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Q9VQ08

- Q9VQ08_DROME

UniProt

Q9VQ08 - Q9VQ08_DROME

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Protein
Submitted name:

FI23903p1

Gene

lea

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein homodimerization activity Source: FlyBase
  2. receptor activity Source: FlyBase

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. cardioblast cell fate specification Source: FlyBase
  3. central complex development Source: FlyBase
  4. embryonic heart tube development Source: FlyBase
  5. gonad development Source: FlyBase
  6. mushroom body development Source: FlyBase
  7. neuron migration Source: FlyBase
  8. outflow tract morphogenesis Source: FlyBase
  9. positive regulation of cell-cell adhesion Source: FlyBase
  10. regulation of epithelial cell migration, open tracheal system Source: FlyBase
  11. salivary gland boundary specification Source: FlyBase
  12. synaptic target recognition Source: FlyBase
  13. tracheal outgrowth, open tracheal system Source: FlyBase
  14. ventral cord development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
FI23903p1Imported
Submitted name:
Leak, isoform AImported
Gene namesi
Name:leaImported
Synonyms:lea-RAImported
ORF Names:CG5481Imported, Dmel_CG5481Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0002543. lea.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9VQ08.

Interactioni

Protein-protein interaction databases

MINTiMINT-788772.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118886.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VQ08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLCEMRGMP LRLQPQCLTN ESEIQIKIKS KIKNKTASEI KRRHRNNRDF
60 70 80 90 100
HGERLKIMPV DRSRRAVFPL LLLLAGLNGL TQVGALKGEN PRIIEHPMDT
110 120 130 140 150
TVPKNDPFTF NCQAEGNPTP TIQWFKDGRE LKTDTGSHRI MLPAGGLFFL
160 170 180 190 200
KVIHSRRESD AGTYWCEAKN EFGVARSRNA TLQVAFLRDE FRLEPANTRV
210 220 230 240 250
AQGEVALMEC GAPRGSPEPQ ISWRKNGQTL NLVGNKRIRI VDGGNLAIQE
260 270 280 290 300
ARQSDDGRYQ CVVKNVVGTR ESATAFLKVH VRPFLIRGPQ NQTAVVGSSV
310 320 330 340 350
VFQCRIGGDP LPDVLWRRTA SGGNMPLRRV HVLEDRSLKL DDVTLEDMGE
360 370 380 390 400
YTCEADNAVG GITATGILTV HAPPKFVIRP KNQLVEIGDE VLFECQANGH
410 420 430 440 450
PRPTLYWSVE GNSSLLLPGY RDGRMEVTLT PEGRSVLSIA RFAREDSGKV
460 470 480 490 500
VTCNALNAVG SVSSRTVVSV DTQFELPPPI IEQGPVNQTL PVKSIVVLPC
510 520 530 540 550
RTLGTPVPQV SWYLDGIPID VQEHERRNLS DAGALTISDL QRHEDEGLYT
560 570 580 590 600
CVASNRNGKS SWSGYLRLDT PTNPNIKFFR APELSTYPGP PGKPQMVEKG
610 620 630 640 650
ENSVTLSWTR SNKVGGSSLV GYVIEMFGKN ETDGWVAVGT RVQNTTFTQT
660 670 680 690 700
GLLPGVNYFF LIRAENSHGL SLPSPMSEPI TVGTRYFNSG LDLSEARASL
710 720 730 740 750
LSGDVVELSN ASVVDSTSMK LTWQIINGKY VEGFYVYARQ LPNPIVNNPA
760 770 780 790 800
PVTSNTNPLL GSTSTSASAS ASASALISTK PNIAAAGKRD GETNQSGGGA
810 820 830 840 850
PTPLNTKYRM LTILNGGGAS SCTITGLVQY TLYEFFIVPF YKSVEGKPSN
860 870 880 890 900
SRIARTLEDV PSEAPYGMEA LLLNSSAVFL KWKAPELKDR HGVLLNYHVI
910 920 930 940 950
VRGIDTAHNF SRILTNVTID AASPTLVLAN LTEGVMYTVG VAAGNNAGVG
960 970 980 990 1000
PYCVPATLRL DPITKRLDPF INQRYPINQD HVNDVLTQPW FIILLGAILA
1010 1020 1030 1040 1050
VLMLSFGAMV FVKRKHMMMK QSALNTMRGN HTSDVLKMPS LSARNGNGYW
1060 1070 1080 1090 1100
LDSSTGGMVW RPSPGGDSLE MQKDHIADYA PVCGAPGSPA GGGTSSGGSG
1110 1120 1130 1140 1150
GAGSGASGGD DIHGGHGSER NQQRYVGEYS NIPTDYAEVS SFGKAPSEYG
1160 1170 1180 1190 1200
RHGNASPAPY ATSSILSPHQ QQQQQQPRYQ QRPVPGYGLQ RPMHPHYQQQ
1210 1220 1230 1240 1250
QHQQQQAQQT HQQHQALQQH QQLPPSNIYQ QMSTTSEIYP TNTGPSRSVY
1260 1270 1280 1290 1300
SEQYYYPKDK QRHIHITENK LSNCHTYEAA PGAKQSSPIS SQFASVRRQQ
1310 1320 1330 1340 1350
LPPNCSIGRE SARFKVLNTD QGKNQQNLLD LDGSSMCYNG LADSGCGGSP
1360 1370 1380 1390 1400
SPMAMLMSHE DEHALYHTAD GDLDDMERLY VKVDEQQPPQ QQQQLIPLVP
1410 1420 1430 1440 1450
QHPAEGHLQS WRNQSTRSSR KNGQECIKEP SELIYAPGSV ASERSLLSNS
1460
GSGTSSQPAG HNV
Length:1,463
Mass (Da):159,977
Last modified:October 1, 2002 - v2
Checksum:i177A21647E6BD5A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51375.2.
BT150394 mRNA. Translation: AHA59284.1.
RefSeqiNP_536792.2. NM_080531.4.

Genome annotation databases

EnsemblMetazoaiFBtr0077941; FBpp0077606; FBgn0002543.
GeneIDi44522.
KEGGidme:Dmel_CG5481.
UCSCiCG5481-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF51375.2 .
BT150394 mRNA. Translation: AHA59284.1 .
RefSeqi NP_536792.2. NM_080531.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-788772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0077941 ; FBpp0077606 ; FBgn0002543 .
GeneIDi 44522.
KEGGi dme:Dmel_CG5481.
UCSCi CG5481-RA. d. melanogaster.

Organism-specific databases

CTDi 44522.
FlyBasei FBgn0002543. lea.

Phylogenomic databases

GeneTreei ENSGT00760000118886.

Miscellaneous databases

GenomeRNAii 44522.
NextBioi 837362.

Gene expression databases

Bgeei Q9VQ08.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VQ08_DROME
AccessioniPrimary (citable) accession number: Q9VQ08
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3