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Protein

Cactin

Gene

cactin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral axis specification Source: UniProtKB
  • mRNA splicing, via spliceosome Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Cactin
Alternative name(s):
Cactus-interacting protein
Gene namesi
Name:cactin
ORF Names:CG1676
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031114 cactin

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004192661 – 720CactinAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99Phosphoserine1 Publication1
Modified residuei104Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VR99
PRIDEiQ9VR99

PTM databases

iPTMnetiQ9VR99

Expressioni

Tissue specificityi

Expressed in ovary (at protein level).1 Publication

Developmental stagei

Expressed during embryogenesis (at protein level).1 Publication

Gene expression databases

BgeeiFBgn0031114
ExpressionAtlasiQ9VR99 baseline and differential
GenevisibleiQ9VR99 DM

Interactioni

Subunit structurei

Interacts with cact.1 Publication

Protein-protein interaction databases

BioGridi59332, 45 interactors
IntActiQ9VR99, 11 interactors
STRINGi7227.FBpp0076997

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 159Sequence analysisAdd BLAST51
Coiled coili206 – 236Sequence analysisAdd BLAST31
Coiled coili346 – 375Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 77Arg-richAdd BLAST69

Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2370 Eukaryota
ENOG410XPKF LUCA
GeneTreeiENSGT00390000000097
InParanoidiQ9VR99
OMAiNQTHYDT
OrthoDBiEOG091G08BK

Family and domain databases

InterProiView protein in InterPro
IPR019134 Cactin_C
IPR018816 Cactin_central
PfamiView protein in Pfam
PF10312 Cactin_mid, 1 hit
PF09732 CactinC_cactus, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEKSKHRH RSRSRERRDH RSPDPRSSRN RDRDRERERE KDRDHRDHRD
60 70 80 90 100
KERDQRRERE KDKSRDKKRE HKSRRRRSSS SSSSPSSSTS SSVPGAPRSP
110 120 130 140 150
LVKSPMKLLQ TLEARRLVEQ KDRQRKKEEL KAHETPEEKR ARRLREKQAK
160 170 180 190 200
EQRRRERMGW DNEYQTYSNE DNPFGDSNLT STFHWGKKLE VEGLSNLSTK
210 220 230 240 250
TVEVLSLQKQ LENRRELEKV KKRRQERELE RQVREDDLMM QQRAKEAVQF
260 270 280 290 300
REWQRQEDQF HLEQARLRSE IRIRDGRAKP IDLLAQYVAA GNEPLEECLE
310 320 330 340 350
MQMHEPYVLL NGLPVEELED LLVDIKVYEE LEQGKHIDFW NDMITIVQDE
360 370 380 390 400
LQRQQKLEAE NSSLNQRRDG IHQAVVKDVA DIFRGKNAQQ LEEMRHRIEA
410 420 430 440 450
KISGRADGVD ISYWESLLSQ LKAHMARARL RDRHQALLRE KLSLLKREND
460 470 480 490 500
NETLQEKVAP QVKEEEMETQ DAEDPEVEEG SPEDEEDPLN ELRKTVRLYQ
510 520 530 540 550
AGNYSPRYIR EEDFTGRRAQ NEDVDEPEAE GLLYEEEDDE RRTQRQRLLI
560 570 580 590 600
LHPERVDNNQ LTPQELRMRN EAKQGMQGDE AEFSVETTLD AVPQLATDKY
610 620 630 640 650
RPRKPRYFNR VHTGFEWNKY NQTHYDMDNP PPKIVQGYKF NIFYPDLMDK
660 670 680 690 700
SQTPQYFLTP CADNGDFAVL RFHTGPPYED IAFKIVNREW EFSYKRGFRC
710 720
QFHNNIFQLW FHFKRYRYRR
Length:720
Mass (Da):86,556
Last modified:October 3, 2012 - v3
Checksum:iD7C5175A3925FFDB
GO

Sequence cautioni

The sequence AAF66981 differs from that shown. Reason: Frameshift at position 697.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70 – 71EH → DD in AAF66981 (PubMed:10842059).Curated2
Sequence conflicti93V → M in AAF66981 (PubMed:10842059).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245116 mRNA Translation: AAF66981.1 Frameshift.
AE014298 Genomic DNA Translation: AAF50904.3
RefSeqiNP_523422.4, NM_078698.4

Genome annotation databases

EnsemblMetazoaiFBtr0340400; FBpp0309346; FBgn0031114
GeneIDi33043
KEGGidme:Dmel_CG1676
UCSCiCG1676-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCATIN_DROME
AccessioniPrimary (citable) accession number: Q9VR99
Secondary accession number(s): Q9NBV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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