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Q9VMA7

- TGO1_DROME

UniProt

Q9VMA7 - TGO1_DROME

Protein

Transport and Golgi organization protein 1

Gene

Tango1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier.1 Publication

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. Golgi organization Source: FlyBase
    3. protein secretion Source: UniProtKB

    Keywords - Biological processi

    ER-Golgi transport, Exocytosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transport and Golgi organization protein 1
    Gene namesi
    Name:Tango1
    ORF Names:CG11098
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0031842. Tango1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum exit site Source: FlyBase
    2. Golgi apparatus Source: FlyBase
    3. Golgi cis cisterna Source: FlyBase
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 14301396Transport and Golgi organization protein 1PRO_0000370510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei865 – 8651Phosphoserine1 Publication
    Modified residuei868 – 8681Phosphoserine1 Publication
    Modified residuei1345 – 13451Phosphoserine1 Publication
    Modified residuei1348 – 13481Phosphoserine1 Publication
    Modified residuei1390 – 13901Phosphoserine1 Publication
    Modified residuei1392 – 13921Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9VMA7.
    PRIDEiQ9VMA7.

    Expressioni

    Gene expression databases

    BgeeiQ9VMA7.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0078925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VMA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 796762ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini818 – 1430613CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei797 – 81721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 11159SH3Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili494 – 620127Sequence AnalysisAdd
    BLAST
    Coiled coili869 – 1245377Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi161 – 1644Poly-Thr
    Compositional biasi630 – 6334Poly-His
    Compositional biasi1247 – 12537Poly-Gly
    Compositional biasi1277 – 133357Pro-richAdd
    BLAST
    Compositional biasi1365 – 13684Poly-Arg

    Sequence similaritiesi

    Belongs to the MIA/OTOR family. Tango1 subfamily.Curated
    Contains 1 SH3 domain.Curated

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG133684.
    GeneTreeiENSGT00530000063635.
    InParanoidiQ9VMA7.
    OMAiQASETEH.
    OrthoDBiEOG7X3QQS.
    PhylomeDBiQ9VMA7.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VMA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLTNEKATM QPQLSDLALV LGLLICCLPT LTWAATLSDK RLCADPKCEQ     50
    IISMGIAKIT YAIGGEGLIS FKINSPIRVL SKSAGSNMQL WGVDINGRRG 100
    YANKDFIMEK KILVRDKDLL YEVPVVGPGS PVQSVETPVQ SVETTVQPVL 150
    NASESTDDLA TTTTSPLEIA VDSIVVEHDK LQDQQVPDPT AASKAQVQVI 200
    EGTELPLEAI AATTEGSIVP ETAADPQEAT NLDSTVVDTK EPQALNSEAI 250
    KLQEEPKAQQ PATEAEKPPP LPQAINAELE DADDFDYGDD ETDDDSQQGS 300
    QDNESIVEIA NDNKSINESI ELKPLSVAQL KKTDKVEDSK DETKEKHAEM 350
    EVSKQEDSSL PTETLNVTAL EEQIDQKEFP KQVLDAAVEL KSSDPLPVEE 400
    VTETVAEPPR TIVEDKINEE IVPVSAKIQA KPATVNPTEP IVAQSDAEIK 450
    APSESVISST TPAPVVEEAP QKADPVGLPP LFEKKNFENP NNYYKQLQEE 500
    QEKQRLVAEA EEQKRLQEEA DQQKRLQEEA ALNKRLLEEA EQQKRLQEEA 550
    EQQKRLQEEA ELNKRLLEEA EKQKRLHEES EQLQRSSEEA EPQLSVQEAN 600
    MQQLNDSVDS QSNEIVDNNN RQQPEQYQQH HHHTESAFNH PSTASHTTPT 650
    PDAESPYAAV QEETTEASQT DNHREGVGYV EPVALPATAS PVSEVPIKED 700
    AAGFGLFATI VDTVNNFIGK DPQSDPADSS DELHRILYPG RPEVPPSQRK 750
    AEDFAPADVD GYCARFQAKD EHCHRSISLD NFVEVMADKL VDHSQLLLCV 800
    VIAAISSLFF MFAYYCFCNS SQEGALLSKL NHLERSLLAS HKENLIIKHD 850
    LMTTRTKLAS IEDNSFGSND MVADLKKQLE SELYEKAKLQ EQVGSLERDL 900
    DNAAEAGLEL NKMLSEVLNG QNGDEAFMST VDELQRQLND QEKIIIEINN 950
    SLAEKSRENS ELQYTFTEAT TRLNSELKTL QEDNYELEME KSKLQTRLQE 1000
    IQAETESELA KALEARNYEM QKLQNQIVEL TVKWEREHGD LQTSLAKIEA 1050
    LEDCLKAVGK DAIHNVQELI TSAKTRGELN AVHKKLVELQ SKVEQEEAHK 1100
    QRLESQLQQS SQDVEQLKQD FNQSERDKLE AQTRLEVLSG YFREKENDLK 1150
    KELSLQETKW LQHQGENAST VETQTLMKNE IQTLKSQNDE LRAEIEAQIA 1200
    SHKAQMGTLE NRAHESWLAA RQSERRCEEA LAEAASLRRK LTTMASGGGG 1250
    VGGDPGVMEA IAANGTSVLG AELKTAPSPL PLPGSPLLNM PNPLPFLAAP 1300
    FSPFMGLPPP FLPPTGAGGA RPPPLGRMRS PPPSSRGDRD RERYSDYSDY 1350
    DDYDDDEEDD RGMDRRRRHS GSWGRRHRGS YSHSPRTYRS LSPSDSRYNY 1400
    NDTETDFSPP PSPPPVPSGR SATSRPYSEV 1430
    Length:1,430
    Mass (Da):159,052
    Last modified:October 1, 2002 - v2
    Checksum:iFCF9988A95979349
    GO

