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Q9VR59 (VIP1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

EC=2.7.4.21
EC=2.7.4.24
Alternative name(s):
InsP6 and PP-IP5 kinase
Gene names
Name:l(1)G0196
ORF Names:CG14616
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1696 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Caution

Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.

RNA editing

Edited at positions 1093, 1117 and 1121.
Partially edited. Target of Adar. Ref.3 Ref.4

Sequence caution

The sequence ABN49448.1 differs from that shown. Reason: Frameshift at position 735.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform I (identifier: Q9VR59-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform G (identifier: Q9VR59-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.
Note: No experimental confirmation available.
Isoform H (identifier: Q9VR59-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2-40: SYTELESGYQ...VGFYLGLQDG → EWTWFKDWWR...DDFCYCEVCM
     266-266: D → DVYFS
     1293-1305: LWPQDIVKAAEDE → RKCRKKSVVEWQC
     1306-1696: Missing.
Note: No experimental confirmation available.
Isoform J (identifier: Q9VR59-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PATETAEDTS...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.
Note: No experimental confirmation available.
Isoform K (identifier: Q9VR59-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PVSSPDFGDN...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16961696Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
PRO_0000315697

Regions

Nucleotide binding260 – 2634ATP By similarity
Nucleotide binding269 – 2713ATP By similarity
Nucleotide binding344 – 3463ATP By similarity
Region76 – 772Substrate binding By similarity
Region236 – 2372Substrate binding By similarity
Region349 – 3524Substrate binding By similarity

Sites

Binding site1571ATP By similarity
Binding site2101ATP By similarity
Binding site2171ATP By similarity
Binding site2361ATP By similarity
Binding site2711Substrate By similarity
Binding site2851Substrate By similarity
Binding site2871ATP By similarity
Binding site3321ATP By similarity

Amino acid modifications

Modified residue9741Phosphoserine Ref.6
Modified residue10011Phosphoserine Ref.6
Modified residue10601Phosphoserine Ref.5
Modified residue12551Phosphoserine Ref.6

Natural variations

Alternative sequence2 – 4039SYTEL…GLQDG → EWTWFKDWWRLKKLRSRHQR HKKKLQATAASAEAAVTASA FLAGSGCAESGGSQDPQTNR LHSLDAVPSDGTLARRRHGS RDSLRRNRLLQRQRRSQSAA VRSHRSHDDDDDGEYGPFNV SDYEDYGPNHGSDEESDDFC YCEVCM in isoform H.
VSP_030640
Alternative sequence2661D → DVYFS in isoform H.
VSP_030641
Alternative sequence10901P → PATETAEDTSMDIQPKICIG KCAPGLLTPTVTTTDILKGI RDIAPTATQTSPPTFTPSTT TTTGAAAALFDNTATMSSNR PFTNQFQSIDPTSNDAPHQH HVHQHQYQHHRKTTTTIINN TLNENHTTATITNNTTTTPS CCTKTIAT in isoform J.
VSP_030643
Alternative sequence10901P → PVSSPDFGDNSRTRSSEFGE TCHARVGTASNSDGGGSHPR ADHRTAFQIRVTNSLSFFKI DSSTNELPLSDIDFSLHPPT PQCGPLSHKRFHILTMRRME SCDDGAELEQVRHLPQISPM ATNERPLSSCNCSSSAAQAH SHSKSLMDLAQAVVMTSPQE TGPNSEQGCDPTTAADVSVS SFDDDFQLSSSAPAILMSAH FGNRPVVASLSSMVHVTTSP SASTLQLCRDKDKALASGTS SAHSKATSNSCGQLSMAGSA PVVTENPFRFTVSSLGSAAT NTACFVGSFEPIEEQITSIV EVDSKPLQPEPQVVYNLPTV LITGTASSSELSTKLNSNIL PTVTNAFSAIDTEINDEIGI SKEVGIGTIRITNTHTPCNK ATVTRPDTKIAITTDPQTVT ATETAEDTSMDIQPKICIGK CAPGLLTPTVTTTDILKGIR DIAPTATQTSPPTFTPSTTT TTGAAAALFDNTATMSSNRP FTNQFQSIDPTSNDAPHQHH VHQHQYQHHRKTTTTIINNT LNENHTTATITNNTTTTPSC CTKTIAT in isoform K.
VSP_033593
Alternative sequence1293 – 130513LWPQD…AAEDE → RKCRKKSVVEWQC in isoform H.
VSP_030648
Alternative sequence1293 – 13008LWPQDIVK → QYPTEPSI in isoform G, isoform J and isoform K.
VSP_030649
Alternative sequence1301 – 1696396Missing in isoform G, isoform J and isoform K.
VSP_030650
Alternative sequence1306 – 1696391Missing in isoform H.
VSP_030651
Natural variant10931Q → R in RNA edited version.
Natural variant11171S → G in RNA edited version.
Natural variant11211Q → R in RNA edited version.

Experimental info

Sequence conflict3291C → F in ABN49448. Ref.3
Sequence conflict7341K → KN in ABN49448. Ref.3
Sequence conflict9061Y → H in ABN49448. Ref.3
Sequence conflict10921S → G in AAT94524. Ref.3
Sequence conflict11161H → R in AAT94524. Ref.3
Sequence conflict11241Y → C in AAT94524. Ref.3
Sequence conflict11241Y → C in ABN49448. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform I [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: BB013ECB582C96D3

FASTA1,696188,677
        10         20         30         40         50         60 
MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 

        70         80         90        100        110        120 
SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 

       130        140        150        160        170        180 
VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 

       190        200        210        220        230        240 
SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 

       250        260        270        280        290        300 
RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 

       310        320        330        340        350        360 
KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 

       370        380        390        400        410        420 
CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 

       430        440        450        460        470        480 
MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 

       490        500        510        520        530        540 
KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 

       550        560        570        580        590        600 
ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 

       610        620        630        640        650        660 
MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 

       670        680        690        700        710        720 
FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 

       730        740        750        760        770        780 
HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 

       790        800        810        820        830        840 
AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 

       850        860        870        880        890        900 
GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 

       910        920        930        940        950        960 
IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 

       970        980        990       1000       1010       1020 
DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 

      1030       1040       1050       1060       1070       1080 
IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 

      1090       1100       1110       1120       1130       1140 
PTSGVCAKEP DSQVSVSVSA SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS 

      1150       1160       1170       1180       1190       1200 
ANSLFSTAVI SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL 

      1210       1220       1230       1240       1250       1260 
AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF DRRGSESGST 

      1270       1280       1290       1300       1310       1320 
ADAHLRLLSE SQCPNLDDSN TELRESLAGK MELWPQDIVK AAEDEELNLS ELETKPSLDL 

      1330       1340       1350       1360       1370       1380 
TMEIMERGVA GIASIQPMNR DSDETMGGGV FLSVCEEQGS GSTCLTPVSF GMDLDLSMVA 

      1390       1400       1410       1420       1430       1440 
NKGSITLSME GFDDDEDATL SAATTPSLLA DCEPRLESCY CCPSHAEAPP EVPSDDPRFG 

      1450       1460       1470       1480       1490       1500 
FALPVRVTQA SPEHARPVRR AHDPVSPRIQ KQISLFEGNA AMATGQEKTE SSGSVGGGAI 

      1510       1520       1530       1540       1550       1560 
LHASINLPAA GPHHLRQDAR LRKFENLTQS TSNSNFPFES NTLKRVPMQT TKDYDNVSHT 

      1570       1580       1590       1600       1610       1620 
QSCINLKSGS SGVLGGSPQR QRGSDGGGVG ASGVPAESRE PTRVHYGRMN STCCSASASP 

      1630       1640       1650       1660       1670       1680 
SPSPGALIVK ERFIEPPKRG VVRGYHGKTQ SMDADFLFNE FLLLPAMAPA KISFDSSDID 

      1690 
QASDDDSPSS SKQRHA 

« Hide

Isoform G [UniParc].

Checksum: 644A2123503DB726
Show »

FASTA1,300146,528
Isoform H [UniParc].

Checksum: 95E98D85E6F735A6
Show »

FASTA1,416159,831
Isoform J [UniParc].

Checksum: 33909E1FE36F5731
Show »

FASTA1,447162,288
Isoform K [UniParc].

Checksum: 803BD74B91DAC0EE
Show »

FASTA1,846204,458

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS G AND H), RNA EDITING OF POSITIONS 1117 AND 1121.
Strain: Berkeley.
Tissue: Embryo and Head.
[4]"RNA editing in Drosophila melanogaster: new targets and functional consequences."
Stapleton M., Carlson J.W., Celniker S.E.
RNA 12:1922-1932(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING OF POSITION 1093; 1117 AND 1121.
[5]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1060, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974; SER-1001 AND SER-1255, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014298 Genomic DNA. Translation: AAN09569.2.
AE014298 Genomic DNA. Translation: AAN09570.3.
AE014298 Genomic DNA. Translation: AAN09571.2.
AE014298 Genomic DNA. Translation: AAN09573.2.
AE014298 Genomic DNA. Translation: ABW09458.2.
BT015295 mRNA. Translation: AAT94524.1.
BT030309 mRNA. Translation: ABN49448.1. Frameshift.
RefSeqNP_001097041.2. NM_001103571.2. [Q9VR59-7]
NP_788950.2. NM_176777.2. [Q9VR59-1]
NP_788951.2. NM_176778.2. [Q9VR59-3]
NP_788952.2. NM_176779.2. [Q9VR59-6]
NP_788953.2. NM_176780.2. [Q9VR59-5]
UniGeneDm.237.

3D structure databases

ProteinModelPortalQ9VR59.
SMRQ9VR59. Positions 66-383.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid59411. 3 interactions.
DIPDIP-21851N.
MINTMINT-1002676.
STRING7227.FBpp0288801.

Proteomic databases

PaxDbQ9VR59.
PRIDEQ9VR59.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0299524; FBpp0288799; FBgn0027279. [Q9VR59-1]
GeneID33137.
KEGGdme:Dmel_CG14616.

Organism-specific databases

FlyBaseFBgn0027279. l(1)G0196.

Phylogenomic databases

eggNOGNOG245915.
GeneTreeENSGT00390000009048.
InParanoidQ9VR59.
KOK13024.
OMAILHASIN.
OrthoDBEOG77M8MT.
PhylomeDBQ9VR59.

Gene expression databases

BgeeQ9VR59.

Family and domain databases

Gene3D3.40.50.1240. 3 hits.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 3 hits.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi33137.
NextBio782108.
PROQ9VR59.

Entry information

Entry nameVIP1_DROME
AccessionPrimary (citable) accession number: Q9VR59
Secondary accession number(s): A2VEZ0 expand/collapse secondary AC list , A8JUU5, Q6AWF3, Q8IQ22, Q8IQ23, Q8IQ24
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase