Q9VQ08 (Q9VQ08_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Leak EMBL AAF51375.2

Gene names

Name:	lea EMBL AAF51375.2 FlyBase FBgn0002543
ORF Names:	CG5481 FlyBase FBgn0002543, Dmel_CG5481 EMBL AAF51375.2

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL AAF51375.2

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1463 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Repeat SAAS SAAS013098
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from mutant phenotype PubMed 11163264PubMed 11163265PubMed 15056612. Source: FlyBase cardioblast cell fate specification Inferred from mutant phenotype PubMed 16888037. Source: FlyBase central complex development Inferred from mutant phenotype PubMed 16003521. Source: FlyBase embryonic heart tube development Inferred from mutant phenotype PubMed 16360689PubMed 16516189PubMed 16888037. Source: FlyBase gonad development Inferred from mutant phenotype PubMed 21377458. Source: FlyBase mushroom body development Inferred from mutant phenotype PubMed 16003521. Source: FlyBase neuron migration Inferred from mutant phenotype PubMed 15296748. Source: FlyBase outflow tract morphogenesis Inferred from genetic interaction PubMed 18250318. Source: FlyBase positive regulation of cell-cell adhesion Inferred from mutant phenotype PubMed 16888037. Source: FlyBase regulation of epithelial cell migration, open tracheal system Inferred from mutant phenotype PubMed 12397103. Source: FlyBase salivary gland boundary specification Inferred from mutant phenotype PubMed 15950216. Source: FlyBase synaptic target recognition Inferred from mutant phenotype PubMed 18817735. Source: FlyBase tracheal outgrowth, open tracheal system Traceable author statement PubMed 12791296. Source: FlyBase ventral cord development Inferred from mutant phenotype PubMed 11163264PubMed 11163265. Source: FlyBase
Molecular_function	receptor activity Traceable author statement PubMed 12885551. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VQ08 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 177A21647E6BD5A9	FASTA	1,463	159,977
	10 20 30 40 50 60 MHLCEMRGMP LRLQPQCLTN ESEIQIKIKS KIKNKTASEI KRRHRNNRDF HGERLKIMPV 70 80 90 100 110 120 DRSRRAVFPL LLLLAGLNGL TQVGALKGEN PRIIEHPMDT TVPKNDPFTF NCQAEGNPTP 130 140 150 160 170 180 TIQWFKDGRE LKTDTGSHRI MLPAGGLFFL KVIHSRRESD AGTYWCEAKN EFGVARSRNA 190 200 210 220 230 240 TLQVAFLRDE FRLEPANTRV AQGEVALMEC GAPRGSPEPQ ISWRKNGQTL NLVGNKRIRI 250 260 270 280 290 300 VDGGNLAIQE ARQSDDGRYQ CVVKNVVGTR ESATAFLKVH VRPFLIRGPQ NQTAVVGSSV 310 320 330 340 350 360 VFQCRIGGDP LPDVLWRRTA SGGNMPLRRV HVLEDRSLKL DDVTLEDMGE YTCEADNAVG 370 380 390 400 410 420 GITATGILTV HAPPKFVIRP KNQLVEIGDE VLFECQANGH PRPTLYWSVE GNSSLLLPGY 430 440 450 460 470 480 RDGRMEVTLT PEGRSVLSIA RFAREDSGKV VTCNALNAVG SVSSRTVVSV DTQFELPPPI 