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Protein

Probable E3 ubiquitin-protein ligase HERC2

Gene

HERC2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4850Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC2 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2
Gene namesi
Name:HERC2
ORF Names:CG11734
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031107. HERC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297411 – 4912Probable E3 ubiquitin-protein ligase HERC2Add BLAST4912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1776Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VR91.
PRIDEiQ9VR91.

PTM databases

iPTMnetiQ9VR91.

Expressioni

Gene expression databases

BgeeiFBgn0031107.
GenevisibleiQ9VR91. DM.

Interactioni

Protein-protein interaction databases

BioGridi59326. 2 interactors.
IntActiQ9VR91. 20 interactors.
STRINGi7227.FBpp0290558.

Structurei

3D structure databases

ProteinModelPortaliQ9VR91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati634 – 685RCC1 1Sequence analysisAdd BLAST52
Repeati686 – 739RCC1 2Sequence analysisAdd BLAST54
Repeati741 – 789RCC1 3Sequence analysisAdd BLAST49
Repeati791 – 843RCC1 4Sequence analysisAdd BLAST53
Repeati844 – 897RCC1 5Sequence analysisAdd BLAST54
Domaini1917 – 1990MIB/HERC2PROSITE-ProRule annotationAdd BLAST74
Domaini2511 – 2557UBAPROSITE-ProRule annotationAdd BLAST47
Domaini2780 – 2958DOCPROSITE-ProRule annotationAdd BLAST179
Repeati2985 – 3036RCC1 6Sequence analysisAdd BLAST52
Repeati3037 – 3090RCC1 7Sequence analysisAdd BLAST54
Repeati3091 – 3142RCC1 8Sequence analysisAdd BLAST52
Repeati3144 – 3194RCC1 9Sequence analysisAdd BLAST51
Repeati3197 – 3248RCC1 10Sequence analysisAdd BLAST52
Repeati3250 – 3300RCC1 11Sequence analysisAdd BLAST51
Repeati3302 – 3352RCC1 12Sequence analysisAdd BLAST51
Repeati4049 – 4099RCC1 13Sequence analysisAdd BLAST51
Repeati4101 – 4153RCC1 14Sequence analysisAdd BLAST53
Repeati4155 – 4205RCC1 15Sequence analysisAdd BLAST51
Repeati4207 – 4259RCC1 16Sequence analysisAdd BLAST53
Repeati4261 – 4311RCC1 17Sequence analysisAdd BLAST51
Repeati4313 – 4363RCC1 18Sequence analysisAdd BLAST51
Repeati4365 – 4415RCC1 19Sequence analysisAdd BLAST51
Domaini4547 – 4882HECTPROSITE-ProRule annotationAdd BLAST336

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 60Gly-richSequence analysisAdd BLAST53
Compositional biasi137 – 163Cys-richSequence analysisAdd BLAST27

