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Protein

Protein krasavietz

Gene

kra

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in memory formation.1 Publication

GO - Molecular functioni

  • ribosome binding Source: FlyBase
  • translation initiation factor binding Source: FlyBase

GO - Biological processi

  • axon midline choice point recognition Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • long-term memory Source: UniProtKB
  • negative regulation of translation Source: FlyBase
  • neuron fate commitment Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein krasavietz
Alternative name(s):
Eukaryotic translation initiation factor 5C domain-containing protein
Short name:
Decp
Short name:
eIF5C domain-containing protein
Protein extra bases
Gene namesi
Name:kra
Synonyms:ecp, eIF-5C, exba
ORF Names:CG2922
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0250753. kra.

Subcellular locationi

GO - Cellular componenti

  • axon Source: FlyBase
  • axonal growth cone Source: FlyBase
  • cytoplasm Source: FlyBase
  • filopodium Source: FlyBase
  • neuronal cell body Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Mutant flies show defective one-day memory but normal learning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Protein krasavietzPRO_0000254625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071Phosphoserine1 Publication
Modified residuei412 – 4121Phosphoserine1 Publication
Modified residuei414 – 4141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VNE2.
PRIDEiQ9VNE2.

PTM databases

iPTMnetiQ9VNE2.

Expressioni

Tissue specificityi

Expressed in mushroom bodies.1 Publication

Gene expression databases

BgeeiQ9VNE2.
GenevisibleiQ9VNE2. DM.

Interactioni

GO - Molecular functioni

  • translation initiation factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi65886. 4 interactions.
IntActiQ9VNE2. 3 interactions.
MINTiMINT-860791.
STRINGi7227.FBpp0078393.

Structurei

3D structure databases

ProteinModelPortaliQ9VNE2.
SMRiQ9VNE2. Positions 322-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini244 – 415172W2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BZW family.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000107041.
InParanoidiQ9VNE2.
OMAiIAYLIQA.
OrthoDBiEOG78PV8V.
PhylomeDBiQ9VNE2.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VNE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKTERPVL SGQRIKTRKR DEREKYDPTG FRDAVIAGLE KTEGDLEQIS
60 70 80 90 100
KYLDSAGNKL DYRRYGEVLF DILIAGGLLV PGGSISQDGE KPRTSYCIFD
110 120 130 140 150
APESMESMRN HEQVFVKLIR RYKYLEKMFE EEMGKVLLFV KGFTPSERIK
160 170 180 190 200
LARMTALWLV NGSVPPNVLL VLNNEHLIKD GIALEFLLEL FQTFKQEKGI
210 220 230 240 250
AYLIQALKKG GLESKLMDFF PPNKRTEEYF KQVFLDKELN EIVKLHKAQA
260 270 280 290 300
SQEAKRELQQ ALIDDINDEK PYNEITSDIK DFSQRTNIPD HEIIVIIWST
310 320 330 340 350
IMSLGEWNKK EELVTDQAVR HLKNYCPLLQ AFASTDRSEL ALILKVQEFC
360 370 380 390 400
YENMNFMKAF QKIILLFYKT EVLSEEIILR WYKEGHSNKG KMHFLEQMRK
410 420
FVEWLQSAEE ESESEDEQKN GE
Length:422
Mass (Da):49,225
Last modified:May 1, 2000 - v1
Checksum:iE99F77F94A41E839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325529 mRNA. Translation: AAK01218.1.
AE014297 Genomic DNA. Translation: AAF51995.1.
AE014297 Genomic DNA. Translation: AAF51996.1.
AE014297 Genomic DNA. Translation: AAG22214.1.
AE014297 Genomic DNA. Translation: AAN13246.1.
AE014297 Genomic DNA. Translation: AAN13247.1.
AE014297 Genomic DNA. Translation: AAN13248.1.
AE014297 Genomic DNA. Translation: AAN13249.1.
AY058505 mRNA. Translation: AAL13734.1.
RefSeqiNP_524238.1. NM_079514.3.
NP_730958.1. NM_169074.2.
NP_730959.1. NM_169075.2.
NP_730960.1. NM_169076.2.
NP_730961.1. NM_169077.2.
NP_730962.1. NM_169078.2.
NP_730963.1. NM_169079.2.
UniGeneiDm.1484.

Genome annotation databases

EnsemblMetazoaiFBtr0078744; FBpp0078393; FBgn0250753.
FBtr0078745; FBpp0078394; FBgn0250753.
FBtr0078746; FBpp0078395; FBgn0250753.
FBtr0078747; FBpp0078396; FBgn0250753.
FBtr0078748; FBpp0078397; FBgn0250753.
FBtr0078749; FBpp0078398; FBgn0250753.
FBtr0078750; FBpp0078399; FBgn0250753.
GeneIDi40680.
KEGGidme:Dmel_CG2922.
UCSCiCG2922-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325529 mRNA. Translation: AAK01218.1.
AE014297 Genomic DNA. Translation: AAF51995.1.
AE014297 Genomic DNA. Translation: AAF51996.1.
AE014297 Genomic DNA. Translation: AAG22214.1.
AE014297 Genomic DNA. Translation: AAN13246.1.
AE014297 Genomic DNA. Translation: AAN13247.1.
AE014297 Genomic DNA. Translation: AAN13248.1.
AE014297 Genomic DNA. Translation: AAN13249.1.
AY058505 mRNA. Translation: AAL13734.1.
RefSeqiNP_524238.1. NM_079514.3.
NP_730958.1. NM_169074.2.
NP_730959.1. NM_169075.2.
NP_730960.1. NM_169076.2.
NP_730961.1. NM_169077.2.
NP_730962.1. NM_169078.2.
NP_730963.1. NM_169079.2.
UniGeneiDm.1484.

3D structure databases

ProteinModelPortaliQ9VNE2.
SMRiQ9VNE2. Positions 322-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65886. 4 interactions.
IntActiQ9VNE2. 3 interactions.
MINTiMINT-860791.
STRINGi7227.FBpp0078393.

PTM databases

iPTMnetiQ9VNE2.

Proteomic databases

PaxDbiQ9VNE2.
PRIDEiQ9VNE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078744; FBpp0078393; FBgn0250753.
FBtr0078745; FBpp0078394; FBgn0250753.
FBtr0078746; FBpp0078395; FBgn0250753.
FBtr0078747; FBpp0078396; FBgn0250753.
FBtr0078748; FBpp0078397; FBgn0250753.
FBtr0078749; FBpp0078398; FBgn0250753.
FBtr0078750; FBpp0078399; FBgn0250753.
GeneIDi40680.
KEGGidme:Dmel_CG2922.
UCSCiCG2922-RB. d. melanogaster.

Organism-specific databases

CTDi40680.
FlyBaseiFBgn0250753. kra.

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000107041.
InParanoidiQ9VNE2.
OMAiIAYLIQA.
OrthoDBiEOG78PV8V.
PhylomeDBiQ9VNE2.

Miscellaneous databases

ChiTaRSiexba. fly.
GenomeRNAii40680.
PROiQ9VNE2.

Gene expression databases

BgeeiQ9VNE2.
GenevisibleiQ9VNE2. DM.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila eIF5C-containing protein gene (Decp)."
    Wan Y., Zhu K., Boulianne G.L., Xie W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; SER-412 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiPKRA_DROME
AccessioniPrimary (citable) accession number: Q9VNE2
Secondary accession number(s): A4V2F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.