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Q9VMA7 (TGO1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transport and Golgi organization protein 1
Gene names
Name:Tango1
ORF Names:CG11098
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1430 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier. Ref.6

Subcellular location

Golgi apparatus membrane; Single-pass type I membrane protein Ref.6.

Sequence similarities

Belongs to the MIA/OTOR family. Tango1 subfamily.

Contains 1 SH3 domain.

Sequence caution

The sequence AAL68225.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAL68225.1 differs from that shown. Reason: Deletion of 12 residues at position 1268 causing a frameshift.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9VMA7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform B (identifier: Q9VMA7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     923-1095: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 14301396Transport and Golgi organization protein 1
PRO_0000370510

Regions

Topological domain35 – 796762Extracellular Potential
Transmembrane797 – 81721Helical; Potential
Topological domain818 – 1430613Cytoplasmic Potential
Domain53 – 11159SH3
Coiled coil494 – 620127 Potential
Coiled coil869 – 1245377 Potential
Compositional bias161 – 1644Poly-Thr
Compositional bias630 – 6334Poly-His
Compositional bias1247 – 12537Poly-Gly
Compositional bias1277 – 133357Pro-rich
Compositional bias1365 – 13684Poly-Arg

Amino acid modifications

Modified residue8651Phosphoserine Ref.5
Modified residue8681Phosphoserine Ref.5
Modified residue13451Phosphoserine Ref.5
Modified residue13481Phosphoserine Ref.5
Modified residue13901Phosphoserine Ref.5
Modified residue13921Phosphoserine Ref.5

Natural variations

Alternative sequence923 – 1095173Missing in isoform B.
VSP_036932

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: FCF9988A95979349

FASTA1,430159,052
        10         20         30         40         50         60 
MRLTNEKATM QPQLSDLALV LGLLICCLPT LTWAATLSDK RLCADPKCEQ IISMGIAKIT 

        70         80         90        100        110        120 
YAIGGEGLIS FKINSPIRVL SKSAGSNMQL WGVDINGRRG YANKDFIMEK KILVRDKDLL 

       130        140        150        160        170        180 
YEVPVVGPGS PVQSVETPVQ SVETTVQPVL NASESTDDLA TTTTSPLEIA VDSIVVEHDK 

       190        200        210        220        230        240 
LQDQQVPDPT AASKAQVQVI EGTELPLEAI AATTEGSIVP ETAADPQEAT NLDSTVVDTK 

       250        260        270        280        290        300 
EPQALNSEAI KLQEEPKAQQ PATEAEKPPP LPQAINAELE DADDFDYGDD ETDDDSQQGS 

       310        320        330        340        350        360 
QDNESIVEIA NDNKSINESI ELKPLSVAQL KKTDKVEDSK DETKEKHAEM EVSKQEDSSL 

       370        380        390        400        410        420 
PTETLNVTAL EEQIDQKEFP KQVLDAAVEL KSSDPLPVEE VTETVAEPPR TIVEDKINEE 

       430        440        450        460        470        480 
IVPVSAKIQA KPATVNPTEP IVAQSDAEIK APSESVISST TPAPVVEEAP QKADPVGLPP 

       490        500        510        520        530        540 
LFEKKNFENP NNYYKQLQEE QEKQRLVAEA EEQKRLQEEA DQQKRLQEEA ALNKRLLEEA 

       550        560        570        580        590        600 
EQQKRLQEEA EQQKRLQEEA ELNKRLLEEA EKQKRLHEES EQLQRSSEEA EPQLSVQEAN 

       610        620        630        640        650        660 
MQQLNDSVDS QSNEIVDNNN RQQPEQYQQH HHHTESAFNH PSTASHTTPT PDAESPYAAV 

       670        680        690        700        710        720 
QEETTEASQT DNHREGVGYV EPVALPATAS PVSEVPIKED AAGFGLFATI VDTVNNFIGK 

       730        740        750        760        770        780 
DPQSDPADSS DELHRILYPG RPEVPPSQRK AEDFAPADVD GYCARFQAKD EHCHRSISLD 

