Reviewed, UniProtKB/Swiss-Prot Q9VQ62 (NPC2_DROME)

Names and origin

Protein names

Recommended name:
    Protein NPC2 homolog
Alternative name(s):
    Niemann Pick type C2 protein homolog

Gene names

Name:	NPC2
ORF Names:	CG7291

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the NPC2 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
dock	Q9VPU1	1	EBI-183186,EBI-189398

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 148	132	Protein NPC2 homolog		PRO_0000019866
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Disulfide bond	24 ↔ 140		By similarity
	Disulfide bond	39 ↔ 46		By similarity
	Disulfide bond	92 ↔ 99		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9VQ62-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5AE2D4BC2AE03D49	FASTA	148	16,021
	10 20 30 40 50 60 MLRYAVIACA ALVVFAGALE FSDCGSKTGK FTRVAIEGCD TTKAECILKR NTTVSFSIDF 70 80 90 100 110 120 ALAEEATAVK TVVHGKVLGI EMPFPLANPD ACVDSGLKCP LEKDESYRYT ATLPVLRSYP 130 140 KVSVLVKWEL QDQDGADIIC VEIPAKIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014134 Genomic DNA. Translation: AAF51319.1. AY118810 mRNA. Translation: AAM50670.1. BT001844 mRNA. Translation: AAN71605.1.
RefSeq	NP_608637.1.
UniGene	Dm.7263
3D structure databases
HSSP	HSSP built from PDB template 1NEP based on UniProtKB P79345.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:23438N.
IntAct	Q9VQ62. 2 interactions.
Proteomic databases
PRIDE	Q9VQ62.
Genome annotation databases
Ensembl	FBgn0031381. Drosophila melanogaster. [Contig view]
GeneID	33374.
KEGG	dme:Dmel_CG7291.
NMPDR	fig|7227.3.peg.307.
Organism-specific databases
FlyBase	FBgn0031381. NPC2.
Phylogenomic databases
HOGENOM	Q9VQ62.
OMA	Q9VQ62. VTFTSNT.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-006915-MON.
Gene expression databases
ArrayExpress	Q9VQ62.
GermOnline	CG7291. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003172. MD-2_lipid-recog. [Graphical view]
Gene3D	G3DSA:2.60.40.770. MD-2_lipid-recog. 1 hit.
Pfam	PF02221. E1_DerP2_DerF2. 1 hit. [Graphical view]
SMART	SM00737. ML. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	783259.

Entry information

Entry name

NPC2_DROME

Accession

Primary (citable) accession number: Q9VQ62

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project