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Protein

Putative odorant receptor 83c

Gene

Or83c

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).By similarity

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: FlyBase

Keywordsi

Molecular functionReceptor, Transducer
Biological processOlfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Putative odorant receptor 83c
Gene namesi
Name:Or83c
ORF Names:CG15581
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037399. Or83c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 70ExtracellularSequence analysis10
Transmembranei71 – 90Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini91 – 136CytoplasmicSequence analysisAdd BLAST46
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 186ExtracellularSequence analysisAdd BLAST29
Transmembranei187 – 207Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini208 – 282CytoplasmicSequence analysisAdd BLAST75
Transmembranei283 – 299Helical; Name=5Sequence analysisAdd BLAST17
Topological domaini300 – 305ExtracellularSequence analysis6
Transmembranei306 – 326Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini327 – 365CytoplasmicSequence analysisAdd BLAST39
Transmembranei366 – 386Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini387 – 397ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742731 – 397Putative odorant receptor 83cAdd BLAST397

Proteomic databases

PaxDbiQ9VNK9.
PRIDEiQ9VNK9.

Expressioni

Tissue specificityi

Expressed in olfactory sensory neurons in the antenna.1 Publication

Gene expression databases

BgeeiFBgn0037399.
ExpressionAtlasiQ9VNK9. differential.
GenevisibleiQ9VNK9. DM.

Interactioni

Subunit structurei

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).By similarity

Protein-protein interaction databases

BioGridi65948. 3 interactors.
IntActiQ9VNK9. 1 interactor.
STRINGi7227.FBpp0078269.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JH2K. Eukaryota.
ENOG4111AKI. LUCA.
GeneTreeiENSGT00530000064384.
InParanoidiQ9VNK9.
KOiK08471.
OMAiYRTWTTI.
OrthoDBiEOG091G07OU.
PhylomeDBiQ9VNK9.

Family and domain databases

InterProiView protein in InterPro
IPR004117. 7tm6_olfct_rcpt.
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiView protein in Pfam
PF02949. 7tm_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VNK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSESPSSR FRELSKYINS LTNLLGVDFL SPKLKFNYRT WTTIFAIANY
60 70 80 90 100
TGFTVFTILN NGGDWRVGLK ASLMTGGLFH GLGKFLTCLL KHQDMRRLVL
110 120 130 140 150
YSQSIYDEYE TRGDSYHRTL NSNIDRLLGI MKIIRNGYVF AFCLMELLPL
160 170 180 190 200
AMLMYDGTRV TAMQYLIPGL PLENNYCYVV TYMIQTVTML VQGVGFYSGD
210 220 230 240 250
LFVFLGLTQI LTFADMLQVK VKELNDALEQ KAEYRALVRV GASIDGAENR
260 270 280 290 300
QRLLLDVIRW HQLFTDYCRA INALYYELIA TQVLSMALAM MLSFCINLSS
310 320 330 340 350
FHMPSAIFFV VSAYSMSIYC ILGTILEFAY DQVYESICNV TWYELSGEQR
360 370 380 390
KLFGFLLRES QYPHNIQILG VMSLSVRTAL QIVKLIYSVS MMMMNRA
Length:397
Mass (Da):45,487
Last modified:June 1, 2001 - v2
Checksum:i59CA3EF415BB711A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF51921.2.
RefSeqiNP_524244.2. NM_079520.3.
UniGeneiDm.27213.

Genome annotation databases

EnsemblMetazoaiFBtr0078620; FBpp0078269; FBgn0037399.
GeneIDi40744.
KEGGidme:Dmel_CG15581.

Similar proteinsi

Entry informationi

Entry nameiOR83C_DROME
AccessioniPrimary (citable) accession number: Q9VNK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families