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Q9VQZ6

- ELP3_DROME

UniProt

Q9VQZ6 - ELP3_DROME

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Protein

Probable elongator complex protein 3

Gene
Elp3, CG15433
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi114 – 1141Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. acetyltransferase activity Source: FlyBase
  2. histone acetyltransferase activity Source: UniProtKB-EC
  3. iron-sulfur cluster binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. cytoskeletal matrix organization at active zone Source: FlyBase
  2. locomotory behavior Source: FlyBase
  3. peptidyl-lysine acetylation Source: FlyBase
  4. regulation of photoreceptor cell axon guidance Source: FlyBase
  5. regulation of protein kinase activity Source: GOC
  6. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. sleep Source: FlyBase
  8. synapse organization Source: FlyBase
  9. synaptic growth at neuromuscular junction Source: FlyBase
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:Elp3
ORF Names:CG15433
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031604. Elp3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. synapse Source: FlyBase
  3. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Probable elongator complex protein 3PRO_0000283992Add
BLAST

Proteomic databases

PaxDbiQ9VQZ6.
PRIDEiQ9VQZ6.

Expressioni

Gene expression databases

BgeeiQ9VQZ6.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Protein-protein interaction databases

BioGridi59843. 1 interaction.
STRINGi7227.FBpp0077129.

Structurei

3D structure databases

ProteinModelPortaliQ9VQZ6.
SMRiQ9VQZ6. Positions 492-541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 552155N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.

Phylogenomic databases

eggNOGiCOG1243.
GeneTreeiENSGT00390000013141.
InParanoidiQ9VQZ6.
KOiK07739.
OMAiGYKVVSH.
OrthoDBiEOG7V765W.
PhylomeDBiQ9VQZ6.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VQZ6-1 [UniParc]FASTAAdd to Basket

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MKAKKKLGVG LSRQERQVLV IGEIIQELLK AHEAKKDVNL NRMKSLVASK    50
YGLDSSPRLV DIIAAVPQDA KKILLPKLRA KPIRTASGIA VVAVMCKPHR 100
CPHINMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RSRYDPFLQT 150
RHRVEQLKQL GHSVDKVEFI VMGGTFMCLP EEYRDYFIRN LHDALSGHSS 200
ANVAEAVRYS EKSRTKCIGI TIETRPDYCL KRHISDMLSY GCTRLEIGVQ 250
SVYEDVARDT NRGHTVRAVC ESFQLGKDAG YKIVTHMMPD LPNVDFERDI 300
EQFIEYFENP AFRSDGLKIY PTLVIRGTGL YELWKTGRYK SYPPSMLVDL 350
VAKILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTTC 400
RDVRTREVGI QEIHNKVRPY EIELIRRDYV ANGGWETFLS YEDPEQDILV 450
GLLRLRKCSP DTFRPELKGE CSIVRELHVY GSVVPVNARD PTKFQHQGFG 500
MLLMEEAERI AREEHGSTKL AVISGVGTRN YYRKMGYQLD GPYMSKSIEE 550
NN 552
Length:552
Mass (Da):62,821
Last modified:May 1, 2000 - v1
Checksum:i3CE7D4D46EEE0C1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51012.1.
AY089621 mRNA. Translation: AAL90359.1.
RefSeqiNP_608834.1. NM_134990.3.
UniGeneiDm.12505.

Genome annotation databases

EnsemblMetazoaiFBtr0077439; FBpp0077129; FBgn0031604.
GeneIDi33649.
KEGGidme:Dmel_CG15433.
UCSCiCG15433-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51012.1 .
AY089621 mRNA. Translation: AAL90359.1 .
RefSeqi NP_608834.1. NM_134990.3.
UniGenei Dm.12505.

3D structure databases

ProteinModelPortali Q9VQZ6.
SMRi Q9VQZ6. Positions 492-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 59843. 1 interaction.
STRINGi 7227.FBpp0077129.

Proteomic databases

PaxDbi Q9VQZ6.
PRIDEi Q9VQZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0077439 ; FBpp0077129 ; FBgn0031604 .
GeneIDi 33649.
KEGGi dme:Dmel_CG15433.
UCSCi CG15433-RA. d. melanogaster.

Organism-specific databases

CTDi 55140.
FlyBasei FBgn0031604. Elp3.

Phylogenomic databases

eggNOGi COG1243.
GeneTreei ENSGT00390000013141.
InParanoidi Q9VQZ6.
KOi K07739.
OMAi GYKVVSH.
OrthoDBi EOG7V765W.
PhylomeDBi Q9VQZ6.

Miscellaneous databases

GenomeRNAii 33649.
NextBioi 784609.
PROi Q9VQZ6.

Gene expression databases

Bgeei Q9VQZ6.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiELP3_DROME
AccessioniPrimary (citable) accession number: Q9VQZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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