Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Aatf

Gene

Aatf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a general inhibitor of the histone deacetylase HDAC1.By similarity

GO - Biological processi

  • negative regulation of programmed cell death Source: FlyBase
  • neurogenesis Source: FlyBase
  • oogenesis Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Aatf
Alternative name(s):
Apoptosis antagonizing transcription factor ortholog
Gene namesi
Name:Aatf
ORF Names:CG11188
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031851. Aatf.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: FlyBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Protein AatfPRO_0000056620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Phosphoserine1 Publication
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei32 – 321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VM95.
PRIDEiQ9VM95.

PTM databases

iPTMnetiQ9VM95.

Expressioni

Gene expression databases

BgeeiFBgn0031851.
GenevisibleiQ9VM95. DM.

Interactioni

Protein-protein interaction databases

BioGridi60096. 7 interactions.
IntActiQ9VM95. 5 interactions.
MINTiMINT-282020.
STRINGi7227.FBpp0078929.

Family & Domainsi

Sequence similaritiesi

Belongs to the AATF family.Curated

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
InParanoidiQ9VM95.
KOiK14782.
OMAiQLHPPDE.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9VM95.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VM95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKSKKQPQ TVAEKVSKLL AHPNESDSAE DSDFDVATGP RLVDFEEEEY
60 70 80 90 100
DLPDARSTDF RKRNVKLLSE QSDRYKGKIS SRKELDDDED KDDEQEVSYE
110 120 130 140 150
ESDEDDENLT NFKQKLNAGG AEDSEEETAA GHSESGEESE EIESNLTDFK
160 170 180 190 200
KKFEAGDFKY DDDEEEDDDS EEEDHSQESE GDDDDSEDDE AEDDAIKPSD
210 220 230 240 250
VMSKTNHQAE IQKGLAVQNQ LRIWERLLEL RINTQKFTSK ANQLPAPETL
260 270 280 290 300
TKLASESDEL QSVLNEAQER SSKLLQQLLS LQSALHQQYS EMKKSVKRKQ
310 320 330 340 350
PTEDSGPAVK KFGSVLQSNF QQMIGYRNEV LLKWDDRTKL LTPGAGVKRK
360 370 380 390 400
SLQEDYDIIK KIGSALANRE ALVEKSQTPK NSQAEQQENT PVQRLKHIYD
410 420 430 440 450
DSDFYHQQLR ELIEYKASTS SNMSEITKQF VELQKLRQKM KKKVDTRASK
460 470 480
GRKLRYVVHN KLINFMAPNE SSDWTDASKS ELYKSLFV
Length:488
Mass (Da):55,953
Last modified:May 1, 2000 - v1
Checksum:iA7E5FE36967E38A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52427.1.
AY071275 mRNA. Translation: AAL48897.1.
RefSeqiNP_609066.1. NM_135222.3.
UniGeneiDm.6016.

Genome annotation databases

EnsemblMetazoaiFBtr0079299; FBpp0078929; FBgn0031851.
GeneIDi33943.
KEGGidme:Dmel_CG11188.
UCSCiCG11188-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52427.1.
AY071275 mRNA. Translation: AAL48897.1.
RefSeqiNP_609066.1. NM_135222.3.
UniGeneiDm.6016.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60096. 7 interactions.
IntActiQ9VM95. 5 interactions.
MINTiMINT-282020.
STRINGi7227.FBpp0078929.

PTM databases

iPTMnetiQ9VM95.

Proteomic databases

PaxDbiQ9VM95.
PRIDEiQ9VM95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079299; FBpp0078929; FBgn0031851.
GeneIDi33943.
KEGGidme:Dmel_CG11188.
UCSCiCG11188-RA. d. melanogaster.

Organism-specific databases

CTDi26574.
FlyBaseiFBgn0031851. Aatf.

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
InParanoidiQ9VM95.
KOiK14782.
OMAiQLHPPDE.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9VM95.

Miscellaneous databases

GenomeRNAii33943.
PROiQ9VM95.

Gene expression databases

BgeeiFBgn0031851.
GenevisibleiQ9VM95. DM.

Family and domain databases

InterProiIPR025160. AATF.
IPR012617. AATF_C.
[Graphical view]
PfamiPF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAATF_DROME
AccessioniPrimary (citable) accession number: Q9VM95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.