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Q9VN93

- CPR1_DROME

UniProt

Q9VN93 - CPR1_DROME

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Protein
Putative cysteine proteinase CG12163
Gene
CG12163
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a role in autophagic cell death.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei418 – 4181 By similarityBy similarity
Active sitei555 – 5551 By similarityBy similarity
Active sitei581 – 5811 By similarityBy similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity Source: InterPro
  2. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. autophagic cell death Source: FlyBase
  2. chaeta development Source: FlyBase
  3. salivary gland cell autophagic cell death Source: FlyBase
  4. wing disc development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiREACT_180993. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.A27.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cysteine proteinase CG12163 (EC:3.4.22.-)
Gene namesi
ORF Names:CG12163
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260462. CG12163.

Subcellular locationi

GO - Cellular componenti

  1. fusome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Propeptidei21 – 393373Activation peptide By similarity
PRO_0000026368Add
BLAST
Chaini394 – 614221Putative cysteine proteinase CG12163By similarity
PRO_0000026369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi415 ↔ 456 By similarityBy similarity
Disulfide bondi449 ↔ 489 By similarityBy similarity
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi548 ↔ 602 By similarityBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9VN93.
PRIDEiQ9VN93.

Expressioni

Gene expression databases

BgeeiQ9VN93.

Interactioni

Protein-protein interaction databases

BioGridi65841. 4 interactions.
DIPiDIP-17491N.
IntActiQ9VN93. 1 interaction.
MINTiMINT-763966.

Structurei

3D structure databases

ProteinModelPortaliQ9VN93.
SMRiQ9VN93. Positions 194-273, 318-613.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00750000117440.
InParanoidiQ9VN93.
KOiK01373.
OMAiGPRWGEQ.
OrthoDBiEOG7DJSKG.
PhylomeDBiQ9VN93.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR000010. Prot_inh_cystat.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00043. CY. 1 hit.
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A1 Publication (identifier: Q9VN93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLFAAATVA LVLLLGQAAG EELAEERAGQ AQGDAESTES SETTTDQAVS    50
EPPITLVHVL NPGEREYLSP NLIGVQNIAM TFLPLSMNFV NIIDAFREIT 100
AGVRYEILLN ALDTKAIQPA EADIVCRLVI LEKPWLRTQW GDKHRELVTS 150
NCTDPAVNSV AGDPAEKARL LNEKYVHRSR RSANDILGRH KPYDEEAAKA 200
QLQKSLDKLT AGEGPHYKIV KVYSASRQVD SGILTRIDAD LIDGSEEQHR 250
CIVDIWTKVW VRKDEHEITF KCRNQPVVQA RHTRSVEWAE KKTHKKHSHR 300
FDKVDHLFYK FQVRFGRRYV STAERQMRLR IFRQNLKTIE ELNANEMGSA 350
KYGITEFADM TSSEYKERTG LWQRDEAKAT GGSAAVVPAY HGELPKEFDW 400
RQKDAVTQVK NQGSCGSCWA FSVTGNIEGL YAVKTGELKE FSEQELLDCD 450
TTDSACNGGL MDNAYKAIKD IGGLEYEAEY PYKAKKNQCH FNRTLSHVQV 500
AGFVDLPKGN ETAMQEWLLA NGPISIGINA NAMQFYRGGV SHPWKALCSK 550
KNLDHGVLVV GYGVSDYPNF HKTLPYWIVK NSWGPRWGEQ GYYRVYRGDN 600
TCGVSEMATS AVLA 614

Note: No experimental confirmation available.

Length:614
Mass (Da):68,961
Last modified:July 11, 2003 - v2
Checksum:iC44D32383375E032
GO
Isoform B1 Publication (identifier: Q9VN93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-175: Missing.

Note: No experimental confirmation available.

Show »
Length:475
Mass (Da):53,545
Checksum:i130DE83869498EF1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei37 – 175139Missing in isoform B. 1 Publication
VSP_050566Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF52055.2.
AE014297 Genomic DNA. Translation: AAN13266.1.
AY121614 mRNA. Translation: AAM51941.1. Sequence problems.
BT003231 mRNA. Translation: AAO24986.1.
RefSeqiNP_649521.1. NM_141264.4. [Q9VN93-2]
NP_730901.1. NM_169033.4. [Q9VN93-1]
NP_730902.2. NM_169034.4.
UniGeneiDm.7315.

Genome annotation databases

EnsemblMetazoaiFBtr0078823; FBpp0078465; FBgn0260462. [Q9VN93-1]
GeneIDi40628.
KEGGidme:Dmel_CG12163.
UCSCiCG12163-RA. d. melanogaster. [Q9VN93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF52055.2 .
AE014297 Genomic DNA. Translation: AAN13266.1 .
AY121614 mRNA. Translation: AAM51941.1 . Sequence problems.
BT003231 mRNA. Translation: AAO24986.1 .
RefSeqi NP_649521.1. NM_141264.4. [Q9VN93-2 ]
NP_730901.1. NM_169033.4. [Q9VN93-1 ]
NP_730902.2. NM_169034.4.
UniGenei Dm.7315.

3D structure databases

ProteinModelPortali Q9VN93.
SMRi Q9VN93. Positions 194-273, 318-613.
ModBasei Search...

Protein-protein interaction databases

BioGridi 65841. 4 interactions.
DIPi DIP-17491N.
IntActi Q9VN93. 1 interaction.
MINTi MINT-763966.

Protein family/group databases

MEROPSi C01.A27.

Proteomic databases

PaxDbi Q9VN93.
PRIDEi Q9VN93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0078823 ; FBpp0078465 ; FBgn0260462 . [Q9VN93-1 ]
GeneIDi 40628.
KEGGi dme:Dmel_CG12163.
UCSCi CG12163-RA. d. melanogaster. [Q9VN93-1 ]

Organism-specific databases

FlyBasei FBgn0260462. CG12163.

Phylogenomic databases

eggNOGi COG4870.
GeneTreei ENSGT00750000117440.
InParanoidi Q9VN93.
KOi K01373.
OMAi GPRWGEQ.
OrthoDBi EOG7DJSKG.
PhylomeDBi Q9VN93.

Enzyme and pathway databases

Reactomei REACT_180993. MHC class II antigen presentation.

Miscellaneous databases

GenomeRNAii 40628.
NextBioi 819744.
PROi Q9VN93.

Gene expression databases

Bgeei Q9VN93.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR000010. Prot_inh_cystat.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00043. CY. 1 hit.
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Head, Larva and Pupae.
  4. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCPR1_DROME
AccessioniPrimary (citable) accession number: Q9VN93
Secondary accession number(s): Q867H7, Q9VN92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi