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Q9VR54 (Q9VR54_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435
Gene names
ORF Names:CG14619 FlyBase FBgn0031187 EMBL AAL39948.1, Dmel_CG14619 EMBL AAF50952.2
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435

Sequence similarities

Belongs to the peptidase C19 family. RuleBase RU004434

Sequences

Sequence LengthMass (Da)Tools
Q9VR54 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 55E83B2064855679

FASTA85691,988
        10         20         30         40         50         60 
MRVIAPRRSS TSAAGSGSLY GTSAVGTSSG STTSSNSTSG SHHISITGSG AVDRTSGGAA 

        70         80         90        100        110        120 
TNGYSRISSS YDRGSSLSKW LPTSSGGSNS SGYGSSYYPT SYSTFSANSG SSSASYAPRS 

       130        140        150        160        170        180 
SVQRSSVGTT SSTSYMSGGS GSSSSAYRTS SYLSGSSYDS PTYSRYGLPR KAASRITTNG 

       190        200        210        220        230        240 
DSLSGSAKRE DYGLRRGHDT VKKPPISGGS VGHNCSSSTA SRDTKAVDGN KRLSSSSSSP 

       250        260        270        280        290        300 
SLARLVATSG LDIYEKYSPA NYKPNCELSR SRSGHSETDL ENGSNKETTP TCTVTLDRPW 

       310        320        330        340        350        360 
SSTSRYSRLY RNSSDAGGDS SASAKKLGSG KYSISSSSSS GDVPTATFTL RSKRTRRNQA 

       370        380        390        400        410        420 
EEVPTSTGVE QAGPAAPPPT PPPPPPPPPP TNGHKPAESN GGLEAKLNGL SLLSTSPKRN 

       430        440        450        460        470        480 
AIYERNQETA DDAGVSQDTA DNADVSTSAT FKLNDSSKTL ARSGTGSSST ARSVLPPMTP 

       490        500        510        520        530        540 
TSSRYWDRDS GTSRSSIGTS SALNSSSLKH NSDDGYKTAS SSRDEKSEGL CGLRNIGNTC 

       550        560        570        580        590        600 
FMNSVIQCLS HTQELTRFLR SHHGSRSLST KDQQILHEFA KLIQEMWTAN VHTVTPMELK 

       610        620        630        640        650        660 
RAFSTKHRMY SDYNQQDAQE FLRFFLDSLH SALNSGVKGE TLNIDDNLSD NKKADLTWEW 

       670        680        690        700        710        720 
YTRHENSLVR DLFVGQLKST LKCTTCGNTS VTFDPFWDLS VPLPSSSRCK LEACLDLFIR 

       730        740        750        760        770        780 
EEVLDGDEMP TCAKCKTRRK CTKSFTIQRF PKYLVIHLKR FSETRWSKLS NIVEFPTSDS 

       790        800        810        820        830        840 
ELNMGSYGAN SNSNVHYSLY AISNHMGSTA GGHYVALCKH PVSRKWHEFN DNIVSDALSE 

       850 
NHLVSSSAYI LFYERT

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. expand/collapse author list , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014298 Genomic DNA. Translation: AAF50952.2.
AY069803 mRNA. Translation: AAL39948.1.
AE014298 Genomic DNA. Translation: AAN09564.1.
AE014298 Genomic DNA. Translation: AAN09565.1.
RefSeqNP_608462.1. NM_134618.2.
NP_728453.1. NM_167775.1.
NP_728454.1. NM_167776.1.
UniGeneDm.1945.

3D structure databases

HSSPHSSP built from PDB template 1NBF based on UniProtKB Q93009.
ProteinModelPortalQ9VR54.
SMRQ9VR54. Positions 528-856.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9VR54. 8 interactions.
MINTMINT-1753866.

Protein family/group databases

MEROPSC19.A24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0077346; FBpp0077038; FBgn0031187.
FBtr0077347; FBpp0077039; FBgn0031187.
FBtr0077348; FBpp0077040; FBgn0031187.
GeneID33132.
KEGGdme:Dmel_CG14619.
UCSCCG14619-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0031187. CG14619.

Phylogenomic databases

GeneTreeEMGT00050000001408.
InParanoidQ9VR54.
OMAEKYSPAN.
PhylomeDBQ9VR54.

Gene expression databases

ArrayExpressQ9VR54.
BgeeQ9VR54.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
[Graphical view]
KOK11833.
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio782065.

Entry information

Entry nameQ9VR54_DROME
AccessionPrimary (citable) accession number: Q9VR54
Secondary accession number(s): Q8T9E4
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info