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Protein

60S ribosomal protein L37a

Gene

RpL37A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L37a
Gene namesi
Name:RpL37A
ORF Names:CG5827
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0261608. RpL37A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001398272 – 9260S ribosomal protein L37aAdd BLAST91

Proteomic databases

PaxDbiQ9VMU4.
PRIDEiQ9VMU4.

Expressioni

Gene expression databases

BgeeiFBgn0261608.
ExpressionAtlasiQ9VMU4. differential.
GenevisibleiQ9VMU4. DM.

Interactioni

Protein-protein interaction databases

BioGridi69275. 3 interactors.
IntActiQ9VMU4. 3 interactors.
MINTiMINT-943843.
STRINGi7227.FBpp0291726.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cp1-92[»]
ProteinModelPortaliQ9VMU4.
SMRiQ9VMU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0402. Eukaryota.
COG1997. LUCA.
GeneTreeiENSGT00390000016988.
InParanoidiQ9VMU4.
KOiK02921.
OMAiISTGIWQ.
OrthoDBiEOG091G107U.
PhylomeDBiQ9VMU4.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae. 1 hit.
InterProiView protein in InterPro
IPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF01780. Ribosomal_L37ae. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. eL43_euk_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VMU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRTKKVGI VGKYGTRYGA SLRKMVKKME ITQHSKYTCS FCGKDSMKRA
60 70 80 90
VVGIWSCKRC KRTVAGGAWV YSTTAAASVR SAVRRLRETK EQ
Length:92
Mass (Da):10,311
Last modified:January 23, 2007 - v3
Checksum:iF8D85A34503C1FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52217.1.
AE014134 Genomic DNA. Translation: AAN10530.1.
AY071189 mRNA. Translation: AAL48811.1.
AY071725 mRNA. Translation: AAL49347.1.
RefSeqiNP_001188691.1. NM_001201762.1.
NP_524781.1. NM_080042.4.
NP_723060.1. NM_164628.3.
UniGeneiDm.1819.

Genome annotation databases

EnsemblMetazoaiFBtr0079016; FBpp0078655; FBgn0261608.
FBtr0079017; FBpp0078656; FBgn0261608.
FBtr0302570; FBpp0291726; FBgn0261608.
GeneIDi44783.
KEGGidme:Dmel_CG5827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52217.1.
AE014134 Genomic DNA. Translation: AAN10530.1.
AY071189 mRNA. Translation: AAL48811.1.
AY071725 mRNA. Translation: AAL49347.1.
RefSeqiNP_001188691.1. NM_001201762.1.
NP_524781.1. NM_080042.4.
NP_723060.1. NM_164628.3.
UniGeneiDm.1819.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cp1-92[»]
ProteinModelPortaliQ9VMU4.
SMRiQ9VMU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69275. 3 interactors.
IntActiQ9VMU4. 3 interactors.
MINTiMINT-943843.
STRINGi7227.FBpp0291726.

Proteomic databases

PaxDbiQ9VMU4.
PRIDEiQ9VMU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079016; FBpp0078655; FBgn0261608.
FBtr0079017; FBpp0078656; FBgn0261608.
FBtr0302570; FBpp0291726; FBgn0261608.
GeneIDi44783.
KEGGidme:Dmel_CG5827.

Organism-specific databases

CTDi6168.
FlyBaseiFBgn0261608. RpL37A.

Phylogenomic databases

eggNOGiKOG0402. Eukaryota.
COG1997. LUCA.
GeneTreeiENSGT00390000016988.
InParanoidiQ9VMU4.
KOiK02921.
OMAiISTGIWQ.
OrthoDBiEOG091G107U.
PhylomeDBiQ9VMU4.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL37A. fly.
GenomeRNAii44783.
PROiPR:Q9VMU4.

Gene expression databases

BgeeiFBgn0261608.
ExpressionAtlasiQ9VMU4. differential.
GenevisibleiQ9VMU4. DM.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae. 1 hit.
InterProiView protein in InterPro
IPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF01780. Ribosomal_L37ae. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. eL43_euk_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL37A_DROME
AccessioniPrimary (citable) accession number: Q9VMU4
Secondary accession number(s): A4V081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.