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Protein

Protein sister of odd and bowel

Gene

sob

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis. DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity). May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri395 – 417C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • blastoderm segmentation Source: UniProtKB
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • periodic partitioning by pair rule gene Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of transcription, DNA-templated Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Pair-rule protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sister of odd and bowel
Gene namesi
Name:sobImported
ORF Names:CG3242
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004892 sob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469281 – 578Protein sister of odd and bowelAdd BLAST578

Proteomic databases

PaxDbiQ9VQS7
PRIDEiQ9VQS7

Expressioni

Tissue specificityi

Has two temporally distinct modes of expression during early embryogenesis; expressed in seven stripes at the blastoderm stage. Also expressed in a non-periodic domain at the anterior of the embryo. During gastrulation, the seven primary stripes are supplemented by seven secondary stripes that appear in alternate segments. This results in the labelling of each of the 14 segments in the extended germ band. Expression is relatively weak at the blastoderm stage, gaining in intensity at gastrulation. Expressed in the invaginating stomodeum and proctodeum of the embryonic gut. By stage 13, expressed in the region that will form the proventriculus and in a wide ring at the most posterior portion of the midgut. Expression continues in the gut through the remainder of embryogenesis. Expressed in the proximal Malpighian tubules, brain and pharyngeal muscles during late embryogenesis. Expressed weakly in a segmentally repeated pattern in the leg disk at the distal edge of each presumptive leg segment except in tarsal segments 1 to 4.3 Publications

Gene expression databases

BgeeiFBgn0004892
GenevisibleiQ9VQS7 DM

Interactioni

Protein-protein interaction databases

BioGridi59790, 6 interactors
IntActiQ9VQS7, 1 interactor
STRINGi7227.FBpp0077247

Structurei

3D structure databases

ProteinModelPortaliQ9VQS7
SMRiQ9VQS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 303Ala-richSequence analysisAdd BLAST295
Compositional biasi182 – 256Ser-richSequence analysisAdd BLAST75

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri395 – 417C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
InParanoidiQ9VQS7
KOiK09215
OMAiKKSESCN
OrthoDBiEOG091G0LRE

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q9VQS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVKHLSAA AAAAAAAATC SDSPAKAAAS PAASSDIAEA LGELKASATA
60 70 80 90 100
AASSASKAAT SKHHSNNNHK PSAAATATAA HKKSESCNSN GNKCTAATSP
110 120 130 140 150
IGSKTSNAAM AAATATAAAA TNDLAAAAAV VLSLQGTMVS SLQQAALLPA
160 170 180 190 200
NSAAAAALNL QALESYLALQ RLTGKSDVFR FSNSNTGSSN SNNATTCNSS
210 220 230 240 250
SSEADNNALP SLIDIANIEL KSSCSSSSSG EPPLTAATAS AAATSSPSSN
260 270 280 290 300
NSNSTSTPTT SKCVPLPSIG TVSAAVAAAA AAAAAAASQQ AALDCATAAE
310 320 330 340 350
LAAECDLPLL DGEDALSFEA GDLDSSYGSF MFNPSAFSQA ETDSALHSLQ
360 370 380 390 400
ATMYQDKMSV ISGAAGGVGA GAVGGLEEAG SSAAAAAAQR SKKQFICKFC
410 420 430 440 450
NRQFTKSYNL LIHERTHTDE RPYSCDICGK AFRRQDHLRD HRYIHSKEKP
460 470 480 490 500
FKCAECGKGF CQSRTLAVHK ILHMEESPHK CPVCNRSFNQ RSNLKTHLLT
510 520 530 540 550
HTDIKPYNCA SCGKVFRRNC DLRRHSLTHN LSAGVGGVVG GNLSDPFGSG
560 570
SSSSSELGLP TGSASTAASS RDLVAVSD
Length:578
Mass (Da):58,455
Last modified:May 1, 2000 - v1
Checksum:i0F600954CFA7D8D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176S → P in AAC47282 (PubMed:8878683).Curated1
Sequence conflicti188 – 189SS → G in AAC47282 (PubMed:8878683).Curated2
Sequence conflicti546P → L in AAC47282 (PubMed:8878683).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62004 mRNA Translation: AAC47282.1
AE014134 Genomic DNA Translation: AAF51087.1
BT003205 mRNA Translation: AAO24960.1
PIRiS72227
RefSeqiNP_476882.1, NM_057534.4
UniGeneiDm.4726

Genome annotation databases

EnsemblMetazoaiFBtr0077558; FBpp0077247; FBgn0004892
GeneIDi33581
KEGGidme:Dmel_CG3242

Similar proteinsi

Entry informationi

Entry nameiSOB_DROME
AccessioniPrimary (citable) accession number: Q9VQS7
Secondary accession number(s): Q24571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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