Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 3 subunit F-1

Gene

eIF3-S5-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • autophagic cell death Source: FlyBase
  • positive regulation of Notch signaling pathway Source: FlyBase
  • protein deubiquitination Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • translational initiation Source: FlyBase

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.

Protein family/group databases

MEROPSiM67.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit F-1UniRule annotation
Short name:
eIF3f-1UniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 5-1UniRule annotation
Gene namesi
Name:eIF3-S5-1UniRule annotation
ORF Names:CG9769
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037270. CG9769.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003643031 – 280Eukaryotic translation initiation factor 3 subunit F-1Add BLAST280

Proteomic databases

PaxDbiQ9VN50.
PRIDEiQ9VN50.

Expressioni

Gene expression databases

BgeeiFBgn0037270.
GenevisibleiQ9VN50. DM.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi65804. 18 interactors.
IntActiQ9VN50. 1 interactor.
MINTiMINT-891663.
STRINGi7227.FBpp0078532.

Structurei

3D structure databases

ProteinModelPortaliQ9VN50.
SMRiQ9VN50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 112MPNUniRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2975. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
InParanoidiQ9VN50.
KOiK03249.
OMAiAVDMEYH.
OrthoDBiEOG091G0EMR.
PhylomeDBiQ9VN50.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiView protein in InterPro
IPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
PANTHERiPTHR10540:SF14. PTHR10540:SF14. 1 hit.
PfamiView protein in Pfam
PF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
SMARTiView protein in SMART
SM00232. JAB_MPN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VN50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALNLTVRV HPVVLFQVVD AFERRNADSH RVIGTLLGSV DKGVVEVTNC
60 70 80 90 100
FCVPHKEHDD QVEAELSYAL DMYDLNRKVN SNESVVGWWA TGNDVTNHSS
110 120 130 140 150
VIHEYYAREC NNPVHLTVDT SLQGGRMGLR AYVCIQLGVP GGKSGCMFTP
160 170 180 190 200
IPVELTSYEP ETFGLKLLQK TVGVSPAHRP KTVPPMLDLA QISEASTKLQ
210 220 230 240 250
SLLDLILKYV DDVIAHKVTP DNAVGRQLLD LIHSVPHMTH EQFTQMFNAN
260 270 280
VRNLLLVITL SQLIKTQLQL NEKLTFLPTA
Length:280
Mass (Da):31,105
Last modified:May 1, 2000 - v1
Checksum:iA860162E65005E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF52101.1.
AY118972 mRNA. Translation: AAM50832.1.
RefSeqiNP_649489.1. NM_141232.3.
UniGeneiDm.11029.

Genome annotation databases

EnsemblMetazoaiFBtr0078892; FBpp0078532; FBgn0037270.
GeneIDi40587.
KEGGidme:Dmel_CG9769.
UCSCiCG9769-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiEI3F1_DROME
AccessioniPrimary (citable) accession number: Q9VN50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families