    Sequence cautioni

    The sequence AAL68225.1 differs from that shown. Reason: Deletion of 12 residues at position 1268 causing a frameshift.
    The sequence AAL68225.1 differs from that shown. Reason: Deletion of 172 residues at position 924.
    The sequence AAL68225.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52414.2.
    AE014134 Genomic DNA. Translation: AAF52413.3.
    BT003314 mRNA. Translation: AAO25074.1.
    AY075391 mRNA. Translation: AAL68225.1. Sequence problems.
    RefSeqiNP_609058.2. NM_135214.4.
    NP_723198.2. NM_164697.3.
    UniGeneiDm.330.

    Genome annotation databases

    EnsemblMetazoaiFBtr0079295; FBpp0078925; FBgn0031842.
    FBtr0303224; FBpp0292316; FBgn0031842.
    GeneIDi33930.
    KEGGidme:Dmel_CG11098.
    UCSCiCG11098-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52414.2 .
    AE014134 Genomic DNA. Translation: AAF52413.3 .
    BT003314 mRNA. Translation: AAO25074.1 .
    AY075391 mRNA. Translation: AAL68225.1 . Sequence problems.
    RefSeqi NP_609058.2. NM_135214.4.
    NP_723198.2. NM_164697.3.
    UniGenei Dm.330.

    3D structure databases

    ProteinModelPortali Q9VMA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0078925.

    Proteomic databases

    PaxDbi Q9VMA7.
    PRIDEi Q9VMA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0079295 ; FBpp0078925 ; FBgn0031842 .
    FBtr0303224 ; FBpp0292316 ; FBgn0031842 .
    GeneIDi 33930.
    KEGGi dme:Dmel_CG11098.
    UCSCi CG11098-RA. d. melanogaster.

    Organism-specific databases

    CTDi 33930.
    FlyBasei FBgn0031842. Tango1.

    Phylogenomic databases

    eggNOGi NOG133684.
    GeneTreei ENSGT00530000063635.
    InParanoidi Q9VMA7.
    OMAi QASETEH.
    OrthoDBi EOG7X3QQS.
    PhylomeDBi Q9VMA7.

    Miscellaneous databases

    GenomeRNAii 33930.
    NextBioi 785974.

    Gene expression databases

    Bgeei Q9VMA7.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-1430.
      Strain: Berkeley.
      Tissue: Embryo.
    5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-865; SER-868; SER-1345; SER-1348; SER-1390 AND SER-1392, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.
    6. "Functional genomics reveals genes involved in protein secretion and Golgi organization."
      Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H., Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.
      Nature 439:604-607(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTGO1_DROME
    AccessioniPrimary (citable) accession number: Q9VMA7
    Secondary accession number(s): Q8SY42, Q9VMA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3