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Q9VPZ7

- Q9VPZ7_DROME

UniProt

Q9VPZ7 - Q9VPZ7_DROME

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Protein
Submitted name:

LP22668p

Gene

robo3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. central complex development Source: FlyBase
  3. gonad development Source: FlyBase
  4. mushroom body development Source: FlyBase
  5. neuron recognition Source: FlyBase
  6. ventral cord development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_246260. Signaling by Robo receptor.
REACT_246981. Inactivation of Cdc42 and Rac.
REACT_256055. Role of Abl in Robo-Slit signaling.
REACT_257137. Regulation of Commissural axon pathfinding by Slit and Robo.

Names & Taxonomyi

Protein namesi
Submitted name:
LP22668pImported
Submitted name:
Robo3, isoform AImported
Submitted name:
Robo3, isoform BImported
Gene namesi
Name:robo3Imported
ORF Names:CG5423Imported, Dmel_CG5423Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0041097. robo3.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-332111.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118840.
OMAiNITENKM.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VPZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLRFVFIVF LLKWTHAQGS HPPRIVEHPI DTTVPRHEPA TLNCKAEGSP
60 70 80 90 100
TPTIQWYKDG VPLKILPGSH RITLPAGGLF FLKVVNSRRE TDAGIYWCEA
110 120 130 140 150
KNELGVARSR NATLQVAVLR DEFRLEPQNT RIAQGDTALL ECAAPRGIPE
160 170 180 190 200
PTVTWKKGGQ KLDLEGSKRV RIVDGGNLAI QDARQTDEGQ YQCIAKNPVG
210 220 230 240 250
VRESSLATLK VHVKPYIIRG PHDQTVLEGA SVTFPCRVGG DPMPDVLWLR
260 270 280 290 300
TASGGNMPLD RVSVLEDRSL RLERVTIADE GEYSCEADNV VGAITAMGTL
310 320 330 340 350
TVYAPPKFIQ RPASKSVELG ADTSFECRAI GNPKPTIFWT IKNNSTLIFP
360 370 380 390 400
GAPPLDRFHS LNTEEGHSIL TLTRFQRTDK DLVILCNAMN EVASITSRVQ
410 420 430 440 450
LSLDSQEDRP PPIIISGPVN QTLPIKSLAT LQCKAIGLPS PTISWYRDGI
460 470 480 490 500
PVQPSSKLNI TTSGDLIISD LDRQQDQGLY TCVASSRAGK STWSGFLRIE
510 520 530 540 550
LPTNPNIKFY RAPEQTKCPS APGQPKILNA TASALTIVWP TSDKAGASSF
560 570 580 590 600
LGYSVEMYCT NQSRTWIPIA SRLSEPIFTV ESLTQGAAYM FIVRAENSLG
610 620 630 640 650
FSPPSPISEP ITAGKLVGVR DGSESTGTSQ LLLSDVETLL QANDVVELLE
660 670 680 690 700
ANASDSTTAR LSWDIDSGQY IEGFYLYARE LHSSEYKMVT LLNKGQGLSS
710 720 730 740 750
CTVPGLAKAS TYEFFLVPFY KSIVGKPSNS RRMRTLEDVP EAPPYGMEAI
760 770 780 790 800
QFNRTSVFLK WLPPQPNRTR NGILTSYNVV VKGLDVHNTT RIFKNMTIDA
810 820 830 840 850
AAPTLLLANL TTGVTYYIAV AAATRVGVGP FSKPAVLRID ARTQSLDTGY
860 870 880 890 900
TRYPISRDIA DDFLTQTWFI VLLGSIIAII VFLLGALVLF KRYQFIKQTS
910 920 930 940 950
LGSLHGNHAI GTVRKFPTLP LNGGGAVGAG GSNSTAAAGQ SGHGLWIDPT
960 970 980 990 1000
SGVWRQAAGG GNPGGVGSCT TKEQLPGYAQ ATAQQGQQPT LLPDYERLSP
1010 1020 1030 1040 1050
LNMPDYAEVA CSTFKSPTHG APPMGGGGGG QSASLYDSCG AYATTNVVAN
1060 1070 1080 1090 1100
VKLYQNRYAT KPNQSSGSNN NNHQGNDYQS TGMYSAPPSA HYGCLEPKQQ
1110 1120 1130 1140 1150
QQQQQPNLMT TSTASTAILT NSPAKVKKIN ITENKMDQLE GKSERTNPFN
1160 1170 1180 1190 1200
QQQQLLLASN ALKQGLGAYA NTTLAAQMAS GGGAGTLRRQ RQPKTLYKSE
1210 1220 1230 1240 1250
NNILGKSGLR QNTMNASVGA PSNGQMDFLT GGPPSEGGDF SGLGLCNSTN
1260 1270 1280 1290 1300
QLLNDWASSA SIAAPGDYHF GSKQPSKQHL YVKAKDGTWS AVSSDAYQSF
1310 1320 1330 1340
KHQQQHHPFL AGSGDNTKSL ASVNSLAGDS KFLSSFGSSA NV
Length:1,342
Mass (Da):144,665
Last modified:October 1, 2002 - v2
Checksum:i4D93F1684A8CFC01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51387.2.
BT015246 mRNA. Translation: AAT94475.1.
AE014134 Genomic DNA. Translation: AGB92403.1.
RefSeqiNP_001259866.1. NM_001272937.1.
NP_608592.2. NM_134748.4.
UniGeneiDm.3365.

Genome annotation databases

EnsemblMetazoaiFBtr0077921; FBpp0077587; FBgn0041097.
GeneIDi33314.
KEGGidme:Dmel_CG5423.
UCSCiCG5423-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51387.2 .
BT015246 mRNA. Translation: AAT94475.1 .
AE014134 Genomic DNA. Translation: AGB92403.1 .
RefSeqi NP_001259866.1. NM_001272937.1.
NP_608592.2. NM_134748.4.
UniGenei Dm.3365.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-332111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0077921 ; FBpp0077587 ; FBgn0041097 .
GeneIDi 33314.
KEGGi dme:Dmel_CG5423.
UCSCi CG5423-RA. d. melanogaster.

Organism-specific databases

CTDi 64221.
FlyBasei FBgn0041097. robo3.

Phylogenomic databases

GeneTreei ENSGT00760000118840.
OMAi NITENKM.

Enzyme and pathway databases

Reactomei REACT_246260. Signaling by Robo receptor.
REACT_246981. Inactivation of Cdc42 and Rac.
REACT_256055. Role of Abl in Robo-Slit signaling.
REACT_257137. Regulation of Commissural axon pathfinding by Slit and Robo.

Miscellaneous databases

GenomeRNAii 33314.
NextBioi 782999.
PROi Q9VPZ7.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Rubin G.M., Celniker S.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VPZ7_DROME
AccessioniPrimary (citable) accession number: Q9VPZ7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3