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Q9VQZ6

- ELP3_DROME

UniProt

Q9VQZ6 - ELP3_DROME

Protein

Probable elongator complex protein 3

Gene

Elp3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi114 – 1141Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. acetyltransferase activity Source: FlyBase
    2. histone acetyltransferase activity Source: UniProtKB-EC
    3. iron-sulfur cluster binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. phosphorylase kinase regulator activity Source: UniProtKB

    GO - Biological processi

    1. cytoskeletal matrix organization at active zone Source: FlyBase
    2. locomotory behavior Source: FlyBase
    3. peptidyl-lysine acetylation Source: FlyBase
    4. regulation of photoreceptor cell axon guidance Source: FlyBase
    5. regulation of protein kinase activity Source: GOC
    6. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. sleep Source: FlyBase
    8. synapse organization Source: FlyBase
    9. synaptic growth at neuromuscular junction Source: FlyBase
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:Elp3
    ORF Names:CG15433
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0031604. Elp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. synapse Source: FlyBase
    3. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Probable elongator complex protein 3PRO_0000283992Add
    BLAST

    Proteomic databases

    PaxDbiQ9VQZ6.
    PRIDEiQ9VQZ6.

    Expressioni

    Gene expression databases

    BgeeiQ9VQZ6.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Protein-protein interaction databases

    BioGridi59843. 1 interaction.
    STRINGi7227.FBpp0077129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VQZ6.
    SMRiQ9VQZ6. Positions 492-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini398 – 552155N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    GeneTreeiENSGT00390000013141.
    InParanoidiQ9VQZ6.
    KOiK07739.
    OMAiGYKVVSH.
    OrthoDBiEOG7V765W.
    PhylomeDBiQ9VQZ6.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VQZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAKKKLGVG LSRQERQVLV IGEIIQELLK AHEAKKDVNL NRMKSLVASK    50
    YGLDSSPRLV DIIAAVPQDA KKILLPKLRA KPIRTASGIA VVAVMCKPHR 100
    CPHINMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RSRYDPFLQT 150
    RHRVEQLKQL GHSVDKVEFI VMGGTFMCLP EEYRDYFIRN LHDALSGHSS 200
    ANVAEAVRYS EKSRTKCIGI TIETRPDYCL KRHISDMLSY GCTRLEIGVQ 250
    SVYEDVARDT NRGHTVRAVC ESFQLGKDAG YKIVTHMMPD LPNVDFERDI 300
    EQFIEYFENP AFRSDGLKIY PTLVIRGTGL YELWKTGRYK SYPPSMLVDL 350
    VAKILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTTC 400
    RDVRTREVGI QEIHNKVRPY EIELIRRDYV ANGGWETFLS YEDPEQDILV 450
    GLLRLRKCSP DTFRPELKGE CSIVRELHVY GSVVPVNARD PTKFQHQGFG 500
    MLLMEEAERI AREEHGSTKL AVISGVGTRN YYRKMGYQLD GPYMSKSIEE 550
    NN 552
    Length:552
    Mass (Da):62,821
    Last modified:May 1, 2000 - v1
    Checksum:i3CE7D4D46EEE0C1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51012.1.
    AY089621 mRNA. Translation: AAL90359.1.
    RefSeqiNP_608834.1. NM_134990.3.
    UniGeneiDm.12505.

    Genome annotation databases

    EnsemblMetazoaiFBtr0077439; FBpp0077129; FBgn0031604.
    GeneIDi33649.
    KEGGidme:Dmel_CG15433.
    UCSCiCG15433-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51012.1 .
    AY089621 mRNA. Translation: AAL90359.1 .
    RefSeqi NP_608834.1. NM_134990.3.
    UniGenei Dm.12505.

    3D structure databases

    ProteinModelPortali Q9VQZ6.
    SMRi Q9VQZ6. Positions 492-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 59843. 1 interaction.
    STRINGi 7227.FBpp0077129.

    Proteomic databases

    PaxDbi Q9VQZ6.
    PRIDEi Q9VQZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0077439 ; FBpp0077129 ; FBgn0031604 .
    GeneIDi 33649.
    KEGGi dme:Dmel_CG15433.
    UCSCi CG15433-RA. d. melanogaster.

    Organism-specific databases

    CTDi 55140.
    FlyBasei FBgn0031604. Elp3.

    Phylogenomic databases

    eggNOGi COG1243.
    GeneTreei ENSGT00390000013141.
    InParanoidi Q9VQZ6.
    KOi K07739.
    OMAi GYKVVSH.
    OrthoDBi EOG7V765W.
    PhylomeDBi Q9VQZ6.

    Miscellaneous databases

    GenomeRNAii 33649.
    NextBioi 784609.
    PROi Q9VQZ6.

    Gene expression databases

    Bgeei Q9VQZ6.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiELP3_DROME
    AccessioniPrimary (citable) accession number: Q9VQZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3