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Protein

WW domain-containing oxidoreductase

Gene

Wwox

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei288Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 134NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: FlyBase
  • regulation of reactive oxygen species metabolic process Source: FlyBase
  • response to ionizing radiation Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Wnt signaling pathway
LigandNADP

Enzyme and pathway databases

ReactomeiR-DME-1251985. Nuclear signaling by ERBB4.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
SignaLinkiQ9VLU5.

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:Wwox
ORF Names:CG7221
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031972. Wwox.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548201 – 409WW domain-containing oxidoreductaseAdd BLAST409

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VLU5.
PRIDEiQ9VLU5.

Expressioni

Gene expression databases

BgeeiFBgn0031972.
ExpressionAtlasiQ9VLU5. differential.
GenevisibleiQ9VLU5. DM.

Interactioni

Protein-protein interaction databases

BioGridi60224. 8 interactors.
IntActiQ9VLU5. 7 interactors.
MINTiMINT-749455.
STRINGi7227.FBpp0079172.

Structurei

3D structure databases

ProteinModelPortaliQ9VLU5.
SMRiQ9VLU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 44WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini52 – 86WW 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
InParanoidiQ9VLU5.
KOiK19329.
OMAiAATSIYC.
OrthoDBiEOG091G0EI5.
PhylomeDBiQ9VLU5.

Family and domain databases

CDDicd00201. WW. 2 hits.
InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
PRINTSiPR00081. GDHRDH.
SMARTiView protein in SMART
SM00456. WW. 2 hits.
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS50020. WW_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9VLU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALPDTDSE DELPPGWEER ATDDGTVCYV NQQGKTSQWT HPRTGRSKRI
60 70 80 90 100
TGELPLGWEK YYDEQGKRFM FLNKETQQRT NVDPRLAFAV EEPTQNVAQV
110 120 130 140 150
RQRFDSCSTA LQVLHGKDLH GRTALITGAN CGIGYETARS LAHHGCEIIF
160 170 180 190 200
ACRNRSSAEA AIERIAQERP AARSRCRFAA LDLSSLRSVQ RFVEEIKQSV
210 220 230 240 250
SHIDYLILNA GVFALPYTRT VDGLETTFQV SHLSHFYLTL QLETLFDYKT
260 270 280 290 300
RIIVLSSESH RFANLPVENL AVHHLSPPPE KYWSMMAYNN AKLCNVLFAQ
310 320 330 340 350
ELAQRWKQRG ISVFSLHPGN MVSSDLSRNY WFYRLLFAIV RPFTKSLQQA
360 370 380 390 400
AATSIYCATA NELTGLSGLY FNNCFFCEPS KLSKSAALQQ QLWKLSENLI

AELVEQEQH
Length:409
Mass (Da):46,511
Last modified:May 1, 2000 - v1
Checksum:i7893BF4C39A7454C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52587.1.
AY119574 mRNA. Translation: AAM50228.1.
RefSeqiNP_001285735.1. NM_001298806.1.
NP_609171.1. NM_135327.4.
UniGeneiDm.19795.

Genome annotation databases

EnsemblMetazoaiFBtr0079550; FBpp0079172; FBgn0031972.
FBtr0343384; FBpp0310039; FBgn0031972.
GeneIDi34090.
KEGGidme:Dmel_CG7221.
UCSCiCG7221-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiWWOX_DROME
AccessioniPrimary (citable) accession number: Q9VLU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families