Sequence similaritiesi

Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 1 MIB/HERC2 domain.PROSITE-ProRule annotation
Contains 19 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0939. Eukaryota.
KOG1426. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
InParanoidiQ9VR91.
KOiK10595.
OMAiIMEMGFT.
OrthoDBiEOG091G000E.
PhylomeDBiQ9VR91.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 3 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR021097. CPH_domain.
IPR000859. CUB_dom.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR008979. Galactose-bd-like.
IPR000569. HECT_dom.
IPR010606. Mib_Herc2.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR014722. Rib_L2_dom2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF11515. Cul7. 1 hit.
PF00173. Cyt-b5. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF00415. RCC1. 15 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 18 hits.
PS50030. UBA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: Q9VR91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFNRQASGGA GSSGQGAGSS QTASAAPVSA GVGVGGGGGA SGAAAGAGSA
60 70 80 90 100
AGSGSGSGSG SAAPPSHSPD LYLRPLPFLD AKWLRADLIA SLRNAADGAV
110 120 130 140 150
LWNHLIQDCE LVSSPTAPLL NARGQLSYLG DDGKHYCGAQ QLKCSCCQPE
160 170 180 190 200
YCGPLSACNC DGCRPLDSDT AIKKLTTQAA AQQAAHLSQA TDMVLSGWLW
210 220 230 240 250
SQPPSQQARL DCQRSMISEL QELALRAAGN CLSAQHLRQQ LFIYERYFVA
260 270 280 290 300
LKRERERERK STTSAQAVAS VTTANTTIAA TTANAAVESQ PAEQQAEHGA
310 320 330 340 350
LGLARVATHA ALNFSFAFLR RAWRSGEDTE MCSELLSEAL ASLQELPEAT
360 370 380 390 400
LFEAAVVSSL WLEVMERSIK FLRLVALGDP MGNRCTAPLN DRHTALCLLL
410 420 430 440 450
ELGVQKGTLA ATLECVVLLL LLWEKDRAGN DNRDMPRKTG APLQRILLRY
460 470 480 490 500
QKIGATAKGG GIAGGEPAPV ASATETFLRF LSLPKSSAAI VDLRRAAVVI
510 520 530 540 550
ISHLDRMVQP LMPRCLLRGG QATAASSSSA PQQRIYALGW PSLSKDQQGF
560 570 580 590 600
SAEPTLSWSG ESAGVPTLSC RFQIKQVACC ETQMLILSQE GKLYTWRLAK
610 620 630 640 650
PEAEPLPMEE VAHDVFISIA GHCEGRHFLA IDSNHNAYSW GTGEDHRLGH
660 670 680 690 700
GDTHARAVPT KIAALEQHCV QSVYCGCSYS AAITCGGNLL TWGRGTYARL
710 720 730 740 750
GHGNSDDRSL PTLVVALSDH MVVDVALGSG DAHSLALTSE GLVFAWGDGD
760 770 780 790 800
YGKLGNGNCN GSLQPILVES LPRVQRVFAG SQFSVALSSE GQLYTWGKAT
810 820 830 840 850
CLGHQLVERS VQGCSVPRLV SSLQHKRIVD VAVSVAHCLA LSSSGEVFGW
860 870 880 890 900
GRNDSQQICP ASVSSEPLLR TPILVSLPTF PASGIACTSA QSLVWTQSSH
910 920 930 940 950
QGVPRRAPFV VDLGEPTFRL LDQLLGMCSS QDNRQTPNQE SECIAVACLN
960 970 980 990 1000
LFRLQLLALI ANGVEPRQVG LASGSRLLCS LKTRILGLAG GSQVLRTIQV
1010 1020 1030 1040 1050
AAQQALQDGW SVLLPTAAER AQTLTSLLPS EPGQASSAGH RFMTDLLVSS
1060 1070 1080 1090 1100
LMAEGGLESA LQHAIRLESS SCSADCGDGV HLPLLQLITR LLSNNAALSQ
1110 1120 1130 1140 1150
TRLSPTLGKQ QEKEEEEREQ QHQEPSTSPS LSLLHRFQRL LLSHIHQAQP
1160 1170 1180 1190 1200
EEETTGAEAL LLQYMHALIP ACVATLQKAH ELALQCREPG ENSFGQMVGH
1210 1220 1230 1240 1250
LGRVLQADIS DALLNELLVG LLLLKRDRPQ CLGGLRWARL FLPLLRVLDR
1260 1270 1280 1290 1300
LNRALGEGEL RDGDDMGWPG IICRGGPKGG PPPADPETHY VRRADMENLL
1310 1320 1330 1340 1350
LDGSRCIILA GYVCDLSGYN CESETLRSVL DSGLGKDLTA EMSSQVHRTA
1360 1370 1380 1390 1400
MEHILEHHKL GKYMVQASTE EKSSAPGPSR LTHFSSECAL AQLLGLVANL
1410 1420 1430 1440 1450
MCSGPALQPA ELQCRQLDKS SLLSGGLQLL QPSNPFDEEK GEARSSHSCH
1460 1470 1480 1490 1500
STAGNTPTEL PPPLPMQQQL APGRGKSQLQ LRADAFISGL AEARVSEPPV
1510 1520 1530 1540 1550
AAWLALTERY CKAHNLMWHQ EFATEHPVQE LERLLSAVLI RHQYLGGLVL
1560 1570 1580 1590 1600
NALETEVPPP RQLGEIIRLV HQAKWSVVRT RQQLNRSYKE VCAPILERLR
1610 1620 1630 1640 1650
FLLYEVRPAI SPQQRGLRRL PILQRPPRFK MLVRRLLQEL RSSRQPAKPE
1660 1670 1680 1690 1700
DLLNASIQQE QEKKPQSMPK QELEEQEEEE TLLRRLNERQ IHGEGELDPA
1710 1720 1730 1740 1750
LMQDIVDFAL QDSCDVETAR RAMYCQMQRY QLRLAGLQIV QQLLELHGLL
1760 1770 1780 1790 1800
DAAQYSLLNG FLGLHLKSTS SGGGSTGSGS SLHVLGQLNM ISAYQKARLL
1810 1820 1830 1840 1850
LAQSRVLDWA VRELRRLVNQ EQQGHARGKD STNLGTYVLL KRLPRARFLL
1860 1870 1880 1890 1900
SVFGLLAKEL GPNELGFLIN SGLLGTVLGL LAQTGGEGAT GGQVHGELSI
1910 1920 1930 1940 1950
LYEDSVLKQK SSKAQLSGPD LAKLMKIGTR IVRGADWKWG DQDGNPPGEG
1960 1970 1980 1990 2000
RIISEVGEDG WVRVEWYTGA TNSYRMGKEG QYDLQLADSA LNVASPTEPE
2010 2020 2030 2040 2050
REDVSGSEAS PTSDSHPSKL LRHCAAKLLQ ILAVGTGLHG AQLDKDALRG
2060 2070 2080 2090 2100
MTSMFRTIIY PKPSMSNISY ALGWLNLGFI RAISGDCPRL CLELSTPGWL
2110 2120 2130 2140 2150
SHYLSLLEQP AGNEAGVYRQ LHCLRLLQLI LAQWGAEEEP RMPALVHQLF
2160 2170 2180 2190 2200
ATLGRIALHC PGDASLLPTA EGKARVLLTA SHSGSVAEEL VALLRRLHTL
2210 2220 2230 2240 2250
PSWNPVINSF LAQKLCVAAE LLAEQSHSTA LDSEQVFVLG VLGAMGGHDL
2260 2270 2280 2290 2300
RPRVGLHCFH EGSHMVIASF TPKGRCLLAP GGVGSGVGFV KVQLPAVMPH
2310 2320 2330 2340 2350
LDHTVFSLSR LPMNEMLLNA WTVLLYGPAP ELRELPSSAD GRLDLALLRA
2360 2370 2380 2390 2400
QQLQMAVLHT NGVLYRHQVA LRRILKQRAP GSIYASPDEP DRSDAESQQP
2410 2420 2430 2440 2450
GEQDQQLSSG SGQEPQLLIQ CILLRATQAS PVKACYSYMD LATAALNCIQ
2460 2470 2480 2490 2500
SLATQAHQEL SEGGGVPPNG RALSSPPQPT MVHGVPVYNV ARKEQKPSEQ
2510 2520 2530 2540 2550
VEQKSKWPAA ATDAQLIGQI MEMGFTRRTV ELALKQLSLQ AEIMPTPEQI
2560 2570 2580 2590 2600
VQWILEHPDV CANTIEEDTL PLASSASSHD PEADSDNECP SSNSTTSSST
2610 2620 2630 2640 2650
SSDTVEGQPM AVSGPAPPVK FESRKDFQTA DLYALYVRGL VRPGMTVRCC
2660 2670 2680 2690 2700
RDFEEIKQGD MGTVLIVDTE GLHDLNVQVD WRNHGSTYWV CFVHIELVEA
2710 2720 2730 2740 2750
AQTHHQPRPP PIAVGARVRL RTSSLRYGML CPLRLGRSQG SSAIGVVSSV
2760 2770 2780 2790 2800
RSKQLTVDFP DQPAWQGHIN EVELVASQPT SATLPSLGDS CSQMPPSDLI
2810 2820 2830 2840 2850
EDWSRCIRSL TVSSNEAAAK HLLNGSNQPW QSCSSGPCRH WIRLELHDRI
2860 2870 2880 2890 2900
LVHSLTLKVS PEDHSHMPSL LEIRVGDCVD SLKEYTWIPV PAGASRVLLM
2910 2920 2930 2940 2950
QQVPTYYPWV EVVVKQCQNN GIQCKIHGIK FVGRRQQPDL QHILANAQFL
2960 2970 2980 2990 3000
ASEYSAGVGP GSTAGAGAVS TSHEEAAAAP EQDLPCTVMV WGLNDKEQLG
3010 3020 3030 3040 3050
GLKGSKVKVP TFSQTISRLR PIHIAGGSKS LFIVSQDGKV YACGEGTNGR
3060 3070 3080 3090 3100
LGLGVTHNVP LPHQLPVLRQ YVVKKVAVHS GGKHALALTL DGKVFSWGEG
3110 3120 3130 3140 3150
EDGKLGHGNR TTLDKPRLVE ALRAKKIRDV ACGSSHSAAI SSQGELYTWG
3160 3170 3180 3190 3200
LGEYGRLGHG DNTTQLKPKL VTALAGRRVV QVACGSRDAQ TLALTEDGAV
3210 3220 3230 3240 3250
FSWGDGDFGK LGRGGSEGSD TPHEIERLSG IGVVQIECGA QFSLALTRAG
3260 3270 3280 3290 3300
EVWTWGKGDY YRLGHGGDQH VRKPQPIGGL RGRRVIHVAV GALHCLAVTD
3310 3320 3330 3340 3350
AGQVYAWGDN DHGQQGSGNT FVNKKPALVI GLDAVFVNRV ACGSSHSIAW
3360 3370 3380 3390 3400
GLPNASSDEE KRGPVPFSST RDPLGGSSLG IYEAETMQTL KQEAKPLNQS
3410 3420 3430 3440 3450
SLSESLALET PAARQAALGH VLRAMSILQA RQLIVAALTS HSKVNFKERG
3460 3470 3480 3490 3500
AVGGEEDHLI GGPIMGAPLQ LAETIAQGGG EAPADATDAG LQEHSPEAAV
3510 3520 3530 3540 3550
DALTGGMSGG ANTLPPLSAG PLSAFQSLTG SLSMSGSLSS SALPQHKHSR
3560 3570 3580 3590 3600
MSASAMSVMA ATMTQQEEML SHISHCHGLD DFGGLLGEPE AKSLVELLKL
3610 3620 3630 3640 3650
AVCGRCGPPS TSQTIADTLI SLGAGTPAVA AMLLETCITE LEDLCTSRHC
3660 3670 3680 3690 3700
LGKLPKPVMQ ESSHPYVDNV NVTGVVRIPG AEMLRLEFDS QCSTEKRNDP
3710 3720 3730 3740 3750
LVIMDGTGRV LAMRSGREFA HWAPEIRVLG DELRWKFSSD SSVNGWGWRF
3760 3770 3780 3790 3800
WVHAIMPAAT LGESGSDRAV LSQPSMALVM SLLDSRLAPR QPSVLLRLAS
3810 3820 3830 3840 3850
ALAACSQLGA LTTAQRIWSL RKLHAVLLLE QAPRPQDPSL STLLQPLIPE
3860 3870 3880 3890 3900
LLRQYEYEEP QVRGGIHLMH SDYFKTLAAL ACDMQLDAAL PATSSSSSSS
3910 3920 3930 3940 3950
AAPGAISSTG DVHKWAWFKR YCIAVRVAQS LIRRTELPRA FCLEVRKKFA
3960 3970 3980 3990 4000
EMLPSSSSNS NANPGCQSPG ASMLNSTTSL SSSTVSNVSP PPGITGEQPD
4010 4020 4030 4040 4050
LHCHAHQLES TSTLLHEDHT LFQAPHDAQL LQWLNRRPDD WALSWGGAST
4060 4070 4080 4090 4100
IYGWGHNHRG QLGGLEGSRI KTPTPCEALS LLRPVQLAGG EQSLFAVTPD
4110 4120 4130 4140 4150
GKLFATGYGS GGRLGVGGSD SWAIPTLLGS LQHVFVKKVA VNSGGKHCLA
4160 4170 4180 4190 4200
LTTEGEVYAW GEGEDGKLGH GNRMSYDRPK LVEHLNGMSV ADIACGSAHS
4210 4220 4230 4240 4250
AAITASGHVL TWGKGRYGRL GHGDSEDQLR PKLVEALLGY RAIDIACGSG
4260 4270 4280 4290 4300
DAQTLCITDD DNVWSWGDGD YGKLGRGGSD GCKLPYKIES LAGLGVVKVE
4310 4320 4330 4340 4350
CGSQFSVALT KSGAVYTWGK GDFHRLGHGS VDHVRRPKKV AALQGKKIIS
4360 4370 4380 4390 4400
IATGSLHCVA CSDSGEVYTW GDNDEGQLGD GTVTAIQRPR LVAALQGKHI
4410 4420 4430 4440 4450
VKVTCGSAHT LALSTSQLSE RLRPLPNPPL EYDLVRDLAP EALHARLILL
4460 4470 4480 4490 4500
HHFSELVCPC LAMLPISGDL SLGALKDVLV YNIKEAAFRK VIQTTMVRDK
4510 4520 4530 4540 4550
QHGPVIELNR IQVKRSRNRC NGLAGIDGMK SVFGQMVQKL PLLTQEALAL
4560 4570 4580 4590 4600
PHRVWKVKFV GESVDDCGGG YSESIAEMCD ELQNGSVPLL INTPNGRGEA
4610 4620 4630 4640 4650
GANRDCFLLD PTLSSVLQMN MFRFLGVLMG IAVRTGSPLS INLAEPVWRQ
4660 4670 4680 4690 4700
LTGEVLRPTD LTEVDRDYVA GLLCIRNMDD DPKLFTALEL PFSTSSARGH
4710 4720 4730 4740 4750
EVPLSTRYTH ISPRNRAEYV RLALGFRLHE FDEQVKAVRD GMSKVIPVPL
4760 4770 4780 4790 4800
LSLFSAAELQ AMVCGSPDIP LGLLKSVATY KGFDPSSALV TWFWEVMEEF
4810 4820 4830 4840 4850
TNQERSLFLR FVWGRTRLPR TIADFRGRDF VLQVLEKNPP DHFLPESYTC
4860 4870 4880 4890 4900
FFLLKMPRYS CKAVLLEKLK YAIHFCKSID TDEYARVAMG EPTEATGSED
4910
NSDLESVASH EG
Length:4,912
Mass (Da):529,997
Last modified:April 4, 2006 - v3
Checksum:i39F45CEBEB6350DF
GO
Isoform A1 Publication (identifier: Q9VR91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-636: HN → RK
     637-4912: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:636
Mass (Da):67,367
Checksum:i80E4E5C3B295B8F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4388R → W in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4393A → T in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4481Y → C in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4575I → T in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4652T → M in AAF61856 (PubMed:10720573).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051976635 – 636HN → RK in isoform A. 1 Publication2
Alternative sequenceiVSP_051977637 – 4912Missing in isoform A. 1 PublicationAdd BLAST4276

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF50913.3.
AY113293 mRNA. Translation: AAM29298.1.
AF189221 mRNA. Translation: AAF61856.1.
RefSeqiNP_608388.2. NM_134544.3. [Q9VR91-1]

Genome annotation databases

EnsemblMetazoaiFBtr0301344; FBpp0290558; FBgn0031107. [Q9VR91-1]
GeneIDi33035.
KEGGidme:Dmel_CG11734.
UCSCiCG11734-RB. d. melanogaster. [Q9VR91-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF50913.3.
AY113293 mRNA. Translation: AAM29298.1.
AF189221 mRNA. Translation: AAF61856.1.
RefSeqiNP_608388.2. NM_134544.3. [Q9VR91-1]

3D structure databases

ProteinModelPortaliQ9VR91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59326. 2 interactors.
IntActiQ9VR91. 20 interactors.
STRINGi7227.FBpp0290558.

PTM databases

iPTMnetiQ9VR91.

Proteomic databases

PaxDbiQ9VR91.
PRIDEiQ9VR91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0301344; FBpp0290558; FBgn0031107. [Q9VR91-1]
GeneIDi33035.
KEGGidme:Dmel_CG11734.
UCSCiCG11734-RB. d. melanogaster. [Q9VR91-1]

Organism-specific databases

CTDi8924.
FlyBaseiFBgn0031107. HERC2.

Phylogenomic databases

eggNOGiKOG0939. Eukaryota.
KOG1426. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
InParanoidiQ9VR91.
KOiK10595.
OMAiIMEMGFT.
OrthoDBiEOG091G000E.
PhylomeDBiQ9VR91.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Miscellaneous databases

GenomeRNAii33035.
PROiQ9VR91.

Gene expression databases

BgeeiFBgn0031107.
GenevisibleiQ9VR91. DM.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 3 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR021097. CPH_domain.
IPR000859. CUB_dom.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR008979. Galactose-bd-like.
IPR000569. HECT_dom.
IPR010606. Mib_Herc2.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR014722. Rib_L2_dom2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF11515. Cul7. 1 hit.
PF00173. Cyt-b5. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF00415. RCC1. 15 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 18 hits.
PS50030. UBA. 1 hit.
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Entry informationi

Entry nameiHERC2_DROME
AccessioniPrimary (citable) accession number: Q9VR91
Secondary accession number(s): Q8MZ96, Q9N2R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.