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Protein

Retinoblastoma-binding protein 5 homolog

Gene

Rbbp5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.2 Publications

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-3214841 PKMTs methylate histone lysines
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoblastoma-binding protein 5 homologBy similarity
Gene namesi
Name:Rbbp5Imported
ORF Names:CG5585
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036973 Rbbp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004293811 – 489Retinoblastoma-binding protein 5 homologAdd BLAST489

Proteomic databases

PaxDbiQ9VPH8
PRIDEiQ9VPH8

Expressioni

Gene expression databases

BgeeiFBgn0036973
GenevisibleiQ9VPH8 DM

Interactioni

Subunit structurei

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6.2 Publications

Protein-protein interaction databases

BioGridi65500, 4 interactors
IntActiQ9VPH8, 3 interactors
MINTiQ9VPH8
STRINGi7227.FBpp0077900

Structurei

3D structure databases

ProteinModelPortaliQ9VPH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 63WD 1Sequence analysisAdd BLAST42
Repeati64 – 103WD 2Sequence analysisAdd BLAST40
Repeati147 – 187WD 3Sequence analysisAdd BLAST41
Repeati195 – 234WD 4Sequence analysisAdd BLAST40
Repeati248 – 290WD 5Sequence analysisAdd BLAST43
Repeati292 – 330WD 6Sequence analysisAdd BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1273 Eukaryota
ENOG410XTA2 LUCA
GeneTreeiENSGT00530000064100
InParanoidiQ9VPH8
KOiK14961
OMAiFRMPILF
OrthoDBiEOG091G038T
PhylomeDBiQ9VPH8

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037850 RBBP5/Swd1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PANTHERiPTHR44040 PTHR44040, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VPH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLELLESFG QNYPEEFDGS LDCISLAVTC AFNKYGTLLA VGCNDGRIVI
60 70 80 90 100
WDFLTRGIAK IISAHVHPVC SLSWTRNGHK LLSASTDNNV CIWDVLTGEL
110 120 130 140 150
EHKYRFPSPV LKVQFDPRND NRLLVCPMRY AAVLVEVGGT HRCLPLDSDG
160 170 180 190 200
DLNIVASFDR RGKHIYTGNA KGKILVLDVE TFEVVASFRI IVGTSSATAV
210 220 230 240 250
KSIEFARRGD AFLINTSDRV IRVYDSKEII TLGKDGEPEP IQKLQDLVNK
260 270 280 290 300
TTWKKCCFSG DGEYICAGSA RQHALYIWEK SIGNLVKILH GTKGELLLDV
310 320 330 340 350
VWHPVRPIIA SISSGLVSIW AQNQVENWSA FAPDFKELDE NVEYEERESE
360 370 380 390 400
FDIADEDKSV DLNADAQQDE EIEVDVQKVE PVAAFCSSDE EGEDENALQF
410 420 430 440 450
LPMAPEVEDP EDGWTGQDGL EPSAVMLGHM EPHDYEDDIM ASKRRRMQLY
460 470 480
DVSLPDAPTD ETHPLISSKA SKDKQQPVGG KKAAGRTKK
Length:489
Mass (Da):54,406
Last modified:March 1, 2001 - v2
Checksum:iE959B7F5AA053858
GO

Sequence cautioni

The sequence ACD81779 differs from that shown. Reason: Frameshift at position 207.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51573.2
AY071120 mRNA Translation: AAL48742.1
BT032759 mRNA Translation: ACD81773.1
BT032765 mRNA Translation: ACD81779.1 Frameshift.
RefSeqiNP_649209.1, NM_140952.3
UniGeneiDm.6107

Genome annotation databases

EnsemblMetazoaiFBtr0078242; FBpp0077900; FBgn0036973
GeneIDi40239
KEGGidme:Dmel_CG5585
UCSCiCG5585-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRBBP5_DROME
AccessioniPrimary (citable) accession number: Q9VPH8
Secondary accession number(s): B3DMX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health