Reviewed, UniProtKB/Swiss-Prot Q9VR81 (NAGA_DROME)

Names and origin

Protein names

Recommended name:
    Putative N-acetylglucosamine-6-phosphate deacetylase
    EC=3.5.1.25
Alternative name(s):
    GlcNAc 6-P deacetylase

Gene names

ORF Names:

CG17065

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.
Sequence similarities	Belongs to the nagA family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylglucosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acetylglucosamine-6-phosphate deacetylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Putative N-acetylglucosamine-6-phosphate deacetylase		PRO_0000315780

Sequences

	Sequence		Length	Mass (Da)
	Q9VR81-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 99FBBFE215DE3F55	FASTA	417	45,283
	10 20 30 40 50 60 MDVRIKCNSE EPESPEQKIL ASSQRLLQFT NCRLVRDHRI IHDDLWVRDG RIVNPEPVFF 70 80 90 100 110 120 DERTKAHCRI DCGGAIIAPG YIDLQINGGY GVDFSYDTET IEEGVATVAR GLVKSGVTSF 130 140 150 160 170 180 CPTLVTSPSD SYHTILPRIP AEVPKGAGIL GIHAEGPFIN PQKKGAHPEH CIQTIDKGLS 190 200 210 220 230 240 TLKETYGSLE RIKIITLAPE KVTDPEVIGQ LVERGITVAL GHSMASLSDG ERAVQQGATL 250 260 270 280 290 300 ITHLFNAMLP FHHRDPGLVG LLASDAVPHG RTVYFGIISD GVHTHPAALR IAYRTHPQGL 310 320 330 340 350 360 ILVTDAISAL GLEEGVHHIG QLPLQVKQGK AFIAGTETLC GSIAPMDECV RIFQKATDCS 370 380 390 400 410 VVYAIEAATL HPAQCLKIEK QKGTLDFGSD ADFVLLDDQL RVLSTWIAGV CVHRTVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF50923.1. AY089672 mRNA. Translation: AAL90410.1.
RefSeq	NP_608380.1.
3D structure databases
HSSP	HSSP built from PDB template 1UN7 based on UniProtKB O34450.
SMR	Q9VR81. Positions 28-413.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9VR81.
Proteomic databases
PRIDE	Q9VR81.
Genome annotation databases
Ensembl	FBtr0077340; FBpp0077032; FBgn0031099; Drosophila melanogaster. [Genome view]
GeneID	33026.
KEGG	dme:Dmel_CG17065.
NMPDR	fig|7227.3.peg.18769.
UCSC	CG17065-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0031099. CG17065.
Phylogenomic databases
eggNOG	inNOG06204.
InParanoid	Q9VR81.
OMA	RRILSHG.
PhylomeDB	Q9VR81.
Enzyme and pathway databases
BRENDA	3.5.1.25. 48.
Gene expression databases
ArrayExpress	Q9VR81.
Bgee	Q9VR81.
Family and domain databases
InterPro	IPR006680. Amidohydro_1. IPR003764. GlcNAc_6-P_deAcase. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00221. nagA. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	781576.

Entry information

Entry name

NAGA_DROME

Accession

Primary (citable) accession number: Q9VR81

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project