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Q9VR59

- VIP1_DROME

UniProt

Q9VR59 - VIP1_DROME

Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Gene

l(1)G0196

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.By similarity

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
    ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571ATPBy similarity
    Binding sitei210 – 2101ATPBy similarity
    Binding sitei217 – 2171ATPBy similarity
    Binding sitei236 – 2361ATPBy similarity
    Binding sitei271 – 2711SubstrateBy similarity
    Binding sitei285 – 2851SubstrateBy similarity
    Binding sitei287 – 2871ATPBy similarity
    Binding sitei332 – 3321ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi260 – 2634ATPBy similarity
    Nucleotide bindingi269 – 2713ATPBy similarity
    Nucleotide bindingi344 – 3463ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diphosphoinositol-pentakisphosphate kinase activity Source: UniProtKB
    3. inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB
    4. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    6. inositol hexakisphosphate 5-kinase activity Source: UniProtKB

    GO - Biological processi

    1. inositol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_180772. Synthesis of pyrophosphates in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC:2.7.4.21, EC:2.7.4.24)
    Alternative name(s):
    InsP6 and PP-IP5 kinase
    Gene namesi
    Name:l(1)G0196
    ORF Names:CG14616
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0027279. l(1)G0196.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16961696Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinasePRO_0000315697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei974 – 9741Phosphoserine1 Publication
    Modified residuei1001 – 10011Phosphoserine1 Publication
    Modified residuei1060 – 10601Phosphoserine1 Publication
    Modified residuei1255 – 12551Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9VR59.
    PRIDEiQ9VR59.

    Expressioni

    Gene expression databases

    BgeeiQ9VR59.

    Interactioni

    Protein-protein interaction databases

    BioGridi59411. 3 interactions.
    DIPiDIP-21851N.
    MINTiMINT-1002676.
    STRINGi7227.FBpp0288801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VR59.
    SMRiQ9VR59. Positions 66-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 772Substrate bindingBy similarity
    Regioni236 – 2372Substrate bindingBy similarity
    Regioni349 – 3524Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG245915.
    GeneTreeiENSGT00390000009048.
    InParanoidiQ9VR59.
    KOiK13024.
    OMAiILHASIN.
    OrthoDBiEOG77M8MT.
    PhylomeDBiQ9VR59.

    Family and domain databases

    Gene3Di3.40.50.1240. 3 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 3 hits.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform I (identifier: Q9VR59-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN     50
    DGMDSDTSTS SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT 100
    FEENVILREP VQNWPTCDCL VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM 150
    QYDIQDRRRV YAILEKEGIE IPRYAVLDRD SPDPKHHELI ESEDHVEVNG 200
    ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS RSSVYSPESR 250
    VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 300
    KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF 350
    VKNSNKYYDD CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM 400
    MELRCVVAVI RHGDRTPKQK MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP 450
    KQLQEILDIA RFLLSEIHTK AHAEIEEKES KLEQLKNVLE MYGHFSGINR 500
    KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG ELTPAGRIQA 550
    EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 600
    MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR 650
    LHELMQNDRE FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE 700
    LLHIISIKKD DPKTKDAILY HGETWDLMRC RWEKIEKDFS TKSKLFDISK 750
    IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY AKNLADIVIP QEYGLTPQEK 800
    LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH GVASPQRHVR 850
    TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 900
    IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD 950
    NACNVSLQSS DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI 1000
    SPAFGFNRLE LRSKQFKSKP IPIGAHHTVS GHEAMDLAKR LNEELASHQQ 1050
    QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR PTSGVCAKEP DSQVSVSVSA 1100
    SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS ANSLFSTAVI 1150
    SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL 1200
    AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF 1250
    DRRGSESGST ADAHLRLLSE SQCPNLDDSN TELRESLAGK MELWPQDIVK 1300
    AAEDEELNLS ELETKPSLDL TMEIMERGVA GIASIQPMNR DSDETMGGGV 1350
    FLSVCEEQGS GSTCLTPVSF GMDLDLSMVA NKGSITLSME GFDDDEDATL 1400
    SAATTPSLLA DCEPRLESCY CCPSHAEAPP EVPSDDPRFG FALPVRVTQA 1450
    SPEHARPVRR AHDPVSPRIQ KQISLFEGNA AMATGQEKTE SSGSVGGGAI 1500
    LHASINLPAA GPHHLRQDAR LRKFENLTQS TSNSNFPFES NTLKRVPMQT 1550
    TKDYDNVSHT QSCINLKSGS SGVLGGSPQR QRGSDGGGVG ASGVPAESRE 1600
    PTRVHYGRMN STCCSASASP SPSPGALIVK ERFIEPPKRG VVRGYHGKTQ 1650
    SMDADFLFNE FLLLPAMAPA KISFDSSDID QASDDDSPSS SKQRHA 1696

    Note: No experimental confirmation available.

    Length:1,696
    Mass (Da):188,677
    Last modified:June 16, 2009 - v2
    Checksum:iBB013ECB582C96D3
    GO
    Isoform G (identifier: Q9VR59-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1293-1300: LWPQDIVK → QYPTEPSI
         1301-1696: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,300
    Mass (Da):146,528
    Checksum:i644A2123503DB726
    GO
    Isoform H (identifier: Q9VR59-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-40: SYTELESGYQ...VGFYLGLQDG → EWTWFKDWWR...DDFCYCEVCM
         266-266: D → DVYFS
         1293-1305: LWPQDIVKAAEDE → RKCRKKSVVEWQC
         1306-1696: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,416
    Mass (Da):159,831
    Checksum:i95E98D85E6F735A6
    GO
    Isoform J (identifier: Q9VR59-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1090-1090: P → PATETAEDTS...PSCCTKTIAT
         1293-1300: LWPQDIVK → QYPTEPSI
         1301-1696: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,447
    Mass (Da):162,288
    Checksum:i33909E1FE36F5731
    GO
    Isoform K (identifier: Q9VR59-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1090-1090: P → PVSSPDFGDN...PSCCTKTIAT
         1293-1300: LWPQDIVK → QYPTEPSI
         1301-1696: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,846
    Mass (Da):204,458
    Checksum:i803BD74B91DAC0EE
    GO

    Sequence cautioni

    The sequence ABN49448.1 differs from that shown. Reason: Frameshift at position 735.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti329 – 3291C → F in ABN49448. 1 PublicationCurated
    Sequence conflicti734 – 7341K → KN in ABN49448. 1 PublicationCurated
    Sequence conflicti906 – 9061Y → H in ABN49448. 1 PublicationCurated
    Sequence conflicti1092 – 10921S → G in AAT94524. 1 PublicationCurated
    Sequence conflicti1116 – 11161H → R in AAT94524. 1 PublicationCurated
    Sequence conflicti1124 – 11241Y → C in AAT94524. 1 PublicationCurated
    Sequence conflicti1124 – 11241Y → C in ABN49448. 1 PublicationCurated

    RNA editingi

    Partially edited. Target of Adar.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1093 – 10931Q → R in RNA edited version.
    Natural varianti1117 – 11171S → G in RNA edited version.
    Natural varianti1121 – 11211Q → R in RNA edited version.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 4039SYTEL…GLQDG → EWTWFKDWWRLKKLRSRHQR HKKKLQATAASAEAAVTASA FLAGSGCAESGGSQDPQTNR LHSLDAVPSDGTLARRRHGS RDSLRRNRLLQRQRRSQSAA VRSHRSHDDDDDGEYGPFNV SDYEDYGPNHGSDEESDDFC YCEVCM in isoform H. 1 PublicationVSP_030640Add
    BLAST
    Alternative sequencei266 – 2661D → DVYFS in isoform H. 1 PublicationVSP_030641
    Alternative sequencei1090 – 10901P → PATETAEDTSMDIQPKICIG KCAPGLLTPTVTTTDILKGI RDIAPTATQTSPPTFTPSTT TTTGAAAALFDNTATMSSNR PFTNQFQSIDPTSNDAPHQH HVHQHQYQHHRKTTTTIINN TLNENHTTATITNNTTTTPS CCTKTIAT in isoform J. CuratedVSP_030643
    Alternative sequencei1090 – 10901P → PVSSPDFGDNSRTRSSEFGE TCHARVGTASNSDGGGSHPR ADHRTAFQIRVTNSLSFFKI DSSTNELPLSDIDFSLHPPT PQCGPLSHKRFHILTMRRME SCDDGAELEQVRHLPQISPM ATNERPLSSCNCSSSAAQAH SHSKSLMDLAQAVVMTSPQE TGPNSEQGCDPTTAADVSVS SFDDDFQLSSSAPAILMSAH FGNRPVVASLSSMVHVTTSP SASTLQLCRDKDKALASGTS SAHSKATSNSCGQLSMAGSA PVVTENPFRFTVSSLGSAAT NTACFVGSFEPIEEQITSIV EVDSKPLQPEPQVVYNLPTV LITGTASSSELSTKLNSNIL PTVTNAFSAIDTEINDEIGI SKEVGIGTIRITNTHTPCNK ATVTRPDTKIAITTDPQTVT ATETAEDTSMDIQPKICIGK CAPGLLTPTVTTTDILKGIR DIAPTATQTSPPTFTPSTTT TTGAAAALFDNTATMSSNRP FTNQFQSIDPTSNDAPHQHH VHQHQYQHHRKTTTTIINNT LNENHTTATITNNTTTTPSC CTKTIAT in isoform K. CuratedVSP_033593
    Alternative sequencei1293 – 130513LWPQD…AAEDE → RKCRKKSVVEWQC in isoform H. 1 PublicationVSP_030648Add
    BLAST
    Alternative sequencei1293 – 13008LWPQDIVK → QYPTEPSI in isoform G, isoform J and isoform K. 1 PublicationVSP_030649
    Alternative sequencei1301 – 1696396Missing in isoform G, isoform J and isoform K. 1 PublicationVSP_030650Add
    BLAST
    Alternative sequencei1306 – 1696391Missing in isoform H. 1 PublicationVSP_030651Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAN09569.2.
    AE014298 Genomic DNA. Translation: AAN09570.3.
    AE014298 Genomic DNA. Translation: AAN09571.2.
    AE014298 Genomic DNA. Translation: AAN09573.2.
    AE014298 Genomic DNA. Translation: ABW09458.2.
    BT015295 mRNA. Translation: AAT94524.1.
    BT030309 mRNA. Translation: ABN49448.1. Frameshift.
    RefSeqiNP_001097041.2. NM_001103571.2. [Q9VR59-7]
    NP_788950.2. NM_176777.2. [Q9VR59-1]
    NP_788951.2. NM_176778.2. [Q9VR59-3]
    NP_788952.2. NM_176779.2. [Q9VR59-6]
    NP_788953.2. NM_176780.2. [Q9VR59-5]
    UniGeneiDm.237.

    Genome annotation databases

    EnsemblMetazoaiFBtr0299524; FBpp0288799; FBgn0027279. [Q9VR59-1]
    GeneIDi33137.
    KEGGidme:Dmel_CG14616.

    Keywords - Coding sequence diversityi

    Alternative splicing, RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAN09569.2 .
    AE014298 Genomic DNA. Translation: AAN09570.3 .
    AE014298 Genomic DNA. Translation: AAN09571.2 .
    AE014298 Genomic DNA. Translation: AAN09573.2 .
    AE014298 Genomic DNA. Translation: ABW09458.2 .
    BT015295 mRNA. Translation: AAT94524.1 .
    BT030309 mRNA. Translation: ABN49448.1 . Frameshift.
    RefSeqi NP_001097041.2. NM_001103571.2. [Q9VR59-7 ]
    NP_788950.2. NM_176777.2. [Q9VR59-1 ]
    NP_788951.2. NM_176778.2. [Q9VR59-3 ]
    NP_788952.2. NM_176779.2. [Q9VR59-6 ]
    NP_788953.2. NM_176780.2. [Q9VR59-5 ]
    UniGenei Dm.237.

    3D structure databases

    ProteinModelPortali Q9VR59.
    SMRi Q9VR59. Positions 66-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 59411. 3 interactions.
    DIPi DIP-21851N.
    MINTi MINT-1002676.
    STRINGi 7227.FBpp0288801.

    Proteomic databases

    PaxDbi Q9VR59.
    PRIDEi Q9VR59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0299524 ; FBpp0288799 ; FBgn0027279 . [Q9VR59-1 ]
    GeneIDi 33137.
    KEGGi dme:Dmel_CG14616.

    Organism-specific databases

    FlyBasei FBgn0027279. l(1)G0196.

    Phylogenomic databases

    eggNOGi NOG245915.
    GeneTreei ENSGT00390000009048.
    InParanoidi Q9VR59.
    KOi K13024.
    OMAi ILHASIN.
    OrthoDBi EOG77M8MT.
    PhylomeDBi Q9VR59.

    Enzyme and pathway databases

    Reactomei REACT_180772. Synthesis of pyrophosphates in the cytosol.

    Miscellaneous databases

    GenomeRNAii 33137.
    NextBioi 782108.
    PROi Q9VR59.

    Gene expression databases

    Bgeei Q9VR59.

    Family and domain databases

    Gene3Di 3.40.50.1240. 3 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 3 hits.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS G AND H), RNA EDITING OF POSITIONS 1117 AND 1121.
      Strain: Berkeley.
      Tissue: Embryo and Head.
    4. "RNA editing in Drosophila melanogaster: new targets and functional consequences."
      Stapleton M., Carlson J.W., Celniker S.E.
      RNA 12:1922-1932(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING OF POSITION 1093; 1117 AND 1121.
    5. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
      Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
      Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1060, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974; SER-1001 AND SER-1255, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiVIP1_DROME
    AccessioniPrimary (citable) accession number: Q9VR59
    Secondary accession number(s): A2VEZ0
    , A8JUU5, Q6AWF3, Q8IQ22, Q8IQ23, Q8IQ24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3