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Q9VMA7

- TGO1_DROME

UniProt

Q9VMA7 - TGO1_DROME

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Protein
Transport and Golgi organization protein 1
Gene
Tango1, CG11098
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier.1 Publication

GO - Biological processi

  1. Golgi organization Source: FlyBase
  2. exocytosis Source: UniProtKB-KW
  3. protein secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 1
Gene namesi
Name:Tango1
ORF Names:CG11098
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031842. Tango1.

Subcellular locationi

Golgi apparatus membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 796762Extracellular Reviewed prediction
Add
BLAST
Transmembranei797 – 81721Helical; Reviewed prediction
Add
BLAST
Topological domaini818 – 1430613Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: FlyBase
  2. Golgi cis cisterna Source: FlyBase
  3. Golgi membrane Source: UniProtKB-SubCell
  4. endoplasmic reticulum exit site Source: FlyBase
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 14301396Transport and Golgi organization protein 1
PRO_0000370510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei865 – 8651Phosphoserine1 Publication
Modified residuei868 – 8681Phosphoserine1 Publication
Modified residuei1345 – 13451Phosphoserine1 Publication
Modified residuei1348 – 13481Phosphoserine1 Publication
Modified residuei1390 – 13901Phosphoserine1 Publication
Modified residuei1392 – 13921Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VMA7.
PRIDEiQ9VMA7.

Expressioni

Gene expression databases

BgeeiQ9VMA7.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0078925.

Structurei

3D structure databases

ProteinModelPortaliQ9VMA7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 11159SH3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili494 – 620127 Reviewed prediction
Add
BLAST
Coiled coili869 – 1245377 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi161 – 1644Poly-Thr
Compositional biasi630 – 6334Poly-His
Compositional biasi1247 – 12537Poly-Gly
Compositional biasi1277 – 133357Pro-rich
Add
BLAST
Compositional biasi1365 – 13684Poly-Arg

Sequence similaritiesi

Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133684.
GeneTreeiENSGT00530000063635.
InParanoidiQ9VMA7.
OMAiQASETEH.
OrthoDBiEOG7X3QQS.
PhylomeDBiQ9VMA7.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VMA7-1 [UniParc]FASTAAdd to Basket

« Hide

MRLTNEKATM QPQLSDLALV LGLLICCLPT LTWAATLSDK RLCADPKCEQ     50
IISMGIAKIT YAIGGEGLIS FKINSPIRVL SKSAGSNMQL WGVDINGRRG 100
YANKDFIMEK KILVRDKDLL YEVPVVGPGS PVQSVETPVQ SVETTVQPVL 150
NASESTDDLA TTTTSPLEIA VDSIVVEHDK LQDQQVPDPT AASKAQVQVI 200
EGTELPLEAI AATTEGSIVP ETAADPQEAT NLDSTVVDTK EPQALNSEAI 250
KLQEEPKAQQ PATEAEKPPP LPQAINAELE DADDFDYGDD ETDDDSQQGS 300
QDNESIVEIA NDNKSINESI ELKPLSVAQL KKTDKVEDSK DETKEKHAEM 350
EVSKQEDSSL PTETLNVTAL EEQIDQKEFP KQVLDAAVEL KSSDPLPVEE 400
VTETVAEPPR TIVEDKINEE IVPVSAKIQA KPATVNPTEP IVAQSDAEIK 450
APSESVISST TPAPVVEEAP QKADPVGLPP LFEKKNFENP NNYYKQLQEE 500
QEKQRLVAEA EEQKRLQEEA DQQKRLQEEA ALNKRLLEEA EQQKRLQEEA 550
EQQKRLQEEA ELNKRLLEEA EKQKRLHEES EQLQRSSEEA EPQLSVQEAN 600
MQQLNDSVDS QSNEIVDNNN RQQPEQYQQH HHHTESAFNH PSTASHTTPT 650
PDAESPYAAV QEETTEASQT DNHREGVGYV EPVALPATAS PVSEVPIKED 700
AAGFGLFATI VDTVNNFIGK DPQSDPADSS DELHRILYPG RPEVPPSQRK 750
AEDFAPADVD GYCARFQAKD EHCHRSISLD NFVEVMADKL VDHSQLLLCV 800
VIAAISSLFF MFAYYCFCNS SQEGALLSKL NHLERSLLAS HKENLIIKHD 850
LMTTRTKLAS IEDNSFGSND MVADLKKQLE SELYEKAKLQ EQVGSLERDL 900
DNAAEAGLEL NKMLSEVLNG QNGDEAFMST VDELQRQLND QEKIIIEINN 950
SLAEKSRENS ELQYTFTEAT TRLNSELKTL QEDNYELEME KSKLQTRLQE 1000
IQAETESELA KALEARNYEM QKLQNQIVEL TVKWEREHGD LQTSLAKIEA 1050
LEDCLKAVGK DAIHNVQELI TSAKTRGELN AVHKKLVELQ SKVEQEEAHK 1100
QRLESQLQQS SQDVEQLKQD FNQSERDKLE AQTRLEVLSG YFREKENDLK 1150
KELSLQETKW LQHQGENAST VETQTLMKNE IQTLKSQNDE LRAEIEAQIA 1200
SHKAQMGTLE NRAHESWLAA RQSERRCEEA LAEAASLRRK LTTMASGGGG 1250
VGGDPGVMEA IAANGTSVLG AELKTAPSPL PLPGSPLLNM PNPLPFLAAP 1300
FSPFMGLPPP FLPPTGAGGA RPPPLGRMRS PPPSSRGDRD RERYSDYSDY 1350
DDYDDDEEDD RGMDRRRRHS GSWGRRHRGS YSHSPRTYRS LSPSDSRYNY 1400
NDTETDFSPP PSPPPVPSGR SATSRPYSEV 1430
Length:1,430
Mass (Da):159,052
Last modified:October 1, 2002 - v2
Checksum:iFCF9988A95979349
GO

Sequence cautioni

The sequence AAL68225.1 differs from that shown. Reason: Deletion of 12 residues at position 1268 causing a frameshift.
The sequence AAL68225.1 differs from that shown. Reason: Deletion of 172 residues at position 924.
The sequence AAL68225.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF52414.2.
AE014134 Genomic DNA. Translation: AAF52413.3.
BT003314 mRNA. Translation: AAO25074.1.
AY075391 mRNA. Translation: AAL68225.1. Sequence problems.
RefSeqiNP_609058.2. NM_135214.4.
NP_723198.2. NM_164697.3.
UniGeneiDm.330.

Genome annotation databases

EnsemblMetazoaiFBtr0079295; FBpp0078925; FBgn0031842.
FBtr0303224; FBpp0292316; FBgn0031842.
GeneIDi33930.
KEGGidme:Dmel_CG11098.
UCSCiCG11098-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF52414.2 .
AE014134 Genomic DNA. Translation: AAF52413.3 .
BT003314 mRNA. Translation: AAO25074.1 .
AY075391 mRNA. Translation: AAL68225.1 . Sequence problems.
RefSeqi NP_609058.2. NM_135214.4.
NP_723198.2. NM_164697.3.
UniGenei Dm.330.

3D structure databases

ProteinModelPortali Q9VMA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0078925.

Proteomic databases

PaxDbi Q9VMA7.
PRIDEi Q9VMA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0079295 ; FBpp0078925 ; FBgn0031842 .
FBtr0303224 ; FBpp0292316 ; FBgn0031842 .
GeneIDi 33930.
KEGGi dme:Dmel_CG11098.
UCSCi CG11098-RA. d. melanogaster.

Organism-specific databases

CTDi 33930.
FlyBasei FBgn0031842. Tango1.

Phylogenomic databases

eggNOGi NOG133684.
GeneTreei ENSGT00530000063635.
InParanoidi Q9VMA7.
OMAi QASETEH.
OrthoDBi EOG7X3QQS.
PhylomeDBi Q9VMA7.

Miscellaneous databases

GenomeRNAii 33930.
NextBioi 785974.

Gene expression databases

Bgeei Q9VMA7.

Family and domain databases

InterProi IPR001452. SH3_domain.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 472-1430.
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-865; SER-868; SER-1345; SER-1348; SER-1390 AND SER-1392, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.
  6. "Functional genomics reveals genes involved in protein secretion and Golgi organization."
    Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H., Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V.
    Nature 439:604-607(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTGO1_DROME
AccessioniPrimary (citable) accession number: Q9VMA7
Secondary accession number(s): Q8SY42, Q9VMA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi