Q9VRA6 (Q9VRA6_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RhoGAP19D, isoform A EMBL AAF50897.2

Gene names

Name:	RhoGAP19D EMBL AAF50897.2
ORF Names:	Dmel_CG1412 EMBL AAF50897.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	2181 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VRA6 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: AB833FCA94412D07	FASTA	2,181	229,767
	10 20 30 40 50 60 MLQNSNGAAA AHSAASAVAT PAAAASAAAA AAAAAVAAAA NNAALAASSI QPKLIVIRRR 70 80 90 100 110 120 PNQGFGFTLR HFIAYPPEDD QASSSASGLV SGSATAATAA SVSTNWPQEA SSAAGSNSGS 130 140 150 160 170 180 SSSVGVAGIT GLEPTSPTSL PPYQVKAMET IFIKEVQANG PAHYANLQTG DRVLMVNNQP 190 200 210 220 230 240 IAGIAYSTIV SMIKQTPAVL TLHVVPKECD VLQMHYTSIA HTPESNRLTM STHSPSLLAN 250 260 270 280 290 300 GSHKTTFPAA AAVAAPPHQH QQQQQQLISY PAVAAVTTST PAGSPQSQSQ SQSHSHPNTH 310 320 330 340 350 360 HAPSLHGGSR SGSITSTASG GITVLSQPFY PQQQQQQQQQ QQHRHPALTG GSSSIDFGDM 370 380 390 400 410 420 AHGLRQHQQQ QQHLYQQQQQ HHQFMRANQP PNLTVLSASS ATNTPTPTAR QPKSATSHNQ 430 440 450 460 470 480 ALYAVGAGPS SAAGSGSGSL SGGSENSDLM IRLRESIKQK EEFLKSPVPA SMSSASSING 490 500 510 520 530 540 NQAQSSSPAQ QQHLQQHQQH FFPSHTPPGG VQVVVPPPRS RHQVMLKQQQ QQQQQHQQHH 550 560 570 580 590 600 VLGYDMYHSG GKLVQRSSTA PGSVCHQHQQ QQQHHLYHQQ QHQQLQQTQH RQVMINNNAK 610 620 630 640 650 660 YAKDLDYFET LQETGVTNKV FERKLVSHMS KGFDPFKPLS INTSALESSA STSSTSATTT 670 680 690 700 710 720 VKKQSVLYES LQQHPLAKYH QTQQQTTTTT TVDGQTSSRM ELHKATLANA TIDPVPVGSS 730 740 750 760 770 780 TAAIVDSASG SGNVVRRYKP LSSSSFDEGK PMRRISYLRA TNNETDFNAE AAAGGDAAAT 790 800 810 820 830 840 GASGPASASA ASSAPGPTPS SAPAPAPAPA PLPISIPIPV AAVVEPQKTK SLVEEHPDPT 850 860 870 880 890 900 YDVIGGTGGG HEFIETPNGL EDVRLSAHGS RRASMSSDMR SSIHIDAELN GKYVPNELEA 910 920 930 940 950 960 FETEIEIKSS CINGKRMSEY RSWRQVKLEI KGDLLRIYSG RHAKSEHNVI ELDIRNFKFF 970 980 990 1000 1010 1020 DESMDKKKYL IRMQSKPSPS GAHLASLGNE LNLDEGHDKL LTSSGSSSAN EPAANAASAL 1030 1040 1050 1060 1070 1080 TASTSSSTCS SGPYTEILFK TKSSNEMKRL FGLLQWKDSL NYDDNEHQPQ GKQLAEPQKT 1090 1100 1110 1120 1130 1140 VASASYLDDV QGGASAADSS PLSSHSGGIA DASGSHHVSA LPAAAAIVAA TSDSISPVMK 1150 1160 1170 1180 1190 1200 ARKSSSHKHI PDKDLGSPKS KNWKDLLFRR GGSGSGGVSH HDLASPSACA AKQIGSIGVP 1210 1220 1230 1240 1250 1260 LRSCPMSKVN AYVPHLVEVC TNIVETKGLG VVGIYRIPGN KAAISELSEL VNTKDFQFES 1270 1280 1290 1300 1310 1320 CASDDRWEDV NVVSSLLKLF IRSLPDALMP ASYYINFIEA DKKFGLERIV LLREIVESLP 1330 1340 1350 1360 1370 1380 RHPYETMKHL IRHLCRVSGN CDVNRMEPKN LAIIFGPSII RTPNDTLETA VKDMKHQCRI 1390 1400 1410 1420 1430 1440 VELLVTQYDY FFEGGSLPDI AEVSGGTAAV SAAQPQQQTQ EDQTSMLLHN LSKIERITER 1450 1460 1470 1480 1490 1500 ETTRTSRFMP QLRRKTHGKR SAVNSDTYSG ESVLVSGSSS NTTTTTTTTT HTTSSTSSSN 1510 1520 1530 1540 1550 1560 TITTTISTTT IQQRRAQRKA VQSICDQALI LLLPTPVSSV SLPFQSLDYA KASASASASA 1570 1580 1590 1600 1610 1620 SSTASTSSSS TLHSGGKASA SSSSSSTTKF SSSSSSACST TAVAISSSIS ATSSKLLSAN 1630 1640 1650 1660 1670 1680 FKKRSTGGFL GSRSSHQTRK ASLDEKDSGQ SSGSLGHSLG VGINLAKEQQ RSSVDISILL 1690 1700 1710 1720 1730 1740 TDDDSSSRLS DTGSMSLTTI TDTLDSKLRN LRSGSESNDE NGSPEFPKNR RHTLGQPLHM 1750 1760 1770 1780 1790 1800 HSENIPYADE SPERLFHQFC NPLETAPLSL HLSRSCTATN TIGGDEKPSK QSGGVAPLPP 1810 1820 1830 1840 1850 1860 SLLKAAHKLQ HSATVPIHQG SSTAPTSGAA TPVGTPTGSG GAGAIPSRSS SSSVTTLTKS 1870 1880 1890 1900 1910 1920 IQPRFSNYLS YERGNAAAGG AERVVGSAGG AASDDDSEGS TTSDPKEKLL LGERPSPSFF 1930 1940 1950 1960 1970 1980 IERYNKKRRD HRLFRSASFN CRNYSTRHIT AQTSGGVAAG VSGGVAGAVA VGVACCQALS 1990 2000 2010 2020 2030 2040 TTGLTKDEKT DMNLTKKRQI QNKQNRSIKR RHTVGGPHDY SASNGGCSNH SHGHDLAAIN 2050 2060 2070 2080 2090 2100 YNHHNRHHQQ QLLKLGSATS GGGGSGAAAA ETTTTTTTTT TVLRRLGTGQ AGAEASVALP 2110 2120 2130 2140 2150 2160 ASSSGSSSNN NNSPQSDGSN GNGGGVAGVA SNAPPTGVGV GGNNSSGSSS NSSSTSTTPA 2170 2180 GNGDQVLEVG IRIKNISRGR F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF50897.2.
RefSeq	NP_608396.2. NM_134552.4.
UniGene	Dm.7998.
3D structure databases
HSSP	HSSP built from PDB template 1UEW based on UniProtKB Q86UL8.
ProteinModelPortal	Q9VRA6.
SMR	Q9VRA6. Positions 48-214, 1195-1392.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077320; FBpp0077012; FBgn0031118.
GeneID	33048.
KEGG	dme:Dmel_CG1412.
NMPDR	fig|7227.3.peg.18799.
UCSC	CG1412-RA. d. melanogaster.
Organism-specific databases
CTD	33048.
FlyBase	FBgn0031118. RhoGAP19D.
Phylogenomic databases
GeneTree	EMGT00050000001404.
InParanoid	Q9VRA6.
OMA	AMETIFI.
PhylomeDB	Q9VRA6.
Gene expression databases
ArrayExpress	Q9VRA6.
Bgee	Q9VRA6.
Family and domain databases
InterPro	IPR001478. PDZ/DHR/GLGF. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:1.10.555.10. RhoGAP. 1 hit.
Pfam	PF00595. PDZ. 1 hit. PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	781688.

Entry information

Entry name

Q9VRA6_DROME

Accession

Primary (citable) accession number: Q9VRA6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)