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Protein
Submitted name:

LP22668p

Gene

robo3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • axon guidance Source: FlyBase
  • central complex development Source: FlyBase
  • gonad development Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron recognition Source: FlyBase
  • ventral cord development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-376176 Signaling by ROBO receptors
R-DME-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-DME-428890 Role of ABL in ROBO-SLIT signaling
R-DME-9010553 Regulation of expression of SLITs and ROBOs

Names & Taxonomyi

Protein namesi
Submitted name:
LP22668pImported
Submitted name:
Roundabout 3, isoform AImported
Submitted name:
Roundabout 3, isoform BImported
Gene namesi
Name:robo3Imported
Synonyms:CG14345Imported, CT17158Imported, Dmel\CG5423Imported, dRobo-3Imported, Robo 3Imported, Robo-3Imported, ROBO3Imported, Robo3Imported
ORF Names:CG5423Imported, Dmel_CG5423Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0041097 robo3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei868 – 890HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501510054920 – 1342Sequence analysisAdd BLAST1323

Expressioni

Gene expression databases

BgeeiFBgn0041097

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0077587

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 115Ig-likeInterPro annotationAdd BLAST93
Domaini121 – 207Ig-likeInterPro annotationAdd BLAST87
Domaini215 – 301Ig-likeInterPro annotationAdd BLAST87
Domaini306 – 402Ig-likeInterPro annotationAdd BLAST97
Domaini411 – 494Ig-likeInterPro annotationAdd BLAST84
Domaini521 – 616Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini645 – 738Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini743 – 842Fibronectin type-IIIInterPro annotationAdd BLAST100

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00910000144011
OMAiVHVKPYI
OrthoDBiEOG091G020U

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Q9VPZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRFVFIVF LLKWTHAQGS HPPRIVEHPI DTTVPRHEPA TLNCKAEGSP
60 70 80 90 100
TPTIQWYKDG VPLKILPGSH RITLPAGGLF FLKVVNSRRE TDAGIYWCEA
110 120 130 140 150
KNELGVARSR NATLQVAVLR DEFRLEPQNT RIAQGDTALL ECAAPRGIPE
160 170 180 190 200
PTVTWKKGGQ KLDLEGSKRV RIVDGGNLAI QDARQTDEGQ YQCIAKNPVG
210 220 230 240 250
VRESSLATLK VHVKPYIIRG PHDQTVLEGA SVTFPCRVGG DPMPDVLWLR
260 270 280 290 300
TASGGNMPLD RVSVLEDRSL RLERVTIADE GEYSCEADNV VGAITAMGTL
310 320 330 340 350
TVYAPPKFIQ RPASKSVELG ADTSFECRAI GNPKPTIFWT IKNNSTLIFP
360 370 380 390 400
GAPPLDRFHS LNTEEGHSIL TLTRFQRTDK DLVILCNAMN EVASITSRVQ
410 420 430 440 450
LSLDSQEDRP PPIIISGPVN QTLPIKSLAT LQCKAIGLPS PTISWYRDGI
460 470 480 490 500
PVQPSSKLNI TTSGDLIISD LDRQQDQGLY TCVASSRAGK STWSGFLRIE
510 520 530 540 550
LPTNPNIKFY RAPEQTKCPS APGQPKILNA TASALTIVWP TSDKAGASSF
560 570 580 590 600
LGYSVEMYCT NQSRTWIPIA SRLSEPIFTV ESLTQGAAYM FIVRAENSLG
610 620 630 640 650
FSPPSPISEP ITAGKLVGVR DGSESTGTSQ LLLSDVETLL QANDVVELLE
660 670 680 690 700
ANASDSTTAR LSWDIDSGQY IEGFYLYARE LHSSEYKMVT LLNKGQGLSS
710 720 730 740 750
CTVPGLAKAS TYEFFLVPFY KSIVGKPSNS RRMRTLEDVP EAPPYGMEAI
760 770 780 790 800
QFNRTSVFLK WLPPQPNRTR NGILTSYNVV VKGLDVHNTT RIFKNMTIDA
810 820 830 840 850
AAPTLLLANL TTGVTYYIAV AAATRVGVGP FSKPAVLRID ARTQSLDTGY
860 870 880 890 900
TRYPISRDIA DDFLTQTWFI VLLGSIIAII VFLLGALVLF KRYQFIKQTS
910 920 930 940 950
LGSLHGNHAI GTVRKFPTLP LNGGGAVGAG GSNSTAAAGQ SGHGLWIDPT
960 970 980 990 1000
SGVWRQAAGG GNPGGVGSCT TKEQLPGYAQ ATAQQGQQPT LLPDYERLSP
1010 1020 1030 1040 1050
LNMPDYAEVA CSTFKSPTHG APPMGGGGGG QSASLYDSCG AYATTNVVAN
1060 1070 1080 1090 1100
VKLYQNRYAT KPNQSSGSNN NNHQGNDYQS TGMYSAPPSA HYGCLEPKQQ
1110 1120 1130 1140 1150
QQQQQPNLMT TSTASTAILT NSPAKVKKIN ITENKMDQLE GKSERTNPFN
1160 1170 1180 1190 1200
QQQQLLLASN ALKQGLGAYA NTTLAAQMAS GGGAGTLRRQ RQPKTLYKSE
1210 1220 1230 1240 1250
NNILGKSGLR QNTMNASVGA PSNGQMDFLT GGPPSEGGDF SGLGLCNSTN
1260 1270 1280 1290 1300
QLLNDWASSA SIAAPGDYHF GSKQPSKQHL YVKAKDGTWS AVSSDAYQSF
1310 1320 1330 1340
KHQQQHHPFL AGSGDNTKSL ASVNSLAGDS KFLSSFGSSA NV
Length:1,342
Mass (Da):144,665
Last modified:October 1, 2002 - v2
Checksum:i4D93F1684A8CFC01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51387.2
BT015246 mRNA Translation: AAT94475.1
AE014134 Genomic DNA Translation: AGB92403.1
RefSeqiNP_001259866.1, NM_001272937.1
NP_608592.2, NM_134748.4
UniGeneiDm.3365

Genome annotation databases

EnsemblMetazoaiFBtr0077921; FBpp0077587; FBgn0041097
FBtr0335384; FBpp0307368; FBgn0041097
GeneIDi33314
KEGGidme:Dmel_CG5423
UCSCiCG5423-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VPZ7_DROME
AccessioniPrimary (citable) accession number: Q9VPZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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