Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9VMA2 (GALT_DROME)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Probable galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene names
ORF Names: CG9232
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Catalytic activity

UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.

Cofactor

Binds 1 iron ion per subunit Potential.

Binds 1 zinc ion per subunit Potential.

Pathway

Carbohydrate metabolism; galactose metabolism.

Sequence similarities

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9VM921EBI-92316,EBI-137205

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Probable galactose-1-phosphate uridylyltransferase
PRO_0000169886

Sites

Active site1651Tele-UMP-histidine intermediate By similarity
Metal binding541Zinc Potential
Metal binding1631Zinc Potential
Metal binding2801Iron Potential
Metal binding2991Iron Potential

Experimental info

Sequence conflict3051P → T in AAL90262. Ref.3

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9VMA2-1 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: C946229E44C2B6AD

FASTA35040,447
        10         20         30         40         50         60 
MQFVASEHPH RRLNPLNGQW VLVCPHRTQR PWSGQQEKAQ KNELPEFDPT NPLCPGVTRP 

        70         80         90        100        110        120 
NGIQTPEYES TYVFENDFPA LVEVVPVPPN NDDPLFQIAP ARGNCRVMCF HPKSNLTLPT 

       130        140        150        160        170        180 
MSAAEIVVVI DEWISQFNEL SAKYAWVQIF ENKGAAMGCS NPHPHCQIWS CSFLPTEPQL 

       190        200        210        220        230        240 
KQERLRAYYA TNERPMLADY VERELQRQER IVIENRDWLV VVPFWATWPF ETMLISRNNN 

       250        260        270        280        290        300 
KRINDLTAEQ RYNLALTIKE LTTKYDNLFQ CSFPYSMGWH GAPTGPEHAH ASSAHWTLHA 

       310        320        330        340        350 
IYYPPLLRSA SVRKFMVGFE LLAMAQRDLT PEQAAQRLRE VDGKCHYLEK

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[4]Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AE014134 Genomic DNA. Translation: AAF52419.2.
AY089524 mRNA. Translation: AAL90262.1.
BT058003 mRNA. Translation: ACM16713.1.
RefSeqNP_609062.2.
UniGeneDm.332

3D structure databases

HSSPHSSP built from PDB template 1HXP based on UniProtKB P09148.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:18538N.
IntActQ9VMA2. 5 interactions.
STRINGQ9VMA2.

Genome annotation databases

EnsemblFBtr0079322; FBpp0078951; FBgn0031845; Drosophila melanogaster. [Genome view]
GeneID33935.
KEGGdme:Dmel_CG9232.
NMPDRfig|7227.3.peg.1101.
UCSCCG9232-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0031845. CG9232.

Phylogenomic databases

HOGENOMQ9VMA2.
OMAFEMLGEP.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-007694-MON.
BRENDA2.7.7.12. 48.

Gene expression databases

ArrayExpressQ9VMA2.
BgeeQ9VMA2.
GermOnlineCG9232. Drosophila melanogaster.

Family and domain databases

InterProIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011151. His_triad_motif.
[Graphical view]
Gene3DG3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHERPTHR11943. GalP_UDPtransf1. 1 hit.
PfamPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000808. GalT. 1 hit.
ProDomPD005051. GalP_Utransf. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00209. galT_1. 1 hit.
PROSITEPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio786001.

Hide | Top

Entry information

Entry nameGALT_DROME
AccessionPrimary (citable) accession number: Q9VMA2
Secondary accession number(s): B9EQS8, Q8SXN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2001
Last modified: November 3, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents