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Protein

Putative cysteine proteinase CG12163

Gene

CG12163

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in autophagic cell death.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei418 – 4181By similarity
Active sitei555 – 5551By similarity
Active sitei581 – 5811By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: InterPro
  2. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. autophagic cell death Source: FlyBase
  2. chaeta development Source: FlyBase
  3. salivary gland cell autophagic cell death Source: FlyBase
  4. wing disc development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiREACT_323034. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.A27.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cysteine proteinase CG12163 (EC:3.4.22.-)
Gene namesi
ORF Names:CG12163
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260462. CG12163.

Subcellular locationi

GO - Cellular componenti

  1. fusome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 393373Activation peptideBy similarityPRO_0000026368Add
BLAST
Chaini394 – 614221Putative cysteine proteinase CG12163PRO_0000026369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi415 ↔ 456By similarity
Disulfide bondi449 ↔ 489By similarity
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi548 ↔ 602By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9VN93.
PRIDEiQ9VN93.

Expressioni

Gene expression databases

BgeeiQ9VN93.
ExpressionAtlasiQ9VN93. differential.

Interactioni

Protein-protein interaction databases

BioGridi65841. 4 interactions.
DIPiDIP-17491N.
IntActiQ9VN93. 3 interactions.
MINTiMINT-763966.

Structurei

3D structure databases

ProteinModelPortaliQ9VN93.
SMRiQ9VN93. Positions 86-138, 188-273, 318-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
InParanoidiQ9VN93.
KOiK01373.
OMAiGPRWGEQ.
OrthoDBiEOG7DJSKG.
PhylomeDBiQ9VN93.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR000010. Prot_inh_cystat.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00043. CY. 1 hit.
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: Q9VN93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLFAAATVA LVLLLGQAAG EELAEERAGQ AQGDAESTES SETTTDQAVS
60 70 80 90 100
EPPITLVHVL NPGEREYLSP NLIGVQNIAM TFLPLSMNFV NIIDAFREIT
110 120 130 140 150
AGVRYEILLN ALDTKAIQPA EADIVCRLVI LEKPWLRTQW GDKHRELVTS
160 170 180 190 200
NCTDPAVNSV AGDPAEKARL LNEKYVHRSR RSANDILGRH KPYDEEAAKA
210 220 230 240 250
QLQKSLDKLT AGEGPHYKIV KVYSASRQVD SGILTRIDAD LIDGSEEQHR
260 270 280 290 300
CIVDIWTKVW VRKDEHEITF KCRNQPVVQA RHTRSVEWAE KKTHKKHSHR
310 320 330 340 350
FDKVDHLFYK FQVRFGRRYV STAERQMRLR IFRQNLKTIE ELNANEMGSA
360 370 380 390 400
KYGITEFADM TSSEYKERTG LWQRDEAKAT GGSAAVVPAY HGELPKEFDW
410 420 430 440 450
RQKDAVTQVK NQGSCGSCWA FSVTGNIEGL YAVKTGELKE FSEQELLDCD
460 470 480 490 500
TTDSACNGGL MDNAYKAIKD IGGLEYEAEY PYKAKKNQCH FNRTLSHVQV
510 520 530 540 550
AGFVDLPKGN ETAMQEWLLA NGPISIGINA NAMQFYRGGV SHPWKALCSK
560 570 580 590 600
KNLDHGVLVV GYGVSDYPNF HKTLPYWIVK NSWGPRWGEQ GYYRVYRGDN
610
TCGVSEMATS AVLA

Note: No experimental confirmation available.Curated

Length:614
Mass (Da):68,961
Last modified:July 10, 2003 - v2
Checksum:iC44D32383375E032
GO
Isoform B1 Publication (identifier: Q9VN93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-175: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:475
Mass (Da):53,545
Checksum:i130DE83869498EF1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 175139Missing in isoform B. 1 PublicationVSP_050566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52055.2.
AE014297 Genomic DNA. Translation: AAN13266.1.
AY121614 mRNA. Translation: AAM51941.1. Sequence problems.
BT003231 mRNA. Translation: AAO24986.1.
RefSeqiNP_649521.1. NM_141264.4. [Q9VN93-2]
NP_730901.1. NM_169033.4. [Q9VN93-1]
NP_730902.2. NM_169034.4.
UniGeneiDm.7315.

Genome annotation databases

EnsemblMetazoaiFBtr0078823; FBpp0078465; FBgn0260462. [Q9VN93-1]
GeneIDi40628.
KEGGidme:Dmel_CG12163.
UCSCiCG12163-RA. d. melanogaster. [Q9VN93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52055.2.
AE014297 Genomic DNA. Translation: AAN13266.1.
AY121614 mRNA. Translation: AAM51941.1. Sequence problems.
BT003231 mRNA. Translation: AAO24986.1.
RefSeqiNP_649521.1. NM_141264.4. [Q9VN93-2]
NP_730901.1. NM_169033.4. [Q9VN93-1]
NP_730902.2. NM_169034.4.
UniGeneiDm.7315.

3D structure databases

ProteinModelPortaliQ9VN93.
SMRiQ9VN93. Positions 86-138, 188-273, 318-613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65841. 4 interactions.
DIPiDIP-17491N.
IntActiQ9VN93. 3 interactions.
MINTiMINT-763966.

Protein family/group databases

MEROPSiC01.A27.

Proteomic databases

PaxDbiQ9VN93.
PRIDEiQ9VN93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078823; FBpp0078465; FBgn0260462. [Q9VN93-1]
GeneIDi40628.
KEGGidme:Dmel_CG12163.
UCSCiCG12163-RA. d. melanogaster. [Q9VN93-1]

Organism-specific databases

FlyBaseiFBgn0260462. CG12163.

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
InParanoidiQ9VN93.
KOiK01373.
OMAiGPRWGEQ.
OrthoDBiEOG7DJSKG.
PhylomeDBiQ9VN93.

Enzyme and pathway databases

ReactomeiREACT_323034. MHC class II antigen presentation.

Miscellaneous databases

GenomeRNAii40628.
NextBioi819744.
PROiQ9VN93.

Gene expression databases

BgeeiQ9VN93.
ExpressionAtlasiQ9VN93. differential.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR000010. Prot_inh_cystat.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00043. CY. 1 hit.
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley1 Publication.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley1 Publication.
    Tissue: Head1 Publication, Larva1 Publication and Pupae1 Publication.
  4. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCPR1_DROME
AccessioniPrimary (citable) accession number: Q9VN93
Secondary accession number(s): Q867H7, Q9VN92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2003
Last sequence update: July 10, 2003
Last modified: March 31, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.