Reviewed, UniProtKB/Swiss-Prot Q9VPW1 (ASTE_DROME)

Names and origin

Protein names

Recommended name:
    Protein asteroid

Gene names

Name:	ast
ORF Names:	CG4426

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	854 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May function in EGF receptor signaling. May play a role in compound eye morphogenesis. Ref.5
Tissue specificity	Expressed in the proliferative tissues of embryos and in the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal disks. Ref.5
Developmental stage	Expressed at higher levels during the embryonic and pupal stages of development. Expressed in proliferating tissues of the presumptive mesoderm in stage 7 gastrulating embryos. Expressed in the mesectoderm and anterior and posterior midgut primordia of stage 9 embryos. Also expressed in proliferating cells of the central nervous system during germ-band retraction. Ref.5
Sequence similarities	Belongs to the asteroid family.
Sequence caution	The sequence AAC05483.1 differs from that shown. Reason: Frameshift at position 800.

Ontologies

Keywords
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	compound eye photoreceptor fate commitment Ref.5 Inferred from mutant phenotype. Source: UniProtKB epidermal growth factor receptor signaling pathway Ref.5 Inferred from mutant phenotype. Source: UniProtKB imaginal disc-derived wing morphogenesis Inferred from mutant phenotype. Source: FlyBase larval somatic muscle development Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 854	854	Protein asteroid		PRO_0000310462
Experimental info
	Sequence conflict	263	1	A → G in AAC05483. Ref.5
	Sequence conflict	496	1	C → G in AAC05483. Ref.5
	Sequence conflict	509	1	I → M in AAC05483. Ref.5
	Sequence conflict	534	1	M → I in AAC05483. Ref.5
	Sequence conflict	568	1	E → V in AAC05483. Ref.5
	Sequence conflict	670	1	A → T in AAC05483. Ref.5
	Sequence conflict	798	1	T → R in AAK93494. Ref.3
	Sequence conflict	812	1	R → C in AAC05483. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9VPW1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2C51D6616254F0D6	FASTA	854	98,376
	10 20 30 40 50 60 MGVRGLTSYI AQRAEIYLKP HELHSTALVI DGDNLSCNLY KDVTGSYSAF GGDYDDFYRA 70 80 90 100 110 120 VVQFFQVLAE CNIRPYVLMD GGYEERKLRT VSTRLRNKIS VIKKINPNAS ITLFPLHLKE 130 140 150 160 170 180 VFVDAVRDCG VPVMRCVFEA DDELAALARK LNCPVLSYDS DFYIHNVKYI PLITLTVKVL 190 200 210 220 230 240 TKQVKDKNSS NQKDSRDLRH CEAKNVKKRT RANKIVTGIQ TTGLTASTKG SSKTYKYLDC 250 260 270 280 290 300 CIYRVSHLCG RGTLSPEKLP LFAALLGNDY IARSAFKNFF AAGMGKAGRS RKLKLQQKRI 310 320 330 340 350 360 QVILTWLKEE TAESALAKVL SRLKKNQRDS LVSQVNAAIS GYSNELCHAY DYFDEHYENA 370 380 390 400 410 420 FPYIEPVSEE ECSDDEHSSS SDEKFSDVEE GEDQEEADNQ DEEQQEENQD VDSGDEEEEE 430 440 450 460 470 480 ADEGLELEVE DKTLLFPQWF LDKLYPAHLP RSFVDLMHLR KYINNPQIEH FPFHDSNEVA 490 500 510 520 530 540 LPILNYVFAL LHHVECEKIE LPLEVDMDIE GSTVPYLTYL TRALRVTNVR YFKMPIEKKP 550 560 570 580 590 600 AYPFDPLSPD ARHLRAVFED NAPNADTEKL FSKLDQLPED LRLYFLAIIY WLHRSEHCDL 610 620 630 640 650 660 LHLHSLILSL VVLRTIDVTI PAEREVKTFL KRFGKTLKAE RAVRDKEAAE GIKRGIKPAL 670 680 690 700 710 720 LELSVPDRMA HVPKSDCYLT QERLLPHFHM QEIFKKKFDL YSTTVIHAFA EFQAVVYQLN 730 740 750 760 770 780 GLNSLLDFPL LSPRMNQLYC GAFLYNMYDV LRNRADVRYH VENFLLPDSK LMFDFYCYLY 790 800 810 820 830 840 DWCAEFIPTW KRLEVDPTAA KALQKKRLKK QRQAARKVEL REAIADPNAE MVEDADPEND 850 FFDLNNKFCA LKVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[5]	"The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr." Kotarski M.A., Leonard D.A., Bennett S.A., Bishop C.P., Wahn S.D., Sedore S.A., Shrader M. Genome 41:295-302(1998) [PubMed: 9644838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-815, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014134 Genomic DNA. Translation: AAF51424.1. AY052070 mRNA. Translation: AAK93494.1. BT044345 mRNA. Translation: ACH92410.1. AF047010 Genomic DNA. Translation: AAC05483.1. Frameshift.
RefSeq	NP_523451.2.
UniGene	Dm.2886
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VPW1. 1 interaction.
Proteomic databases
PRIDE	Q9VPW1.
Genome annotation databases
Ensembl	FBgn0015905. Drosophila melanogaster. [Contig view]
GeneID	33282.
KEGG	dme:Dmel_CG4426.
NMPDR	fig|7227.3.peg.184.
Organism-specific databases
FlyBase	FBgn0015905. ast.
Phylogenomic databases
OMA	Q9VPW1. DSDFYIH.
Gene expression databases
ArrayExpress	Q9VPW1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	782838.

Entry information

Entry name

ASTE_DROME

Accession

Primary (citable) accession number: Q9VPW1
Secondary accession number(s): B5RJ71, O61517, Q960G8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project