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Protein

Probable Golgi SNAP receptor complex member 2

Gene

Membrin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: GO_Central

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi to vacuole transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • phagocytosis Source: FlyBase
  • protein targeting to vacuole Source: GO_Central
  • retrograde transport, endosome to Golgi Source: GO_Central
  • terminal branching, open tracheal system Source: FlyBase
  • trachea morphogenesis Source: FlyBase
  • vesicle fusion Source: FlyBase
  • vesicle fusion with Golgi apparatus Source: GO_Central
  • vesicle-mediated transport Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DME-5694530. Cargo concentration in the ER.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Golgi SNAP receptor complex member 2
Gene namesi
Name:MembrinImported
ORF Names:CG4780Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260856. Membrin.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 194CytoplasmicSequence analysisAdd BLAST194
Transmembranei195 – 215Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini216VesicularSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125531 – 216Probable Golgi SNAP receptor complex member 2Add BLAST216

Proteomic databases

PaxDbiQ9VRL2.
PRIDEiQ9VRL2.

Expressioni

Gene expression databases

BgeeiFBgn0260856.
GenevisibleiQ9VRL2. DM.

Interactioni

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi64080. 26 interactors.
DIPiDIP-21257N.
IntActiQ9VRL2. 1 interactor.
MINTiMINT-820161.
STRINGi7227.FBpp0076849.

Structurei

3D structure databases

ProteinModelPortaliQ9VRL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili62 – 103Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3251. Eukaryota.
ENOG4111M37. LUCA.
GeneTreeiENSGT00490000043403.
InParanoidiQ9VRL2.
KOiK08496.
OMAiRSFTTND.
OrthoDBiEOG091G0KS8.
PhylomeDBiQ9VRL2.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VRL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLYHQTNN VVKDIERDFQ RLSQLSAQES LDVENGIQLK ITQANANCDR
60 70 80 90 100
LDVLLYKVPP SQRQSSKLRV DQLKYDLRHL QTSLQTARER RQRRMQEISE
110 120 130 140 150
REQLLNHRFT ANSAQPEETR LQLDYELQHH TQLGNAHRGV DDMIASGSGI
160 170 180 190 200
LESLISQRMT LGGAHKRIQA IGSTLGLSNH TMKLIERRLV EDRRIFIGGV
210
VVTLLIIALI IYFLVL
Length:216
Mass (Da):24,833
Last modified:May 1, 2000 - v1
Checksum:i3CD23EA81BA9851F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125Y → H in AAM51119 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50783.1.
AY119259 mRNA. Translation: AAM51119.1.
BT044445 mRNA. Translation: ACH92510.1.
RefSeqiNP_647960.1. NM_139703.4.
UniGeneiDm.18872.

Genome annotation databases

EnsemblMetazoaiFBtr0077145; FBpp0076849; FBgn0260856.
GeneIDi38614.
KEGGidme:Dmel_CG4780.
UCSCiCG4780-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50783.1.
AY119259 mRNA. Translation: AAM51119.1.
BT044445 mRNA. Translation: ACH92510.1.
RefSeqiNP_647960.1. NM_139703.4.
UniGeneiDm.18872.

3D structure databases

ProteinModelPortaliQ9VRL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64080. 26 interactors.
DIPiDIP-21257N.
IntActiQ9VRL2. 1 interactor.
MINTiMINT-820161.
STRINGi7227.FBpp0076849.

Proteomic databases

PaxDbiQ9VRL2.
PRIDEiQ9VRL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077145; FBpp0076849; FBgn0260856.
GeneIDi38614.
KEGGidme:Dmel_CG4780.
UCSCiCG4780-RA. d. melanogaster.

Organism-specific databases

CTDi38614.
FlyBaseiFBgn0260856. Membrin.

Phylogenomic databases

eggNOGiKOG3251. Eukaryota.
ENOG4111M37. LUCA.
GeneTreeiENSGT00490000043403.
InParanoidiQ9VRL2.
KOiK08496.
OMAiRSFTTND.
OrthoDBiEOG091G0KS8.
PhylomeDBiQ9VRL2.

Enzyme and pathway databases

ReactomeiR-DME-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-DME-5694530. Cargo concentration in the ER.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811438. Intra-Golgi traffic.

Miscellaneous databases

GenomeRNAii38614.
PROiQ9VRL2.

Gene expression databases

BgeeiFBgn0260856.
GenevisibleiQ9VRL2. DM.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR2_DROME
AccessioniPrimary (citable) accession number: Q9VRL2
Secondary accession number(s): B5RJH1, Q8MRU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.