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Protein

Eukaryotic translation initiation factor 3 subunit F-1

Gene

eIF3-S5-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • autophagic cell death Source: FlyBase
  • formation of translation preinitiation complex Source: UniProtKB-HAMAP
  • positive regulation of Notch signaling pathway Source: FlyBase
  • protein deubiquitination Source: FlyBase
  • regulation of translational initiation Source: UniProtKB-HAMAP
  • salivary gland cell autophagic cell death Source: FlyBase
  • translational initiation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.

Protein family/group databases

MEROPSiM67.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit F-1UniRule annotation
Short name:
eIF3f-1UniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 5-1UniRule annotation
Gene namesi
Name:eIF3-S5-1UniRule annotation
ORF Names:CG9769
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037270. CG9769.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003643031 – 280Eukaryotic translation initiation factor 3 subunit F-1Add BLAST280

Proteomic databases

PaxDbiQ9VN50.
PRIDEiQ9VN50.

Expressioni

Gene expression databases

BgeeiFBgn0037270.
GenevisibleiQ9VN50. DM.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi65804. 18 interactors.
IntActiQ9VN50. 1 interactor.
MINTiMINT-891663.
STRINGi7227.FBpp0078532.

Structurei

3D structure databases

ProteinModelPortaliQ9VN50.
SMRiQ9VN50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 112MPNUniRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation
Contains 1 MPN (JAB/Mov34) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG2975. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
InParanoidiQ9VN50.
KOiK03249.
OMAiRECNNPI.
OrthoDBiEOG091G0EMR.
PhylomeDBiQ9VN50.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiIPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VN50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALNLTVRV HPVVLFQVVD AFERRNADSH RVIGTLLGSV DKGVVEVTNC
60 70 80 90 100
FCVPHKEHDD QVEAELSYAL DMYDLNRKVN SNESVVGWWA TGNDVTNHSS
110 120 130 140 150
VIHEYYAREC NNPVHLTVDT SLQGGRMGLR AYVCIQLGVP GGKSGCMFTP
160 170 180 190 200
IPVELTSYEP ETFGLKLLQK TVGVSPAHRP KTVPPMLDLA QISEASTKLQ
210 220 230 240 250
SLLDLILKYV DDVIAHKVTP DNAVGRQLLD LIHSVPHMTH EQFTQMFNAN
260 270 280
VRNLLLVITL SQLIKTQLQL NEKLTFLPTA
Length:280
Mass (Da):31,105
Last modified:May 1, 2000 - v1
Checksum:iA860162E65005E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52101.1.
AY118972 mRNA. Translation: AAM50832.1.
RefSeqiNP_649489.1. NM_141232.3.
UniGeneiDm.11029.

Genome annotation databases

EnsemblMetazoaiFBtr0078892; FBpp0078532; FBgn0037270.
GeneIDi40587.
KEGGidme:Dmel_CG9769.
UCSCiCG9769-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52101.1.
AY118972 mRNA. Translation: AAM50832.1.
RefSeqiNP_649489.1. NM_141232.3.
UniGeneiDm.11029.

3D structure databases

ProteinModelPortaliQ9VN50.
SMRiQ9VN50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65804. 18 interactors.
IntActiQ9VN50. 1 interactor.
MINTiMINT-891663.
STRINGi7227.FBpp0078532.

Protein family/group databases

MEROPSiM67.974.

Proteomic databases

PaxDbiQ9VN50.
PRIDEiQ9VN50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078892; FBpp0078532; FBgn0037270.
GeneIDi40587.
KEGGidme:Dmel_CG9769.
UCSCiCG9769-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0037270. CG9769.

Phylogenomic databases

eggNOGiKOG2975. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
InParanoidiQ9VN50.
KOiK03249.
OMAiRECNNPI.
OrthoDBiEOG091G0EMR.
PhylomeDBiQ9VN50.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

ChiTaRSiCG9769. fly.
GenomeRNAii40587.
PROiQ9VN50.

Gene expression databases

BgeeiFBgn0037270.
GenevisibleiQ9VN50. DM.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiIPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI3F1_DROME
AccessioniPrimary (citable) accession number: Q9VN50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.