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Protein

Protein krasavietz

Gene

kra

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in memory formation.1 Publication

GO - Molecular functioni

  • ribosomal small subunit binding Source: FlyBase
  • ribosome binding Source: FlyBase
  • translation initiation factor binding Source: FlyBase

GO - Biological processi

  • axon midline choice point recognition Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • long-term memory Source: UniProtKB
  • negative regulation of translation Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • positive regulation of filopodium assembly Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein krasavietz
Alternative name(s):
Eukaryotic translation initiation factor 5C domain-containing protein
Short name:
Decp
Short name:
eIF5C domain-containing protein
Protein extra bases
Gene namesi
Name:kra
Synonyms:ecp, eIF-5C, exba
ORF Names:CG2922
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0250753 kra

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Mutant flies show defective one-day memory but normal learning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546251 – 422Protein krasavietzAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407Phosphoserine1 Publication1
Modified residuei412Phosphoserine1 Publication1
Modified residuei414Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VNE2
PRIDEiQ9VNE2

PTM databases

iPTMnetiQ9VNE2

Expressioni

Tissue specificityi

Expressed in mushroom bodies.1 Publication

Gene expression databases

BgeeiFBgn0250753
GenevisibleiQ9VNE2 DM

Interactioni

GO - Molecular functioni

  • translation initiation factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi65886, 15 interactors
IntActiQ9VNE2, 5 interactors
STRINGi7227.FBpp0078393

Structurei

3D structure databases

ProteinModelPortaliQ9VNE2
SMRiQ9VNE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini244 – 415W2PROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297 Eukaryota
ENOG410XR08 LUCA
GeneTreeiENSGT00390000012561
HOGENOMiHOG000107041
InParanoidiQ9VNE2
OMAiMTALWIS
OrthoDBiEOG091G090E
PhylomeDBiQ9VNE2

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VNE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKTERPVL SGQRIKTRKR DEREKYDPTG FRDAVIAGLE KTEGDLEQIS
60 70 80 90 100
KYLDSAGNKL DYRRYGEVLF DILIAGGLLV PGGSISQDGE KPRTSYCIFD
110 120 130 140 150
APESMESMRN HEQVFVKLIR RYKYLEKMFE EEMGKVLLFV KGFTPSERIK
160 170 180 190 200
LARMTALWLV NGSVPPNVLL VLNNEHLIKD GIALEFLLEL FQTFKQEKGI
210 220 230 240 250
AYLIQALKKG GLESKLMDFF PPNKRTEEYF KQVFLDKELN EIVKLHKAQA
260 270 280 290 300
SQEAKRELQQ ALIDDINDEK PYNEITSDIK DFSQRTNIPD HEIIVIIWST
310 320 330 340 350
IMSLGEWNKK EELVTDQAVR HLKNYCPLLQ AFASTDRSEL ALILKVQEFC
360 370 380 390 400
YENMNFMKAF QKIILLFYKT EVLSEEIILR WYKEGHSNKG KMHFLEQMRK
410 420
FVEWLQSAEE ESESEDEQKN GE
Length:422
Mass (Da):49,225
Last modified:May 1, 2000 - v1
Checksum:iE99F77F94A41E839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325529 mRNA Translation: AAK01218.1
AE014297 Genomic DNA Translation: AAF51995.1
AE014297 Genomic DNA Translation: AAF51996.1
AE014297 Genomic DNA Translation: AAG22214.1
AE014297 Genomic DNA Translation: AAN13246.1
AE014297 Genomic DNA Translation: AAN13247.1
AE014297 Genomic DNA Translation: AAN13248.1
AE014297 Genomic DNA Translation: AAN13249.1
AY058505 mRNA Translation: AAL13734.1
RefSeqiNP_524238.1, NM_079514.3
NP_730958.1, NM_169074.2
NP_730959.1, NM_169075.2
NP_730960.1, NM_169076.2
NP_730961.1, NM_169077.2
NP_730962.1, NM_169078.2
NP_730963.1, NM_169079.2
UniGeneiDm.1484

Genome annotation databases

EnsemblMetazoaiFBtr0078744; FBpp0078393; FBgn0250753
FBtr0078745; FBpp0078394; FBgn0250753
FBtr0078746; FBpp0078395; FBgn0250753
FBtr0078747; FBpp0078396; FBgn0250753
FBtr0078748; FBpp0078397; FBgn0250753
FBtr0078749; FBpp0078398; FBgn0250753
FBtr0078750; FBpp0078399; FBgn0250753
GeneIDi40680
KEGGidme:Dmel_CG2922
UCSCiCG2922-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPKRA_DROME
AccessioniPrimary (citable) accession number: Q9VNE2
Secondary accession number(s): A4V2F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health