMKLIERRLV EDRRIFIGGV 200
    VVTLLIIALI IYFLVL 216
    Length:216
    Mass (Da):24,833
    Last modified:May 1, 2000 - v1
    Checksum:i3CD23EA81BA9851F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251Y → H in AAM51119. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF50783.1.
    AY119259 mRNA. Translation: AAM51119.1.
    BT044445 mRNA. Translation: ACH92510.1.
    RefSeqiNP_647960.1. NM_139703.4.
    UniGeneiDm.18872.

    Genome annotation databases

    EnsemblMetazoaiFBtr0077145; FBpp0076849; FBgn0260856.
    GeneIDi38614.
    KEGGidme:Dmel_CG4780.
    UCSCiCG4780-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF50783.1 .
    AY119259 mRNA. Translation: AAM51119.1 .
    BT044445 mRNA. Translation: ACH92510.1 .
    RefSeqi NP_647960.1. NM_139703.4.
    UniGenei Dm.18872.

    3D structure databases

    ProteinModelPortali Q9VRL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 64080. 26 interactions.
    DIPi DIP-21257N.
    IntActi Q9VRL2. 1 interaction.
    MINTi MINT-820161.

    Proteomic databases

    PaxDbi Q9VRL2.
    PRIDEi Q9VRL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0077145 ; FBpp0076849 ; FBgn0260856 .
    GeneIDi 38614.
    KEGGi dme:Dmel_CG4780.
    UCSCi CG4780-RA. d. melanogaster.

    Organism-specific databases

    CTDi 38614.
    FlyBasei FBgn0260856. membrin.

    Phylogenomic databases

    eggNOGi NOG148687.
    GeneTreei ENSGT00490000043403.
    InParanoidi Q9VRL2.
    KOi K08496.
    OMAi QNAHRGM.
    OrthoDBi EOG73RBCP.
    PhylomeDBi Q9VRL2.

    Enzyme and pathway databases

    Reactomei REACT_180717. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    GenomeRNAii 38614.
    NextBioi 809534.
    PROi Q9VRL2.

    Gene expression databases

    Bgeei Q9VRL2.

    Family and domain databases

    InterProi IPR027027. GOSR2/Membrin/Bos1.
    [Graphical view ]
    PIRSFi PIRSF028865. Membrin-2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
    5. "A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila."
      Littleton J.T.
      J. Cell Biol. 150:F77-F82(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiGOSR2_DROME
    AccessioniPrimary (citable) accession number: Q9VRL2
    Secondary accession number(s): B5RJH1, Q8MRU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3