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Protein
Submitted name:

Lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform A

Gene

LKRSDH

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • histone arginine methylation Source: FlyBase
  • regulation of histone methylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Enzyme and pathway databases

ReactomeiR-DME-71064. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform AImported
Submitted name:
Lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform BImported (EC:1.5.1.7Imported)
Gene namesi
Name:LKRSDHImported
ORF Names:CG7144Imported, Dmel_CG7144Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0025687. LKRSDH.

Expressioni

Gene expression databases

BgeeiFBgn0025687.

Interactioni

Protein-protein interaction databases

MINTiMINT-849080.
STRINGi7227.FBpp0079118.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 155131AlaDh_PNT_NInterPro annotationAdd
BLAST
Domaini195 – 398204AlaDh_PNT_CInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0172. Eukaryota.
COG1748. LUCA.
GeneTreeiENSGT00390000013249.
KOiK14157.
OMAiYGPEEKD.
OrthoDBiEOG091G03D7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR016040. NAD(P)-bd_dom.
IPR032095. Sacchrp_dh_C.
IPR005097. Sacchrp_dh_NADP.
[Graphical view]
PfamiPF05222. AlaDh_PNT_N. 1 hit.
PF16653. Sacchrp_dh_C. 1 hit.
PF03435. Sacchrp_dh_NADP. 1 hit.
[Graphical view]
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VLX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRVIQLRAT IAHPFTRQRH SRVIAIRRED QSVWERRAPF GPTHVQKLVK
60 70 80 90 100
QNVKVIVQPS NRRAYPMQAY MQAGAHIQED ISDASVIFGV KQVPIDALIP
110 120 130 140 150
GKTYCFFSHT IKAQESNMPL LDAILEKKIR LIDYERIIDE RGARQVAFGK
160 170 180 190 200
YAGVAGMVNI LHGIGLRLLA LGHHTPFMHI GPAHNYRNSS MARQAIRDCG
210 220 230 240 250
YEISLGMMPK SIGPLTFVFT GSGNVSQGAQ EVFSELPIEY VPPEMLRKVA
260 270 280 290 300
EHGNQNKLYG CEVSRSDHLE RREGGGFDAK EYDEFPERYI STFSTKIAPY
310 320 330 340 350
ASVIVNGIYW AVGSPKLISI PDAKNLLRPA NTPWLPTSKG SPALPHRMLA
360 370 380 390 400
ICDISADPGG SIEFMNECTT IDTPFCLYDA DRNKDTKSFK GPGVLVCSID
410 420 430 440 450
NMPTQLPRES TDLFGELLAP HVHDIIKSDA KKPLAEENFS YPIQSAIIAS
460 470 480 490 500
NGQLTEGFQY IQELRESQSH RSRHKMEGSS ESDKKVLVLG AGMVSAPLVE
510 520 530 540 550
WLHREKDVSI TVCSQVKEEA DRLAQQYAGV DSVYLDVNES TGHLQELCGR
560 570 580 590 600
ADVVVSLLPY SLHGMVARYC VAEGTHMVTA SYLNDEISGL HEEAKAKGVT
610 620 630 640 650
IMNEVGLDPG IDHLLALECI HEVQDKGAVV ESFVSYCGGL PAPEHSNNAL
660 670 680 690 700
RYKFSWSPRG VLLNTLSAAK YLSQGQIVEI SGGGELMSSP RSLDFLPGFA
710 720 730 740 750
LEGFPNRDST KYGNLYGLGR DVHTLLRGTI RYKGFSESIK PMQLLGLIDP
760 770 780 790 800
EPHALLHPSG PDVTWRQLVI HLMGMSDSTI FYENLKQKLT ERIGDVDGIE
810 820 830 840 850
SLGLLDDTPV VKLNTPLDTL SHYLSKRLAF ERDERDLVVL RHEVGIRWPD
860 870 880 890 900
GRREERGINF VVYGQPQGHS AMAMTVGKPA AIAAKMILDG EIQERGVLLP
910 920
FTPDIYRPML QRLRSEGLTA TETSRWLN
Length:928
Mass (Da):103,125
Last modified:October 1, 2002 - v2
Checksum:iBD7CC51E88718BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52559.2.
AE014134 Genomic DNA. Translation: AHN54234.1.
RefSeqiNP_001285719.1. NM_001298790.1.
NP_609150.2. NM_135306.3.

Genome annotation databases

EnsemblMetazoaiFBtr0079495; FBpp0079118; FBgn0025687.
FBtr0343404; FBpp0310050; FBgn0025687.
GeneIDi34064.
KEGGidme:Dmel_CG7144.
UCSCiCG7144-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52559.2.
AE014134 Genomic DNA. Translation: AHN54234.1.
RefSeqiNP_001285719.1. NM_001298790.1.
NP_609150.2. NM_135306.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-849080.
STRINGi7227.FBpp0079118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079495; FBpp0079118; FBgn0025687.
FBtr0343404; FBpp0310050; FBgn0025687.
GeneIDi34064.
KEGGidme:Dmel_CG7144.
UCSCiCG7144-RA. d. melanogaster.

Organism-specific databases

CTDi34064.
FlyBaseiFBgn0025687. LKRSDH.

Phylogenomic databases

eggNOGiKOG0172. Eukaryota.
COG1748. LUCA.
GeneTreeiENSGT00390000013249.
KOiK14157.
OMAiYGPEEKD.
OrthoDBiEOG091G03D7.

Enzyme and pathway databases

ReactomeiR-DME-71064. Lysine catabolism.

Miscellaneous databases

ChiTaRSiLkr. fly.
LKR. fly.
GenomeRNAii34064.

Gene expression databases

BgeeiFBgn0025687.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR016040. NAD(P)-bd_dom.
IPR032095. Sacchrp_dh_C.
IPR005097. Sacchrp_dh_NADP.
[Graphical view]
PfamiPF05222. AlaDh_PNT_N. 1 hit.
PF16653. Sacchrp_dh_C. 1 hit.
PF03435. Sacchrp_dh_NADP. 1 hit.
[Graphical view]
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VLX0_DROME
AccessioniPrimary (citable) accession number: Q9VLX0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.