Q9VLT5 (POE_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein purity of essence

Alternative name(s):
Interaction calmodulin and colossal molecular mass protein
Protein Calossin
Protein pushover

Gene names

Name:	poe
Synonyms:	calo, push
ORF Names:	CG14472

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	5322 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in growth of the perineurial glial layer of the larval peripheral nerve. May have a role in male fertility and eye development or function. Ref.1 Ref.4 Ref.6
Subunit structure	May bind calmodulin.
Tissue specificity	Expressed in embryonic central nervous system and adult testes. Ref.1
Disruption phenotype	Flies increase the growth of the perineurial glial layer of the larval peripheral nerve and exhibit male sterility due to the inhibition of sperm individualisation. Ref.1
Sequence similarities	Belongs to the UBR4 family. Contains 1 UBR-type zinc finger.
Sequence caution	The sequence AAM50858.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Sensory transduction Vision
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Calmodulin-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	perineurial glial growth Inferred from mutant phenotype Ref.1. Source: FlyBase response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sperm individualization Inferred from mutant phenotype PubMed 9550716PubMed 12737804. Source: FlyBase visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calmodulin binding Non-traceable author statement PubMed 99030403. Source: UniProtKB ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG11892	Q7K025	1	EBI-175222,EBI-100350

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A Ref.1 (identifier: Q9VLT5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B Ref.1 (identifier: Q9VLT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4119-4120: LP → TL
     4121-5322: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 5322	5322	Protein purity of essence		PRO_0000245794
Regions
	Zinc finger	1794 – 1863	70	UBR-type
Amino acid modifications
	Modified residue	167	1	Phosphoserine Ref.8
	Modified residue	599	1	Phosphothreonine Ref.8
	Modified residue	600	1	Phosphoserine Ref.8
	Modified residue	1167	1	Phosphoserine Ref.8
	Modified residue	1168	1	Phosphoserine Ref.8
	Modified residue	1171	1	Phosphoserine Ref.8
	Modified residue	1894	1	Phosphoserine Ref.7 Ref.8
	Modified residue	3013	1	Phosphothreonine Ref.8
	Modified residue	3014	1	Phosphoserine Ref.8
	Modified residue	3051	1	Phosphoserine Ref.8
	Modified residue	3057	1	Phosphoserine Ref.8
	Modified residue	3510	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	4119 – 4120	2	LP → TL in isoform B. Ref.1		VSP_052089
	Alternative sequence	4121 – 5322	1202	Missing in isoform B. Ref.1		VSP_052090
Experimental info
	Sequence conflict	675	1	S → T in AAD20449. Ref.1
	Sequence conflict	675	1	S → T in AAD20450. Ref.1
	Sequence conflict	947	1	I → T in AAD20449. Ref.1
	Sequence conflict	1405	1	S → A in AAD20449. Ref.1
	Sequence conflict	1405	1	S → A in AAD20450. Ref.1
	Sequence conflict	1621	1	N → D in AAD20449. Ref.1
	Sequence conflict	1621	1	N → D in AAD20450. Ref.1
	Sequence conflict	2965	1	L → P in CAA76940. Ref.4
	Sequence conflict	3105	1	A → T in AAD20450. Ref.1
	Sequence conflict	3159 – 3164	6	DYVEIG → GLCGNW in AAD20450. Ref.1
	Sequence conflict	3257	1	G → A in CAA76940. Ref.4
	Sequence conflict	4011	1	D → H in AAD20449. Ref.1
	Sequence conflict	4812	1	V → G in CAA76940. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3890824E00F2DB50	FASTA	5,322	590,702
	10 20 30 40 50 60 MSAHSGGTDW NSVVKALILN RTGALNKNEV VNLLKAITRC EHDFFEEESN FTQFYTAFAA 70 80 90 100 110 120 LAADKLMQIK TICQTQICQL HDATAVLIRF IIYRLPRVSV YETKWLLGAL KMLCEGRECP 130 140 150 160 170 180 ASASSSMFDY NAVANVLKSC KHPESTTKSI MPSSSSSGSG ASNDKESPKS EIKRSRSDLS 190 200 210 220 230 240 SVILQQLIAP LEPGKMTWVP LSEEVTDCTE QILAANVEYF QEQNGVDTLL DVCVSLPILN 250 260 270 280 290 300 RYRSKYMETI NGGKSLYLPL TQVEATAVKS SMNHMLTDLT ILSQAQALIE MQPLTPSRIE 310 320 330 340 350 360 RLSMCGIAAL YNAVLTSIAT SVLGMSQASS SQKQTASTSQ GSGVGGSSGG QSNKDHDDFE 370 380 390 400 410 420 DQACSIVNKA LEIYSNIGHM FKTSARIHVY QNHLCYGSWL LISGIQGAMG ASGSGGSSSD 430 440 450 460 470 480 SASKSASKAT KSGSEAGTAP TTPIARVNLF KVQQGFGELN AAIANHSIKL LSELIEDLKV 490 500 510 520 530 540 EAACGQSLES TELPEPAQFD ILQNYSSLER IVRVLNTATL HQLFTFLATV AYRKACTLKR 550 560 570 580 590 600 ASAKDRTECE PISYSDSTTY FNDSLSCSDN SEEDDSESYL GHWFKETLSP ETHDDNANTS 610 620 630 640 650 660 TQERAEQKSA LVPKLDEPHE YLDLAADIFC FLDQFLANRH AYMQRYVKAG VSDQQMLLMA 670 680 690 700 710 720 NIIKDFDRDV MRNESDQGSG NAPAASAGAG TSAGASTKWQ TSMIRFSGAA GRYIHNLIST 730 740 750 760 770 780 SLLSEQLQSN LLQHLSISPW STDTNTWPLQ VYPSTLSVLV QILLLKPTQE KEAACLSVWH 790 800 810 820 830 840 RLINTLVEGV CSSNTASDSD YEDLNIEHAQ LLLFLFHSLN LMQKKSILLL TAGGVIRCAE 850 860 870 880 890 900 VCRGISEDRP VKNSQIMLLS RLLLFLEYLM KHLYNAPPEL LDQVRWNLFS VSSMPDTQKI 910 920 930 940 950 960 TDLLNCRTKL NSYCRHDIEE NFRKSAGEYG SSIRPTFYSL VMGDPEISYW AQEFKLDGLA 970 980 990 1000 1010 1020 WNFILCTPDK LKYPLLVDAL TDILSITDMS MYSKEKDKEA SMHNLCAIQY CFTIAWKLNL 1030 1040 1050 1060 1070 1080 GLPPSTSHVE SLKAERSPNL HSLMWSIRLP LASSHYLVVS SLIKQGMYTQ YAETLWTHVG 1090 1100 1110 1120 1130 1140 DIGADIKYSL KQTILGVEAF NSQMNGNGTP RLSDLILFDS LVAHMQAVAW ANKEGLKWPR 1150 1160 1170 1180 1190 1200 KESEDAAGEQ SAGTSLTSSS NDPELYSSNE SIDDQKLKQD DDGKLSSDLQ KYNQLVNELM 1210 1220 1230 1240 1250 1260 VKLMNSYQLL SVIVRGQMLK QLSSSTPEKA LNLIVPIVSD KPAIMLELHA AFLKLLPNED 1270 1280 1290 1300 1310 1320 KQLIANEWPK CLMVNDFAFN GKQHPVEPYI LNVIDAHIIE LTRGSNYSTL HTLKHCLKSI 1330 1340 1350 1360 1370 1380 LQLFELLLPH RTANAEVETQ LKQLLISSML DMRTDYLQGH SEHCLREILS GLTQEAQKLL 1390 1400 1410 1420 1430 1440 LYEHMVGYCY RMLKEFAADL RQPQSAGPSG GAPLDQDRAM FNESMLFAVL KTMFKMLEKP 1450 1460 1470 1480 1490 1500 VAVQAMRQFF KDQRSGSLTT LLLSFTGTSL PVSYARKMLQ FVNRLFQLSL QADSQFQHED 1510 1520 1530 1540 1550 1560 LVECFSELAT VDVARLKQWL GHIIYGPNVS TDVSTSEALD TTCRMLTSIL QPSSSSSSNA 1570 1580 1590 1600 1610 1620 QTPTNMATVS AMPSISDQLD PMEIEYDCGT AAGGGESNPG TGGAAANTSQ ILSLWQAAQP 1630 1640 1650 1660 1670 1680 NPSEESSQAC DHSDSERNGA LLLSFVKSLV KDQSKASQIA PPLFQALLQL GQTLISPPQE 1690 1700 1710 1720 1730 1740 GCDFADVLQI MITLADASPA RGHVALFNTT LLWLELAKLQ LPDKHLKHAE NVSAQLRYLS 1750 1760 1770 1780 1790 1800 ELLQSIGFRG SRQHNPPWDD ELQTDIDELY DELAEEGEQD SLLDDSDEDT LNNKLCTFSQ 1810 1820 1830 1840 1850 1860 TQKEFMNQHW YHCHTCNMIN TVGVCSVCAR VCHKGHDVSY AKYGNFFCDC GAKEDGSCQA 1870 1880 1890 1900 1910 1920 LSRRIGSNEV RDSAGIGSYL PSHMSLLAGK KRSSLPVGQP VLTRKDSLTN ERIAVLTKLL 1930 1940 1950 1960 1970 1980 EPYRETLQHQ DQWLLVVRCI LEYFDLLLPS INENCMLYSI VGCHKRATAA LERLHLLEQS 1990 2000 2010 2020 2030 2040 FQVTDQLMFA TLGSQEGAFE NVRMNYSGDQ GQTIKHLLSS GVVRRVAFCC LSSPHGRRQQ 2050 2060 2070 2080 2090 2100 LAVSHEKGKV TILQLSALLK QADASKRKLT LTQLSSAPIA CTVISLAANP CNEDCLAVCG 2110 2120 2130 2140 2150 2160 LKECHILTFS SSGSTNEHIV VNPQLENGNY IKKAVWLPGS QTLLAVVTSD YVKIYDLAVD 2170 2180 2190 2200 2210 2220 TYSPKYYYLV AVGKIRDCTF VYQDGNYNML TFASSGYIYT QQLDQQSLAV HGDFYVTNTL 2230 2240 2250 2260 2270 2280 ELSHQHIKDI AGHIGGGGVS IYYSHTLQLL FYSYSCGRSF FSPLTNVSEG VKGIYHLDTN 2290 2300 2310 2320 2330 2340 SASKSASKGP LQPLVQWTEV TGHPGLVYAS MQTSNNPIIL MITPERIYLQ EIKAQSAKSR 2350 2360 2370 2380 2390 2400 IMDVVGIRHA VAGVEKTTLL LLCEDGSLRI FSAQPEYTSF WLSPQVQPFG NQLYSSTLMA 2410 2420 2430 2440 2450 2460 KGGGSGSTSK SKSNTASGKM TSRKASQQQK QPTAGGQPVF PIDFFEHCNM LADVEFGGND 2470 2480 2490 2500 2510 2520 LLQIYNKQKL KTRLFSTGMF VASTRSNGFT LEVINNDPNV VIVGIRVLIG TQDVQRAPQS 2530 2540 2550 2560 2570 2580 VTILGRTIPT PVRRARWFDI PLTREEMLQS DKLLKVVFAK APDPEHVTLL DCIEVYGKSK 2590 2600 2610 2620 2630 2640 ELVGWPDESE DVTVPGSSAP AVSSSQASSA NFGEGFNCIT QLDRMANHLL EVMDCALHLL 2650 2660 2670 2680 2690 2700 GSGVPASMRQ KAVKTASALL LLPTPNPVQT QARYVLATLY GTRALYHNYK DGVLLQFVNR 2710 2720 2730 2740 2750 2760 ELQSMQPKLE KLETLREIDP EAFYRLVLMV RGIANARPQS LAKICVENNY DIVPTLMGIV 2770 2780 2790 2800 2810 2820 LELHKVTPTL DEPVNIVKRG LCQPETIVHC LVEIMYGFAL ADPGQVGRMT KYFIDLLKHD 2830 2840 2850 2860 2870 2880 ASVISHSAKE ALILLLSPRM KRRKVAIVTP