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Q9VR99

- CATIN_DROME

UniProt

Q9VR99 - CATIN_DROME

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Protein

Cactin

Gene

cactin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway.1 Publication

GO - Biological processi

  1. dorsal/ventral axis specification Source: UniProtKB
  2. mRNA splicing, via spliceosome Source: FlyBase
  3. neurogenesis Source: FlyBase
  4. neuron projection morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Cactin
Alternative name(s):
Cactus-interacting protein
Gene namesi
Name:cactin
ORF Names:CG1676
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031114. cactin.

Subcellular locationi

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720CactinPRO_0000419266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991Phosphoserine1 Publication
Modified residuei104 – 1041Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9VR99.

Expressioni

Tissue specificityi

Expressed in ovary (at protein level).1 Publication

Developmental stagei

Expressed during embryogenesis (at protein level).1 Publication

Gene expression databases

BgeeiQ9VR99.

Interactioni

Subunit structurei

Interacts with cact.1 Publication

Protein-protein interaction databases

IntActiQ9VR99. 11 interactions.
MINTiMINT-307793.
STRINGi7227.FBpp0076997.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili109 – 15951Sequence AnalysisAdd
BLAST
Coiled coili206 – 23631Sequence AnalysisAdd
BLAST
Coiled coili346 – 37530Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 7769Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ9VR99.
OrthoDBiEOG7XM2Z3.

Family and domain databases

InterProiIPR019134. Cactin_C.
IPR018816. Cactin_central.
[Graphical view]
PfamiPF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.
[Graphical view]
SMARTiSM01050. CactinC_cactus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VR99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKEKSKHRH RSRSRERRDH RSPDPRSSRN RDRDRERERE KDRDHRDHRD
60 70 80 90 100
KERDQRRERE KDKSRDKKRE HKSRRRRSSS SSSSPSSSTS SSVPGAPRSP
110 120 130 140 150
LVKSPMKLLQ TLEARRLVEQ KDRQRKKEEL KAHETPEEKR ARRLREKQAK
160 170 180 190 200
EQRRRERMGW DNEYQTYSNE DNPFGDSNLT STFHWGKKLE VEGLSNLSTK
210 220 230 240 250
TVEVLSLQKQ LENRRELEKV KKRRQERELE RQVREDDLMM QQRAKEAVQF
260 270 280 290 300
REWQRQEDQF HLEQARLRSE IRIRDGRAKP IDLLAQYVAA GNEPLEECLE
310 320 330 340 350
MQMHEPYVLL NGLPVEELED LLVDIKVYEE LEQGKHIDFW NDMITIVQDE
360 370 380 390 400
LQRQQKLEAE NSSLNQRRDG IHQAVVKDVA DIFRGKNAQQ LEEMRHRIEA
410 420 430 440 450
KISGRADGVD ISYWESLLSQ LKAHMARARL RDRHQALLRE KLSLLKREND
460 470 480 490 500
NETLQEKVAP QVKEEEMETQ DAEDPEVEEG SPEDEEDPLN ELRKTVRLYQ
510 520 530 540 550
AGNYSPRYIR EEDFTGRRAQ NEDVDEPEAE GLLYEEEDDE RRTQRQRLLI
560 570 580 590 600
LHPERVDNNQ LTPQELRMRN EAKQGMQGDE AEFSVETTLD AVPQLATDKY
610 620 630 640 650
RPRKPRYFNR VHTGFEWNKY NQTHYDMDNP PPKIVQGYKF NIFYPDLMDK
660 670 680 690 700
SQTPQYFLTP CADNGDFAVL RFHTGPPYED IAFKIVNREW EFSYKRGFRC
710 720
QFHNNIFQLW FHFKRYRYRR
Length:720
Mass (Da):86,556
Last modified:October 3, 2012 - v3
Checksum:iD7C5175A3925FFDB
GO

Sequence cautioni

The sequence AAF66981.1 differs from that shown. Reason: Frameshift at position 697.
The sequence AAF50904.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 712EH → DD in AAF66981. (PubMed:10842059)Curated
Sequence conflicti93 – 931V → M in AAF66981. (PubMed:10842059)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245116 mRNA. Translation: AAF66981.1. Frameshift.
AE014298 Genomic DNA. Translation: AAF50904.2. Different initiation.
RefSeqiNP_523422.4. NM_078698.4.

Genome annotation databases

GeneIDi33043.
UCSCiCG1676-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245116 mRNA. Translation: AAF66981.1 . Frameshift.
AE014298 Genomic DNA. Translation: AAF50904.2 . Different initiation.
RefSeqi NP_523422.4. NM_078698.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9VR99. 11 interactions.
MINTi MINT-307793.
STRINGi 7227.FBpp0076997.

Proteomic databases

PRIDEi Q9VR99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 33043.
UCSCi CG1676-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0031114. cactin.

Phylogenomic databases

InParanoidi Q9VR99.
OrthoDBi EOG7XM2Z3.

Miscellaneous databases

GenomeRNAii 33043.
NextBioi 781659.

Gene expression databases

Bgeei Q9VR99.

Family and domain databases

InterProi IPR019134. Cactin_C.
IPR018816. Cactin_central.
[Graphical view ]
Pfami PF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.
[Graphical view ]
SMARTi SM01050. CactinC_cactus. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function."
    Lin P., Huang L.H., Steward R.
    Mech. Dev. 94:57-65(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CACT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Ovary.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-104, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCATIN_DROME
AccessioniPrimary (citable) accession number: Q9VR99
Secondary accession number(s): Q9NBV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3