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Protein

Putative cysteine proteinase CG12163

Gene

CG12163

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in autophagic cell death.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei418By similarity1
Active sitei555By similarity1
Active sitei581By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-DME-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiI29.005

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cysteine proteinase CG12163 (EC:3.4.22.-)
Gene namesi
ORF Names:CG12163
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260462 CG12163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000002636821 – 393Activation peptideBy similarityAdd BLAST373
ChainiPRO_0000026369394 – 614Putative cysteine proteinase CG12163Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 456By similarity
Disulfide bondi449 ↔ 489By similarity
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi548 ↔ 602By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9VN93
PRIDEiQ9VN93

Expressioni

Gene expression databases

BgeeiFBgn0260462
ExpressionAtlasiQ9VN93 baseline and differential
GenevisibleiQ9VN93 DM

Interactioni

Protein-protein interaction databases

BioGridi65841, 10 interactors
DIPiDIP-17491N
IntActiQ9VN93, 3 interactors
STRINGi7227.FBpp0078465

Structurei

3D structure databases

ProteinModelPortaliQ9VN93
SMRiQ9VN93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
InParanoidiQ9VN93
KOiK01373
OMAiHLFHKFQ
OrthoDBiEOG091G05SD
PhylomeDBiQ9VN93

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: Q9VN93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLFAAATVA LVLLLGQAAG EELAEERAGQ AQGDAESTES SETTTDQAVS
60 70 80 90 100
EPPITLVHVL NPGEREYLSP NLIGVQNIAM TFLPLSMNFV NIIDAFREIT
110 120 130 140 150
AGVRYEILLN ALDTKAIQPA EADIVCRLVI LEKPWLRTQW GDKHRELVTS
160 170 180 190 200
NCTDPAVNSV AGDPAEKARL LNEKYVHRSR RSANDILGRH KPYDEEAAKA
210 220 230 240 250
QLQKSLDKLT AGEGPHYKIV KVYSASRQVD SGILTRIDAD LIDGSEEQHR
260 270 280 290 300
CIVDIWTKVW VRKDEHEITF KCRNQPVVQA RHTRSVEWAE KKTHKKHSHR
310 320 330 340 350
FDKVDHLFYK FQVRFGRRYV STAERQMRLR IFRQNLKTIE ELNANEMGSA
360 370 380 390 400
KYGITEFADM TSSEYKERTG LWQRDEAKAT GGSAAVVPAY HGELPKEFDW
410 420 430 440 450
RQKDAVTQVK NQGSCGSCWA FSVTGNIEGL YAVKTGELKE FSEQELLDCD
460 470 480 490 500
TTDSACNGGL MDNAYKAIKD IGGLEYEAEY PYKAKKNQCH FNRTLSHVQV
510 520 530 540 550
AGFVDLPKGN ETAMQEWLLA NGPISIGINA NAMQFYRGGV SHPWKALCSK
560 570 580 590 600
KNLDHGVLVV GYGVSDYPNF HKTLPYWIVK NSWGPRWGEQ GYYRVYRGDN
610
TCGVSEMATS AVLA
Note: No experimental confirmation available.Curated
Length:614
Mass (Da):68,961
Last modified:July 11, 2003 - v2
Checksum:iC44D32383375E032
GO
Isoform B1 Publication (identifier: Q9VN93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-175: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:475
Mass (Da):53,545
Checksum:i130DE83869498EF1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05056637 – 175Missing in isoform B. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52055.2
AE014297 Genomic DNA Translation: AAN13266.1
AY121614 mRNA Translation: AAM51941.1 Sequence problems.
BT003231 mRNA Translation: AAO24986.1
RefSeqiNP_649521.1, NM_141264.4 [Q9VN93-2]
NP_730901.1, NM_169033.4 [Q9VN93-1]
NP_730902.2, NM_169034.4
UniGeneiDm.7315

Genome annotation databases

EnsemblMetazoaiFBtr0078822; FBpp0078464; FBgn0260462 [Q9VN93-2]
FBtr0078823; FBpp0078465; FBgn0260462 [Q9VN93-1]
GeneIDi40628
KEGGidme:Dmel_CG12163
UCSCiCG12163-RA d. melanogaster [Q9VN93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCPR1_DROME
AccessioniPrimary (citable) accession number: Q9VN93
Secondary accession number(s): Q867H7, Q9VN92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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