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Protein

Calcium-transporting ATPase

Gene

SPoCk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: FlyBase
  • manganese-transporting ATPase activity Source: FlyBase

GO - Biological processi

  • calcium ion transport Source: FlyBase
  • calcium-mediated signaling Source: FlyBase
  • fluid transport Source: FlyBase
  • sequestering of calcium ion Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:SPoCkImported
Synonyms:anon-WO0118547.249Imported, Dmel\CG32451Imported, SPoCKImported
ORF Names:CG14449Imported, CG32451Imported, CG7651Imported, Dmel_CG32451Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0052451. SPoCk.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 79HelicalUniRule annotationAdd BLAST19
Transmembranei85 – 104HelicalUniRule annotationAdd BLAST20
Transmembranei252 – 270HelicalUniRule annotationAdd BLAST19
Transmembranei282 – 306HelicalUniRule annotationAdd BLAST25
Transmembranei758 – 777HelicalUniRule annotationAdd BLAST20
Transmembranei828 – 846HelicalUniRule annotationAdd BLAST19
Transmembranei858 – 879HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • peroxisome Source: FlyBase

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9VNR2.

Expressioni

Gene expression databases

BgeeiFBgn0052451.
ExpressionAtlasiQ9VNR2. differential.
GenevisibleiQ9VNR2. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VNR2. 2 interactors.
MINTiMINT-321839.

Structurei

3D structure databases

ProteinModelPortaliQ9VNR2.
SMRiQ9VNR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 81Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00890000139334.
OrthoDBiEOG091G0NXU.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VNR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSTSESST HSASEVAGRL QVDVRTGLKW TEAKYRAKII GHNELLLVAE
60 70 80 90 100
DPTWKKYIEQ FRNPLILLLL GSALVSVIMK QFDDAVSITI AILIVVTVAF
110 120 130 140 150
IQEYRSEKSL EELKKLVPPE CHCLREGRLD TFLARELVPG DIVHLNVGDR
160 170 180 190 200
VPADVRLFEA VDLSIDESSF TGETEPARKI TDVLLNNTNV KDHSNMKNIA
210 220 230 240 250
FMGTLVRCGN GKGIVVSTGE RSEFGEVFKM MQAEEAPKTP LQKSMDILGA
260 270 280 290 300
QLSFYSFLII GVIMLLGWLQ GKPLSEMFNI SVSLAVAAIP EGLPIVVTVT
310 320 330 340 350
LALGVMRMAK RNSIVKKLPT VETLGCVNVI CSDKTGTLTK NEMTATIIIT
360 370 380 390 400
SDGYMADVTG AGYNDQGEIH IRHCNNVEMA KTNITNLLEI GAVCNNAYIQ
410 420 430 440 450
NGTLLGQPTE GALVAVAMKN GMYATAENYV RIQEYPFSSE QKMMAVKCIH
460 470 480 490 500
KYNNNKEEIF FAKGALETLL PQCTKYQFGT QTVPLTKQNE AEFLAEAYEI
510 520 530 540 550
GRKGLRVLAL AKGRSMQDLI YCGLVGITDP PRPLVRESIE MLMQSGVRVK
560 570 580 590 600
MVTGDAQETA LAIANLIGID TIHHQTLSGQ EMDQMNEHQL DKVANNVSVF
610 620 630 640 650
YRVSPRHKLE IVKSLQRSGN IVGMTGDGVN DGVALKKADI GIAMGKNGTD
660 670 680 690 700
VCKEAADMIL VNDDFHTIIA AIEEGKGIFY NIRNFVRFQL STSIAALALI
710 720 730 740 750
ALATLMDIAN PLNAMQILWI NIIMDGPPAQ SLGVEPVDHD VLKQKPRNVK
760 770 780 790 800
QPMITKSVVV NVLLSASIIV LGTLWVFQRE MADGTLGKTK RDTTMTFTCF
810 820 830 840 850
VFFDMFNALS CRSQTKSVFT IGLTTNRMFL LAVAFSIIGQ MLVVYFPPLQ
860 870 880 890 900
MVFQTEALTP YDIFFLVSLT SSVLVVSEIK KWFERTMERK MYSTRSELDF

V
Length:901
Mass (Da):99,546
Last modified:May 1, 2000 - v1
Checksum:iDBB417DC2CA110DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF51860.1.
RefSeqiNP_730745.1. NM_168963.4.
UniGeneiDm.31157.

Genome annotation databases

EnsemblMetazoaiFBtr0078531; FBpp0078183; FBgn0052451.
FBtr0113437; FBpp0112349; FBgn0052451.
GeneIDi40495.
UCSCiCG32451-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VNR2_DROME
AccessioniPrimary (citable) accession number: Q9VNR2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported