Reviewed, UniProtKB/Swiss-Prot Q9VQ57 (DERL1_DROME)

Names and origin

Protein names

Recommended name:
    Derlin-1
Alternative name(s):
    DER1-like protein 1

Gene names

ORF Names:

CG10908

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Induction	By endoplasmic reticulum (ER) stress.
Sequence similarities	Belongs to the derlin family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ER-associated protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Derlin-1		PRO_0000219052
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	1 Potential
	Topological domain	39 – 58	20	Lumenal Potential
	Transmembrane	59 – 79	21	2 Potential
	Topological domain	80 – 99	20	Cytoplasmic Potential
	Transmembrane	100 – 120	21	3 Potential
	Topological domain	121 – 156	36	Lumenal Potential
	Transmembrane	157 – 177	21	4 Potential
	Topological domain	178 – 245	68	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9VQ57-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C8378A1637AE2CAE	FASTA	245	28,256
	10 20 30 40 50 60 MDAGVWYRSL PRFTRYWLTA TVVLSMLCRF DVIPLHWLHL DRSAVFSKLQ LWRCMTSLFV 70 80 90 100 110 120 FPISSNTAFH FLINCFFIVQ YSSKLEKDQY SRSPADYLYL LIVSAVLANI GGMIFNVYFL 130 140 150 160 170 180 MDTLVLAITY IWCQLNKDVT VSFWFGTRFK AMYLPWVLAA FEFIFHFSLA SLVGIFVGHV 190 200 210 220 230 240 YYFFKFQYSQ DLGGTPLLET PQFLKRLVPD VSGGFGGFGL PPESRAPPRQ ATESPWGRGM TLGRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014134 Genomic DNA. Translation: AAF51324.1. AY069069 mRNA. Translation: AAL39214.1.
RefSeq	NP_608632.1.
UniGene	Dm.2301
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VQ57. 1 interaction.
Proteomic databases
PRIDE	Q9VQ57.
Genome annotation databases
Ensembl	FBgn0031376. Drosophila melanogaster. [Contig view]
GeneID	33369.
KEGG	dme:Dmel_CG10908.
NMPDR	fig|7227.3.peg.301.
Organism-specific databases
FlyBase	FBgn0031376. CG10908.
Phylogenomic databases
HOGENOM	Q9VQ57.
OMA	Q9VQ57. YFFLMFK.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-006908-MON.
Gene expression databases
ArrayExpress	Q9VQ57.
GermOnline	CG10908. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007599. DER1. [Graphical view]
PANTHER	PTHR11009. DER1. 1 hit.
Pfam	PF04511. DER1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	783230.

Entry information

Entry name

DERL1_DROME

Accession

Primary (citable) accession number: Q9VQ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project