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Protein

Palmitoyltransferase

Gene

GABPI

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: FlyBase
  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:GABPIImported
ORF Names:CG17257Imported, Dmel_CG17257Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031495. GABPI.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei121 – 137HelicalUniRule annotationAdd BLAST17
Transmembranei149 – 167HelicalUniRule annotationAdd BLAST19
Transmembranei179 – 196HelicalUniRule annotationAdd BLAST18
Transmembranei308 – 330HelicalUniRule annotationAdd BLAST23
Transmembranei364 – 384HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0031495.

Interactioni

Protein-protein interaction databases

IntActiQ9VQK9. 2 interactors.
MINTiMINT-282738.
STRINGi7227.FBpp0077337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 399zf-DHHCInterPro annotationAdd BLAST137

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
OMAiRWITCKS.
OrthoDBiEOG091G0JCR.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VQK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLMTAGTSN FLSAAWRSEA EESKSKENGS LCCCEYVAED SRERSHILGC
60 70 80 90 100
CCNCVDFDLV CTRLVTCRAI DRRNIDGMLI AFQDRLRLPW RGGAKRISPA
110 120 130 140 150
AVAPAFIVPL MLGLATLNSK TAIVLMLTLV GFTIWGMELA KRTATRTNFF
160 170 180 190 200
LSWLVFSVFY MIIIFEFQVP LLELAPEENY ALMFFSCAAL YCLYSAKALS
210 220 230 240 250
PLNLVSAQYG TTPKDELPGI AEASSGEEQA EAQTTLQMES VLSLDDDEVG
260 270 280 290 300
DMDTAERSGL MHGQPNICEI CRKVTPRRAY HCPVCGTCVK RRDHHSYWLN
310 320 330 340 350
CCIGERNYVW YIVGLALSEI ALLLGANLTL TSICHPFMVV RPLGYPVLLP
360 370 380 390 400
DDCSEVFEGF DLGISFVVAC YALLISSYIA FILARQAYLW WKGSTLHEYK
410 420
RTSNAAGRNR IWSNWRAILK
Length:420
Mass (Da):47,014
Last modified:October 1, 2002 - v2
Checksum:i6467FD9BD4169315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51157.2.
AY069413 mRNA. Translation: AAL39558.1.
AE014134 Genomic DNA. Translation: AAN10406.1.
RefSeqiNP_608741.1. NM_134897.5.
NP_722869.1. NM_164522.3.
UniGeneiDm.2142.

Genome annotation databases

EnsemblMetazoaiFBtr0077651; FBpp0077336; FBgn0031495.
FBtr0077652; FBpp0077337; FBgn0031495.
GeneIDi33516.
UCSCiCG17257-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51157.2.
AY069413 mRNA. Translation: AAL39558.1.
AE014134 Genomic DNA. Translation: AAN10406.1.
RefSeqiNP_608741.1. NM_134897.5.
NP_722869.1. NM_164522.3.
UniGeneiDm.2142.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VQK9. 2 interactors.
MINTiMINT-282738.
STRINGi7227.FBpp0077337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077651; FBpp0077336; FBgn0031495.
FBtr0077652; FBpp0077337; FBgn0031495.
GeneIDi33516.
UCSCiCG17257-RA. d. melanogaster.

Organism-specific databases

CTDi33516.
FlyBaseiFBgn0031495. GABPI.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
OMAiRWITCKS.
OrthoDBiEOG091G0JCR.

Miscellaneous databases

GenomeRNAii33516.

Gene expression databases

BgeeiFBgn0031495.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VQK9_DROME
AccessioniPrimary (citable) accession number: Q9VQK9
Secondary accession number(s): Q8T0C4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: April 12, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.