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Q9VR99 (CATIN_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cactin
Alternative name(s):
Cactus-interacting protein
Gene names
Name:cactin
ORF Names:CG1676
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway. Ref.1

Subunit structure

Interacts with cact. Ref.1

Tissue specificity

Expressed in ovary (at protein level). Ref.1

Developmental stage

Expressed during embryogenesis (at protein level). Ref.1

Sequence similarities

Belongs to the CACTIN family.

Sequence caution

The sequence AAF50904.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAF66981.1 differs from that shown. Reason: Frameshift at position 697.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 720720Cactin
PRO_0000419266

Regions

Coiled coil109 – 15951 Potential
Coiled coil206 – 23631 Potential
Coiled coil346 – 37530 Potential
Compositional bias9 – 7769Arg-rich

Amino acid modifications

Modified residue991Phosphoserine Ref.4
Modified residue1041Phosphoserine Ref.4

Experimental info

Sequence conflict70 – 712EH → DD in AAF66981. Ref.1
Sequence conflict931V → M in AAF66981. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9VR99 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: D7C5175A3925FFDB

FASTA72086,556
        10         20         30         40         50         60 
MPKEKSKHRH RSRSRERRDH RSPDPRSSRN RDRDRERERE KDRDHRDHRD KERDQRRERE 

        70         80         90        100        110        120 
KDKSRDKKRE HKSRRRRSSS SSSSPSSSTS SSVPGAPRSP LVKSPMKLLQ TLEARRLVEQ 

       130        140        150        160        170        180 
KDRQRKKEEL KAHETPEEKR ARRLREKQAK EQRRRERMGW DNEYQTYSNE DNPFGDSNLT 

       190        200        210        220        230        240 
STFHWGKKLE VEGLSNLSTK TVEVLSLQKQ LENRRELEKV KKRRQERELE RQVREDDLMM 

       250        260        270        280        290        300 
QQRAKEAVQF REWQRQEDQF HLEQARLRSE IRIRDGRAKP IDLLAQYVAA GNEPLEECLE 

       310        320        330        340        350        360 
MQMHEPYVLL NGLPVEELED LLVDIKVYEE LEQGKHIDFW NDMITIVQDE LQRQQKLEAE 

       370        380        390        400        410        420 
NSSLNQRRDG IHQAVVKDVA DIFRGKNAQQ LEEMRHRIEA KISGRADGVD ISYWESLLSQ 

       430        440        450        460        470        480 
LKAHMARARL RDRHQALLRE KLSLLKREND NETLQEKVAP QVKEEEMETQ DAEDPEVEEG 

       490        500        510        520        530        540 
SPEDEEDPLN ELRKTVRLYQ AGNYSPRYIR EEDFTGRRAQ NEDVDEPEAE GLLYEEEDDE 

       550        560        570        580        590        600 
RRTQRQRLLI LHPERVDNNQ LTPQELRMRN EAKQGMQGDE AEFSVETTLD AVPQLATDKY 

       610        620        630        640        650        660 
RPRKPRYFNR VHTGFEWNKY NQTHYDMDNP PPKIVQGYKF NIFYPDLMDK SQTPQYFLTP 

       670        680        690        700        710        720 
CADNGDFAVL RFHTGPPYED IAFKIVNREW EFSYKRGFRC QFHNNIFQLW FHFKRYRYRR 

« Hide

References

« Hide 'large scale' references
[1]"Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function."
Lin P., Huang L.H., Steward R.
Mech. Dev. 94:57-65(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CACT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Ovary.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-104, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF245116 mRNA. Translation: AAF66981.1. Frameshift.
AE014298 Genomic DNA. Translation: AAF50904.2. Different initiation.
RefSeqNP_523422.3. NM_078698.3.
UniGeneDm.2875.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9VR99. 11 interactions.
MINTMINT-307793.
STRING7227.FBpp0076997.

Proteomic databases

PRIDEQ9VR99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID33043.
KEGGdme:Dmel_CG1676.
UCSCCG1676-RA. d. melanogaster.

Organism-specific databases

CTD58509.
FlyBaseFBgn0031114. cactin.

Phylogenomic databases

InParanoidQ9VR99.
OrthoDBEOG7XM2Z3.

Gene expression databases

BgeeQ9VR99.

Family and domain databases

InterProIPR019134. Cactin_C.
IPR018816. Cactin_dom.
[Graphical view]
PfamPF10312. Cactin_mid. 1 hit.
PF09732. CactinC_cactus. 1 hit.
[Graphical view]
SMARTSM01050. CactinC_cactus. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi33043.
NextBio781659.

Entry information

Entry nameCATIN_DROME
AccessionPrimary (citable) accession number: Q9VR99
Secondary accession number(s): Q9NBV5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase