Q9VR59 (VIP1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
EC=2.7.4.21
EC=2.7.4.24

Alternative name(s):
InsP6 and PP-IP5 kinase

Gene names

Name:	l(1)G0196
ORF Names:	CG14616

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1696 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.
Catalytic activity	ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown). ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Caution	Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.
RNA editing	Edited at positions 1093, 1117 and 1121. Partially edited. Target of Adar. Ref.3 Ref.4
Sequence caution	The sequence ABN49448.1 differs from that shown. Reason: Frameshift at position 735.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing RNA editing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inositol metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diphosphoinositol-pentakisphosphate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB inositol hexakisphosphate 1-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 5-kinase activity Inferred from sequence or structural similarity. Source: UniProtKB inositol-1,3,4,5,6-pentakisphosphate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform I (identifier: Q9VR59-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform G (identifier: Q9VR59-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Note: No experimental confirmation available.

Isoform H (identifier: Q9VR59-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2-40: SYTELESGYQ...VGFYLGLQDG → EWTWFKDWWR...DDFCYCEVCM
     266-266: D → DVYFS
     1293-1305: LWPQDIVKAAEDE → RKCRKKSVVEWQC
     1306-1696: Missing.

Note: No experimental confirmation available.

Isoform J (identifier: Q9VR59-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PATETAEDTS...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Note: No experimental confirmation available.

Isoform K (identifier: Q9VR59-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1090: P → PVSSPDFGDN...PSCCTKTIAT
     1293-1300: LWPQDIVK → QYPTEPSI
     1301-1696: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1696	1696	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase		PRO_0000315697
Regions
	Nucleotide binding	260 – 263	4	ATP By similarity
	Nucleotide binding	269 – 271	3	ATP By similarity
	Nucleotide binding	344 – 346	3	ATP By similarity
	Region	76 – 77	2	Substrate binding By similarity
	Region	236 – 237	2	Substrate binding By similarity
	Region	349 – 352	4	Substrate binding By similarity
Sites
	Binding site	157	1	ATP By similarity
	Binding site	210	1	ATP By similarity
	Binding site	217	1	ATP By similarity
	Binding site	236	1	ATP By similarity
	Binding site	271	1	Substrate By similarity
	Binding site	285	1	Substrate By similarity
	Binding site	287	1	ATP By similarity
	Binding site	332	1	ATP By similarity
Amino acid modifications
	Modified residue	974	1	Phosphoserine Ref.6
	Modified residue	1001	1	Phosphoserine Ref.6
	Modified residue	1060	1	Phosphoserine Ref.5
	Modified residue	1255	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	2 – 40	39	SYTEL…GLQDG → EWTWFKDWWRLKKLRSRHQR HKKKLQATAASAEAAVTASA FLAGSGCAESGGSQDPQTNR LHSLDAVPSDGTLARRRHGS RDSLRRNRLLQRQRRSQSAA VRSHRSHDDDDDGEYGPFNV SDYEDYGPNHGSDEESDDFC YCEVCM in isoform H.		VSP_030640
	Alternative sequence	266	1	D → DVYFS in isoform H.		VSP_030641
	Alternative sequence	1090	1	P → PATETAEDTSMDIQPKICIG KCAPGLLTPTVTTTDILKGI RDIAPTATQTSPPTFTPSTT TTTGAAAALFDNTATMSSNR PFTNQFQSIDPTSNDAPHQH HVHQHQYQHHRKTTTTIINN TLNENHTTATITNNTTTTPS CCTKTIAT in isoform J.		VSP_030643
	Alternative sequence	1090	1	P → PVSSPDFGDNSRTRSSEFGE TCHARVGTASNSDGGGSHPR ADHRTAFQIRVTNSLSFFKI DSSTNELPLSDIDFSLHPPT PQCGPLSHKRFHILTMRRME SCDDGAELEQVRHLPQISPM ATNERPLSSCNCSSSAAQAH SHSKSLMDLAQAVVMTSPQE TGPNSEQGCDPTTAADVSVS SFDDDFQLSSSAPAILMSAH FGNRPVVASLSSMVHVTTSP SASTLQLCRDKDKALASGTS SAHSKATSNSCGQLSMAGSA PVVTENPFRFTVSSLGSAAT NTACFVGSFEPIEEQITSIV EVDSKPLQPEPQVVYNLPTV LITGTASSSELSTKLNSNIL PTVTNAFSAIDTEINDEIGI SKEVGIGTIRITNTHTPCNK ATVTRPDTKIAITTDPQTVT ATETAEDTSMDIQPKICIGK CAPGLLTPTVTTTDILKGIR DIAPTATQTSPPTFTPSTTT TTGAAAALFDNTATMSSNRP FTNQFQSIDPTSNDAPHQHH VHQHQYQHHRKTTTTIINNT LNENHTTATITNNTTTTPSC CTKTIAT in isoform K.		VSP_033593
	Alternative sequence	1293 – 1305	13	LWPQD…AAEDE → RKCRKKSVVEWQC in isoform H.		VSP_030648
	Alternative sequence	1293 – 1300	8	LWPQDIVK → QYPTEPSI in isoform G, isoform J and isoform K.		VSP_030649
	Alternative sequence	1301 – 1696	396	Missing in isoform G, isoform J and isoform K.		VSP_030650
	Alternative sequence	1306 – 1696	391	Missing in isoform H.		VSP_030651
	Natural variant	1093	1	Q → R in RNA edited version.
	Natural variant	1117	1	S → G in RNA edited version.
	Natural variant	1121	1	Q → R in RNA edited version.
Experimental info
	Sequence conflict	329	1	C → F in ABN49448. Ref.3
	Sequence conflict	734	1	K → KN in ABN49448. Ref.3
	Sequence conflict	906	1	Y → H in ABN49448. Ref.3
	Sequence conflict	1092	1	S → G in AAT94524. Ref.3
	Sequence conflict	1116	1	H → R in AAT94524. Ref.3
	Sequence conflict	1124	1	Y → C in AAT94524. Ref.3
	Sequence conflict	1124	1	Y → C in ABN49448. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform I [UniParc]. Last modified June 16, 2009. Version 2. Checksum: BB013ECB582C96D3	FASTA	1,696	188,677
	10 20 30 40 50 60 MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 70 80 90 100 110 120 SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 130 140 150 160 170 180 VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 190 200 210 220 230 240 SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 250 260 270 280 290 300 RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 310 320 330 340 350 360 KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 370 380 390 400 410 420 CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 430 440 450 460 470 480 MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 490 500 510 520 530 540 KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 550 560 570 580 590 600 ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 610 620 630 640 650 660 MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 670 680 690 700 710 720 FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 730 740 750 760 770 780 HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 790 800 810 820 830 840 AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 850 860 870 880 890 900 GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 910 920 930 940 950 960 IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 970 980 990 1000 1010 1020 DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 1030 1040 1050 1060 1070 1080 IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 1090 1100 1110 1120 1130 1140 PTSGVCAKEP DSQVSVSVSA SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS 1150 1160 1170 1180 1190 1200 ANSLFSTAVI SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL 1210 1220 1230 1240 1250 1260 AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF DRRGSESGST 1270 1280 1290 1300 1310 1320 ADAHLRLLSE SQCPNLDDSN TELRESLAGK MELWPQDIVK AAEDEELNLS ELETKPSLDL 1330 1340 1350 1360 1370 1380 TMEIMERGVA GIASIQPMNR DSDETMGGGV FLSVCEEQGS GSTCLTPVSF GMDLDLSMVA 1390 1400 1410 1420 1430 1440 NKGSITLSME GFDDDEDATL SAATTPSLLA DCEPRLESCY CCPSHAEAPP EVPSDDPRFG 1450 1460 1470 1480 1490 1500 FALPVRVTQA SPEHARPVRR AHDPVSPRIQ KQISLFEGNA AMATGQEKTE SSGSVGGGAI 1510 1520 1530 1540 1550 1560 LHASINLPAA GPHHLRQDAR LRKFENLTQS TSNSNFPFES NTLKRVPMQT TKDYDNVSHT 1570 1580 1590 1600 1610 1620 QSCINLKSGS SGVLGGSPQR QRGSDGGGVG ASGVPAESRE PTRVHYGRMN STCCSASASP 1630 1640 1650 1660 1670 1680 SPSPGALIVK ERFIEPPKRG VVRGYHGKTQ SMDADFLFNE FLLLPAMAPA KISFDSSDID 1690 QASDDDSPSS SKQRHA
	Isoform G [UniParc]. Checksum: 644A2123503DB726	FASTA	1,300	146,528
	10 20 30 40 50 60 MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 70 80 90 100 110 120 SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 130 140 150 160 170 180 VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 190 200 210 220 230 240 SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 250 260 270 280 290 300 RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 310 320 330 340 350 360 KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 370 380 390 400 410 420 CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 430 440 450 460 470 480 MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 490 500 510 520 530 540 KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 550 560 570 580 590 600 ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 610 620 630 640 650 660 MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 670 680 690 700 710 720 FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 730 740 750 760 770 780 HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 790 800 810 820 830 840 AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 850 860 870 880 890 900 GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 910 920 930 940 950 960 IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 970 980 990 1000 1010 1020 DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 1030 1040 1050 1060 1070 1080 IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 1090 1100 1110 1120 1130 1140 PTSGVCAKEP DSQVSVSVSA SVSSANASTS SRRQRHSIAG QMSYMKMLGF GGFSKKMATS 1150 1160 1170 1180 1190 1200 ANSLFSTAVI SGSSSAPNLR DMITVSSSGF GDVPPIRPLE TLHNALSLRK LDSFLQDMIL 1210 1220 1230 1240 1250 1260 AQIFKTPTGS PPRGFSKNTL PAVSSMTLTA SNQTEVVEHE PISTTVTPTF DRRGSESGST 1270 1280 1290 1300 ADAHLRLLSE SQCPNLDDSN TELRESLAGK MEQYPTEPSI
	Isoform H [UniParc]. Checksum: 95E98D85E6F735A6	FASTA	1,416	159,831
	10 20 30 40 50 60 MEWTWFKDWW RLKKLRSRHQ RHKKKLQATA ASAEAAVTAS AFLAGSGCAE SGGSQDPQTN 70 80 90 100 110 120 RLHSLDAVPS DGTLARRRHG SRDSLRRNRL LQRQRRSQSA AVRSHRSHDD DDDGEYGPFN 130 140 150 160 170 180 VSDYEDYGPN HGSDEESDDF CYCEVCMNGD TDFGDSNDGM DSDTSTSSSN SKQVVVGICA 190 200 210 220 230 240 MAKKTQSKPM KEILTRLGEF EFIKLVTFEE NVILREPVQN WPTCDCLVSF HSKGFPLEKA 250 260 270 280 290 300 IEYAQLRNPF VLNNLHMQYD IQDRRRVYAI LEKEGIEIPR YAVLDRDSPD PKHHELIESE 310 320 330 340 350 360 DHVEVNGITF NKPFVEKPVS AEDHNIYIYY PTSAGGGSQR LFRKIGSRSS VYSPESRVRK 370 380 390 400 410 420 TGSFIYEDFM PTDVYFSGTD VKVYTVGPDY AHAEARKSPA LDGKVERDSE GKEIRYPVIL 430 440 450 460 470 480 NHSEKLISRK VCLAFKQTVC GFDLLRANGK SYVCDVNGFS FVKNSNKYYD DCAKILGNMI 490 500 510 520 530 540 LRELTPTLHI PWSVPFQLDD PPIVPTTFGK MMELRCVVAV IRHGDRTPKQ KMKVEVRHPK 550 560 570 580 590 600 FFEIFEKYDG YKLGHVKLKR PKQLQEILDI ARFLLSEIHT KAHAEIEEKE SKLEQLKNVL 610 620 630 640 650 660 EMYGHFSGIN RKVQMKYQPK GRPRGSSSDD TNLAADQPVE PSLVLILKWG GELTPAGRIQ 670 680 690 700 710 720 AEELGRIFRC MYPGGQGRSD YSGTQGLGLL RLHSTFRHDL KIYASDEGRV QMTAAAFAKG 730 740 750 760 770 780 LLALEGELTP ILVQMVKSAN TNGLLDNDCD SSKYQNLAKG RLHELMQNDR EFSKEDRELI 790 800 810 820 830 840 NPCNSKSITQ ALDFVKNPVD CCHHVHLLIR ELLHIISIKK DDPKTKDAIL YHGETWDLMR 850 860 870 880 890 900 CRWEKIEKDF STKSKLFDIS KIPDIYDCIK YDLQHNQHTL QYDQAEELYI YAKNLADIVI 910 920 930 940 950 960 PQEYGLTPQE KLAIGQGICS PLLRKIKGDL QRNIDEVEDE FMNRLNPHYS HGVASPQRHV 970 980 990 1000 1010 1020 RTRLYFTSES HVHSLLTVLR YGGLLNVVTD EQWRRAMDYI SMVSELNYMS QIVIMLYEDP 1030 1040 1050 1060 1070 1080 TKDPTSEERF HVELHFSPGV NCCVQKNLPP GPGFRPHSHG DNACNVSLQS SDESNPARIE 1090 1100 1110 1120 1130 1140 EENDSNSGEE REGKKRGTSG QRSTDRSAER ISPAFGFNRL ELRSKQFKSK PIPIGAHHTV 1150 1160 1170 1180 1190 1200 SGHEAMDLAK RLNEELASHQ QQQNQQLRPI SPDIRAVTPD CEPRSRSFEQ RPTSGVCAKE 1210 1220 1230 1240 1250 1260 PDSQVSVSVS ASVSSANAST SSRRQRHSIA GQMSYMKMLG FGGFSKKMAT SANSLFSTAV 1270 1280 1290 1300 1310 1320 ISGSSSAPNL RDMITVSSSG FGDVPPIRPL ETLHNALSLR KLDSFLQDMI LAQIFKTPTG 1330 1340 1350 1360 1370 1380 SPPRGFSKNT LPAVSSMTLT ASNQTEVVEH EPISTTVTPT FDRRGSESGS TADAHLRLLS 1390 1400 1410 ESQCPNLDDS NTELRESLAG KMERKCRKKS VVEWQC
	Isoform J [UniParc]. Checksum: 33909E1FE36F5731	FASTA	1,447	162,288
	10 20 30 40 50 60 MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 70 80 90 100 110 120 SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 130 140 150 160 170 180 VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 190 200 210 220 230 240 SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 250 260 270 280 290 300 RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 310 320 330 340 350 360 KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 370 380 390 400 410 420 CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 430 440 450 460 470 480 MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 490 500 510 520 530 540 KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 550 560 570 580 590 600 ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 610 620 630 640 650 660 MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 670 680 690 700 710 720 FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 730 740 750 760 770 780 HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 790 800 810 820 830 840 AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 850 860 870 880 890 900 GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 910 920 930 940 950 960 IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 970 980 990 1000 1010 1020 DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 1030 1040 1050 1060 1070 1080 IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 1090 1100 1110 1120 1130 1140 PTSGVCAKEP ATETAEDTSM DIQPKICIGK CAPGLLTPTV TTTDILKGIR DIAPTATQTS 1150 1160 1170 1180 1190 1200 PPTFTPSTTT TTGAAAALFD NTATMSSNRP FTNQFQSIDP TSNDAPHQHH VHQHQYQHHR 1210 1220 1230 1240 1250 1260 KTTTTIINNT LNENHTTATI TNNTTTTPSC CTKTIATDSQ VSVSVSASVS SANASTSSRR 1270 1280 1290 1300 1310 1320 QRHSIAGQMS YMKMLGFGGF SKKMATSANS LFSTAVISGS SSAPNLRDMI TVSSSGFGDV 1330 1340 1350 1360 1370 1380 PPIRPLETLH NALSLRKLDS FLQDMILAQI FKTPTGSPPR GFSKNTLPAV SSMTLTASNQ 1390 1400 1410 1420 1430 1440 TEVVEHEPIS TTVTPTFDRR GSESGSTADA HLRLLSESQC PNLDDSNTEL RESLAGKMEQ YPTEPSI
	Isoform K [UniParc]. Checksum: 803BD74B91DAC0EE	FASTA	1,846	204,458
	10 20 30 40 50 60 MSYTELESGY QDISQQHQQQ NPHQSQPQQR VGFYLGLQDG NGDTDFGDSN DGMDSDTSTS 70 80 90 100 110 120 SSNSKQVVVG ICAMAKKTQS KPMKEILTRL GEFEFIKLVT FEENVILREP VQNWPTCDCL 130 140 150 160 170 180 VSFHSKGFPL EKAIEYAQLR NPFVLNNLHM QYDIQDRRRV YAILEKEGIE IPRYAVLDRD 190 200 210 220 230 240 SPDPKHHELI ESEDHVEVNG ITFNKPFVEK PVSAEDHNIY IYYPTSAGGG SQRLFRKIGS 250 260 270 280 290 300 RSSVYSPESR VRKTGSFIYE DFMPTDGTDV KVYTVGPDYA HAEARKSPAL DGKVERDSEG 310 320 330 340 350 360 KEIRYPVILN HSEKLISRKV CLAFKQTVCG FDLLRANGKS YVCDVNGFSF VKNSNKYYDD 370 380 390 400 410 420 CAKILGNMIL RELTPTLHIP WSVPFQLDDP PIVPTTFGKM MELRCVVAVI RHGDRTPKQK 430 440 450 460 470 480 MKVEVRHPKF FEIFEKYDGY KLGHVKLKRP KQLQEILDIA RFLLSEIHTK AHAEIEEKES 490 500 510 520 530 540 KLEQLKNVLE MYGHFSGINR KVQMKYQPKG RPRGSSSDDT NLAADQPVEP SLVLILKWGG 550 560 570 580 590 600 ELTPAGRIQA EELGRIFRCM YPGGQGRSDY SGTQGLGLLR LHSTFRHDLK IYASDEGRVQ 610 620 630 640 650 660 MTAAAFAKGL LALEGELTPI LVQMVKSANT NGLLDNDCDS SKYQNLAKGR LHELMQNDRE 670 680 690 700 710 720 FSKEDRELIN PCNSKSITQA LDFVKNPVDC CHHVHLLIRE LLHIISIKKD DPKTKDAILY 730 740 750 760 770 780 HGETWDLMRC RWEKIEKDFS TKSKLFDISK IPDIYDCIKY DLQHNQHTLQ YDQAEELYIY 790 800 810 820 830 840 AKNLADIVIP QEYGLTPQEK LAIGQGICSP LLRKIKGDLQ RNIDEVEDEF MNRLNPHYSH 850 860 870 880 890 900 GVASPQRHVR TRLYFTSESH VHSLLTVLRY GGLLNVVTDE QWRRAMDYIS MVSELNYMSQ 910 920 930 940 950 960 IVIMLYEDPT KDPTSEERFH VELHFSPGVN CCVQKNLPPG PGFRPHSHGD NACNVSLQSS 970 980 990 1000 1010 1020 DESNPARIEE ENDSNSGEER EGKKRGTSGQ RSTDRSAERI SPAFGFNRLE LRSKQFKSKP 1030 1040 1050 1060 1070 1080 IPIGAHHTVS GHEAMDLAKR LNEELASHQQ QQNQQLRPIS PDIRAVTPDC EPRSRSFEQR 1090 1100 1110 1120 1130 1140 PTSGVCAKEP VSSPDFGDNS RTRSSEFGET CHARVGTASN SDGGGSHPRA DHRTAFQIRV 1150 1160 1170 1180 1190 1200 TNSLSFFKID SSTNELPLSD IDFSLHPPTP QCGPLSHKRF HILTMRRMES CDDGAELEQV 1210 1220 1230 1240 1250 1260 RHLPQISPMA TNERPLSSCN CSSSAAQAHS HSKSLMDLAQ AVVMTSPQET GPNSEQGCDP 1270 1280 1290 1300 1310 1320 TTAADVSVSS FDDDFQLSSS APAILMSAHF GNRPVVASLS SMVHVTTSPS ASTLQLCRDK 1330 1340 1350 1360 1370 1380 DKALASGTSS AHSKATSNSC GQLSMAGSAP VVTENPFRFT VSSLGSAATN TACFVGSFEP 1390 1400 1410 1420 1430 1440 IEEQITSIVE VDSKPLQPEP QVVYNLPTVL ITGTASSSEL STKLNSNILP TVTNAFSAID 1450 1460 1470 1480 1490 1500 TEINDEIGIS KEVGIGTIRI TNTHTPCNKA TVTRPDTKIA ITTDPQTVTA TETAEDTSMD 1510 1520 1530 1540 1550 1560 IQPKICIGKC APGLLTPTVT TTDILKGIRD IAPTATQTSP PTFTPSTTTT TGAAAALFDN 1570 1580 1590 1600 1610 1620 TATMSSNRPF TNQFQSIDPT SNDAPHQHHV HQHQYQHHRK TTTTIINNTL NENHTTATIT 1630 1640 1650 1660 1670 1680 NNTTTTPSCC TKTIATDSQV SVSVSASVSS ANASTSSRRQ RHSIAGQMSY MKMLGFGGFS 1690 1700 1710 1720 1730 1740 KKMATSANSL FSTAVISGSS SAPNLRDMIT VSSSGFGDVP PIRPLETLHN ALSLRKLDSF 1750 1760 1770 1780 1790 1800 LQDMILAQIF KTPTGSPPRG FSKNTLPAVS SMTLTASNQT EVVEHEPIST TVTPTFDRRG 1810 1820 1830 1840 SESGSTADAH LRLLSESQCP NLDDSNTELR ESLAGKMEQY PTEPSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[3]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS G AND H), RNA EDITING OF POSITIONS 1117 AND 1121. Strain: Berkeley. Tissue: Embryo and Head.
[4]	"RNA editing in Drosophila melanogaster: new targets and functional consequences." Stapleton M., Carlson J.W., Celniker S.E. RNA 12:1922-1932(2006) [PubMed] [Europe PMC] [Abstract] Cited for: RNA EDITING OF POSITION 1093; 1117 AND 1121.
[5]	"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1060, MASS SPECTROMETRY.
[6]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-974; SER-1001 AND SER-1255, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAN09569.2. AE014298 Genomic DNA. Translation: AAN09570.3. AE014298 Genomic DNA. Translation: AAN09571.2. AE014298 Genomic DNA. Translation: AAN09573.2. AE014298 Genomic DNA. Translation: ABW09458.2. BT015295 mRNA. Translation: AAT94524.1. BT030309 mRNA. Translation: ABN49448.1. Frameshift.
RefSeq	NP_001097041.2. NM_001103571.2. NP_788950.2. NM_176777.2. NP_788951.2. NM_176778.2. NP_788952.2. NM_176779.2. NP_788953.2. NM_176780.2.
UniGene	Dm.237.
3D structure databases
ProteinModelPortal	Q9VR59.
SMR	Q9VR59. Positions 66-383.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-21851N.
MINT	MINT-1002676.
STRING	7227.FBpp0288801.
Proteomic databases
PaxDb	Q9VR59.
PRIDE	Q9VR59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0299524; FBpp0288799; FBgn0027279.
GeneID	33137.
KEGG	dme:Dmel_CG14616.
Organism-specific databases
FlyBase	FBgn0027279. l(1)G0196.
Phylogenomic databases
eggNOG	NOG245915.
GeneTree	ENSGT00390000009048.
InParanoid	Q9VR59.
KO	K13024.
OMA	DGFPLEK.
OrthoDB	EOG473N63.
Gene expression databases
Bgee	Q9VR59.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	33137.
NextBio	782108.

Entry information

Entry name

VIP1_DROME

Accession

Primary (citable) accession number: Q9VR59
Secondary accession number(s): A2VEZ0 , A8JUU5, Q6AWF3, Q8IQ22, Q8IQ23, Q8IQ24

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project