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Protein

Thioredoxin reductase 2, mitochondrial

Gene

Trxr-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.By similarity

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei489Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 79FADBy similarityAdd BLAST18

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: FlyBase
  • response to oxygen radical Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiR-DME-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase 2, mitochondrial (EC:1.8.1.9)
Short name:
TrxR-2
Gene namesi
Name:Trxr-2
ORF Names:CG11401
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0037170 Trxr-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030293? – 516Thioredoxin reductase 2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 84Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9VNT5
PRIDEiQ9VNT5

Expressioni

Gene expression databases

BgeeiFBgn0037170
GenevisibleiQ9VNT5 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi657092 interactors.
DIPiDIP-19796N
IntActiQ9VNT5 1 interactor.
STRINGi7227.FBpp0078166

Structurei

3D structure databases

ProteinModelPortaliQ9VNT5
SMRiQ9VNT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
GeneTreeiENSGT00390000007578
InParanoidiQ9VNT5
KOiK22182
OMAiGLECACF
OrthoDBiEOG091G03IU
PhylomeDBiQ9VNT5

Family and domain databases

Gene3Di3.30.390.301 hit
3.50.50.603 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR006338 Thioredoxin/glutathione_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01438 TGR, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VNT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIKFLRSS THNALRSSLG WCRLAASRPR YDYDLVVLGG GSAGLACAKE
60 70 80 90 100
AAGCGARVLC FDYVKPTPVG TKWGIGGTCV NVGCIPKKLM HQASLLGEAV
110 120 130 140 150
HEAVAYGWNV DDTNIRPDWR KLVRSVQNHI KSVNWVTRVD LRDKKVEYVN
160 170 180 190 200
SMATFRDSHT IEYVAMPGAE HRQVTSEYVV VAVGGRPRYP DIPGAVELGI
210 220 230 240 250
TSDDIFSYER EPGRTLVVGA GYVGLECACF LKGLGYEPTV MVRSIVLRGF
260 270 280 290 300
DRQMSELLAA MMTERGIPFL GTTIPKAVER QADGRLLVRY RNTTTQMDGS
310 320 330 340 350
DVFDTVLWAI GRKGLIEDLN LDAAGVKTHD DKIVVDAAEA TSVPHIFAVG
360 370 380 390 400
DIIYGRPELT PVAILSGRLL ARRLFAGSTQ LMDYADVATT VFTPLEYSCV
410 420 430 440 450
GMSEETAIEL RGADNIEVFH GYYKPTEFFI PQKSVRHCYL KAVAEVSGDQ
460 470 480 490 500
KILGLHYIGP VAGEVIQGFA AALKTGLTVK TLLNTVGIHP TTAEEFTRLS
510
ITKRSGRDPT PASCCS
Length:516
Mass (Da):56,277
Last modified:May 1, 2000 - v1
Checksum:iD82A89CBF6A4B7E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236866 Genomic DNA Translation: AAF64152.1
AE014296 Genomic DNA Translation: AAF51835.1
AY121613 mRNA Translation: AAM51940.1
RefSeqiNP_524216.1, NM_079492.3
UniGeneiDm.2498

Genome annotation databases

EnsemblMetazoaiFBtr0078514; FBpp0078166; FBgn0037170
GeneIDi40475
KEGGidme:Dmel_CG11401

Similar proteinsi

Entry informationi

Entry nameiTRXR2_DROME
AccessioniPrimary (citable) accession number: Q9VNT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome