Reviewed,
UniProtKB/Swiss-Prot Q9VQX4 (PNCB_DROME)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Nicotinate phosphoribosyltransferase Short name=NAPRTase EC=2.4.2.11 | ||
| Gene names |
| ||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||
| Taxonomic identifier | 7227 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 555 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity. |
| Catalytic activity | Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. |
| Sequence similarities | Belongs to the NAPRTase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyridine nucleotide biosynthesis |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stressInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytosol Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9VQX4-1) Also known as: A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9VQX4-2) Also known as: C; The sequence of this isoform differs from the canonical sequence as follows: 304-304: K → KSRETEQANT...YLPKYVEKSF |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 555 | 555 | Nicotinate phosphoribosyltransferase | PRO_0000315686 | |||||
Natural variations | |||||||||
| Alternative sequence | 304 | 1 | K → KSRETEQANTEPKHINDIKS ENSPPKPKASPSTNGHQNGQ GVGHVNGHKTTNGHQNGSAQ NNGSRTPKDTDIQDTSTSTT TTKTTATATGTLKTTTTVSN GTAYLPKYVEKSF in isoform 2. | VSP_030614 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014134 Genomic DNA. Translation: AAF51037.2. AE014134 Genomic DNA. Translation: AAN11169.1. AE014134 Genomic DNA. Translation: AAN11170.1. AE014134 Genomic DNA. Translation: AAN11171.1. AE014134 Genomic DNA. Translation: AAN11172.1. AE014134 Genomic DNA. Translation: ABV53616.1. AY119468 mRNA. Translation: AAM50122.1. |
| RefSeq | NP_001097077.1. NP_608818.4. NP_722961.1. NP_722962.1. NP_722963.1. NP_722964.1. |
| UniGene | Dm.11340 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2F7F based on UniProtKB Q830Y8. |
| SMR | Q9VQX4. Positions 27-545. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9VQX4. |
Genome annotation databases | |
| Ensembl | FBtr0077479; FBpp0077168; FBgn0031589; Drosophila melanogaster. [Genome view] FBtr0077480; FBpp0077169; FBgn0031589; Drosophila melanogaster. [Genome view] FBtr0077481; FBpp0077170; FBgn0031589; Drosophila melanogaster. [Genome view] FBtr0077482; FBpp0077171; FBgn0031589; Drosophila melanogaster. [Genome view] FBtr0077483; FBpp0077172; FBgn0031589; Drosophila melanogaster. [Genome view] FBtr0113020; FBpp0111933; FBgn0031589; Drosophila melanogaster. [Genome view] |
| GeneID | 33626. |
| KEGG | dme:Dmel_CG3714. |
| NMPDR | fig|7227.3.peg.686. |
| UCSC | CG3714-RA. d. melanogaster. |
Organism-specific databases | |
| FlyBase | FBgn0031589. CG3714. |
Phylogenomic databases | |
| eggNOG | inNOG04590. |
| InParanoid | Q9VQX4. |
| OMA | CDVWAIP. |
| PhylomeDB | Q9VQX4. |
Enzyme and pathway databases | |
| BRENDA | 2.4.2.11. 48. |
Gene expression databases | |
| ArrayExpress | Q9VQX4. |
| Bgee | Q9VQX4. |
Family and domain databases | |
| InterPro | IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. [Graphical view] |
| PANTHER | PTHR11098:SF1. NAPRTase. 1 hit. |
| Pfam | PF04095. NAPRTase. 1 hit. [Graphical view] |
| PIRSF | PIRSF000484. NAPRT. 1 hit. |
| TIGRFAMs | TIGR01513. NAPRTase_put. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 784493. |
Entry information
| Entry name | PNCB_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9VQX4 Secondary accession number(s): Q8MRQ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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