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Q9VQX4

- PNCB_DROME

UniProt

Q9VQX4 - PNCB_DROME

Protein

Nicotinate phosphoribosyltransferase

Gene

CG3714

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro
    3. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Gene namesi
    ORF Names:CG3714
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0031589. CG3714.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Nicotinate phosphoribosyltransferasePRO_0000315686Add
    BLAST

    Proteomic databases

    PaxDbiQ9VQX4.

    Expressioni

    Gene expression databases

    BgeeiQ9VQX4.

    Interactioni

    Protein-protein interaction databases

    BioGridi59823. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VQX4.
    SMRiQ9VQX4. Positions 106-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    GeneTreeiENSGT00390000002664.
    InParanoidiQ9VQX4.
    KOiK00763.
    OMAiNDLGYHA.
    OrthoDBiEOG7N63MH.
    PhylomeDBiQ9VQX4.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9VQX4-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNDRELGCAG GQFMDRGRMN QNGVVQPLLT DLYQITMAYA YWKSDKTDDT    50
    AVFDLFFRNN PFHGEFTIFA GLEECLKFLD SFHYSQSDIE YLKQTLPEGI 100
    EHEFFEYLGN LTARDVTLYA IDEGTVAFPR VPIIKIEGPL IIVQLLETTL 150
    LTLVNYASLM ATNAARYRMV AGKHVKLLEF GLRRAQGPDG GLSASKYSYT 200
    GGFDGTSNVL AGKLFNIPVK GTHAHAYITS FSSIGELKTR LIKHKQTGIL 250
    EDLLEHAVRH RALLSHLLDV STEESSEGEL AAMVSYAIAF PDGFMALVDT 300
    YDVKRSGLLN FSAVALALND LGYHALGIRI DSGDLAYLSC LARETFEKVA 350
    ERFKVPWFNK LTIVASNDIN EDTILSLNEQ GHKIDCFGIG THLVTCQRQP 400
    ALGCVYKLVE INGQPRIKLS QDVEKVTMPG NKNAYRLYSA DGHALIDLLQ 450
    KVSEPPPAVG QKVLCRHPFQ ESKRAYVIPS HVESLYKVYW KSGKICQQLP 500
    TLEQVREKVQ ISLKTLRNDH KRTLNPTPYK VAVSDNLYNF IHDLWLQNAP 550
    IGELS 555
    Length:555
    Mass (Da):62,165
    Last modified:October 1, 2002 - v2
    Checksum:iCA1E8C7954DD0F41
    GO
    Isoform 2 (identifier: Q9VQX4-2) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         304-304: K → KSRETEQANT...YLPKYVEKSF

    Show »
    Length:667
    Mass (Da):73,971
    Checksum:i93CEC4DDF3DED751
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei304 – 3041K → KSRETEQANTEPKHINDIKS ENSPPKPKASPSTNGHQNGQ GVGHVNGHKTTNGHQNGSAQ NNGSRTPKDTDIQDTSTSTT TTKTTATATGTLKTTTTVSN GTAYLPKYVEKSF in isoform 2. 1 PublicationVSP_030614

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51037.2.
    AE014134 Genomic DNA. Translation: AAN11169.1.
    AE014134 Genomic DNA. Translation: AAN11170.1.
    AE014134 Genomic DNA. Translation: AAN11171.1.
    AE014134 Genomic DNA. Translation: AAN11172.1.
    AE014134 Genomic DNA. Translation: ABV53616.1.
    AY119468 mRNA. Translation: AAM50122.1.
    RefSeqiNP_001097077.1. NM_001103607.2. [Q9VQX4-2]
    NP_608818.4. NM_134974.5. [Q9VQX4-2]
    NP_722961.1. NM_164572.2. [Q9VQX4-1]
    NP_722962.1. NM_164573.2. [Q9VQX4-2]
    NP_722963.1. NM_164574.2. [Q9VQX4-2]
    NP_722964.1. NM_164575.2. [Q9VQX4-2]
    UniGeneiDm.11340.

    Genome annotation databases

    EnsemblMetazoaiFBtr0077481; FBpp0077170; FBgn0031589. [Q9VQX4-1]
    GeneIDi33626.
    KEGGidme:Dmel_CG3714.
    UCSCiCG3714-RA. d. melanogaster. [Q9VQX4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51037.2 .
    AE014134 Genomic DNA. Translation: AAN11169.1 .
    AE014134 Genomic DNA. Translation: AAN11170.1 .
    AE014134 Genomic DNA. Translation: AAN11171.1 .
    AE014134 Genomic DNA. Translation: AAN11172.1 .
    AE014134 Genomic DNA. Translation: ABV53616.1 .
    AY119468 mRNA. Translation: AAM50122.1 .
    RefSeqi NP_001097077.1. NM_001103607.2. [Q9VQX4-2 ]
    NP_608818.4. NM_134974.5. [Q9VQX4-2 ]
    NP_722961.1. NM_164572.2. [Q9VQX4-1 ]
    NP_722962.1. NM_164573.2. [Q9VQX4-2 ]
    NP_722963.1. NM_164574.2. [Q9VQX4-2 ]
    NP_722964.1. NM_164575.2. [Q9VQX4-2 ]
    UniGenei Dm.11340.

    3D structure databases

    ProteinModelPortali Q9VQX4.
    SMRi Q9VQX4. Positions 106-517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 59823. 1 interaction.

    Proteomic databases

    PaxDbi Q9VQX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0077481 ; FBpp0077170 ; FBgn0031589 . [Q9VQX4-1 ]
    GeneIDi 33626.
    KEGGi dme:Dmel_CG3714.
    UCSCi CG3714-RA. d. melanogaster. [Q9VQX4-1 ]

    Organism-specific databases

    FlyBasei FBgn0031589. CG3714.

    Phylogenomic databases

    eggNOGi COG1488.
    GeneTreei ENSGT00390000002664.
    InParanoidi Q9VQX4.
    KOi K00763.
    OMAi NDLGYHA.
    OrthoDBi EOG7N63MH.
    PhylomeDBi Q9VQX4.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    GenomeRNAii 33626.
    NextBioi 784493.
    PROi Q9VQX4.

    Gene expression databases

    Bgeei Q9VQX4.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiPNCB_DROME
    AccessioniPrimary (citable) accession number: Q9VQX4
    Secondary accession number(s): Q8MRQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3