490 500 510 520 530 540 IEQGPVNQTL PVKSIVVLPC RTLGTPVPQV SWYLDGIPID VQEHERRNLS DAGALTISDL 550 560 570 580 590 600 QRHEDEGLYT CVASNRNGKS SWSGYLRLDT PTNPNIKFFR APELSTYPGP PGKPQMVEKG 610 620 630 640 650 660 ENSVTLSWTR SNKVGGSSLV GYVIEMFGKN ETDGWVAVGT RVQNTTFTQT GLLPGVNYFF 670 680 690 700 710 720 LIRAENSHGL SLPSPMSEPI TVGTRYFNSG LDLSEARASL LSGDVVELSN ASVVDSTSMK 730 740 750 760 770 780 LTWQIINGKY VEGFYVYARQ LPNPIVNNPA PVTSNTNPLL GSTSTSASAS ASASALISTK 790 800 810 820 830 840 PNIAAAGKRD GETNQSGGGA PTPLNTKYRM LTILNGGGAS SCTITGLVQY TLYEFFIVPF 850 860 870 880 890 900 YKSVEGKPSN SRIARTLEDV PSEAPYGMEA LLLNSSAVFL KWKAPELKDR HGVLLNYHVI 910 920 930 940 950 960 VRGIDTAHNF SRILTNVTID AASPTLVLAN LTEGVMYTVG VAAGNNAGVG PYCVPATLRL 970 980 990 1000 1010 1020 DPITKRLDPF INQRYPINQD HVNDVLTQPW FIILLGAILA VLMLSFGAMV FVKRKHMMMK 1030 1040 1050 1060 1070 1080 QSALNTMRGN HTSDVLKMPS LSARNGNGYW LDSSTGGMVW RPSPGGDSLE MQKDHIADYA 1090 1100 1110 1120 1130 1140 PVCGAPGSPA GGGTSSGGSG GAGSGASGGD DIHGGHGSER NQQRYVGEYS NIPTDYAEVS 1150 1160 1170 1180 1190 1200 SFGKAPSEYG RHGNASPAPY ATSSILSPHQ QQQQQQPRYQ QRPVPGYGLQ RPMHPHYQQQ 1210 1220 1230 1240 1250 1260 QHQQQQAQQT HQQHQALQQH QQLPPSNIYQ QMSTTSEIYP TNTGPSRSVY SEQYYYPKDK 1270 1280 1290 1300 1310 1320 QRHIHITENK LSNCHTYEAA PGAKQSSPIS SQFASVRRQQ LPPNCSIGRE SARFKVLNTD 1330 1340 1350 1360 1370 1380 QGKNQQNLLD LDGSSMCYNG LADSGCGGSP SPMAMLMSHE DEHALYHTAD GDLDDMERLY 1390 1400 1410 1420 1430 1440 VKVDEQQPPQ QQQQLIPLVP QHPAEGHLQS WRNQSTRSSR KNGQECIKEP SELIYAPGSV 1450 1460 ASERSLLSNS GSGTSSQPAG HNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083-RESEARCH0083(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: AAF51375.2.
RefSeq	NP_536792.2. NM_080531.3.
UniGene	Dm.1441.
3D structure databases
ProteinModelPortal	Q9VQ08.
SMR	Q9VQ08. Positions 54-680.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VQ08. 2 interactions.
MINT	MINT-788772.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077941; FBpp0077606; FBgn0002543.
GeneID	44522.
KEGG	dme:Dmel_CG5481.
UCSC	CG5481-RA. d. melanogaster.
Organism-specific databases
CTD	44522.
FlyBase	FBgn0002543. lea.
Phylogenomic databases
GeneTree	ENSGT00680000099931.
InParanoid	Q9VQ08.
OMA	PQNQTAV.
PhylomeDB	Q9VQ08.
Gene expression databases
ArrayExpress	Q9VQ08.
Bgee	Q9VQ08.
Family and domain databases
Gene3D	2.60.40.10. 9 hits.
InterPro	IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF07679. I-set. 4 hits. [Graphical view]
SMART	SM00060. FN3. 3 hits. SM00409. IG. 1 hit. SM00408. IGc2. 4 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 3 hits. PS50835. IG_LIKE. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	44522.
NextBio	837362.

Entry information

Entry name

Q9VQ08_DROME

Accession

Primary (citable) accession number: Q9VQ08

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)