UniProtKB - Q9VNT5 (TRXR2_DROME)
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Protein
Thioredoxin reductase 2, mitochondrial
Gene
Trxr-2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.By similarity
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activityi
Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.By similarity
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 489 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 79 | FADBy similarityAdd BLAST | 18 |
GO - Molecular functioni
- electron transfer activity Source: InterPro
- flavin adenine dinucleotide binding Source: InterPro
- thioredoxin-disulfide reductase activity Source: FlyBase
GO - Biological processi
- cell redox homeostasis Source: FlyBase
- response to oxygen radical Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
Reactomei | R-DME-3299685 Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Trxr-2 ORF Names:CG11401 |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0037170 Trxr-2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000030293 | ? – 516 | Thioredoxin reductase 2, mitochondrial | ||
Transit peptidei | 1 – ? | MitochondrionSequence analysis |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 79 ↔ 84 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q9VNT5 |
PRIDEi | Q9VNT5 |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
BioGridi | 657092 interactors. |
DIPi | DIP-19796N |
IntActi | Q9VNT5 1 interactor. |
STRINGi | 7227.FBpp0078166 |
Structurei
3D structure databases
ProteinModelPortali | Q9VNT5 |
SMRi | Q9VNT5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active center, Transit peptidePhylogenomic databases
eggNOGi | KOG0405 Eukaryota COG1249 LUCA |
GeneTreei | ENSGT00390000007578 |
InParanoidi | Q9VNT5 |
KOi | K22182 |
OMAi | GLECACF |
OrthoDBi | EOG091G03IU |
PhylomeDBi | Q9VNT5 |
Family and domain databases
Gene3Di | 3.30.390.301 hit 3.50.50.603 hits |
InterProi | View protein in InterPro IPR036188 FAD/NAD-bd_sf IPR023753 FAD/NAD-binding_dom IPR016156 FAD/NAD-linked_Rdtase_dimer_sf IPR001100 Pyr_nuc-diS_OxRdtase IPR004099 Pyr_nucl-diS_OxRdtase_dimer IPR012999 Pyr_OxRdtase_I_AS IPR006338 Thioredoxin/glutathione_Rdtase |
Pfami | View protein in Pfam PF07992 Pyr_redox_2, 1 hit PF02852 Pyr_redox_dim, 1 hit |
PIRSFi | PIRSF000350 Mercury_reductase_MerA, 1 hit |
SUPFAMi | SSF51905 SSF51905, 1 hit SSF55424 SSF55424, 1 hit |
TIGRFAMsi | TIGR01438 TGR, 1 hit |
PROSITEi | View protein in PROSITE PS00076 PYRIDINE_REDOX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9VNT5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTIKFLRSS THNALRSSLG WCRLAASRPR YDYDLVVLGG GSAGLACAKE
60 70 80 90 100
AAGCGARVLC FDYVKPTPVG TKWGIGGTCV NVGCIPKKLM HQASLLGEAV
110 120 130 140 150
HEAVAYGWNV DDTNIRPDWR KLVRSVQNHI KSVNWVTRVD LRDKKVEYVN
160 170 180 190 200
SMATFRDSHT IEYVAMPGAE HRQVTSEYVV VAVGGRPRYP DIPGAVELGI
210 220 230 240 250
TSDDIFSYER EPGRTLVVGA GYVGLECACF LKGLGYEPTV MVRSIVLRGF
260 270 280 290 300
DRQMSELLAA MMTERGIPFL GTTIPKAVER QADGRLLVRY RNTTTQMDGS
310 320 330 340 350
DVFDTVLWAI GRKGLIEDLN LDAAGVKTHD DKIVVDAAEA TSVPHIFAVG
360 370 380 390 400
DIIYGRPELT PVAILSGRLL ARRLFAGSTQ LMDYADVATT VFTPLEYSCV
410 420 430 440 450
GMSEETAIEL RGADNIEVFH GYYKPTEFFI PQKSVRHCYL KAVAEVSGDQ
460 470 480 490 500
KILGLHYIGP VAGEVIQGFA AALKTGLTVK TLLNTVGIHP TTAEEFTRLS
510
ITKRSGRDPT PASCCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236866 Genomic DNA Translation: AAF64152.1 AE014296 Genomic DNA Translation: AAF51835.1 AY121613 mRNA Translation: AAM51940.1 |
RefSeqi | NP_524216.1, NM_079492.3 |
UniGenei | Dm.2498 |
Genome annotation databases
EnsemblMetazoai | FBtr0078514; FBpp0078166; FBgn0037170 |
GeneIDi | 40475 |
KEGGi | dme:Dmel_CG11401 |
Similar proteinsi
Entry informationi
Entry namei | TRXR2_DROME | |
Accessioni | Q9VNT5Primary (citable) accession number: Q9VNT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |