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Protein

Cystathionine beta-synthase

Gene

Cbs

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine + L-homocysteine = L-cystathionine + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Iron (heme axial ligand); via tele nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

  • cysteine biosynthetic process from serine Source: UniProtKB-UniRule
  • cysteine biosynthetic process via cystathionine Source: UniProtKB-UniRule
  • determination of adult lifespan Source: FlyBase
  • homocysteine metabolic process Source: FlyBase
  • response to endoplasmic reticulum stress Source: FlyBase

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Cysteine biosynthesisUniRule annotation
LigandHemeCombined sources, Iron, Metal-binding, Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BRENDAi4.2.1.22 1994
ReactomeiR-DME-1614603 Cysteine formation from homocysteine

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-synthaseUniRule annotation (EC:4.2.1.22UniRule annotation)
Gene namesi
Name:CbsImported
Synonyms:CBSImported, dCBSImported, DmCBSImported, Dmel\CG1753Imported
ORF Names:CG1753Imported, Dmel_CG1753Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031148 Cbs

Subcellular locationi

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88N6-(pyridoxal phosphate)lysineCombined sources1

Proteomic databases

PRIDEiQ9VRD9

Expressioni

Gene expression databases

BgeeiFBgn0031148

Interactioni

Protein-protein interaction databases

DIPiDIP-59487N
IntActiQ9VRD9, 5 interactors
STRINGi7227.FBpp0076937

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PC2X-ray1.80A1-522[»]
3PC3X-ray1.55A1-522[»]
3PC4X-ray1.70A1-522[»]
SMRiQ9VRD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini385 – 445CBSInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1252 Eukaryota
COG0031 LUCA
GeneTreeiENSGT00510000047027
KOiK01697
OMAiSYLSKFA
OrthoDBiEOG091G02TP

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR005857 Cysta_beta_synth
IPR001216 P-phosphate_BS
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF00291 PALP, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01137 cysta_beta, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 1 hit
PS00901 CYS_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VRD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQPKPYERP ADFIDPGKPS KCKWHLGTAE KSPHIHRGIA HRQQITPNIL
60 70 80 90 100
EVIGCTPLVK LNNIPASDGI ECEMYAKCEF LNPGGSVKDR IGYRMVQDAE
110 120 130 140 150
EQGLLKPGYT IIEPTSGNTG IGLAMACAVK GYKCIIVMPE KMSNEKVSAL
160 170 180 190 200
RTLGAKIIRT PTEAAYDSPE GLIYVAQQLQ RETPNSIVLD QYRNAGNPLA
210 220 230 240 250
HYDGTAAEIL WQLDNKVDMI VVSAGTAGTI SGIGRKIKEQ VPSCQIVGVD
260 270 280 290 300
PYGSILARPA ELNKTDVQFY EVEGIGYDFP PTVFDDTVVD VWTKIGDSDC
310 320 330 340 350
FPMSRRLNAE EGLLCGGSSG GAMHAALEHA RKLKKGQRCV VILPDGIRNY
360 370 380 390 400
MTKFVSDNWM EARNFKEPVN EHGHWWWSLA IAELELPAPP VILKSDATVG
410 420 430 440 450
EAIALMKKHR VDQLPVVDQD DGSVLGVVGQ ETLITQIVSM NRQQSDPAIK
460 470 480 490 500
ALNKRVIRLN ESEILGKLAR VLEVDPSVLI LGKNPAGKVE LKALATKLDV
510 520
TTFIAAGKQK PKANGTTNGG SH
Length:522
Mass (Da):56,882
Last modified:May 1, 2000 - v1
Checksum:i880D12F37E9D7CC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50862.1
AE014298 Genomic DNA Translation: AAF50863.1
AY058508 mRNA Translation: AAL13737.1
AE014298 Genomic DNA Translation: AHN59978.1
RefSeqiNP_001285508.1, NM_001298579.1
NP_608424.1, NM_134580.3
NP_728384.1, NM_167726.2
UniGeneiDm.4181

Genome annotation databases

EnsemblMetazoaiFBtr0077244; FBpp0076937; FBgn0031148
FBtr0077245; FBpp0076938; FBgn0031148
FBtr0340437; FBpp0309380; FBgn0031148
GeneIDi33081
KEGGidme:Dmel_CG1753
UCSCiCG1753-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VRD9_DROME
AccessioniPrimary (citable) accession number: Q9VRD9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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