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Protein

Congested-like trachea protein

Gene

colt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative mitochondrial carrier of unknown solute specificity. Required for gas-filling of the tracheal system at hatching time of the embryo and for normal epithelial morphogenesis of the wings.1 Publication

GO - Molecular functioni

GO - Biological processi

  • acyl carnitine transport Source: FlyBase
  • carnitine transport Source: FlyBase
  • epithelial cell morphogenesis Source: FlyBase
  • liquid clearance, open tracheal system Source: FlyBase
  • mitochondrial transport Source: FlyBase
  • phagocytosis Source: FlyBase
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-DME-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Congested-like trachea protein
Gene namesi
Name:colt
ORF Names:CG3057
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0019830. colt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei177 – 19620Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Flies display defects in the unfolding and expansion of the wings resulting in a loss of venation and a marked decrease in their size. Lethality is polyphasic with flies dying during early larval development and displaying apparently collapsed tracheal trees.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Congested-like trachea proteinPRO_0000090608Add
BLAST

Proteomic databases

PaxDbiQ9VQG4.
PRIDEiQ9VQG4.

Expressioni

Developmental stagei

Expressed both maternally and zygotically during all developmental stages.1 Publication

Gene expression databases

BgeeiFBgn0019830.
GenevisibleiQ9VQG4. DM.

Interactioni

Protein-protein interaction databases

BioGridi59693. 3 interactions.
MINTiMINT-1627970.
STRINGi7227.FBpp0077414.

Structurei

3D structure databases

ProteinModelPortaliQ9VQG4.
SMRiQ9VQG4. Positions 19-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 10492Solcar 1Add
BLAST
Repeati113 – 20290Solcar 2Add
BLAST
Repeati212 – 29887Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000142815.
InParanoidiQ9VQG4.
KOiK15109.
OMAiVCIPADV.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9VQG4.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VQG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTENVSTE RKANPVKSFL TGGFGGICNV LSGHPLDTIK VRLQTMPRPA
60 70 80 90 100
PGEQPLYRGT FDCAAKTIKN EGVRGLYKGM SAPLTGVAPI FAMCFAGYAL
110 120 130 140 150
GKRLQQRGED AKLTYPQIFV AGSFSGLFST LIMAPGERIK VLLQTQQGQG
160 170 180 190 200
GERKYNGMID CAGKLYKEGG LRSVFKGSCA TMLRDLPANG LYFLVYEALQ
210 220 230 240 250
DVAKSKSETG QISTASTIFA GGVAGMAYWI LGMPADVLKS RLQSAPEGTY
260 270 280 290 300
KHGIRSVFKD LIVKDGPLAL YRGVTPIMLR AFPANAACFF GIELANKFFN

IVAPNF
Length:306
Mass (Da):32,952
Last modified:May 1, 2000 - v1
Checksum:iFA66FF1DA600F5F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961A → T in CAA73099 (PubMed:9409834).Curated
Sequence conflicti186 – 1872LP → FA in CAA73099 (PubMed:9409834).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12495 Genomic DNA. Translation: CAA73099.1.
AE014134 Genomic DNA. Translation: AAF51209.1.
AE014134 Genomic DNA. Translation: AAS64622.1.
AE014134 Genomic DNA. Translation: AAS64623.1.
AE014134 Genomic DNA. Translation: AAS64624.1.
AY069277 mRNA. Translation: AAL39422.1.
RefSeqiNP_477221.1. NM_057873.5.
NP_995616.1. NM_205894.1.
UniGeneiDm.19772.
Dm.36746.

Genome annotation databases

EnsemblMetazoaiFBtr0077731; FBpp0077414; FBgn0019830.
FBtr0077734; FBpp0089377; FBgn0019830.
GeneIDi33470.
KEGGidme:Dmel_CG3057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12495 Genomic DNA. Translation: CAA73099.1.
AE014134 Genomic DNA. Translation: AAF51209.1.
AE014134 Genomic DNA. Translation: AAS64622.1.
AE014134 Genomic DNA. Translation: AAS64623.1.
AE014134 Genomic DNA. Translation: AAS64624.1.
AY069277 mRNA. Translation: AAL39422.1.
RefSeqiNP_477221.1. NM_057873.5.
NP_995616.1. NM_205894.1.
UniGeneiDm.19772.
Dm.36746.

3D structure databases

ProteinModelPortaliQ9VQG4.
SMRiQ9VQG4. Positions 19-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59693. 3 interactions.
MINTiMINT-1627970.
STRINGi7227.FBpp0077414.

Proteomic databases

PaxDbiQ9VQG4.
PRIDEiQ9VQG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077731; FBpp0077414; FBgn0019830.
FBtr0077734; FBpp0089377; FBgn0019830.
GeneIDi33470.
KEGGidme:Dmel_CG3057.

Organism-specific databases

CTDi33470.
FlyBaseiFBgn0019830. colt.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000142815.
InParanoidiQ9VQG4.
KOiK15109.
OMAiVCIPADV.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9VQG4.

Enzyme and pathway databases

ReactomeiR-DME-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

ChiTaRSicolt. fly.
GenomeRNAii33470.
PROiQ9VQG4.

Gene expression databases

BgeeiFBgn0019830.
GenevisibleiQ9VQG4. DM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOLT_DROME
AccessioniPrimary (citable) accession number: Q9VQG4
Secondary accession number(s): A4V020, O01396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.