       790        800        810        820        830        840 
NFVEVMADKL VDHSQLLLCV VIAAISSLFF MFAYYCFCNS SQEGALLSKL NHLERSLLAS 

       850        860        870        880        890        900 
HKENLIIKHD LMTTRTKLAS IEDNSFGSND MVADLKKQLE SELYEKAKLQ EQVGSLERDL 

       910        920        930        940        950        960 
DNAAEAGLEL NKMLSEVLNG QNGDEAFMST VDELQRQLND QEKIIIEINN SLAEKSRENS 

       970        980        990       1000       1010       1020 
ELQYTFTEAT TRLNSELKTL QEDNYELEME KSKLQTRLQE IQAETESELA KALEARNYEM 

      1030       1040       1050       1060       1070       1080 
QKLQNQIVEL TVKWEREHGD LQTSLAKIEA LEDCLKAVGK DAIHNVQELI TSAKTRGELN 

      1090       1100       1110       1120       1130       1140 
AVHKKLVELQ SKVEQEEAHK QRLESQLQQS SQDVEQLKQD FNQSERDKLE AQTRLEVLSG 

      1150       1160       1170       1180       1190       1200 
YFREKENDLK KELSLQETKW LQHQGENAST VETQTLMKNE IQTLKSQNDE LRAEIEAQIA 

      1210       1220       1230       1240       1250       1260 
SHKAQMGTLE NRAHESWLAA RQSERRCEEA LAEAASLRRK LTTMASGGGG VGGDPGVMEA 

      1270       1280       1290       1300       1310       1320 
IAANGTSVLG AELKTAPSPL PLPGSPLLNM PNPLPFLAAP FSPFMGLPPP FLPPTGAGGA 

      1330       1340       1350       1360       1370       1380 
RPPPLGRMRS PPPSSRGDRD RERYSDYSDY DDYDDDEEDD RGMDRRRRHS GSWGRRHRGS 

      1390       1400       1410       1420       1430 
YSHSPRTYRS LSPSDSRYNY NDTETDFSPP PSPPPVPSGR SATSRPYSEV 

« Hide

Isoform B [UniParc].

Checksum: 5843F0540EEA9511
Show »

FASTA1,257139,137

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: Berkeley.
Tissue: Head.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-1430 (ISOFORM B).
Strain: Berkeley.
Tissue: Embryo.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-865; SER-868; SER-1345; SER-1348; SER-1390 AND SER-1392, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
[6]"Functional genomics reveals genes involved in protein secretion and Golgi organization."
Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H., Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.
Nature 439:604-607(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014134 Genomic DNA. Translation: AAF52414.2.
AE014134 Genomic DNA. Translation: AAF52413.2.
BT003314 mRNA. Translation: AAO25074.1.
AY075391 mRNA. Translation: AAL68225.1. Sequence problems.
RefSeqNP_609058.2. NM_135214.4.
NP_723198.2. NM_164697.3.
UniGeneDm.330.

3D structure databases

ProteinModelPortalQ9VMA7.
SMRQ9VMA7. Positions 36-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0078925.

Proteomic databases

PaxDbQ9VMA7.
PRIDEQ9VMA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0079295; FBpp0078925; FBgn0031842. [Q9VMA7-1]
FBtr0303224; FBpp0292316; FBgn0031842. [Q9VMA7-1]
GeneID33930.
KEGGdme:Dmel_CG11098.
UCSCCG11098-RA. d. melanogaster. [Q9VMA7-1]

Organism-specific databases

CTD33930.
FlyBaseFBgn0031842. Tango1.

Phylogenomic databases

eggNOGNOG133684.
GeneTreeENSGT00530000063635.
InParanoidQ9VMA7.
OMAQASETEH.
OrthoDBEOG7X3QQS.
PhylomeDBQ9VMA7.

Gene expression databases

BgeeQ9VMA7.

Family and domain databases

InterProIPR001452. SH3_domain.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi33930.
NextBio785974.

Entry information

Entry nameTGO1_DROME
AccessionPrimary (citable) accession number: Q9VMA7
Secondary accession number(s): Q8SY42, Q9VMA8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase