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Protein
Submitted name:

GH19970p

Gene

SLC5A11

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adult feeding behavior Source: FlyBase
  • behavioral response to nutrient Source: FlyBase
  • transmembrane transport Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-189200. Hexose transport.
R-DME-209968. Thyroxine biosynthesis.
R-DME-428643. Organic anion transporters.
R-DME-428808. Na+-dependent glucose transporters.
R-DME-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.21.5.8. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Submitted name:
GH19970pImported
Submitted name:
Sodium/solute co-transporter-like 5A11Imported
Gene namesi
Name:SLC5A11Imported
ORF Names:CG8451Imported, Dmel_CG8451Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031998. SLC5A11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3820HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10120HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13826HelicalSequence analysisAdd
BLAST
Transmembranei158 – 18225HelicalSequence analysisAdd
BLAST
Transmembranei188 – 20720HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Transmembranei269 – 28719HelicalSequence analysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence analysisAdd
BLAST
Transmembranei368 – 39225HelicalSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Transmembranei438 – 46225HelicalSequence analysisAdd
BLAST
Transmembranei469 – 48719HelicalSequence analysisAdd
BLAST
Transmembranei537 – 55620HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

MINTiMINT-870243.
STRINGi7227.FBpp0079253.

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
OMAiAFVSVCC.
OrthoDBiEOG70PBX7.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VLR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVAKKGME NYRFGSVDYA VFLGMIVLST STGIYFGCIK KSKVKLEEAE
60 70 80 90 100
PTLPTTTPKR RKHDFGSEKM SEYLLGSRNL KVFPVAMSLI ASYISGVTIL
110 120 130 140 150
GTTSEIYNYG TQYWFIAIAI MLQGIAVSYV YIPVFSALQV GSSYEYLEMR
160 170 180 190 200
FHSVVRSIAS FMFILDEILF LPFIVYVPAI ALNQVSGINL HVIAVVIVVV
210 220 230 240 250
CVFYTFVGGI KAVVHTDAWQ VLVMFLSVLA VAILATVYAN GLNVLFDDAA
260 270 280 290 300
KGGRLIFNNT NPSPYVRHTV WSVLIGGFSY WTSFNAVNQT MVQRYMSLPS
310 320 330 340 350
LKKARASMAI FTIGVAAFVS VCCYVGLLIY EMYKDCDPLS AGLITHDDQL
360 370 380 390 400
LPLFVVQSVG HIYGMSGLFI AGIFGAALSS LSVVLNSTSL VILEDIVRGC
410 420 430 440 450
FKMQPSERAS TILVKSTVIV LGFVALSLVF VLEQLSGILS ICTSMTAIAA
460 470 480 490 500
GTTFGLFTLG MLVPWANTVG TAVGGIASAL LAGWISFGTQ FTIAAGELNS
510 520 530 540 550
QKLPVSVEGC VGNVTLRENI WVDEEQVFPL YRLSYHWINP IGVATVIVVG
560 570 580 590 600
ALVSLVTKPT NMKTLDPDLI SPVIHRFLPK ECFSGRNLHA QAHKNLLNVS
Length:600
Mass (Da):65,298
Last modified:October 1, 2002 - v2
Checksum:i1DB8690F75597A35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52616.2.
AY058420 mRNA. Translation: AAL13649.1.
RefSeqiNP_609192.1. NM_135348.3.
UniGeneiDm.349.

Genome annotation databases

EnsemblMetazoaiFBtr0079637; FBpp0079253; FBgn0031998.
GeneIDi34117.
KEGGidme:Dmel_CG8451.
UCSCiCG8451-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52616.2.
AY058420 mRNA. Translation: AAL13649.1.
RefSeqiNP_609192.1. NM_135348.3.
UniGeneiDm.349.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-870243.
STRINGi7227.FBpp0079253.

Protein family/group databases

TCDBi2.A.21.5.8. the solute:sodium symporter (sss) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079637; FBpp0079253; FBgn0031998.
GeneIDi34117.
KEGGidme:Dmel_CG8451.
UCSCiCG8451-RA. d. melanogaster.

Organism-specific databases

CTDi115584.
FlyBaseiFBgn0031998. SLC5A11.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
OMAiAFVSVCC.
OrthoDBiEOG70PBX7.

Enzyme and pathway databases

ReactomeiR-DME-189200. Hexose transport.
R-DME-209968. Thyroxine biosynthesis.
R-DME-428643. Organic anion transporters.
R-DME-428808. Na+-dependent glucose transporters.
R-DME-429593. Inositol transporters.

Miscellaneous databases

GenomeRNAii34117.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VLR8_DROME
AccessioniPrimary (citable) accession number: Q9VLR8
Secondary accession number(s): Q95TZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.