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Protein

Rab3 GTPase-activating protein catalytic subunit

Gene

CG31935

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein catalytic subunit
Gene namesi
ORF Names:CG31935
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0051935. CG31935.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916611 – 916Rab3 GTPase-activating protein catalytic subunitAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei543Phosphoserine1 Publication1
Modified residuei544Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VQ26.
PRIDEiQ9VQ26.

PTM databases

iPTMnetiQ9VQ26.

Expressioni

Gene expression databases

BgeeiFBgn0051935.
ExpressionAtlasiQ9VQ26. differential.
GenevisibleiQ9VQ26. DM.

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of CG31935 and rab3-GAP/CG7061.By similarity

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi59582. 2 interactors.
IntActiQ9VQ26. 1 interactor.
STRINGi7227.FBpp0077582.

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab3-GAP catalytic subunit family.Curated

Phylogenomic databases

eggNOGiKOG2390. Eukaryota.
ENOG410Y2R4. LUCA.
GeneTreeiENSGT00390000006705.
InParanoidiQ9VQ26.
KOiK18270.
OMAiADFLRWH.
OrthoDBiEOG091G023S.
PhylomeDBiQ9VQ26.

Family and domain databases

InterProiView protein in InterPro
IPR026147. Rab3-GAP_cat_su.
PANTHERiPTHR21422. PTHR21422. 1 hit.
PfamiView protein in Pfam
PF13890. Rab3-GTPase_cat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VQ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEIDDNEF YRENFSADSD WEVFNAQLGE ILQKWDVSSD SETRNLKSEE
60 70 80 90 100
IFSCNWKVER EKLDMLRNGI EVEYHQAILE DEELVRAEAK EITCLQRTSC
110 120 130 140 150
HHDLMSTGNS FGPPIRSSQE LHILARIYGL RRFIVLHPVN PTLNYMRSTS
160 170 180 190 200
EFNFFLSAVA VVSAEVQSLV PIFVQIYDPK WNYYTGVALA PALRTNFRLI
210 220 230 240 250
GLEKAPPECR FLMGLLTLFR EKVPTSYTQA AMISVCTTYA LDTMRIRMPM
260 270 280 290 300
YVPFDHGLSS EDIVVDGEVS HLEVQQFCAL PHGYKPESRT EIYLVYTWPE
310 320 330 340 350
LSEHVAFDSE QRSDFVPAKA PLGKIYLSVE ASSYLSCCLR DYQSVAEVTR
360 370 380 390 400
SLESFVGRNF SGTSSGAEAA SNPLDRITEH KLTKRRERSF ELPSQAGLTK
410 420 430 440 450
RLPGPMTESE LSELLAYLFP DMHPEMALFP YAKKNFTDKF DPMRIKSAVP
460 470 480 490 500
DSLVCRLSCL LATCHAHLGS VEGMAQVWAA FTRQLRLLWD NSLMVPGISA
510 520 530 540 550
GFPDTRTCLL HQKLQMLNVC VERRVQREAN SKRKSEGMVG KASSEEEEDE
560 570 580 590 600
DDDEGEFFDC DDLTAGAGSP TKAVLSLKPE GRLRRLNNER LLEEPDEYLY
610 620 630 640 650
IPDTQEPVPK TEDQLQDDAE VMLKLGPGSG LTTQMMCTSL LSDMEAFKAA
660 670 680 690 700
NPRGIMEDFI RWYSPKDWEE VTDELGQVKH QLSIRMTTEG NTWQKVWEQA
710 720 730 740 750
QAVPVSRQKR LFDDTNEALK VLHYLETRKM HEIYNLTVIP LLHSAILKLA
760 770 780 790 800
DILSNAELED LFSSQIEKLL SDLCRLSRSH SDELPSIKPL LDDLAELERR
810 820 830 840 850
FYQFKCFERL SGYPKRSSLQ QVKLQFEEIL RNDNCCTIVN RRLTAAGDGT
860 870 880 890 900
LYDILIPKLE EDMADRLISK DYIIRLDGDT KTTEKGLYLG PQFMRAIVTG
910
EKLRLCGAFT ESTAFV
Length:916
Mass (Da):104,431
Last modified:October 1, 2002 - v2
Checksum:i7625F4D48BA54F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51356.2.
RefSeqiNP_608608.2. NM_134764.3.
UniGeneiDm.33640.

Genome annotation databases

EnsemblMetazoaiFBtr0077916; FBpp0077582; FBgn0051935.
GeneIDi33338.
KEGGidme:Dmel_CG31935.
UCSCiCG31935-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiRB3GP_DROME
AccessioniPrimary (citable) accession number: Q9VQ26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families