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Q9VM35

- U2QL1_DROME

UniProt

Q9VM35 - U2QL1_DROME

Protein

Ubiquitin-conjugating enzyme E2Q-like protein CG4502

Gene

CG4502

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei234 – 2341Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9VM35.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2Q-like protein CG4502 (EC:6.3.2.19)
    Gene namesi
    ORF Names:CG4502
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0031896. CG4502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Ubiquitin-conjugating enzyme E2Q-like protein CG4502PRO_0000335813Add
    BLAST

    Proteomic databases

    PRIDEiQ9VM35.

    Expressioni

    Gene expression databases

    BgeeiQ9VM35.

    Interactioni

    Protein-protein interaction databases

    BioGridi60148. 2 interactions.
    MINTiMINT-1763215.
    STRINGi7227.FBpp0079044.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VM35.
    SMRiQ9VM35. Positions 142-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 4120Poly-AsnAdd
    BLAST
    Compositional biasi53 – 6614Poly-AsnAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272407.
    GeneTreeiENSGT00390000018573.
    InParanoidiQ9VM35.
    KOiK10582.
    OMAiDSLFEWH.
    OrthoDBiEOG7F512D.
    PhylomeDBiQ9VM35.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VM35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRSKERVV TAFRKIFHKS SNNNNNNNNN HNNNINNNNN NDKVDGATGS    50
    SPNINNNNNN NNNNNNHDGA AAPSSAGGVA VAGGAVGSSG SSGAAKNAVV 100
    RMAAEQAVWD SPGKRRRQDH KVAPTTERQL VAAPDHTIRT RRLMKEYREM 150
    ERLQAKNDAV FTVELVNDSL FEWHVRLHVI DPDSPLARDM AEMGVPAILL 200
    HLSFPDNFPF APPFMRVVEP HIEKGYVMEG GAICMELLTP RGWASAYTVE 250
    AVIMQFAASV VKGQGRIARK PKSTKEFTRR QAEESFRSLV KTHEKYGWVT 300
    PALSDG 306
    Length:306
    Mass (Da):33,670
    Last modified:May 1, 2000 - v1
    Checksum:i75897876D46A813A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52492.1.
    AE014134 Genomic DNA. Translation: AAF52493.1.
    AY060422 mRNA. Translation: AAL25461.1.
    RefSeqiNP_609103.1. NM_135259.3.
    NP_723260.1. NM_164741.2.
    UniGeneiDm.340.

    Genome annotation databases

    EnsemblMetazoaiFBtr0079416; FBpp0079044; FBgn0031896.
    FBtr0079417; FBpp0079045; FBgn0031896.
    GeneIDi34002.
    KEGGidme:Dmel_CG4502.
    UCSCiCG4502-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52492.1 .
    AE014134 Genomic DNA. Translation: AAF52493.1 .
    AY060422 mRNA. Translation: AAL25461.1 .
    RefSeqi NP_609103.1. NM_135259.3.
    NP_723260.1. NM_164741.2.
    UniGenei Dm.340.

    3D structure databases

    ProteinModelPortali Q9VM35.
    SMRi Q9VM35. Positions 142-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60148. 2 interactions.
    MINTi MINT-1763215.
    STRINGi 7227.FBpp0079044.

    Proteomic databases

    PRIDEi Q9VM35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0079416 ; FBpp0079044 ; FBgn0031896 .
    FBtr0079417 ; FBpp0079045 ; FBgn0031896 .
    GeneIDi 34002.
    KEGGi dme:Dmel_CG4502.
    UCSCi CG4502-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0031896. CG4502.

    Phylogenomic databases

    eggNOGi NOG272407.
    GeneTreei ENSGT00390000018573.
    InParanoidi Q9VM35.
    KOi K10582.
    OMAi DSLFEWH.
    OrthoDBi EOG7F512D.
    PhylomeDBi Q9VM35.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q9VM35.

    Miscellaneous databases

    ChiTaRSi CG4502. drosophila.
    GenomeRNAii 34002.
    NextBioi 786370.

    Gene expression databases

    Bgeei Q9VM35.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiU2QL1_DROME
    AccessioniPrimary (citable) accession number: Q9VM35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3