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Protein

Transport and Golgi organization protein 1

Gene

Tango1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier.1 Publication

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • Golgi organization Source: FlyBase
  • positive regulation of secretion Source: FlyBase
  • protein secretion Source: UniProtKB
  • secretory granule organization Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 1
Gene namesi
Name:Tango1
ORF Names:CG11098
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031842. Tango1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 796762ExtracellularSequence AnalysisAdd
BLAST
Transmembranei797 – 81721HelicalSequence AnalysisAdd
BLAST
Topological domaini818 – 1430613CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum exit site Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • Golgi cis cisterna Source: FlyBase
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 14301396Transport and Golgi organization protein 1PRO_0000370510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei865 – 8651Phosphoserine1 Publication
Modified residuei868 – 8681Phosphoserine1 Publication
Modified residuei1345 – 13451Phosphoserine1 Publication
Modified residuei1348 – 13481Phosphoserine1 Publication
Modified residuei1390 – 13901Phosphoserine1 Publication
Modified residuei1392 – 13921Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VMA7.
PRIDEiQ9VMA7.

Expressioni

Gene expression databases

BgeeiQ9VMA7.
GenevisibleiQ9VMA7. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VMA7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9VMA7.
SMRiQ9VMA7. Positions 54-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 11159SH3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili494 – 620127Sequence AnalysisAdd
BLAST
Coiled coili869 – 1245377Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi161 – 1644Poly-Thr
Compositional biasi630 – 6334Poly-His
Compositional biasi1247 – 12537Poly-Gly
Compositional biasi1277 – 133357Pro-richAdd
BLAST
Compositional biasi1365 – 13684Poly-Arg

Sequence similaritiesi

Belongs to the MIA/OTOR family. Tango1 subfamily.Curated
Contains 1 SH3 domain.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133684.
GeneTreeiENSGT00530000063635.
InParanoidiQ9VMA7.
OMAiFNQSERD.
OrthoDBiEOG7X3QQS.
PhylomeDBiQ9VMA7.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VMA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTNEKATM QPQLSDLALV LGLLICCLPT LTWAATLSDK RLCADPKCEQ
60 70 80 90 100
IISMGIAKIT YAIGGEGLIS FKINSPIRVL SKSAGSNMQL WGVDINGRRG
110 120 130 140 150
YANKDFIMEK KILVRDKDLL YEVPVVGPGS PVQSVETPVQ SVETTVQPVL
160 170 180 190 200
NASESTDDLA TTTTSPLEIA VDSIVVEHDK LQDQQVPDPT AASKAQVQVI
210 220 230 240 250
EGTELPLEAI AATTEGSIVP ETAADPQEAT NLDSTVVDTK EPQALNSEAI
260 270 280 290 300
KLQEEPKAQQ PATEAEKPPP LPQAINAELE DADDFDYGDD ETDDDSQQGS
310 320 330 340 350
QDNESIVEIA NDNKSINESI ELKPLSVAQL KKTDKVEDSK DETKEKHAEM
360 370 380 390 400
EVSKQEDSSL PTETLNVTAL EEQIDQKEFP KQVLDAAVEL KSSDPLPVEE
410 420 430 440 450
VTETVAEPPR TIVEDKINEE IVPVSAKIQA KPATVNPTEP IVAQSDAEIK
460 470 480 490 500
APSESVISST TPAPVVEEAP QKADPVGLPP LFEKKNFENP NNYYKQLQEE
510 520 530 540 550
QEKQRLVAEA EEQKRLQEEA DQQKRLQEEA ALNKRLLEEA EQQKRLQEEA
560 570 580 590 600
EQQKRLQEEA ELNKRLLEEA EKQKRLHEES EQLQRSSEEA EPQLSVQEAN
610 620 630 640 650
MQQLNDSVDS QSNEIVDNNN RQQPEQYQQH HHHTESAFNH PSTASHTTPT
660 670 680 690 700
PDAESPYAAV QEETTEASQT DNHREGVGYV EPVALPATAS PVSEVPIKED
710 720 730 740 750
AAGFGLFATI VDTVNNFIGK DPQSDPADSS DELHRILYPG RPEVPPSQRK
760 770 780 790 800
AEDFAPADVD GYCARFQAKD EHCHRSISLD NFVEVMADKL VDHSQLLLCV
810 820 830 840 850
VIAAISSLFF MFAYYCFCNS SQEGALLSKL NHLERSLLAS HKENLIIKHD
860 870 880 890 900
LMTTRTKLAS IEDNSFGSND MVADLKKQLE SELYEKAKLQ EQVGSLERDL
910 920 930 940 950
DNAAEAGLEL NKMLSEVLNG QNGDEAFMST VDELQRQLND QEKIIIEINN
960 970 980 990 1000
SLAEKSRENS ELQYTFTEAT TRLNSELKTL QEDNYELEME KSKLQTRLQE
1010 1020 1030 1040 1050
IQAETESELA KALEARNYEM QKLQNQIVEL TVKWEREHGD LQTSLAKIEA
1060 1070 1080 1090 1100
LEDCLKAVGK DAIHNVQELI TSAKTRGELN AVHKKLVELQ SKVEQEEAHK
1110 1120 1130 1140 1150
QRLESQLQQS SQDVEQLKQD FNQSERDKLE AQTRLEVLSG YFREKENDLK
1160 1170 1180 1190 1200
KELSLQETKW LQHQGENAST VETQTLMKNE IQTLKSQNDE LRAEIEAQIA
1210 1220 1230 1240 1250
SHKAQMGTLE NRAHESWLAA RQSERRCEEA LAEAASLRRK LTTMASGGGG
1260 1270 1280 1290 1300
VGGDPGVMEA IAANGTSVLG AELKTAPSPL PLPGSPLLNM PNPLPFLAAP
1310 1320 1330 1340 1350
FSPFMGLPPP FLPPTGAGGA RPPPLGRMRS PPPSSRGDRD RERYSDYSDY
1360 1370 1380 1390 1400
DDYDDDEEDD RGMDRRRRHS GSWGRRHRGS YSHSPRTYRS LSPSDSRYNY
1410 1420 1430
NDTETDFSPP PSPPPVPSGR SATSRPYSEV
Length:1,430
Mass (Da):159,052
Last modified:October 1, 2002 - v2
Checksum:iFCF9988A95979349
GO

Sequence cautioni

The sequence AAL68225.1 differs from that shown.Deletion of 12 residues at position 1268 causing a frameshift.Curated
The sequence AAL68225.1 differs from that shown.Deletion of 172 residues at position 924.Curated
The sequence AAL68225.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52414.2.
AE014134 Genomic DNA. Translation: AAF52413.3.
BT003314 mRNA. Translation: AAO25074.1.
AY075391 mRNA. Translation: AAL68225.1. Sequence problems.
RefSeqiNP_609058.2. NM_135214.4.
NP_723198.2. NM_164697.3.
UniGeneiDm.330.

Genome annotation databases

EnsemblMetazoaiFBtr0079295; FBpp0078925; FBgn0031842.
FBtr0303224; FBpp0292316; FBgn0031842.
GeneIDi33930.
UCSCiCG11098-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52414.2.
AE014134 Genomic DNA. Translation: AAF52413.3.
BT003314 mRNA. Translation: AAO25074.1.
AY075391 mRNA. Translation: AAL68225.1. Sequence problems.
RefSeqiNP_609058.2. NM_135214.4.
NP_723198.2. NM_164697.3.
UniGeneiDm.330.

3D structure databases

ProteinModelPortaliQ9VMA7.
SMRiQ9VMA7. Positions 54-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VMA7. 1 interaction.

Proteomic databases

PaxDbiQ9VMA7.
PRIDEiQ9VMA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079295; FBpp0078925; FBgn0031842.
FBtr0303224; FBpp0292316; FBgn0031842.
GeneIDi33930.
UCSCiCG11098-RA. d. melanogaster.

Organism-specific databases

CTDi33930.
FlyBaseiFBgn0031842. Tango1.

Phylogenomic databases

eggNOGiNOG133684.
GeneTreeiENSGT00530000063635.
InParanoidiQ9VMA7.
OMAiFNQSERD.
OrthoDBiEOG7X3QQS.
PhylomeDBiQ9VMA7.

Miscellaneous databases

GenomeRNAii33930.
NextBioi785974.
PROiQ9VMA7.

Gene expression databases

BgeeiQ9VMA7.
GenevisibleiQ9VMA7. DM.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-1430.
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-865; SER-868; SER-1345; SER-1348; SER-1390 AND SER-1392, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.
  6. "Functional genomics reveals genes involved in protein secretion and Golgi organization."
    Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H., Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.
    Nature 439:604-607(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTGO1_DROME
AccessioniPrimary (citable) accession number: Q9VMA7
Secondary accession number(s): Q8SY42, Q9VMA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.