UniProtKB - Q9VQZ6 (ELP3_DROME)
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Protein
Probable elongator complex protein 3
Gene
Elp3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).By similarity
Catalytic activityi
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.
Cofactori
[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 101 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 | |
Metal bindingi | 111 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 | |
Metal bindingi | 114 | Iron-sulfur (4Fe-4S-S-AdoMet)By similarity | 1 |
GO - Molecular functioni
- acetyltransferase activity Source: FlyBase
- histone acetyltransferase activity Source: GO_Central
- iron-sulfur cluster binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphorylase kinase regulator activity Source: UniProtKB
GO - Biological processi
- cytoskeletal matrix organization at active zone Source: FlyBase
- hemopoiesis Source: FlyBase
- histone acetylation Source: FlyBase
- instar larval development Source: FlyBase
- locomotory behavior Source: FlyBase
- peptidyl-lysine acetylation Source: FlyBase
- regulation of photoreceptor cell axon guidance Source: FlyBase
- regulation of transcription by RNA polymerase II Source: UniProtKB
- sleep Source: FlyBase
- synapse organization Source: FlyBase
- synaptic growth at neuromuscular junction Source: FlyBase
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine |
Enzyme and pathway databases
BRENDAi | 2.3.1.48. 1994. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Elp3 ORF Names:CG15433 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0031604. Elp3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283992 | 1 – 552 | Probable elongator complex protein 3Add BLAST | 552 |
Proteomic databases
PaxDbi | Q9VQZ6. |
PRIDEi | Q9VQZ6. |
Interactioni
Subunit structurei
Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 59843. 5 interactors. |
IntActi | Q9VQZ6. 1 interactor. |
STRINGi | 7227.FBpp0077129. |
Structurei
3D structure databases
ProteinModelPortali | Q9VQZ6. |
SMRi | Q9VQZ6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 398 – 552 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 155 |
Sequence similaritiesi
Belongs to the ELP3 family.Curated
Phylogenomic databases
eggNOGi | KOG2535. Eukaryota. COG1243. LUCA. |
GeneTreei | ENSGT00390000013141. |
InParanoidi | Q9VQZ6. |
KOi | K07739. |
OMAi | SYTGKEP. |
OrthoDBi | EOG091G03ZS. |
PhylomeDBi | Q9VQZ6. |
Family and domain databases
Gene3Di | 3.80.30.20. 1 hit. |
InterProi | View protein in InterPro IPR016181. Acyl_CoA_acyltransferase. IPR034687. ELP3-like. IPR006638. Elp3/MiaB/NifB. IPR000182. GNAT_dom. IPR032432. Radical_SAM_C. IPR007197. rSAM. IPR023404. rSAM_horseshoe. |
PANTHERi | PTHR11135:SF0. PTHR11135:SF0. 1 hit. |
Pfami | View protein in Pfam PF00583. Acetyltransf_1. 1 hit. PF04055. Radical_SAM. 1 hit. PF16199. Radical_SAM_C. 1 hit. |
PIRSFi | PIRSF005669. Hist_AcTrfase_ELP3. 1 hit. |
SFLDi | SFLDF00344. ELP3-like. 1 hit. |
SMARTi | View protein in SMART SM00729. Elp3. 1 hit. |
SUPFAMi | SSF55729. SSF55729. 1 hit. |
TIGRFAMsi | TIGR01211. ELP3. 1 hit. |
PROSITEi | View protein in PROSITE PS51186. GNAT. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9VQZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAKKKLGVG LSRQERQVLV IGEIIQELLK AHEAKKDVNL NRMKSLVASK
60 70 80 90 100
YGLDSSPRLV DIIAAVPQDA KKILLPKLRA KPIRTASGIA VVAVMCKPHR
110 120 130 140 150
CPHINMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RSRYDPFLQT
160 170 180 190 200
RHRVEQLKQL GHSVDKVEFI VMGGTFMCLP EEYRDYFIRN LHDALSGHSS
210 220 230 240 250
ANVAEAVRYS EKSRTKCIGI TIETRPDYCL KRHISDMLSY GCTRLEIGVQ
260 270 280 290 300
SVYEDVARDT NRGHTVRAVC ESFQLGKDAG YKIVTHMMPD LPNVDFERDI
310 320 330 340 350
EQFIEYFENP AFRSDGLKIY PTLVIRGTGL YELWKTGRYK SYPPSMLVDL
360 370 380 390 400
VAKILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTTC
410 420 430 440 450
RDVRTREVGI QEIHNKVRPY EIELIRRDYV ANGGWETFLS YEDPEQDILV
460 470 480 490 500
GLLRLRKCSP DTFRPELKGE CSIVRELHVY GSVVPVNARD PTKFQHQGFG
510 520 530 540 550
MLLMEEAERI AREEHGSTKL AVISGVGTRN YYRKMGYQLD GPYMSKSIEE
NN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA. Translation: AAF51012.1. AY089621 mRNA. Translation: AAL90359.1. |
RefSeqi | NP_608834.1. NM_134990.3. |
UniGenei | Dm.12505. |
Genome annotation databases
EnsemblMetazoai | FBtr0077439; FBpp0077129; FBgn0031604. |
GeneIDi | 33649. |
KEGGi | dme:Dmel_CG15433. |
UCSCi | CG15433-RA. d. melanogaster. |
Similar proteinsi
Entry informationi
Entry namei | ELP3_DROME | |
Accessioni | Q9VQZ6Primary (citable) accession number: Q9VQZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |