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Protein

Cactin

Gene

cactin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral axis specification Source: UniProtKB
  • mRNA splicing, via spliceosome Source: FlyBase
  • neurogenesis Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Cactin
Alternative name(s):
Cactus-interacting protein
Gene namesi
Name:cactin
ORF Names:CG1676
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031114. cactin.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004192661 – 720CactinAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99Phosphoserine1 Publication1
Modified residuei104Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VR99.
PRIDEiQ9VR99.

PTM databases

iPTMnetiQ9VR99.

Expressioni

Tissue specificityi

Expressed in ovary (at protein level).1 Publication

Developmental stagei

Expressed during embryogenesis (at protein level).1 Publication

Gene expression databases

BgeeiFBgn0031114.
GenevisibleiQ9VR99. DM.

Interactioni

Subunit structurei

Interacts with cact.1 Publication

Protein-protein interaction databases

BioGridi59332. 44 interactors.
IntActiQ9VR99. 11 interactors.
MINTiMINT-307793.
STRINGi7227.FBpp0076997.

Structurei

3D structure databases

ProteinModelPortaliQ9VR99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 159Sequence analysisAdd BLAST51
Coiled coili206 – 236Sequence analysisAdd BLAST31
Coiled coili346 – 375Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 77Arg-richAdd BLAST69

Sequence similaritiesi

Belongs to the CACTIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2370. Eukaryota.
ENOG410XPKF. LUCA.
GeneTreeiENSGT00390000000097.
InParanoidiQ9VR99.
OMAiVMEHQKK.
OrthoDBiEOG091G08BK.

Family and domain databases

InterProiIPR019134. Cactin_C.
IPR018816. Cactin_central.
[Graphical view]
PfamiPF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEKSKHRH RSRSRERRDH RSPDPRSSRN RDRDRERERE KDRDHRDHRD
60 70 80 90 100
KERDQRRERE KDKSRDKKRE HKSRRRRSSS SSSSPSSSTS SSVPGAPRSP
110 120 130 140 150
LVKSPMKLLQ TLEARRLVEQ KDRQRKKEEL KAHETPEEKR ARRLREKQAK
160 170 180 190 200
EQRRRERMGW DNEYQTYSNE DNPFGDSNLT STFHWGKKLE VEGLSNLSTK
210 220 230 240 250
TVEVLSLQKQ LENRRELEKV KKRRQERELE RQVREDDLMM QQRAKEAVQF
260 270 280 290 300
REWQRQEDQF HLEQARLRSE IRIRDGRAKP IDLLAQYVAA GNEPLEECLE
310 320 330 340 350
MQMHEPYVLL NGLPVEELED LLVDIKVYEE LEQGKHIDFW NDMITIVQDE
360 370 380 390 400
LQRQQKLEAE NSSLNQRRDG IHQAVVKDVA DIFRGKNAQQ LEEMRHRIEA
410 420 430 440 450
KISGRADGVD ISYWESLLSQ LKAHMARARL RDRHQALLRE KLSLLKREND
460 470 480 490 500
NETLQEKVAP QVKEEEMETQ DAEDPEVEEG SPEDEEDPLN ELRKTVRLYQ
510 520 530 540 550
AGNYSPRYIR EEDFTGRRAQ NEDVDEPEAE GLLYEEEDDE RRTQRQRLLI
560 570 580 590 600
LHPERVDNNQ LTPQELRMRN EAKQGMQGDE AEFSVETTLD AVPQLATDKY
610 620 630 640 650
RPRKPRYFNR VHTGFEWNKY NQTHYDMDNP PPKIVQGYKF NIFYPDLMDK
660 670 680 690 700
SQTPQYFLTP CADNGDFAVL RFHTGPPYED IAFKIVNREW EFSYKRGFRC
710 720
QFHNNIFQLW FHFKRYRYRR
Length:720
Mass (Da):86,556
Last modified:October 3, 2012 - v3
Checksum:iD7C5175A3925FFDB
GO

Sequence cautioni

The sequence AAF66981 differs from that shown. Reason: Frameshift at position 697.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70 – 71EH → DD in AAF66981 (PubMed:10842059).Curated2
Sequence conflicti93V → M in AAF66981 (PubMed:10842059).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245116 mRNA. Translation: AAF66981.1. Frameshift.
AE014298 Genomic DNA. Translation: AAF50904.3.
RefSeqiNP_523422.4. NM_078698.4.

Genome annotation databases

EnsemblMetazoaiFBtr0340400; FBpp0309346; FBgn0031114.
GeneIDi33043.
KEGGidme:Dmel_CG1676.
UCSCiCG1676-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245116 mRNA. Translation: AAF66981.1. Frameshift.
AE014298 Genomic DNA. Translation: AAF50904.3.
RefSeqiNP_523422.4. NM_078698.4.

3D structure databases

ProteinModelPortaliQ9VR99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59332. 44 interactors.
IntActiQ9VR99. 11 interactors.
MINTiMINT-307793.
STRINGi7227.FBpp0076997.

PTM databases

iPTMnetiQ9VR99.

Proteomic databases

PaxDbiQ9VR99.
PRIDEiQ9VR99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0340400; FBpp0309346; FBgn0031114.
GeneIDi33043.
KEGGidme:Dmel_CG1676.
UCSCiCG1676-RA. d. melanogaster.

Organism-specific databases

CTDi58509.
FlyBaseiFBgn0031114. cactin.

Phylogenomic databases

eggNOGiKOG2370. Eukaryota.
ENOG410XPKF. LUCA.
GeneTreeiENSGT00390000000097.
InParanoidiQ9VR99.
OMAiVMEHQKK.
OrthoDBiEOG091G08BK.

Miscellaneous databases

GenomeRNAii33043.
PROiQ9VR99.

Gene expression databases

BgeeiFBgn0031114.
GenevisibleiQ9VR99. DM.

Family and domain databases

InterProiIPR019134. Cactin_C.
IPR018816. Cactin_central.
[Graphical view]
PfamiPF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATIN_DROME
AccessioniPrimary (citable) accession number: Q9VR99
Secondary accession number(s): Q9NBV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.