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Protein

WW domain-containing oxidoreductase

Gene

Wwox

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei288Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 134NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: FlyBase
  • regulation of reactive oxygen species metabolic process Source: FlyBase
  • response to ionizing radiation Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis, Wnt signaling pathway

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-DME-1251985. Nuclear signaling by ERBB4.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
SignaLinkiQ9VLU5.

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:Wwox
ORF Names:CG7221
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031972. Wwox.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548201 – 409WW domain-containing oxidoreductaseAdd BLAST409

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VLU5.
PRIDEiQ9VLU5.

Expressioni

Gene expression databases

BgeeiFBgn0031972.
ExpressionAtlasiQ9VLU5. baseline.
GenevisibleiQ9VLU5. DM.

Interactioni

Protein-protein interaction databases

BioGridi60224. 6 interactors.
IntActiQ9VLU5. 1 interactor.
MINTiMINT-749455.
STRINGi7227.FBpp0079172.

Structurei

3D structure databases

ProteinModelPortaliQ9VLU5.
SMRiQ9VLU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 44WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini52 – 86WW 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
InParanoidiQ9VLU5.
KOiK19329.
OMAiKYYDEQG.
OrthoDBiEOG091G0EI5.
PhylomeDBiQ9VLU5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VLU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALPDTDSE DELPPGWEER ATDDGTVCYV NQQGKTSQWT HPRTGRSKRI
60 70 80 90 100
TGELPLGWEK YYDEQGKRFM FLNKETQQRT NVDPRLAFAV EEPTQNVAQV
110 120 130 140 150
RQRFDSCSTA LQVLHGKDLH GRTALITGAN CGIGYETARS LAHHGCEIIF
160 170 180 190 200
ACRNRSSAEA AIERIAQERP AARSRCRFAA LDLSSLRSVQ RFVEEIKQSV
210 220 230 240 250
SHIDYLILNA GVFALPYTRT VDGLETTFQV SHLSHFYLTL QLETLFDYKT
260 270 280 290 300
RIIVLSSESH RFANLPVENL AVHHLSPPPE KYWSMMAYNN AKLCNVLFAQ
310 320 330 340 350
ELAQRWKQRG ISVFSLHPGN MVSSDLSRNY WFYRLLFAIV RPFTKSLQQA
360 370 380 390 400
AATSIYCATA NELTGLSGLY FNNCFFCEPS KLSKSAALQQ QLWKLSENLI

AELVEQEQH
Length:409
Mass (Da):46,511
Last modified:May 1, 2000 - v1
Checksum:i7893BF4C39A7454C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52587.1.
AY119574 mRNA. Translation: AAM50228.1.
RefSeqiNP_001285735.1. NM_001298806.1.
NP_609171.1. NM_135327.4.
UniGeneiDm.19795.

Genome annotation databases

EnsemblMetazoaiFBtr0079550; FBpp0079172; FBgn0031972.
FBtr0343384; FBpp0310039; FBgn0031972.
GeneIDi34090.
KEGGidme:Dmel_CG7221.
UCSCiCG7221-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52587.1.
AY119574 mRNA. Translation: AAM50228.1.
RefSeqiNP_001285735.1. NM_001298806.1.
NP_609171.1. NM_135327.4.
UniGeneiDm.19795.

3D structure databases

ProteinModelPortaliQ9VLU5.
SMRiQ9VLU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60224. 6 interactors.
IntActiQ9VLU5. 1 interactor.
MINTiMINT-749455.
STRINGi7227.FBpp0079172.

Proteomic databases

PaxDbiQ9VLU5.
PRIDEiQ9VLU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079550; FBpp0079172; FBgn0031972.
FBtr0343384; FBpp0310039; FBgn0031972.
GeneIDi34090.
KEGGidme:Dmel_CG7221.
UCSCiCG7221-RA. d. melanogaster.

Organism-specific databases

CTDi51741.
FlyBaseiFBgn0031972. Wwox.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
InParanoidiQ9VLU5.
KOiK19329.
OMAiKYYDEQG.
OrthoDBiEOG091G0EI5.
PhylomeDBiQ9VLU5.

Enzyme and pathway databases

ReactomeiR-DME-1251985. Nuclear signaling by ERBB4.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
SignaLinkiQ9VLU5.

Miscellaneous databases

GenomeRNAii34090.
PROiQ9VLU5.

Gene expression databases

BgeeiFBgn0031972.
ExpressionAtlasiQ9VLU5. baseline.
GenevisibleiQ9VLU5. DM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWWOX_DROME
AccessioniPrimary (citable) accession number: Q9VLU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.