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Protein
Submitted name:

GH23732p

Gene

Hph

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • iron ion binding Source: FlyBase
  • L-ascorbic acid binding Source: InterPro
  • peptidyl-proline 4-dioxygenase activity Source: FlyBase
  • peptidyl-proline dioxygenase activity Source: FlyBase
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • cellular response to DNA damage stimulus Source: FlyBase
  • cellular response to hypoxia Source: FlyBase
  • open tracheal system development Source: FlyBase
  • peptidyl-proline hydroxylation Source: FlyBase
  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline Source: FlyBase
  • positive regulation of cell growth Source: FlyBase
  • protein export from nucleus Source: FlyBase
  • protein localization Source: FlyBase
  • response to hypoxia Source: FlyBase
  • terminal branching, open tracheal system Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.

Names & Taxonomyi

Protein namesi
Submitted name:
GH23732pImported
Submitted name:
HIF prolyl hydroxylase, isoform AImported
Gene namesi
Name:HphImported
Synonyms:0303Imported, 04Imported, 31543Imported, anon-EST:Posey69Imported, CG1114Imported, CG14665Imported, CG2676Imported, CG31543Imported, CR31541Imported, dHPHImported, Dm.egl-9Imported, Dmel\CG44015Imported, dmHPHImported, dPHDImported, dPHD2Imported, fgaImported, hphImported, l(3)02255Imported, l(3)82FeImported, l(3)S030304Imported, PHDImported
ORF Names:CG44015Imported, Dmel_CG44015Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0264785. Hph.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0264785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 248Fe2OG dioxygenaseInterPro annotationAdd BLAST99

Phylogenomic databases

eggNOGiKOG3710. Eukaryota.
ENOG410ZHZN. LUCA.
GeneTreeiENSGT00390000001936.
OMAiKHSAHPA.
OrthoDBiEOG091G03SP.

Family and domain databases

InterProiView protein in InterPro
IPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
PfamiView protein in Pfam
PF13640. 2OG-FeII_Oxy_3. 1 hit.
SMARTiView protein in SMART
SM00702. P4Hc. 1 hit.
PROSITEiView protein in PROSITE
PS51471. FE2OG_OXY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VN98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSTTTDYK NFFKHSAHPA NAEQYFRELL DKRERRYEDL CRNIISDMNQ
60 70 80 90 100
YGLSVVDDFL GMETGLKILN EVRSMYNAGA FQDGQVVTNQ TPDAPAVRGD
110 120 130 140 150
KIRGDKIKWV GGNEPGCSNV WYLTNQIDSV VYRVNTMKDN GILGNYHIRE
160 170 180 190 200
RTRAMVACYP GSGTHYVMHV DNPQKDGRVI TAIYYLNINW DARESGGILR
210 220 230 240 250
IRPTPGTTVA DIEPKFDRLI FFWSDIRNPH EVQPAHRTRY AITVWYFDAK
260 270 280 290 300
EREEALIRAK LENSKTNNLA AQAQAQQAEP DSTTTPPAAP ASSASSLPVS
310 320
MSTGTGALNA NVSSNSCATS SEICT
Length:325
Mass (Da):36,301
Last modified:May 1, 2000 - v1
Checksum:i8F3FDCC407FA3466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52050.1.
AY051594 mRNA. Translation: AAK93018.1.
RefSeqiNP_649525.1. NM_141268.3.
UniGeneiDm.20436.

Genome annotation databases

EnsemblMetazoaiFBtr0334275; FBpp0306390; FBgn0264785.
GeneIDi40633.
UCSCiCG31543-RA. d. melanogaster.

Entry informationi

Entry nameiQ9VN98_DROME
AccessioniPrimary (citable) accession number: Q9VN98
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported