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Q9VQ08

- Q9VQ08_DROME

UniProt

Q9VQ08 - Q9VQ08_DROME

Protein
Submitted name:

FI23903p1

Gene

lea

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein homodimerization activity Source: FlyBase
    2. receptor activity Source: FlyBase

    GO - Biological processi

    1. axon guidance Source: FlyBase
    2. cardioblast cell fate specification Source: FlyBase
    3. central complex development Source: FlyBase
    4. embryonic heart tube development Source: FlyBase
    5. gonad development Source: FlyBase
    6. mushroom body development Source: FlyBase
    7. neuron migration Source: FlyBase
    8. outflow tract morphogenesis Source: FlyBase
    9. positive regulation of cell-cell adhesion Source: FlyBase
    10. regulation of epithelial cell migration, open tracheal system Source: FlyBase
    11. salivary gland boundary specification Source: FlyBase
    12. synaptic target recognition Source: FlyBase
    13. tracheal outgrowth, open tracheal system Source: FlyBase
    14. ventral cord development Source: FlyBase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FI23903p1Imported
    Submitted name:
    Leak, isoform AImported
    Gene namesi
    Name:leaImported
    Synonyms:lea-RAImported
    ORF Names:CG5481Imported, Dmel_CG5481Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0002543. lea.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: FlyBase

    Expressioni

    Gene expression databases

    BgeeiQ9VQ08.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-788772.

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108572.
    InParanoidiQ9VQ08.

    Family and domain databases

    Gene3Di2.60.40.10. 9 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VQ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLCEMRGMP LRLQPQCLTN ESEIQIKIKS KIKNKTASEI KRRHRNNRDF     50
    HGERLKIMPV DRSRRAVFPL LLLLAGLNGL TQVGALKGEN PRIIEHPMDT 100
    TVPKNDPFTF NCQAEGNPTP TIQWFKDGRE LKTDTGSHRI MLPAGGLFFL 150
    KVIHSRRESD AGTYWCEAKN EFGVARSRNA TLQVAFLRDE FRLEPANTRV 200
    AQGEVALMEC GAPRGSPEPQ ISWRKNGQTL NLVGNKRIRI VDGGNLAIQE 250
    ARQSDDGRYQ CVVKNVVGTR ESATAFLKVH VRPFLIRGPQ NQTAVVGSSV 300
    VFQCRIGGDP LPDVLWRRTA SGGNMPLRRV HVLEDRSLKL DDVTLEDMGE 350
    YTCEADNAVG GITATGILTV HAPPKFVIRP KNQLVEIGDE VLFECQANGH 400
    PRPTLYWSVE GNSSLLLPGY RDGRMEVTLT PEGRSVLSIA RFAREDSGKV 450
    VTCNALNAVG SVSSRTVVSV DTQFELPPPI IEQGPVNQTL PVKSIVVLPC 500
    RTLGTPVPQV SWYLDGIPID VQEHERRNLS DAGALTISDL QRHEDEGLYT 550
    CVASNRNGKS SWSGYLRLDT PTNPNIKFFR APELSTYPGP PGKPQMVEKG 600
    ENSVTLSWTR SNKVGGSSLV GYVIEMFGKN ETDGWVAVGT RVQNTTFTQT 650
    GLLPGVNYFF LIRAENSHGL SLPSPMSEPI TVGTRYFNSG LDLSEARASL 700
    LSGDVVELSN ASVVDSTSMK LTWQIINGKY VEGFYVYARQ LPNPIVNNPA 750
    PVTSNTNPLL GSTSTSASAS ASASALISTK PNIAAAGKRD GETNQSGGGA 800
    PTPLNTKYRM LTILNGGGAS SCTITGLVQY TLYEFFIVPF YKSVEGKPSN 850
    SRIARTLEDV PSEAPYGMEA LLLNSSAVFL KWKAPELKDR HGVLLNYHVI 900
    VRGIDTAHNF SRILTNVTID AASPTLVLAN LTEGVMYTVG VAAGNNAGVG 950
    PYCVPATLRL DPITKRLDPF INQRYPINQD HVNDVLTQPW FIILLGAILA 1000
    VLMLSFGAMV FVKRKHMMMK QSALNTMRGN HTSDVLKMPS LSARNGNGYW 1050
    LDSSTGGMVW RPSPGGDSLE MQKDHIADYA PVCGAPGSPA GGGTSSGGSG 1100
    GAGSGASGGD DIHGGHGSER NQQRYVGEYS NIPTDYAEVS SFGKAPSEYG 1150
    RHGNASPAPY ATSSILSPHQ QQQQQQPRYQ QRPVPGYGLQ RPMHPHYQQQ 1200
    QHQQQQAQQT HQQHQALQQH QQLPPSNIYQ QMSTTSEIYP TNTGPSRSVY 1250
    SEQYYYPKDK QRHIHITENK LSNCHTYEAA PGAKQSSPIS SQFASVRRQQ 1300
    LPPNCSIGRE SARFKVLNTD QGKNQQNLLD LDGSSMCYNG LADSGCGGSP 1350
    SPMAMLMSHE DEHALYHTAD GDLDDMERLY VKVDEQQPPQ QQQQLIPLVP 1400
    QHPAEGHLQS WRNQSTRSSR KNGQECIKEP SELIYAPGSV ASERSLLSNS 1450
    GSGTSSQPAG HNV 1463
    Length:1,463
    Mass (Da):159,977
    Last modified:October 1, 2002 - v2
    Checksum:i177A21647E6BD5A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51375.2.
    BT150394 mRNA. Translation: AHA59284.1.
    RefSeqiNP_536792.2. NM_080531.3.
    UniGeneiDm.1441.

    Genome annotation databases

    EnsemblMetazoaiFBtr0077941; FBpp0077606; FBgn0002543.
    GeneIDi44522.
    KEGGidme:Dmel_CG5481.
    UCSCiCG5481-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF51375.2 .
    BT150394 mRNA. Translation: AHA59284.1 .
    RefSeqi NP_536792.2. NM_080531.3.
    UniGenei Dm.1441.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-788772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0077941 ; FBpp0077606 ; FBgn0002543 .
    GeneIDi 44522.
    KEGGi dme:Dmel_CG5481.
    UCSCi CG5481-RA. d. melanogaster.

    Organism-specific databases

    CTDi 44522.
    FlyBasei FBgn0002543. lea.

    Phylogenomic databases

    GeneTreei ENSGT00720000108572.
    InParanoidi Q9VQ08.

    Miscellaneous databases

    GenomeRNAii 44522.
    NextBioi 837362.

    Gene expression databases

    Bgeei Q9VQ08.

    Family and domain databases

    Gene3Di 2.60.40.10. 9 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    8. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
      Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9VQ08_DROME
    AccessioniPrimary (citable) accession number: Q9VQ08
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3