PACSTPTPST STMQALQAAA SSAASDIIEE 2890 2900 2910 2920 2930 2940 AAGVVVDGSV GGGGLPEPNA DAEGAAVGVG GVGQQQMLNL EAFMGGGFPR LLGLPEDADD 2950 2960 2970 2980 2990 3000 EAIMDIAIAL SLQQHGGDAN ALQSLQQGLA NLQGIRQATA MAAAVNAAAN VSLGGSDDDE 3010 3020 3030 3040 3050 3060 GSNVATDGST LRTSPAEPAG SGGSESGGSG VESIGGTSAR SSNFGDHANA SPPRQGSTKD 3070 3080 3090 3100 3110 3120 DQEQPGPSGV AGSGGVAVLS AMSSSEDNEA NEDDKLSKLH DLRIAVLESI IQHLGTFDLC 3130 3140 3150 3160 3170 3180 NGLQAIPLIQ VILMLTTDLN GNNERDQQVL HDLLTALVDY VEIGKRGAAA RMETKCPGNE 3190 3200 3210 3220 3230 3240 VRLALLSLFG VLMGKTKSKQ TGTTSPPHQF KDNSSFVAST TANVLSKSGA FVYALEALNT 3250 3260 3270 3280 3290 3300 LLVHWKNVLG DPYAAGGGLA SQSAQASGGA SGPGVQLLKP IKHGPKPDIS ILIPHNYLKN 3310 3320 3330 3340 3350 3360 YPDIFESYDG LLTEIIVRLP YQILRLSSAH PDNYDSGFCE AMTFTLCEYM MLNLNTLLRR 3370 3380 3390 3400 3410 3420 QVRKLLMYIC GSKEKFRMYR DGHSLDAHFR VVKRVCNIVS SKTGAPYNAN PPMLSYDALV 3430 3440 3450 3460 3470 3480 ELTEHLRTCQ EISQMRTGNW QKFCVVHEDA LAMLMEIACY QLDDGVSPII IQLLQAAVCN 3490 3500 3510 3520 3530 3540 LPPPSGSKQA QPQPSTSSAS GKLRTDREKS EDTDAYYSKF DPAQCGTFVH QIFRYACDAL 3550 3560 3570 3580 3590 3600 IIRFVRIFLL ENNITQLRWQ AHSFMTGLFE HANERQREKL LNIFWNLWPL VPTYGRRTAQ 3610 3620 3630 3640 3650 3660 FVDLLGYLTL STRSITERLP EFVSRAVDVL RQQNELLCKH PNAPIYTTLE SILQVNGYYL 3670 3680 3690 3700 3710 3720 ESEPCLVCNN PEVPMANIKL PSVKSDSKYT TTTMIYKLVQ CHTISKLIVR IADLKRTKMV 3730 3740 3750 3760 3770 3780 RTINVYYNNR SVQAVVELKN RPALWHKARS VSLQSAQTEL KIDFPLPITA CNLMIEFADF 3790 3800 3810 3820 3830 3840 FETVSGSSEN LQCPRCSAAV PAYPGVCGNC GENVFQCHKC RAINYDEKDP FLCHSCGFCK 3850 3860 3870 3880 3890 3900 YAKFDFSMYA RVCCAVDPIE SAEDRVKTVS LIHSSLERAD RNYRQLLTNK QMLELLIQKV 3910 3920 3930 3940 3950 3960 AEHRSSDRMV EDNMASVHST SQVNKIIQLL AQKYCVESRT SFEELSKIVQ KVKACRSELV 3970 3980 3990 4000 4010 4020 AYDRQQQDQP PVNPGSTTGA ENPTTNRCYG CALASTEQCL TLLRAMAYNY DCRVCLYSQG 4030 4040 4050 4060 4070 4080 LVSELAEHNL RRGTPLIQEE VRNLLVVLTK DNAEACMHLL QLVTTRVKNA LMGSIPLISL 4090 4100 4110 4120 4130 4140 EAAVHQEMTL LEVLLGQDDI CWEYKLKVIF ELFISNCRLP RGPVTAVLHP CLRIMQNLIC 4150 4160 4170 4180 4190 4200 PVLPGSKPNQ KVATTDLCSM KMFEGNTVDY RAWLNSDRNH EYAAWSKRMP SNNQAKLKNA 4210 4220 4230 4240 4250 4260 KDQNVAASGG SDAPPKSRRE VRVAFLSEKY GKRWRERVLD KQRVIKPLVF NAKWIQPLLF 4270 4280 4290 4300 4310 4320 NANSRFGRQL ACSLLSSLSR TNERRQQALN MLTSFLKHVG EAGEASAEYL MLYKNMATEQ 4330 4340 4350 4360 4370 4380 PWLQYLVLKG VLSQISQLLA IEISKVHRME EYSLSSDLSL GYALRQYVEL LWLLLECPNI 4390 4400 4410 4420 4430 4440 RRTYKTRMLG PVLESYLALR SLVVQRTRLI DDAQEKLLEM LEDMTSGTEE ETRAFMEILI 4450 4460 4470 4480 4490 4500 DTVEKTRMND IKTPVFVFER LYSIIHPEEH DESEFYMTLE KDPQQEDFLQ GRMLGNPYPS 4510 4520 4530 4540 4550 4560 SEMGLGPLMR DVKNKICTDC ELIALLEDDN GMELLVNNKI ISLDLPVKDV YKKVWLAEGG 4570 4580 4590 4600 4610 4620 DRDAMRIVYR MRGLLGDATE EFVETLNNKS QEQVDTEQLY RMANVLADCN GLRVMLERIG 4630 4640 4650 4660 4670 4680 SLQRISRNRE LIQVLLKLFL ICVKVRRCQE VLCQPEIGAI NTLLKVLQMC LQSENDSIQS 4690 4700 4710 4720 4730 4740 AVTEQLLEIM ETILSKAASD TLDSFLQFSL TFGGPEYVSA LISCTDCPNV RNNPSVLRHL 4750 4760 4770 4780 4790 4800 IRVLAALVYG NEVKMALLCE HFKDTLNFNR FDNERTPEEE FKLELFCVLT NQIEHNCIGG 4810 4820 4830 4840 4850 4860 TLKDYIVSLG IVERSLAYIT EHAPCVKPTL LRTDSDELKE FISRPSLKYI LRFLTGLSNH 4870 4880 4890 4900 4910 4920 HEATQVAISK DIIPIIHRLE QVSSDEHVGS LAENLLEALS TDSATAARVQ QVRDFTRAEK 4930 4940 4950 4960 4970 4980 KRLAMATREK QLDALGMRTN EKGQVTAKGS ILQKIEKLRD ETGLTCFICR EGYACQPDKV 4990 5000 5010 5020 5030 5040 LGIYTFTKRC NVEEFELKSR KTIGYTTVTH FNVVHVDCHT SAIRLTRGRD EWERASLQNA 5050 5060 5070 5080 5090 5100 NTRCNGLLPL WGPAVGEAAF SACMTRHSSY MQESTQRCDI SYTSSVHDLK LLLVRFAWER 5110 5120 5130 5140 5150 5160 SFHDDAGGGG PQSNMHFVPY LLFYSVYLLL SSRSAARDSK TLLTYLQAPP SEKWLECGYE 5170 5180 5190 5200 5210 5220 VDGPLFMATI SLSLHSRELW NKHKLAHLKR MIAVAQGRHV SPAVLCKALL APADRQVKDY 5230 5240 5250 5260 5270 5280 TVYKPFLMMW ALVDLIYDNL FKTVSTPKEE DWPISLFDYL RKNDEALLKS TDSILQTLTE 5290 5300 5310 5320 EFLPCTSFVE FCDVAGLLHL IEHPDNFIEE ILAALPSTSS SN
	Isoform B [UniParc]. Checksum: E6D1E2F3C5CC3CD3	FASTA	4,120	453,871
	10 20 30 40 50 60 MSAHSGGTDW NSVVKALILN RTGALNKNEV VNLLKAITRC EHDFFEEESN FTQFYTAFAA 70 80 90 100 110 120 LAADKLMQIK TICQTQICQL HDATAVLIRF IIYRLPRVSV YETKWLLGAL KMLCEGRECP 130 140 150 160 170 180 ASASSSMFDY NAVANVLKSC KHPESTTKSI MPSSSSSGSG ASNDKESPKS EIKRSRSDLS 190 200 210 220 230 240 SVILQQLIAP LEPGKMTWVP LSEEVTDCTE QILAANVEYF QEQNGVDTLL DVCVSLPILN 250 260 270 280 290 300 RYRSKYMETI NGGKSLYLPL TQVEATAVKS SMNHMLTDLT ILSQAQALIE MQPLTPSRIE 310 320 330 340 350 360 RLSMCGIAAL YNAVLTSIAT SVLGMSQASS SQKQTASTSQ GSGVGGSSGG QSNKDHDDFE 370 380 390 400 410 420 DQACSIVNKA LEIYSNIGHM FKTSARIHVY QNHLCYGSWL LISGIQGAMG ASGSGGSSSD 430 440 450 460 470 480 SASKSASKAT KSGSEAGTAP TTPIARVNLF KVQQGFGELN AAIANHSIKL LSELIEDLKV 490 500 510 520 530 540 EAACGQSLES TELPEPAQFD ILQNYSSLER IVRVLNTATL HQLFTFLATV AYRKACTLKR 550 560 570 580 590 600 ASAKDRTECE PISYSDSTTY FNDSLSCSDN SEEDDSESYL GHWFKETLSP ETHDDNANTS 610 620 630 640 650 660 TQERAEQKSA LVPKLDEPHE YLDLAADIFC FLDQFLANRH AYMQRYVKAG VSDQQMLLMA 670 680 690 700 710 720 NIIKDFDRDV MRNESDQGSG NAPAASAGAG TSAGASTKWQ TSMIRFSGAA GRYIHNLIST 730 740 750 760 770 780 SLLSEQLQSN LLQHLSISPW STDTNTWPLQ VYPSTLSVLV QILLLKPTQE KEAACLSVWH 790 800 810 820 830 840 RLINTLVEGV CSSNTASDSD YEDLNIEHAQ LLLFLFHSLN LMQKKSILLL TAGGVIRCAE 850 860 870 880 890 900 VCRGISEDRP VKNSQIMLLS RLLLFLEYLM KHLYNAPPEL LDQVRWNLFS VSSMPDTQKI 910 920 930 940 950 960 TDLLNCRTKL NSYCRHDIEE NFRKSAGEYG SSIRPTFYSL VMGDPEISYW AQEFKLDGLA 970 980 990 1000 1010 1020 WNFILCTPDK LKYPLLVDAL TDILSITDMS MYSKEKDKEA SMHNLCAIQY CFTIAWKLNL 1030 1040 1050 1060 1070 1080 GLPPSTSHVE SLKAERSPNL HSLMWSIRLP LASSHYLVVS SLIKQGMYTQ YAETLWTHVG 1090 1100 1110 1120 1130 1140 DIGADIKYSL KQTILGVEAF NSQMNGNGTP RLSDLILFDS LVAHMQAVAW ANKEGLKWPR 1150 1160 1170 1180 1190 1200 KESEDAAGEQ SAGTSLTSSS NDPELYSSNE SIDDQKLKQD DDGKLSSDLQ KYNQLVNELM 1210 1220 1230 1240 1250 1260 VKLMNSYQLL SVIVRGQMLK QLSSSTPEKA LNLIVPIVSD KPAIMLELHA AFLKLLPNED 1270 1280 1290 1300 1310 1320 KQLIANEWPK CLMVNDFAFN GKQHPVEPYI LNVIDAHIIE LTRGSNYSTL HTLKHCLKSI 1330 1340 1350 1360 1370 1380 LQLFELLLPH RTANAEVETQ LKQLLISSML DMRTDYLQGH SEHCLREILS GLTQEAQKLL 1390 1400 1410 1420 1430 1440 LYEHMVGYCY RMLKEFAADL RQPQSAGPSG GAPLDQDRAM FNESMLFAVL KTMFKMLEKP 1450 1460 1470 1480 1490 1500 VAVQAMRQFF KDQRSGSLTT LLLSFTGTSL PVSYARKMLQ FVNRLFQLSL QADSQFQHED 1510 1520 1530 1540 1550 1560 LVECFSELAT VDVARLKQWL GHIIYGPNVS TDVSTSEALD TTCRMLTSIL QPSSSSSSNA 1570 1580 1590 1600 1610 1620 QTPTNMATVS AMPSISDQLD PMEIEYDCGT AAGGGESNPG TGGAAANTSQ ILSLWQAAQP 1630 1640 1650 1660 1670 1680 NPSEESSQAC DHSDSERNGA LLLSFVKSLV KDQSKASQIA PPLFQALLQL GQTLISPPQE 1690 1700 1710 1720 1730 1740 GCDFADVLQI MITLADASPA RGHVALFNTT LLWLELAKLQ LPDKHLKHAE NVSAQLRYLS 1750 1760 1770 1780 1790 1800 ELLQSIGFRG SRQHNPPWDD ELQTDIDELY DELAEEGEQD SLLDDSDEDT LNNKLCTFSQ 1810 1820 1830 1840 1850 1860 TQKEFMNQHW YHCHTCNMIN TVGVCSVCAR VCHKGHDVSY AKYGNFFCDC GAKEDGSCQA 1870 1880 1890 1900 1910 1920 LSRRIGSNEV RDSAGIGSYL PSHMSLLAGK KRSSLPVGQP VLTRKDSLTN ERIAVLTKLL 1930 1940 1950 1960 1970 1980 EPYRETLQHQ DQWLLVVRCI LEYFDLLLPS INENCMLYSI VGCHKRATAA LERLHLLEQS 1990 2000 2010 2020 2030 2040 FQVTDQLMFA TLGSQEGAFE NVRMNYSGDQ GQTIKHLLSS GVVRRVAFCC LSSPHGRRQQ 2050 2060 2070 2080 2090 2100 LAVSHEKGKV TILQLSALLK QADASKRKLT LTQLSSAPIA CTVISLAANP CNEDCLAVCG 2110 2120 2130 2140 2150 2160 LKECHILTFS SSGSTNEHIV VNPQLENGNY IKKAVWLPGS QTLLAVVTSD YVKIYDLAVD 2170 2180 2190 2200 2210 2220 TYSPKYYYLV AVGKIRDCTF VYQDGNYNML TFASSGYIYT QQLDQQSLAV HGDFYVTNTL 2230 2240 2250 2260 2270 2280 ELSHQHIKDI AGHIGGGGVS IYYSHTLQLL FYSYSCGRSF FSPLTNVSEG VKGIYHLDTN 2290 2300 2310 2320 2330 2340 SASKSASKGP LQPLVQWTEV TGHPGLVYAS MQTSNNPIIL MITPERIYLQ EIKAQSAKSR 2350 2360 2370 2380 2390 2400 IMDVVGIRHA VAGVEKTTLL LLCEDGSLRI FSAQPEYTSF WLSPQVQPFG NQLYSSTLMA 2410 2420 2430 2440 2450 2460 KGGGSGSTSK SKSNTASGKM TSRKASQQQK QPTAGGQPVF PIDFFEHCNM LADVEFGGND 2470 2480 2490 2500 2510 2520 LLQIYNKQKL KTRLFSTGMF VASTRSNGFT LEVINNDPNV VIVGIRVLIG TQDVQRAPQS 2530 2540 2550 2560 2570 2580 VTILGRTIPT PVRRARWFDI PLTREEMLQS DKLLKVVFAK APDPEHVTLL DCIEVYGKSK 2590 2600 2610 2620 2630 2640 ELVGWPDESE DVTVPGSSAP AVSSSQASSA NFGEGFNCIT QLDRMANHLL EVMDCALHLL 2650 2660 2670 2680 2690 2700 GSGVPASMRQ KAVKTASALL LLPTPNPVQT QARYVLATLY GTRALYHNYK DGVLLQFVNR 2710 2720 2730 2740 2750 2760 ELQSMQPKLE KLETLREIDP EAFYRLVLMV RGIANARPQS LAKICVENNY DIVPTLMGIV 2770 2780 2790 2800 2810 2820 LELHKVTPTL DEPVNIVKRG LCQPETIVHC LVEIMYGFAL ADPGQVGRMT KYFIDLLKHD 2830 2840 2850 2860 2870 2880 ASVISHSAKE ALILLLSPRM KRRKVAIVTP PACSTPTPST STMQALQAAA SSAASDIIEE 2890 2900 2910 2920 2930 2940 AAGVVVDGSV GGGGLPEPNA DAEGAAVGVG GVGQQQMLNL EAFMGGGFPR LLGLPEDADD 2950 2960 2970 2980 2990 3000 EAIMDIAIAL SLQQHGGDAN ALQSLQQGLA NLQGIRQATA MAAAVNAAAN VSLGGSDDDE 3010 3020 3030 3040 3050 3060 GSNVATDGST LRTSPAEPAG SGGSESGGSG VESIGGTSAR SSNFGDHANA SPPRQGSTKD 3070 3080 3090 3100 3110 3120 DQEQPGPSGV AGSGGVAVLS AMSSSEDNEA NEDDKLSKLH DLRIAVLESI IQHLGTFDLC 3130 3140 3150 3160 3170 3180 NGLQAIPLIQ VILMLTTDLN GNNERDQQVL HDLLTALVDY VEIGKRGAAA RMETKCPGNE 3190 3200 3210 3220 3230 3240 VRLALLSLFG VLMGKTKSKQ TGTTSPPHQF KDNSSFVAST TANVLSKSGA FVYALEALNT 3250 3260 3270 3280 3290 3300 LLVHWKNVLG DPYAAGGGLA SQSAQASGGA SGPGVQLLKP IKHGPKPDIS ILIPHNYLKN 3310 3320 3330 3340 3350 3360 YPDIFESYDG LLTEIIVRLP YQILRLSSAH PDNYDSGFCE AMTFTLCEYM MLNLNTLLRR 3370 3380 3390 3400 3410 3420 QVRKLLMYIC GSKEKFRMYR DGHSLDAHFR VVKRVCNIVS SKTGAPYNAN PPMLSYDALV 3430 3440 3450 3460 3470 3480 ELTEHLRTCQ EISQMRTGNW QKFCVVHEDA LAMLMEIACY QLDDGVSPII IQLLQAAVCN 3490 3500 3510 3520 3530 3540 LPPPSGSKQA QPQPSTSSAS GKLRTDREKS EDTDAYYSKF DPAQCGTFVH QIFRYACDAL 3550 3560 3570 3580 3590 3600 IIRFVRIFLL ENNITQLRWQ AHSFMTGLFE HANERQREKL LNIFWNLWPL VPTYGRRTAQ 3610 3620 3630 3640 3650 3660 FVDLLGYLTL STRSITERLP EFVSRAVDVL RQQNELLCKH PNAPIYTTLE SILQVNGYYL 3670 3680 3690 3700 3710 3720 ESEPCLVCNN PEVPMANIKL PSVKSDSKYT TTTMIYKLVQ CHTISKLIVR IADLKRTKMV 3730 3740 3750 3760 3770 3780 RTINVYYNNR SVQAVVELKN RPALWHKARS VSLQSAQTEL KIDFPLPITA CNLMIEFADF 3790 3800 3810 3820 3830 3840 FETVSGSSEN LQCPRCSAAV PAYPGVCGNC GENVFQCHKC RAINYDEKDP FLCHSCGFCK 3850 3860 3870 3880 3890 3900 YAKFDFSMYA RVCCAVDPIE SAEDRVKTVS LIHSSLERAD RNYRQLLTNK QMLELLIQKV 3910 3920 3930 3940 3950 3960 AEHRSSDRMV EDNMASVHST SQVNKIIQLL AQKYCVESRT SFEELSKIVQ KVKACRSELV 3970 3980 3990 4000 4010 4020 AYDRQQQDQP PVNPGSTTGA ENPTTNRCYG CALASTEQCL TLLRAMAYNY DCRVCLYSQG 4030 4040 4050 4060 4070 4080 LVSELAEHNL RRGTPLIQEE VRNLLVVLTK DNAEACMHLL QLVTTRVKNA LMGSIPLISL 4090 4100 4110 4120 EAAVHQEMTL LEVLLGQDDI CWEYKLKVIF ELFISNCRTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways." Yager J., Richards S., Hekmat-Scafe D.S., Hurd D.D., Sundaresan V., Caprette D.R., Saxton W.M., Carlson J.R., Stern M. Proc. Natl. Acad. Sci. U.S.A. 98:10445-10450(2001) [PubMed: 11517334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"Retinal targets for calmodulin include proteins implicated in synaptic transmission." Xu X.-Z.S., Wes P.D., Chen H., Li H.-S., Yu M., Morgan S., Liu Y., Montell C. J. Biol. Chem. 273:31297-31307(1998) [PubMed: 9813038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1207-5322 (ISOFORM A), PUTATIVE FUNCTION. Tissue: Retina.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5019-5322 (ISOFORM A). Strain: Berkeley. Tissue: Embryo.
[6]	"Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis." Castrillon D.H., Gonczy P., Alexander S., Rawson R., Eberhart C.G., Viswanathan S., DiNardo S., Wasserman S.A. Genetics 135:489-505(1993) [PubMed: 8244010] [Abstract] Cited for: IDENTIFICATION, PUTATIVE FUNCTION.
[7]	"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1894, MASS SPECTROMETRY.
[8]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; THR-599; SER-600; SER-1167; SER-1168; SER-1171; SER-1894; THR-3013; SER-3014; SER-3051; SER-3057 AND SER-3510, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF096896 Genomic DNA. Translation: AAD20449.1. AF096897 mRNA. Translation: AAD20450.1. AE014134 Genomic DNA. Translation: AAF52598.1. Y17920 mRNA. Translation: CAA76940.1. AY118998 mRNA. Translation: AAM50858.1. Sequence problems.
PIR	T13719.
RefSeq	NP_476986.1. NM_057638.3.
UniGene	Dm.7936.
3D structure databases
ProteinModelPortal	Q9VLT5.
SMR	Q9VLT5. Positions 1793-1859.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VLT5. 4 interactions.
MINT	MINT-863239.
STRING	Q9VLT5.
Proteomic databases
PRIDE	Q9VLT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0079545; FBpp0079167; FBgn0011230.
GeneID	46243.
KEGG	dme:Dmel_CG14472.
Organism-specific databases
CTD	46243.
FlyBase	FBgn0011230. poe.
Phylogenomic databases
eggNOG	NOG236675.
GeneTree	ENSGT00600000084471.
InParanoid	Q9VLT5.
KO	K10691.
OMA	VISHSAK.
OrthoDB	EOG405QFW.
PhylomeDB	Q9VLT5.
Gene expression databases
Bgee	Q9VLT5.
GermOnline	CG14472. Drosophila melanogaster.
Family and domain databases
InterPro	IPR017986. WD40_repeat_dom. IPR003126. Znf_N-recognin. IPR013993. Znf_N-recognin_met. [Graphical view]
Pfam	PF02207. zf-UBR. 1 hit. [Graphical view]
SMART	SM00396. ZnF_UBR1. 1 hit. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS51157. ZF_UBR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	838806.

Entry information

Entry name

POE_DROME

Accession

Primary (citable) accession number: Q9VLT5
Secondary accession number(s): O96958 , Q8MS98, Q9XYD1, Q9XYD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	May 1, 2000
Last modified:	March 21, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project