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Protein

CTD nuclear envelope phosphatase 1 homolog

Gene

Dd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

  • imaginal disc-derived wing vein specification Source: FlyBase
  • negative regulation of BMP signaling pathway Source: FlyBase
  • nuclear envelope organization Source: UniProtKB
  • positive regulation of triglyceride biosynthetic process Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-DME-4419969 Depolymerisation of the Nuclear Lamina

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 homolog (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard homolog
Gene namesi
Name:Dd
Synonyms:l(1)G0269
ORF Names:CG1696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0029067 Dd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 27HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979761 – 243CTD nuclear envelope phosphatase 1 homologAdd BLAST243

Proteomic databases

PaxDbiQ9VRG7
PRIDEiQ9VRG7

Expressioni

Gene expression databases

BgeeiFBgn0029067
ExpressionAtlasiQ9VRG7 baseline and differential
GenevisibleiQ9VRG7 DM

Interactioni

Protein-protein interaction databases

BioGridi59385, 14 interactors
STRINGi7227.FBpp0076921

Structurei

3D structure databases

ProteinModelPortaliQ9VRG7
SMRiQ9VRG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 223FCP1 homologyPROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the dullard family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000017194
HOGENOMiHOG000002447
InParanoidiQ9VRG7
KOiK17617
OrthoDBiEOG091G0GIO
PhylomeDBiQ9VRG7

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VRG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLLQMKFR ALLLLLSKVW TCICFMFNRQ VRAFIQYQPV KYELFPLSPV
60 70 80 90 100
SRHRLSLVQR KTLVLDLDET LIHSHHNAMP RNTVKPGTPH DFTVKVTIDR
110 120 130 140 150
NPVRFFVHKR PHVDYFLDVV SQWYDLVVFT ASMEIYGAAV ADKLDNGRNI
160 170 180 190 200
LRRRYYRQHC TPDYGSYTKD LSAICSDLNR IFIIDNSPGA YRCFPNNAIP
210 220 230 240
IKSWFSDPMD TALLSLLPML DALRFTNDVR SVLSRNLHLH RLW
Length:243
Mass (Da):28,486
Last modified:May 1, 2000 - v1
Checksum:i1E278DD1D8DF60C6
GO

Sequence cautioni

The sequence AAM48350 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50833.1
AY094776 mRNA Translation: AAM11129.1
AY118321 mRNA Translation: AAM48350.1 Different initiation.
RefSeqiNP_608449.1, NM_134605.3
UniGeneiDm.7059

Genome annotation databases

EnsemblMetazoaiFBtr0077226; FBpp0076921; FBgn0029067
GeneIDi33107
KEGGidme:Dmel_CG1696

Similar proteinsi

Entry informationi

Entry nameiCNEP1_DROME
AccessioniPrimary (citable) accession number: Q9VRG7
Secondary accession number(s): Q8MT79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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