UniProtKB - Q9VMN5 (CH60C_DROME)
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Protein
60 kDa heat shock protein homolog 2, mitochondrial
Gene
Hsp60C
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). Essential for proper development of trachea, spermatogonia and spermatocytes.By similarity1 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein binding involved in protein folding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- 'de novo' protein folding Source: FlyBase
- apoptotic mitochondrial changes Source: GO_Central
- chaperone-mediated protein folding Source: GO_Central
- female germline ring canal formation Source: FlyBase
- oogenesis Source: FlyBase
- open tracheal system development Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- protein import into mitochondrial intermembrane space Source: GO_Central
- protein refolding Source: InterPro
- protein targeting to mitochondrion Source: FlyBase
- spermatogenesis Source: FlyBase
Keywordsi
Molecular function | Chaperone, Developmental protein |
Biological process | Differentiation, Oogenesis, Spermatogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 60 kDa heat shock protein homolog 2, mitochondrialAlternative name(s): 60 kDa chaperonin CPN60 Heat shock protein 60 Short name: HSP-60 Hsp60 |
Gene namesi | Name:Hsp60C ORF Names:CG7235 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0031728. Hsp60C. |
Pathology & Biotechi
Disruption phenotypei
Flies are male and female sterile; reduction in numbers of primary and secondary spermatocytes.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 61 | MitochondrionBy similarityAdd BLAST | 61 | |
ChainiPRO_0000005033 | 62 – 576 | 60 kDa heat shock protein homolog 2, mitochondrialAdd BLAST | 515 |
Proteomic databases
PaxDbi | Q9VMN5. |
PRIDEi | Q9VMN5. |
Expressioni
Tissue specificityi
First detectable expression is seen in the posterior part of the dorsal tracheal trunk at stage 14-15, which marks the beginning of terminal tracheation. In the larval gut, expression in proventriculus is stronger than in midgut and hindgut. Malpighian tubules shows low expression and late third instar larval imaginal disks and brain showed moderate expression. In larval ovary and testis, expression is strong in the posterior region.1 Publication
Developmental stagei
Expression first seen in late embryonic stages and continues in larval and adult stages.1 Publication
Gene expression databases
Bgeei | FBgn0031728. |
Genevisiblei | Q9VMN5. DM. |
Interactioni
GO - Molecular functioni
- protein binding involved in protein folding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 59964. 15 interactors. |
DIPi | DIP-20697N. |
IntActi | Q9VMN5. 15 interactors. |
STRINGi | 7227.FBpp0078742. |
Structurei
3D structure databases
ProteinModelPortali | Q9VMN5. |
SMRi | Q9VMN5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the chaperonin (HSP60) family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0356. Eukaryota. COG0459. LUCA. |
GeneTreei | ENSGT00390000005727. |
InParanoidi | Q9VMN5. |
KOi | K04077. |
OMAi | CVIKVGA. |
OrthoDBi | EOG091G04JM. |
PhylomeDBi | Q9VMN5. |
Family and domain databases
CDDi | cd03344. GroEL. 1 hit. |
Gene3Di | 1.10.560.10. 2 hits. 3.30.260.10. 2 hits. 3.50.7.10. 1 hit. |
HAMAPi | MF_00600. CH60. 1 hit. |
InterProi | View protein in InterPro IPR018370. Chaperonin_Cpn60_CS. IPR001844. Chaprnin_Cpn60. IPR002423. Cpn60/TCP-1. IPR027409. GroEL-like_apical_dom_sf. IPR027413. GROEL-like_equatorial_sf. IPR027410. TCP-1-like_intermed_sf. |
PANTHERi | PTHR11353. PTHR11353. 1 hit. |
Pfami | View protein in Pfam PF00118. Cpn60_TCP1. 1 hit. |
PRINTSi | PR00298. CHAPERONIN60. |
SUPFAMi | SSF48592. SSF48592. 2 hits. SSF52029. SSF52029. 1 hit. SSF54849. SSF54849. 1 hit. |
TIGRFAMsi | TIGR02348. GroEL. 1 hit. |
PROSITEi | View protein in PROSITE PS00296. CHAPERONINS_CPN60. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9VMN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMRMFRYTNT LQRTAKISHV LWARNYAKDV RFGPEVRAMM LQGVDVLADA
60 70 80 90 100
VAVTMGPKGR NVIIEQSWGS PKITKDGVTV AKSIALKDKF QNIGAKLVQD
110 120 130 140 150
VANNTNEEAG DGTTTATVLA RAIAKEGFEK ISRGASPVEI RRGVMLAIET
160 170 180 190 200
VKDNLRRLSR PVNTPEEICQ VATISANGDK SVGNLISEAI KKVGRDGVIT
210 220 230 240 250
VKDGKTLCDE LEVIEGMKFD RGYISPYFIN TSKGAKVEFQ DALLLFCEKK
260 270 280 290 300
IKSAPSIVPA LELANAQRKP LVIIAEDLEA EALSTLVVNR LKVGLQVCAV
310 320 330 340 350
KAPGFGDNRK ENLMDMAVAT GGIVFGDEAN MVRLEDIKMS DFGRVGEVVV
360 370 380 390 400
SKDDTMLLKG KGQKAEVEKR VEGLREAIKE STSSYEKEKM QERLARLSSG
410 420 430 440 450
VALLRVGGSS DVEVSEKKDR VIDALNATRA AVEEGIVPGG GTALLRCIQK
460 470 480 490 500
LNDLKGANED QNMGIEIIRR ALRMPCLTIA KNAGVDGAMV VAKVEILDGD
510 520 530 540 550
YGYDALKGEY GNMIERGIID PTKVVRTAIS DAAGVASLLT TAEAVVTELP
560 570
LEEAAAAGAA AGLGALGGMG MGGMGM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 160 | R → Q in AAM29278 (PubMed:12537569).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA. Translation: AAF52277.2. AE014134 Genomic DNA. Translation: AAN10550.2. AE014134 Genomic DNA. Translation: AAN10551.2. AY113273 mRNA. Translation: AAM29278.1. BT001308 mRNA. Translation: AAN71063.1. |
RefSeqi | NP_608948.2. NM_135104.5. NP_723104.2. NM_164654.2. NP_723105.2. NM_164655.3. |
UniGenei | Dm.6406. |
Genome annotation databases
EnsemblMetazoai | FBtr0079110; FBpp0078742; FBgn0031728. FBtr0079111; FBpp0078743; FBgn0031728. FBtr0079112; FBpp0078744; FBgn0031728. |
GeneIDi | 33796. |
KEGGi | dme:Dmel_CG7235. |
UCSCi | CG7235-RA. d. melanogaster. |
Similar proteinsi
Entry informationi
Entry namei | CH60C_DROME | |
Accessioni | Q9VMN5Primary (citable) accession number: Q9VMN5 Secondary accession number(s): A4V087, Q8IHD0, Q8MZB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 10, 2004 | |
Last modified: | March 28, 2018 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |