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Q9VQX4

- PNCB_DROME

UniProt

Q9VQX4 - PNCB_DROME

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Protein

Nicotinate phosphoribosyltransferase

Gene
CG3714
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
ORF Names:CG3714
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031589. CG3714.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Nicotinate phosphoribosyltransferasePRO_0000315686Add
BLAST

Proteomic databases

PaxDbiQ9VQX4.

Expressioni

Gene expression databases

BgeeiQ9VQX4.

Interactioni

Protein-protein interaction databases

BioGridi59823. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9VQX4.
SMRiQ9VQX4. Positions 106-517.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
GeneTreeiENSGT00390000002664.
InParanoidiQ9VQX4.
KOiK00763.
OMAiNDLGYHA.
OrthoDBiEOG7N63MH.
PhylomeDBiQ9VQX4.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9VQX4-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNDRELGCAG GQFMDRGRMN QNGVVQPLLT DLYQITMAYA YWKSDKTDDT    50
AVFDLFFRNN PFHGEFTIFA GLEECLKFLD SFHYSQSDIE YLKQTLPEGI 100
EHEFFEYLGN LTARDVTLYA IDEGTVAFPR VPIIKIEGPL IIVQLLETTL 150
LTLVNYASLM ATNAARYRMV AGKHVKLLEF GLRRAQGPDG GLSASKYSYT 200
GGFDGTSNVL AGKLFNIPVK GTHAHAYITS FSSIGELKTR LIKHKQTGIL 250
EDLLEHAVRH RALLSHLLDV STEESSEGEL AAMVSYAIAF PDGFMALVDT 300
YDVKRSGLLN FSAVALALND LGYHALGIRI DSGDLAYLSC LARETFEKVA 350
ERFKVPWFNK LTIVASNDIN EDTILSLNEQ GHKIDCFGIG THLVTCQRQP 400
ALGCVYKLVE INGQPRIKLS QDVEKVTMPG NKNAYRLYSA DGHALIDLLQ 450
KVSEPPPAVG QKVLCRHPFQ ESKRAYVIPS HVESLYKVYW KSGKICQQLP 500
TLEQVREKVQ ISLKTLRNDH KRTLNPTPYK VAVSDNLYNF IHDLWLQNAP 550
IGELS 555
Length:555
Mass (Da):62,165
Last modified:October 1, 2002 - v2
Checksum:iCA1E8C7954DD0F41
GO
Isoform 2 (identifier: Q9VQX4-2) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     304-304: K → KSRETEQANT...YLPKYVEKSF

Show »
Length:667
Mass (Da):73,971
Checksum:i93CEC4DDF3DED751
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei304 – 3041K → KSRETEQANTEPKHINDIKS ENSPPKPKASPSTNGHQNGQ GVGHVNGHKTTNGHQNGSAQ NNGSRTPKDTDIQDTSTSTT TTKTTATATGTLKTTTTVSN GTAYLPKYVEKSF in isoform 2. VSP_030614

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51037.2.
AE014134 Genomic DNA. Translation: AAN11169.1.
AE014134 Genomic DNA. Translation: AAN11170.1.
AE014134 Genomic DNA. Translation: AAN11171.1.
AE014134 Genomic DNA. Translation: AAN11172.1.
AE014134 Genomic DNA. Translation: ABV53616.1.
AY119468 mRNA. Translation: AAM50122.1.
RefSeqiNP_001097077.1. NM_001103607.2. [Q9VQX4-2]
NP_608818.4. NM_134974.5. [Q9VQX4-2]
NP_722961.1. NM_164572.2. [Q9VQX4-1]
NP_722962.1. NM_164573.2. [Q9VQX4-2]
NP_722963.1. NM_164574.2. [Q9VQX4-2]
NP_722964.1. NM_164575.2. [Q9VQX4-2]
UniGeneiDm.11340.

Genome annotation databases

EnsemblMetazoaiFBtr0077481; FBpp0077170; FBgn0031589. [Q9VQX4-1]
GeneIDi33626.
KEGGidme:Dmel_CG3714.
UCSCiCG3714-RA. d. melanogaster. [Q9VQX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51037.2 .
AE014134 Genomic DNA. Translation: AAN11169.1 .
AE014134 Genomic DNA. Translation: AAN11170.1 .
AE014134 Genomic DNA. Translation: AAN11171.1 .
AE014134 Genomic DNA. Translation: AAN11172.1 .
AE014134 Genomic DNA. Translation: ABV53616.1 .
AY119468 mRNA. Translation: AAM50122.1 .
RefSeqi NP_001097077.1. NM_001103607.2. [Q9VQX4-2 ]
NP_608818.4. NM_134974.5. [Q9VQX4-2 ]
NP_722961.1. NM_164572.2. [Q9VQX4-1 ]
NP_722962.1. NM_164573.2. [Q9VQX4-2 ]
NP_722963.1. NM_164574.2. [Q9VQX4-2 ]
NP_722964.1. NM_164575.2. [Q9VQX4-2 ]
UniGenei Dm.11340.

3D structure databases

ProteinModelPortali Q9VQX4.
SMRi Q9VQX4. Positions 106-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 59823. 1 interaction.

Proteomic databases

PaxDbi Q9VQX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0077481 ; FBpp0077170 ; FBgn0031589 . [Q9VQX4-1 ]
GeneIDi 33626.
KEGGi dme:Dmel_CG3714.
UCSCi CG3714-RA. d. melanogaster. [Q9VQX4-1 ]

Organism-specific databases

FlyBasei FBgn0031589. CG3714.

Phylogenomic databases

eggNOGi COG1488.
GeneTreei ENSGT00390000002664.
InParanoidi Q9VQX4.
KOi K00763.
OMAi NDLGYHA.
OrthoDBi EOG7N63MH.
PhylomeDBi Q9VQX4.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

GenomeRNAii 33626.
NextBioi 784493.
PROi Q9VQX4.

Gene expression databases

Bgeei Q9VQX4.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiPNCB_DROME
AccessioniPrimary (citable) accession number: Q9VQX4
Secondary accession number(s): Q8MRQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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