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Q9VM92 (TTL3B_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tubulin glycylase 3B

Short name=dmTTLL3B
EC=6.3.2.-
Gene names
Name:TTLL3B
ORF Names:CG11201
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis. Ref.4

Subcellular location

Cytoplasmcytoskeleton. Nucleus Ref.4.

Sequence similarities

Contains 1 TTL domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 756756Tubulin glycylase 3B
PRO_0000381796

Regions

Domain272 – 629358TTL
Compositional bias711 – 7144Poly-Lys

Sequences

Sequence LengthMass (Da)Tools
Q9VM92 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 62BD02138F624E27

FASTA75686,109
        10         20         30         40         50         60 
MTTQNTTPAG FTGNRNRYYN PVSKIQSLIH NLDAELVQLC KQCSVQKPLT SLNNSTSLGS 

        70         80         90        100        110        120 
HFSNFGALGG GSGSKTMGGS SSMGSNNFSP DSIGNLLARV RASTPLPRTV TSSPTAPEAQ 

       130        140        150        160        170        180 
KRQMRNVYRT RVIDAYRNRR IFTVYGNYHT VRRALMRRGW LEKLPASRHA KLQSMSEDAL 

       190        200        210        220        230        240 
LEHARRGNDY EAVVISKMIN HFPAFFIWQG KGQRDLCAEV RPFRNRVRRS QFLDFSTKVG 

       250        260        270        280        290        300 
LVGCAEQERW YREDGVCGMS YPRFYRLGGN NLEERMAFIE DYQQTQARSL LLYVREHQPA 

       310        320        330        340        350        360 
ELISENGTIF STTLDFALGK VKKMVRHAEH YSLDDARIKP PTPAEIVENQ TFMVQSTDVL 

       370        380        390        400        410        420 
KSNAKFKVSE KVMAEYARLA GLYLDQIESL RPDYRWDGSR NLWILKPGYQ SRGIGIVIRS 

       430        440        450        460        470        480 
SLDDILQWTS NNQNKKYIVQ KYIERPLLIY RTKFDIRQYM LLTITDTKVS IWTYRDCYLR 

       490        500        510        520        530        540 
FSSQEFTMDD LRESIHLTNN SVQKRYKNKT NRDSRLPKNN MWSLDQFKNY LRIMGAPDGS 

       550        560        570        580        590        600 
WSKTYNGFKQ NLVAVVMASL DETELLQNAF ELYGCDFMLD EHYNPILIEI NSTPDLSPST 

       610        620        630        640        650        660 
EITARICPMV LKDCIRVVVD LPKNPTAATG LFELAFEVNY SINKGADGKP LELNGKQMTL 

       670        680        690        700        710        720 
FENMPRMRNS PRTRLLRKIL NNVKTSTTKK VEKVVEAPAK NVKNPTAKIT KKKKLSASAG 

       730        740        750 
SSTAASAQPS TQNLTTKLIL NPATRENLAL QYTAPK 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[4]"Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."
Rogowski K., Juge F., van Dijk J., Wloga D., Strub J.-M., Levilliers N., Thomas D., Bre M.-H., Van Dorsselaer A., Gaertig J., Janke C.
Cell 137:1076-1087(2009) [PubMed: 19524510] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014134 Genomic DNA. Translation: AAF52431.2.
BT021443 mRNA. Translation: AAX33591.1.
RefSeqNP_609068.2. NM_135224.2.
UniGeneDm.18758.

3D structure databases

ProteinModelPortalQ9VM92.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9VM92. 1 interaction.
MINTMINT-777438.
STRINGQ9VM92.

Proteomic databases

PRIDEQ9VM92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0300056; FBpp0289333; FBgn0031853.
GeneID33946.
KEGGdme:Dmel_CG11201.
UCSCCG11201-RB. d. melanogaster.

Organism-specific databases

CTD33946.
FlyBaseFBgn0031853. TTLL3B.

Phylogenomic databases

eggNOGinNOG06215.
GeneTreeEMGT00050000006867.
InParanoidQ9VM92.
OrthoDBEOG4VT4C7.
PhylomeDBQ9VM92.

Gene expression databases

ArrayExpressQ9VM92.
BgeeQ9VM92.

Family and domain databases

InterProIPR004344. Tub_tyr_ligase.
[Graphical view]
PANTHERPTHR12241. Tub_tyr_ligase. 1 hit.
PfamPF03133. TTL. 1 hit.
[Graphical view]
PROSITEPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio786066.

Entry information

Entry nameTTL3B_DROME
AccessionPrimary (citable) accession number: Q9VM92
Secondary accession number(s): Q5BHY1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families