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Protein
Submitted name:

Dynamin related protein 1, isoform A

Gene

Drp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: FlyBase
  • mitochondrion localization Source: FlyBase
  • mitochondrion organization Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • peroxisome fission Source: InterPro
  • positive regulation of mitochondrial fission Source: FlyBase
  • regulation of mitochondrial fission Source: FlyBase
  • sperm mitochondrion organization Source: FlyBase
  • synaptic vesicle budding from presynaptic endocytic zone membrane Source: FlyBase
  • ventral furrow formation Source: FlyBase

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-75153. Apoptotic execution phase.

Names & Taxonomyi

Protein namesi
Submitted name:
Dynamin related protein 1, isoform AImported
Submitted name:
Dynamin related protein 1, isoform BImported
Submitted name:
FI19305p1Imported
Gene namesi
Name:Drp1Imported
Synonyms:Dmel\CG3210Imported, Dnm1Imported, DRPImported, DrpImported, Drp-1Imported, drp-1Imported, DRP1Imported, drp1Imported, Drp1-RAImported, fratImported, l(2)22FcImported, l(2)22FdImported, l(2)ND2Imported, l(2)ND3Imported
ORF Names:CG3210Imported, Dmel_CG3210Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0026479. Drp1.

Subcellular locationi

GO - Cellular componenti

  • microtubule associated complex Source: FlyBase
  • mitochondrial membrane Source: GO_Central
  • synapse Source: GOC

Expressioni

Gene expression databases

BgeeiFBgn0026479.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-784078.
STRINGi7227.FBpp0077424.

Structurei

3D structure databases

SMRiQ9VQE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 301Dynamin-type G (guanine nucleotide-binding)InterPro annotationAdd BLAST280
Domaini643 – 734GEDInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
KOiK17065.
OMAiHHIPNRR.
OrthoDBiEOG091G02TQ.

Family and domain databases

InterProiView protein in InterPro
IPR030556. DNM1L.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF127. PTHR11566:SF127. 1 hit.
PfamiView protein in Pfam
PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PRINTSiPR00195. DYNAMIN.
SMARTiView protein in SMART
SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VQE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALIPVINK LQDVFNTVGS DSIQLPQIVV LGSQSSGKSS VIESVVGRSF
60 70 80 90 100
LPRGTGIVTR RPLVLQLIYS PLDDRENRSA ENGTSNAEEW GRFLHTKKCF
110 120 130 140 150
TDFDEIRKEI ENETERAAGS NKGICPEPIN LKIFSTHVVN LTLVDLPGIT
160 170 180 190 200
KVPVGDQPED IEAQIKELVL KYIENPNSII LAVTAANTDM ATSEALKLAK
210 220 230 240 250
DVDPDGRRTL AVVTKLDLMD AGTDAIDILC GRVIPVKLGI IGVMNRSQKD
260 270 280 290 300
IMDQKHIDDQ MKDEAAFLQR KYPTLATRNG TPYLAKTLNR LLMHHIRDCL
310 320 330 340 350
PDLKTRVNIM ATQFQSLLNS YGEDVSDKSQ TLLQIITKFS SAYCCTIEGT
360 370 380 390 400
ARNIETTELC GGARMGYIFH ETFGRTLDSI HPLAGLSKMD ILTAIRNATG
410 420 430 440 450
PRPALFVPEV SFELLVKRQI RRLEEPSLRC VELIHEEMQR IVQHCGNEVQ
460 470 480 490 500
QEMLRFPKLH EKIVDVVTQL LRRRLPHTNV MVENIVAIEL AYINTKHPDF
510 520 530 540 550
HKDAALVPSL LKTDSDPYSQ INLGQRRANT PRNHMSPQIS SHSAGSQQPQ
560 570 580 590 600
QQQPPQPNSS QQQYSQVHEQ NHVAENSTPS MASTWLSNIL PPAPTRPDSI
610 620 630 640 650
ENSTNNTPVH NNIVSPVKPV NLLPDVPANH NPRRLTDKEQ KDCDVIEHLI
660 670 680 690 700
KSYFYIVRKS IQDSVPKAIM HFLVNYVKDN LQSELVTHLY KSDKAETLLN
710 720 730
ESDHIAVRRK EAADMLKALT RANHIISEIR ETHMW
Length:735
Mass (Da):82,566
Last modified:May 1, 2000 - v1
Checksum:i7D4961D0352D8642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51235.1.
BT133244 mRNA. Translation: AFB40589.1.
AE014134 Genomic DNA. Translation: AGB92483.1.
RefSeqiNP_001259946.1. NM_001273017.1.
NP_608694.2. NM_134850.3.
UniGeneiDm.272.

Genome annotation databases

EnsemblMetazoaiFBtr0077744; FBpp0077424; FBgn0026479.
FBtr0335173; FBpp0307166; FBgn0026479.
GeneIDi33445.
KEGGidme:Dmel_CG3210.
UCSCiCG3210-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VQE0_DROME
AccessioniPrimary (citable) accession number: Q9VQE0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported