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Protein

60 kDa heat shock protein homolog 1, mitochondrial

Gene

Hsp60B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: FlyBase
  • apoptotic mitochondrial changes Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein import into mitochondrial intermembrane space Source: GO_Central
  • protein refolding Source: FlyBase
  • protein targeting to mitochondrion Source: FlyBase
  • spermatid development Source: FlyBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa heat shock protein homolog 1, mitochondrial
Alternative name(s):
60 kDa chaperonin
CPN60
Heat shock protein 60
Short name:
HSP-60
Hsp60
Gene namesi
Name:Hsp60B
ORF Names:CG2830
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011244. Hsp60B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionBy similarityAdd BLAST55
ChainiPRO_000000503256 – 64860 kDa heat shock protein homolog 1, mitochondrialAdd BLAST593

Proteomic databases

PaxDbiQ9VPS5.
PRIDEiQ9VPS5.

Expressioni

Gene expression databases

BgeeiFBgn0011244.
GenevisibleiQ9VPS5. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi71509. 39 interactors.
DIPiDIP-17907N.
IntActiQ9VPS5. 4 interactors.
MINTiMINT-280322.
STRINGi7227.FBpp0077665.

Structurei

3D structure databases

ProteinModelPortaliQ9VPS5.
SMRiQ9VPS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00390000005727.
HOGENOMiHOG000291639.
InParanoidiQ9VPS5.
KOiK04077.
OMAiWTSPKIT.
OrthoDBiEOG091G04JM.
PhylomeDBiQ9VPS5.

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VPS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSCVPKAI TSSRCFARMY SKDVRFGSGV RAMMIRGVDI LADAVAVTMG
60 70 80 90 100
PKGRSVIVER PWTSPKITKD GFTVARSIAL KDQHMNLGAK LVQDVADNTN
110 120 130 140 150
ESAGDGTTTA TVLARAIAKE GFNQITMGAN PVEIRRGVML AVDVVKDKLK
160 170 180 190 200
EMSKAVETRE EIQQVATLSA NGDTEIGRLI GEATDKVGPR GTITVKDGKR
210 220 230 240 250
LKDELNIIQG LRFDNGYVSP FFVNSSKGSK VEFANALVMI SLKKITGLSQ
260 270 280 290 300
IVKGLEQSLR QRRPLIIIAE DISGEALNAL VLNKLRLGLQ VCAVKSPSYG
310 320 330 340 350
HHRKELIGDI SAATGATIFG DDINYSKMEE AKLEDLGQVG EAVISKDSTM
360 370 380 390 400
LLQGKPKTGL LEMRIQQIQD ELAEKQIKPE QRDRLRQRLS ALTKGVAVLH
410 420 430 440 450
IGGGSEVEVN EKKDRVVDAL NATRAAIEEG IVPGGGTAFL RCIPYLQELK
460 470 480 490 500
TESADLQKGV DIVCNALRMP CQTIAQNAGV DGPMVVAKVL NGSEDYGYDA
510 520 530 540 550
MGDEYCRLVE KGIIDPTKVL RTAITDAAGV ASLLSTTEVV ITDSRNDDLL
560 570 580 590 600
SKLSGAGGGM DDGLDMNMGG LEELAALSGL GGMGGMGGMG GMGGMGGMGG
610 620 630 640
GFGGMGAGGG MSASASNDGP TAEEMNEMVK AIPGMEQVEV RDIDSGMM
Length:648
Mass (Da):68,637
Last modified:May 1, 2000 - v1
Checksum:iE45D44A166C78455
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199K → N in AAK77276 (PubMed:12537569).Curated1
Sequence conflicti581 – 589Missing in AAK77276 (PubMed:12537569).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51467.1.
AY047544 mRNA. Translation: AAK77276.1.
BT001426 mRNA. Translation: AAN71181.1.
RefSeqiNP_524925.1. NM_080186.4.
UniGeneiDm.21712.

Genome annotation databases

EnsemblMetazoaiFBtr0078000; FBpp0077665; FBgn0011244.
GeneIDi48572.
KEGGidme:Dmel_CG2830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF51467.1.
AY047544 mRNA. Translation: AAK77276.1.
BT001426 mRNA. Translation: AAN71181.1.
RefSeqiNP_524925.1. NM_080186.4.
UniGeneiDm.21712.

3D structure databases

ProteinModelPortaliQ9VPS5.
SMRiQ9VPS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71509. 39 interactors.
DIPiDIP-17907N.
IntActiQ9VPS5. 4 interactors.
MINTiMINT-280322.
STRINGi7227.FBpp0077665.

Proteomic databases

PaxDbiQ9VPS5.
PRIDEiQ9VPS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078000; FBpp0077665; FBgn0011244.
GeneIDi48572.
KEGGidme:Dmel_CG2830.

Organism-specific databases

CTDi48572.
FlyBaseiFBgn0011244. Hsp60B.

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00390000005727.
HOGENOMiHOG000291639.
InParanoidiQ9VPS5.
KOiK04077.
OMAiWTSPKIT.
OrthoDBiEOG091G04JM.
PhylomeDBiQ9VPS5.

Miscellaneous databases

ChiTaRSiHsp60B. fly.
GenomeRNAii48572.
PROiPR:Q9VPS5.

Gene expression databases

BgeeiFBgn0011244.
GenevisibleiQ9VPS5. DM.

Family and domain databases

Gene3Di1.10.560.10. 1 hit.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCH60B_DROME
AccessioniPrimary (citable) accession number: Q9VPS5
Secondary accession number(s): Q53YH7, Q961V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.